General information for g13597.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Membrane alanyl aminopeptidase.
Parent gene
- The parent gene g13597 is located on chr_1: 31146756..31149715 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g13597 | g13597.t1 | TTS | g13597.t1 | 31146454 | 31146454 |
| chr_1 | g13597 | g13597.t1 | isoform | g13597.t1 | 31146756 | 31149715 |
| chr_1 | g13597 | g13597.t1 | exon | g13597.t1.exon1 | 31146756 | 31147083 |
| chr_1 | g13597 | g13597.t1 | cds | g13597.t1.CDS1 | 31146756 | 31147083 |
| chr_1 | g13597 | g13597.t1 | exon | g13597.t1.exon2 | 31147305 | 31149715 |
| chr_1 | g13597 | g13597.t1 | cds | g13597.t1.CDS2 | 31147305 | 31149715 |
| chr_1 | g13597 | g13597.t1 | TSS | g13597.t1 | 31149728 | 31149728 |
Sequences
>g13597.t1 Gene=g13597 Length=2739
ATGTCGTGGTTTCAAGTCTTTTTTGTGTTTTTCTTAGGTTCTTCAATCAATTGCATTGAA
AATTTAATTAATTATCGCTTACCAAATGACACTTTTCCTTTAAGTTACGATTTATCATTA
ACAAATTACATTCATGAAAGCAATTTCACATTTAATGGAAATGTAAAAATTCATATTAAA
ATAAAAGAAGAAACACAAACTGTTACACTGCATCGACGTGACATTATTATTGATTCTATA
GATTTGTATGATGGAAATGATATTTTAAAATTGTCTAACTTGCAGTTTGAGTACCTTGAG
GAGTTTGATTTTATCAGAGTAAATTTAGAAACACCTCAAAATAAAGACAGTGAAATTTTC
CTTGATTTTACCTTTAATGGACTGCTAGAAGAAGAAGCAAGTGGATTTTTCAAAACTCCT
TTCATAAATAGTGACTTCAGACAAGAATGGATGGCATTGACAAAATTTGAGTCAATAAAT
GCTAGAAAAGTTTTTGTCTGTTATGATGAACCGCAAATAAAAGCGCCATTTAGAGTTAGA
ATTAGACACGATAAAAATTATCACGCAATATCAAACATGCCAATCGATCGAGTCATCACT
AATGACAATATTTACGTCACAACTGTATTTCAAGAAACTCCAAAAATTCAAACTTATGCT
TTAGCTTTTGTCATTTCAAAGCTTGGTTTTATTGGAAATAATCAGAGTGAAATTGAACAA
AGAATTTTTGGTGATCCTGAGAAAATTCAAAAAGGTTTTGGAAATTTTTCTTTGAAAGTT
GTTGAAAATATTGTTAAGAAATTTAAAGAAATATTTTCAAAGTCAATTCCAATTCCAAAG
CTCGATCATATTGGAATTCCAATGATAAGTGGTGCAAGTGAGCATTATGGACTGATAACT
TATGAAGAAAATTTTCTACTCATTGATGAAAACTTTGATCAGAAAGTCCTTGATTATTTT
CAACCAATAATTATCTCAGTTATTGCTCATGAAATTTCTCATCAATATTTTGGAAACATT
GTGACTCACAGTTGGTGGAATGAACTTTGGTTGACAGAAGGTTTTGCAACTTTTTATCAA
TATTATTTGCCTAGTTTGATTTTTCCGAAATATAATTTTATGGACAAATTTAGAAATGAA
GTTTTAACTTATGCTTTTGACATTGACAGTGATAATGAAATTTCCATGAGTGAATATGTC
GAAAGTCCTTTAGAAATTCAAATGAAATATCATAATGTTGTGTTCGAAAAAGCTGCGGCA
GTTTTAAGAATGTTTTTCATTGCATTTGAAAGTGAAGTTTTCACAAATGGAGTTAAGAAG
TATTTAAATGATAATAAAGACGGTGTTGTGACATCAAATGACTTTTATAAAGCACTTCAA
AGTTCTTATAATGATAAGAATCCAGGAAGTCAACTTGATATCGAGACAATTTTTCAATCA
TGGTCAAATCAAGCTGGGTTTCCAATAATTCATGCAAGAAAAGTAAACAGTTCTGTAATT
TTAACTCAAAATAAATTCAATGATGAAAATTCTTCAAATATTTATAAAATTCCAATAACA
TTTGTCACAAAATCAAAACCATTAACTTCAAAACAGCTTTGGATGACATCACAAACTATG
ATAATTGACAACATTTTGACGTCAGATGATTGGATTATCTTTAATATTCAACAAGTTGGT
TTTTATCGAGTAAATTACAGTCGAGATCTTTGGCAATTAATCATAAATGGATATTCAAAT
GAAATTCACGCAATTAATCGAGAAGTTTTACATGAAGAAATGGAAATTGCATGGCAAAAG
TTGAAAACTTTAAAAATATGTGACTGTTTGCAATTCATGAATGTATTAAAGTATGAAAAG
GATGGAAATGTTTGGGAAAAAGCTGAATATATTGAAAAATTGGATAAATTTTTGCAATTT
AGTGATTTTTATCCACAGTTTAAAGATTTATTGAGTAAAATTGTTGAACCACATTTGAAT
ATTCTAAATGAACCAAAAGTGGATGAAAAGTTTAATCATCTAATTACAAGATGGAGCAAA
GTTGCACAAAATCAAGATTATTTACAGTTTGAATTTGATAAATTACTAAAATTCATGACA
ACAGAAGACGAAAGATACAAGCCAGATTTTTGTTCTGCTTTTAGAGTTGTAAATTCGTCA
ATTTATGAACATTTTATTGAAAAAGTTTTGCATTTTGATGAATTAATCGATCTTGATCTT
GTTTTTGGACTTGGTTGTTCATTAAATAAAAATCAATTGAAAAATTTATACAGAAAAATT
ACTGATCCTTCAAATAATGTTGCTGAATGGATGATTACTGAAATTTTAAGAACATCAATT
GAAGGAAGTGAAATTGGATTGGAAAGTGTTATGGAATTCATACAAGGAAATCTTTGTGAA
TTTAATAAATTATCAGAACACTTCATTGAAGATATAATAATTTTCATGCATCATTACATA
AATTCTGAAAATCATTTAAAGAAATTTAAAATACTATCCCAAGTTTTAAGTGTGACGAAA
ATAGTTCCTCAAAGTTTAATCAATTCAATGATAGAGAGCATAGGAATGAAACTGCAAGCA
AGTGAATGGAAAGAATTAAAAATTTGTATGACAAGAGAACAAACATCTTCAACATATCAA
GCGGAATCAACAACACAAGGAGCTTCTTCAATAAATTTAATGCAAAATAAATTATTTTAT
TTGATGTTTTACCTTCTTTTATTGTTTTGTAAAAATTAA
>g13597.t1 Gene=g13597 Length=912
MSWFQVFFVFFLGSSINCIENLINYRLPNDTFPLSYDLSLTNYIHESNFTFNGNVKIHIK
IKEETQTVTLHRRDIIIDSIDLYDGNDILKLSNLQFEYLEEFDFIRVNLETPQNKDSEIF
LDFTFNGLLEEEASGFFKTPFINSDFRQEWMALTKFESINARKVFVCYDEPQIKAPFRVR
IRHDKNYHAISNMPIDRVITNDNIYVTTVFQETPKIQTYALAFVISKLGFIGNNQSEIEQ
RIFGDPEKIQKGFGNFSLKVVENIVKKFKEIFSKSIPIPKLDHIGIPMISGASEHYGLIT
YEENFLLIDENFDQKVLDYFQPIIISVIAHEISHQYFGNIVTHSWWNELWLTEGFATFYQ
YYLPSLIFPKYNFMDKFRNEVLTYAFDIDSDNEISMSEYVESPLEIQMKYHNVVFEKAAA
VLRMFFIAFESEVFTNGVKKYLNDNKDGVVTSNDFYKALQSSYNDKNPGSQLDIETIFQS
WSNQAGFPIIHARKVNSSVILTQNKFNDENSSNIYKIPITFVTKSKPLTSKQLWMTSQTM
IIDNILTSDDWIIFNIQQVGFYRVNYSRDLWQLIINGYSNEIHAINREVLHEEMEIAWQK
LKTLKICDCLQFMNVLKYEKDGNVWEKAEYIEKLDKFLQFSDFYPQFKDLLSKIVEPHLN
ILNEPKVDEKFNHLITRWSKVAQNQDYLQFEFDKLLKFMTTEDERYKPDFCSAFRVVNSS
IYEHFIEKVLHFDELIDLDLVFGLGCSLNKNQLKNLYRKITDPSNNVAEWMITEILRTSI
EGSEIGLESVMEFIQGNLCEFNKLSEHFIEDIIIFMHHYINSENHLKKFKILSQVLSVTK
IVPQSLINSMIESIGMKLQASEWKELKICMTREQTSSTYQAESTTQGASSINLMQNKLFY
LMFYLLLLFCKN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 24 | g13597.t1 | CDD | cd09601 | M1_APN-Q_like | 34 | 481 | 2.74818E-135 |
| 15 | g13597.t1 | Gene3D | G3DSA:2.60.40.1730 | tricorn interacting facor f3 domain | 22 | 227 | 7.7E-55 |
| 16 | g13597.t1 | Gene3D | G3DSA:1.10.390.60 | - | 231 | 486 | 1.3E-62 |
| 14 | g13597.t1 | Gene3D | G3DSA:2.60.40.1910 | - | 487 | 566 | 1.8E-16 |
| 4 | g13597.t1 | PANTHER | PTHR11533:SF283 | AMINOPEPTIDASE | 24 | 886 | 3.6E-149 |
| 5 | g13597.t1 | PANTHER | PTHR11533 | PROTEASE M1 ZINC METALLOPROTEASE | 24 | 886 | 3.6E-149 |
| 10 | g13597.t1 | PRINTS | PR00756 | Membrane alanyl dipeptidase (M1) family signature | 162 | 177 | 1.8E-21 |
| 7 | g13597.t1 | PRINTS | PR00756 | Membrane alanyl dipeptidase (M1) family signature | 210 | 225 | 1.8E-21 |
| 6 | g13597.t1 | PRINTS | PR00756 | Membrane alanyl dipeptidase (M1) family signature | 288 | 298 | 1.8E-21 |
| 8 | g13597.t1 | PRINTS | PR00756 | Membrane alanyl dipeptidase (M1) family signature | 327 | 342 | 1.8E-21 |
| 9 | g13597.t1 | PRINTS | PR00756 | Membrane alanyl dipeptidase (M1) family signature | 346 | 358 | 1.8E-21 |
| 3 | g13597.t1 | Pfam | PF17900 | Peptidase M1 N-terminal domain | 32 | 219 | 3.3E-38 |
| 2 | g13597.t1 | Pfam | PF01433 | Peptidase family M1 domain | 256 | 481 | 6.1E-43 |
| 1 | g13597.t1 | Pfam | PF11838 | ERAP1-like C-terminal domain | 551 | 830 | 8.2E-14 |
| 19 | g13597.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 18 | - |
| 20 | g13597.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 2 | - |
| 21 | g13597.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 3 | 13 | - |
| 23 | g13597.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 14 | 18 | - |
| 18 | g13597.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 19 | 892 | - |
| 22 | g13597.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 893 | 910 | - |
| 17 | g13597.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 911 | 912 | - |
| 25 | g13597.t1 | ProSitePatterns | PS00018 | EF-hand calcium-binding domain. | 387 | 399 | - |
| 12 | g13597.t1 | SUPERFAMILY | SSF63737 | Leukotriene A4 hydrolase N-terminal domain | 21 | 226 | 1.7E-41 |
| 11 | g13597.t1 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 236 | 491 | 1.14E-52 |
| 13 | g13597.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 18 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008237 | metallopeptidase activity | MF |
| GO:0006508 | proteolysis | BP |
| GO:0008270 | zinc ion binding | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed