Gene loci information

Transcript annotation

  • This transcript has been annotated as Disks large 1 tumor suppressor protein.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g13718 g13718.t15 isoform g13718.t15 32018594 32025763
chr_1 g13718 g13718.t15 exon g13718.t15.exon1 32018594 32018752
chr_1 g13718 g13718.t15 cds g13718.t15.CDS1 32018648 32018752
chr_1 g13718 g13718.t15 exon g13718.t15.exon2 32019009 32019114
chr_1 g13718 g13718.t15 cds g13718.t15.CDS2 32019009 32019114
chr_1 g13718 g13718.t15 exon g13718.t15.exon3 32019764 32019808
chr_1 g13718 g13718.t15 cds g13718.t15.CDS3 32019764 32019808
chr_1 g13718 g13718.t15 exon g13718.t15.exon4 32024517 32024666
chr_1 g13718 g13718.t15 cds g13718.t15.CDS4 32024517 32024666
chr_1 g13718 g13718.t15 exon g13718.t15.exon5 32024727 32024899
chr_1 g13718 g13718.t15 cds g13718.t15.CDS5 32024727 32024899
chr_1 g13718 g13718.t15 exon g13718.t15.exon6 32024959 32025071
chr_1 g13718 g13718.t15 cds g13718.t15.CDS6 32024959 32025071
chr_1 g13718 g13718.t15 exon g13718.t15.exon7 32025132 32025223
chr_1 g13718 g13718.t15 cds g13718.t15.CDS7 32025132 32025223
chr_1 g13718 g13718.t15 exon g13718.t15.exon8 32025283 32025763
chr_1 g13718 g13718.t15 cds g13718.t15.CDS8 32025283 32025389
chr_1 g13718 g13718.t15 TTS g13718.t15 32025764 32025764
chr_1 g13718 g13718.t15 TSS g13718.t15 NA NA

Sequences

>g13718.t15 Gene=g13718 Length=1319
GATGATGAGTGGTGGCAAGCGAGACGCGTCATTGGAGATGGTGAAGAAGATAATATGGGT
ATTGTGCCATCAAAAAGACGCTGGGAGAGAAAACAAAGAGCGAGGGATCGTAGTGTTAAA
TTTCAAGGATACCAAGCACCCGCAAATGTTGCAGAAAAGACGTCAACATTGGACCGAAAA
AAGAAAAATTTCTCATTTAGTCGAAGATTCCCGTTCATGAAGAGTCGTGAAGATGGCAAG
AACGAGGATGGATCAGATCAAGAACCTTTTATGCTATGCTACACACAAGATGATGCCAAT
AATGCTGAAGTATCGGAGGAAAATGTTCTCTCATATGAATCAGTTCAAAGATTGCAAATC
AATTACACACGCCCTGTCATCATTTTGGGTCCATTAAAAGACCGCATCAATGACGATTTG
ATATCAGAATATCCCGACAAATTTGGCAGCTGTGTGCCACATACCACAAGACCGAAACGT
GATTATGAAGTTGACGGTCGAGATTATCATTTCGTTGCATCACGAGAGCAAATGGAACGT
GACATTCAAAATCATCTATTTATCGAAGCAGGACAGTATAATGAAAATCTTTATGGTACT
TCTGTTGCATCTGTACGAGAAGTCGCTGAAAAGCAAGGAAAACATTGCATTTTAGATGTA
TCGGGCAATGCCATTAAGCGACTCCAAGTAGCTCAATTATATCCAATTGCTATTTTTATT
AAGCCAAAATCTGTTGAATCCATTATGGAAATGAATCGTCGAATGACAGAAGAGCAAGCA
AAGAAGACATTTGAACGTGCTCTGAAAATGGAACAAGAATTTGGAGAATATTTCACTGGT
GTCGTACAAGGCGATACGATTGAGGAAATTTATAACAAAACAAAGCAAATGATTTGGGCG
CAATCAGGCAAGGAAATATGGGTGCCGTCGAAAGAATCTCTATGACAGCCTAGTACCACC
ACCTGGACACTACCACCGCGTTTTTCAGCGAGACCCGTTTCGCGAAATCAACAATATCAT
TAAATTAAATTAATTTTTTTAAAACAAAAAAAAGAGAATGGAAAACTATTAACATCGTTT
TTGTAACATAAAAAATTACATATAATCCAATCTTATCTCTCGTCAATATTTTACGTTCTA
ATCATACATATGGTTACGAAAACAATCCATAACTCCATTTAGACGAAACTTACGACATTT
ATATATAAATTCATTTACCTTCTTCCTTTTTATAATTTTTTTTTTTTCTTAATTTTTAAA
ATATTTACCGTAACAAAATTAACATGATGATCAATAAATAAATTGTATTATTTAGACAA

>g13718.t15 Gene=g13718 Length=296
MGIVPSKRRWERKQRARDRSVKFQGYQAPANVAEKTSTLDRKKKNFSFSRRFPFMKSRED
GKNEDGSDQEPFMLCYTQDDANNAEVSEENVLSYESVQRLQINYTRPVIILGPLKDRIND
DLISEYPDKFGSCVPHTTRPKRDYEVDGRDYHFVASREQMERDIQNHLFIEAGQYNENLY
GTSVASVREVAEKQGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSVESIMEMNRRMTEE
QAKKTFERALKMEQEFGEYFTGVVQGDTIEEIYNKTKQMIWAQSGKEIWVPSKESL

Protein features from InterProScan

Transcript Database ID Name Start End E.value
8 g13718.t15 CDD cd00071 GMPK 107 224 2.59661E-29
7 g13718.t15 Gene3D G3DSA:2.30.30.40 SH3 Domains 85 291 1.6E-89
5 g13718.t15 Gene3D G3DSA:3.40.50.300 - 103 285 1.6E-89
6 g13718.t15 Gene3D G3DSA:3.30.63.10 Guanylate Kinase phosphate binding domain 134 195 1.6E-89
11 g13718.t15 MobiDBLite mobidb-lite consensus disorder prediction 1 20 -
12 g13718.t15 MobiDBLite mobidb-lite consensus disorder prediction 1 24 -
2 g13718.t15 PANTHER PTHR23122:SF72 DISKS LARGE 1 TUMOR SUPPRESSOR PROTEIN-LIKE PROTEIN 1 295 3.1E-144
3 g13718.t15 PANTHER PTHR23122 MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK 1 295 3.1E-144
1 g13718.t15 Pfam PF00625 Guanylate kinase 105 282 3.6E-67
9 g13718.t15 ProSitePatterns PS00856 Guanylate kinase-like signature. 137 154 -
13 g13718.t15 ProSiteProfiles PS50052 Guanylate kinase-like domain profile. 105 281 43.158
10 g13718.t15 SMART SM00072 gk_7 104 284 5.2E-75
4 g13718.t15 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases 103 293 1.71E-56

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

There are no GO annotations for this transcript.

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values