General information for g13166.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Neuropathy target esterase sws.
Parent gene
- The parent gene g13166 is located on chr_1: 28312221..28313648 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g13166 | g13166.t1 | TSS | g13166.t1 | 28307051 | 28307051 |
| chr_1 | g13166 | g13166.t1 | isoform | g13166.t1 | 28307133 | 28312221 |
| chr_1 | g13166 | g13166.t1 | exon | g13166.t1.exon1 | 28307133 | 28307231 |
| chr_1 | g13166 | g13166.t1 | cds | g13166.t1.CDS1 | 28307133 | 28307231 |
| chr_1 | g13166 | g13166.t1 | exon | g13166.t1.exon2 | 28307309 | 28307390 |
| chr_1 | g13166 | g13166.t1 | cds | g13166.t1.CDS2 | 28307309 | 28307390 |
| chr_1 | g13166 | g13166.t1 | exon | g13166.t1.exon3 | 28307525 | 28310133 |
| chr_1 | g13166 | g13166.t1 | cds | g13166.t1.CDS3 | 28307525 | 28310133 |
| chr_1 | g13166 | g13166.t1 | exon | g13166.t1.exon4 | 28310193 | 28310343 |
| chr_1 | g13166 | g13166.t1 | cds | g13166.t1.CDS4 | 28310193 | 28310343 |
| chr_1 | g13166 | g13166.t1 | exon | g13166.t1.exon5 | 28310412 | 28310474 |
| chr_1 | g13166 | g13166.t1 | cds | g13166.t1.CDS5 | 28310412 | 28310474 |
| chr_1 | g13166 | g13166.t1 | exon | g13166.t1.exon6 | 28310733 | 28310849 |
| chr_1 | g13166 | g13166.t1 | cds | g13166.t1.CDS6 | 28310733 | 28310849 |
| chr_1 | g13166 | g13166.t1 | exon | g13166.t1.exon7 | 28311527 | 28312221 |
| chr_1 | g13166 | g13166.t1 | cds | g13166.t1.CDS7 | 28311527 | 28312221 |
| chr_1 | g13166 | g13166.t1 | TTS | g13166.t1 | 28312356 | 28312356 |
Sequences
>g13166.t1 Gene=g13166 Length=3816
ATGGATATTGTAGGAATTATAAAGAAGAGCTATAGAAGTTATGGCTCACTATTTTCAGAT
GATTTCATTGCTTTTATTAAAGAATCATCGCAAAATCATATATGGATAACTATCATCGTA
ATACTGCTTACAACTTGTATTCTTATTGCTTGCTATCTTTGGAGAAAGAACCAATTGCGA
AAGCAATCAATTATCGATAGATTAACTGCTTCATTTCTTCATGATGGTCAAACGAGATTT
CGAAAGAGAGACAAGATGCTGTTTTATGGTCGTCGAATGTTGCGAAAGGTAAAGACCATC
AGTGGAACCGGTGGAGAGAAAGGGAGAAAGCGTAAGGCTGTAATGAAATTTGCAAAAAGA
CTTTTGCAACTGCAAAAAGAAAATATGCAACCGCAACTTAATGTCAAAGAACCACCAGCT
GAATATTTCGAAGAAATTACCGATAAAGCAGCTGATAAAGTGCCTATTGATGCCTATTTC
ATGCTACAATCTATTCGTATCTTTGGTCAATTTGAGAAACCAGTATTTTTACGAATCTGT
AAGCATACAGAAGTATTGAATCTTAAAGCTGGTGATTATCTTATTAAAATCGGAGATCCA
GATGATTCAGTTTTTATTGTGCAATCAGGACAAGTTAATGTTTTTCTTAACAATCATGAT
GGTTCATCAATTTCATTAAAAGTCGTAAAAAAAGGTGAAACAGTAACATCATTACTCAGT
TTCATTGACGTCATTGTAGGAAACGAAAGCTGCTACAAAACAGTCACTGCTAAAGCAATT
GAAGATAGTCAAGTTATTCGACTGCCAATGAAGGCTTTGCAAGAAGTCTTTAATGAAAAT
CCAGATATTTTAATTAGAGTTATTCAAGTAATTATGGTTAGATTACAAAGAATTACTATA
AGTGCCCTACACAATTATCTTGGATTAAATATTGAATATATATATGTTTCGCAGAAAAAG
AAACAAGTTCAAAATGCCGGTCTTTTGTCAAATATCGTAAAAGGCTATCAACATAAAAGA
CAAATGTCTGATCAATTTTCTCTTGTGATGACCCATGGTGTAATGAGTTCTGAACAAAAA
CCTGATATGATTAGTGACATTGATTTTCCTATACTTGTACCACGTAGAACCTCAACTATT
CCTCAACAACAACAACAACAACCCTCAGACATTCCAATTGACATTGAATTAATGAAAAGC
ATTGCTACTGATGGATTTTTGAAAGAACTTGGATTAAAAGATGATGATCGTGTATTAATT
GCTGATACTATAGAAATTAAAGAAATTTCACCTGGAACAACTTTAACTCATCAGGGAAGC
GATGACGATGTATTATTGATTTATATCATCACGGGTGGATTAACACTTTTCAATAATCAA
CCTTCGAAAGGTAGTAAGAAAACAGAAACACATTCCATTAACATTCATCCTGGAGAAGTT
GTTGGCGGATTAGCTGTTTTAACAGGAGAAAGTAGTTTATATACAATTAAATCAAGAGTT
TCTTCGAGAGTGGGTTTGATAACAAAAGAAAATGTTTATAAAATAATGCAACAAAAACCT
TCAATTGTTCTTGATTTAGCAAATAGTATAGTAAAAAGTCTGAGTCCTCTTGTGAGACAA
TGTGATTTTGCACTTGATTGGATATTTTTAGAATCTGGACGTGCAGTTTATCGACAAGAT
GAATTATCGGATTGTACTTATATCGTGCTTAATGGTCGTCTTAGATCTGTAATTACACAT
GAAAATGGAAAGAAAGAGATTGTTGGTGAATATGGAAAAGGAGATCTTATTGGAATAGTT
GAAATGATAACTGAATCAAATCGAACAACAACAGTGATGGCTGTTAGAGATTCAGAACTT
GCAAAATTACCTGAGGGTTTATTTAATGCTATAAAATTAAAATATCCGGTTGTTGTGACA
CAATTGATTAGTCTTTTAGGACATAGATTACTTGGCTCAATGAGAAATGCAACAATTGCT
TCAAAAAATATGCCAATCGATTCTTCACCAACAAAACATACATTTTCTACTATAGCAATA
CTCCCAGTGACTGAGGATGTTCCATTAACTGCATTCACCTATGAATTATATCATTCTTTA
TCTGCCATTTGCCCAACTGCTCGTATGACAGCAGATGTTGTACGCAAAACATTAGGAATG
AATATTATGGAATCGTCAAATGAATATCGCTTATTAAGCTACTTATCGCAACAAGAAGAT
CATAATGAAGTTACTTTATACCAATGTGAAAGTGGAACTTTGACACCTTGGACTCAACGT
TGCTTAAGACAAGCTGATGTAGTTTTAATTGTTGGTTTAGCTGATCGTCCACCAACTATT
GGAAAGCTTGAGCGAGAAATAGAAAGATTTGCTATTCGAACAGCGAAAGAATTAGTTCTA
TTACACAACGAAGCAACTAATTCTAATTTAAAACCAGTAAACACACTTCAATGGCTGAAT
CAAAGAACTTGGGTGAACAAACATCATCACATTTTGTGCCCTAAACGAATGTTTACGCGT
AAAAGTCAATATCGTGTTAATGATTTATATACAAAAGTTTTAAACTCCGAACCAAATATT
CATTCAGATTTTTCAAGACTTGCTCGATGGTTGACAGGAAATTCTGTTGGTCTTGTTTTG
GGAGGTGGTGGTGCTAGAGGTGCTGCACATGTTGGAATGCTTAAAGCAATTCAAGAAGCA
TCAATTCCTATTGATATGGTTGGTGGGGTATCAATTGGTGCTTTCATGGGGGCATTATGG
TGCTCTGAACGAAATTTAACTGTTGTCACGCAAAAGGCAAGAGAATGGTGCAAAAAGATG
ACACATTATGGACTACAACTTTTAGACTTGACATATCCAATTACGTCAATGTTTAGTGGA
AAACAGTTCAATAAAACTATTCGAGATACATTTGGCGATAATCTCAAAATTGAAGATTTG
TGGATACCATACTTCACTTTGACTACAGATATCACAGATAGTTGTTCACGAATCCACACT
CATGGTCACCTCTGGCGCTACGTTAGGGCTAGCATGAGTCTTTCAGGCTACATGCCTCCT
CTCTGTGATCCTATCGATGGTCATCATTTACTCGATGGAGGCTACTGCAACAATCTTCCC
TCTGATGTAATGCGAGCTCAAGGAGCAAATATAATTATTGCCATTGATGTAGGATCTCAA
GATGATACTGATTTGACAGATTATGGGGACGATTTGAGTGGCTGGTGGGTTTTATATAAG
CGTTATAATCCATTTACAGCACCAGTAAAAGTAATGAGTATACCAGACATACAAAGTCGA
TTAGCATATGTTTCATGTGTTCGTCAACTCGAACAAGTAAAGAACAGTGATTACTGCGAA
TATTTACGACCACCAATAGATAAATATAAAACTTTAGCATTTGGTTCATTTGATGAGATT
AAAGAAGTTGGTTATGCTTATGGTAAAGCATACTTTGAAAATATTACTAAGAATGGTGGC
ATATCTAAATTCACAAAATGGTCGTTAAAGAAAAATTCGGATGAAAGTCGTGAAACGAGT
CCGATCAACCAATCAACTTATACATTCGTTGATTTAGCACAAATTGTCTGTAAAATTCCA
GAGATATGTCAAGATAAAAATGAAGATTTATCAAGTGAAGACGATTATTTTGCCGGATAT
GCCTCTGAACCATCAACTTTAAGGTCTAGTGCAAAACCACGTCCACTCAGAACAGGCGGT
TCTTTGTCATTATCTGAAAATGAATATGAGAGTGATGACTCAATTTCAGATGCTGGTACT
TCATCACCCATAAAGAAAACAAATGGTGAAATTTAA
>g13166.t1 Gene=g13166 Length=1271
MDIVGIIKKSYRSYGSLFSDDFIAFIKESSQNHIWITIIVILLTTCILIACYLWRKNQLR
KQSIIDRLTASFLHDGQTRFRKRDKMLFYGRRMLRKVKTISGTGGEKGRKRKAVMKFAKR
LLQLQKENMQPQLNVKEPPAEYFEEITDKAADKVPIDAYFMLQSIRIFGQFEKPVFLRIC
KHTEVLNLKAGDYLIKIGDPDDSVFIVQSGQVNVFLNNHDGSSISLKVVKKGETVTSLLS
FIDVIVGNESCYKTVTAKAIEDSQVIRLPMKALQEVFNENPDILIRVIQVIMVRLQRITI
SALHNYLGLNIEYIYVSQKKKQVQNAGLLSNIVKGYQHKRQMSDQFSLVMTHGVMSSEQK
PDMISDIDFPILVPRRTSTIPQQQQQQPSDIPIDIELMKSIATDGFLKELGLKDDDRVLI
ADTIEIKEISPGTTLTHQGSDDDVLLIYIITGGLTLFNNQPSKGSKKTETHSINIHPGEV
VGGLAVLTGESSLYTIKSRVSSRVGLITKENVYKIMQQKPSIVLDLANSIVKSLSPLVRQ
CDFALDWIFLESGRAVYRQDELSDCTYIVLNGRLRSVITHENGKKEIVGEYGKGDLIGIV
EMITESNRTTTVMAVRDSELAKLPEGLFNAIKLKYPVVVTQLISLLGHRLLGSMRNATIA
SKNMPIDSSPTKHTFSTIAILPVTEDVPLTAFTYELYHSLSAICPTARMTADVVRKTLGM
NIMESSNEYRLLSYLSQQEDHNEVTLYQCESGTLTPWTQRCLRQADVVLIVGLADRPPTI
GKLEREIERFAIRTAKELVLLHNEATNSNLKPVNTLQWLNQRTWVNKHHHILCPKRMFTR
KSQYRVNDLYTKVLNSEPNIHSDFSRLARWLTGNSVGLVLGGGGARGAAHVGMLKAIQEA
SIPIDMVGGVSIGAFMGALWCSERNLTVVTQKAREWCKKMTHYGLQLLDLTYPITSMFSG
KQFNKTIRDTFGDNLKIEDLWIPYFTLTTDITDSCSRIHTHGHLWRYVRASMSLSGYMPP
LCDPIDGHHLLDGGYCNNLPSDVMRAQGANIIIAIDVGSQDDTDLTDYGDDLSGWWVLYK
RYNPFTAPVKVMSIPDIQSRLAYVSCVRQLEQVKNSDYCEYLRPPIDKYKTLAFGSFDEI
KEVGYAYGKAYFENITKNGGISKFTKWSLKKNSDESRETSPINQSTYTFVDLAQIVCKIP
EICQDKNEDLSSEDDYFAGYASEPSTLRSSAKPRPLRTGGSLSLSENEYESDDSISDAGT
SSPIKKTNGEI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 21 | g13166.t1 | CDD | cd00038 | CAP_ED | 167 | 288 | 2.32787E-20 |
| 22 | g13166.t1 | CDD | cd00038 | CAP_ED | 411 | 527 | 3.20521E-9 |
| 23 | g13166.t1 | CDD | cd00038 | CAP_ED | 532 | 643 | 4.01411E-21 |
| 20 | g13166.t1 | CDD | cd07225 | Pat_PNPLA6_PNPLA7 | 861 | 1167 | 0.0 |
| 16 | g13166.t1 | Gene3D | G3DSA:2.60.120.10 | Jelly Rolls | 158 | 304 | 3.7E-28 |
| 15 | g13166.t1 | Gene3D | G3DSA:2.60.120.10 | Jelly Rolls | 372 | 545 | 1.2E-13 |
| 14 | g13166.t1 | Gene3D | G3DSA:2.60.120.10 | Jelly Rolls | 548 | 662 | 6.7E-21 |
| 13 | g13166.t1 | Gene3D | G3DSA:3.40.1090.10 | Cytosolic phospholipase A2 catalytic domain | 860 | 986 | 7.0E-26 |
| 29 | g13166.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1224 | 1271 | - |
| 28 | g13166.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1240 | 1271 | - |
| 5 | g13166.t1 | PANTHER | PTHR14226 | NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER | 105 | 384 | 0.0 |
| 7 | g13166.t1 | PANTHER | PTHR14226:SF29 | NEUROPATHY TARGET ESTERASE SWS | 105 | 384 | 0.0 |
| 6 | g13166.t1 | PANTHER | PTHR14226 | NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER | 407 | 1215 | 0.0 |
| 8 | g13166.t1 | PANTHER | PTHR14226:SF29 | NEUROPATHY TARGET ESTERASE SWS | 407 | 1215 | 0.0 |
| 2 | g13166.t1 | Pfam | PF00027 | Cyclic nucleotide-binding domain | 187 | 280 | 1.8E-13 |
| 4 | g13166.t1 | Pfam | PF00027 | Cyclic nucleotide-binding domain | 427 | 518 | 1.3E-7 |
| 3 | g13166.t1 | Pfam | PF00027 | Cyclic nucleotide-binding domain | 550 | 631 | 2.3E-15 |
| 1 | g13166.t1 | Pfam | PF01734 | Patatin-like phospholipase | 878 | 1043 | 5.5E-19 |
| 18 | g13166.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 33 | - |
| 19 | g13166.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 34 | 54 | - |
| 17 | g13166.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 55 | 1271 | - |
| 27 | g13166.t1 | ProSitePatterns | PS01237 | Uncharacterized protein family UPF0028 signature. | 881 | 913 | - |
| 32 | g13166.t1 | ProSiteProfiles | PS50042 | cAMP/cGMP binding motif profile. | 167 | 294 | 14.754 |
| 30 | g13166.t1 | ProSiteProfiles | PS50042 | cAMP/cGMP binding motif profile. | 411 | 516 | 8.43 |
| 31 | g13166.t1 | ProSiteProfiles | PS50042 | cAMP/cGMP binding motif profile. | 522 | 631 | 15.879 |
| 33 | g13166.t1 | ProSiteProfiles | PS51635 | Patatin-like phospholipase (PNPLA) domain profile. | 878 | 1045 | 40.49 |
| 25 | g13166.t1 | SMART | SM00100 | cnmp_10 | 167 | 292 | 1.1E-11 |
| 26 | g13166.t1 | SMART | SM00100 | cnmp_10 | 522 | 647 | 9.2E-5 |
| 12 | g13166.t1 | SUPERFAMILY | SSF51206 | cAMP-binding domain-like | 161 | 298 | 1.7E-24 |
| 10 | g13166.t1 | SUPERFAMILY | SSF51206 | cAMP-binding domain-like | 406 | 527 | 2.49E-11 |
| 11 | g13166.t1 | SUPERFAMILY | SSF51206 | cAMP-binding domain-like | 545 | 655 | 7.73E-22 |
| 9 | g13166.t1 | SUPERFAMILY | SSF52151 | FabD/lysophospholipase-like | 872 | 1159 | 3.14E-56 |
| 24 | g13166.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 32 | 54 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004622 | lysophospholipase activity | MF |
| GO:0046470 | phosphatidylcholine metabolic process | BP |
| GO:0006629 | lipid metabolic process | BP |
KEGG
Orthology
- This transcript has been annotated with K14676 (lysophospholipid hydrolase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
