Gene loci information

Transcript annotation

  • This transcript has been annotated as Disks large 1 tumor suppressor protein.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_1 g13718 g13718.t5 isoform g13718.t5 32010933 32018752
chr_1 g13718 g13718.t5 exon g13718.t5.exon1 32010933 32011097
chr_1 g13718 g13718.t5 TSS g13718.t5 32010936 32010936
chr_1 g13718 g13718.t5 exon g13718.t5.exon2 32012943 32013211
chr_1 g13718 g13718.t5 cds g13718.t5.CDS1 32013125 32013211
chr_1 g13718 g13718.t5 exon g13718.t5.exon3 32016441 32016464
chr_1 g13718 g13718.t5 cds g13718.t5.CDS2 32016441 32016464
chr_1 g13718 g13718.t5 exon g13718.t5.exon4 32016531 32016592
chr_1 g13718 g13718.t5 cds g13718.t5.CDS3 32016531 32016592
chr_1 g13718 g13718.t5 exon g13718.t5.exon5 32016657 32016870
chr_1 g13718 g13718.t5 cds g13718.t5.CDS4 32016657 32016870
chr_1 g13718 g13718.t5 exon g13718.t5.exon6 32016937 32017011
chr_1 g13718 g13718.t5 cds g13718.t5.CDS5 32016937 32017011
chr_1 g13718 g13718.t5 exon g13718.t5.exon7 32017078 32017526
chr_1 g13718 g13718.t5 cds g13718.t5.CDS6 32017078 32017526
chr_1 g13718 g13718.t5 exon g13718.t5.exon8 32017759 32017813
chr_1 g13718 g13718.t5 cds g13718.t5.CDS7 32017759 32017813
chr_1 g13718 g13718.t5 exon g13718.t5.exon9 32017874 32017903
chr_1 g13718 g13718.t5 cds g13718.t5.CDS8 32017874 32017903
chr_1 g13718 g13718.t5 exon g13718.t5.exon10 32018198 32018752
chr_1 g13718 g13718.t5 cds g13718.t5.CDS9 32018198 32018752
chr_1 g13718 g13718.t5 TTS g13718.t5 32019024 32019024

Sequences

>g13718.t5 Gene=g13718 Length=1898
GTACAGTATTTTCTGACGATTTTATTGCAAGAGGTTTCGTTTAATTTAGTTTTGTGGTTT
TATTTAAATTTTAATATGTTAATAAGATGTTTTAATTGTTAAAAAGTGCCTTAAACCATT
ATCGGAAATTCTAAGAAGTGCTTATTCTTTTTAGTTTATTAAAAGGCACAATACCATAAA
ATGTTATATAAATAAAAAGAAAAGTGTGAAAATTTTTGTTGAAAAAAATTGAACTTGACA
TTTACATTAAAGAACGAATCAAAAAATAATTAATCAAATTGATTGGATTTTATCTCTATT
AACAACTATAACTTTGATACTAAGCTAATAATATATAATAAAAAAGTATGACGACACGAA
AGAAGAATAAAAATCAACAGAAGGAGACTGGTGGATTTATAAAAAAGGTTTCATCATTAT
TTAATTTAGATACGGCATCAGCAGGAACGGATGCAAAAGTCAATGGAGATGATCAATGGG
TGCATGAGGAAATCGCTTTATCACGAGGCTCAAGTGGACTCGGATTCAGTATAGCAGGAG
GCACTGATAATCCACACATCGGGACTGATACATCAATTTATATCACAAAAATAATTCCCG
GTGGAGCCGCATATTCAGACGGTCGTATTCAAGTAAATGACATTATTGTATCAGTCAATG
ATGTATCAGTTGTTGATGTTACGCATGCACTTGCTGTTGAAGCGCTTAAAAGTGCTGGTG
ATAGAGTCAAATTGAATGTTAAAAGAAAACGTCCACCAGCCGTTCCACAAACTGCTGAAA
TCGATCTCGTAAAGGGTGACAAAACATTGGGTTTTAGTATAGCAGGAGGCATAGGAAATC
AACATATTCCAGGTGATAATGGAATTTATGTTACAAAAATAATGGATGGTGGAGCAGCAG
CAGTTGATGGTCGACTAAGTATTGGCGACAAATTGCTCAATGTTAAAACAAAGACGATGA
ACAAAAATTTAGAGAATGTTTCACACGAAGATGCTGTTGCAACGCTTAAAGCAATTACTG
ATCGTGTGGTTTTAACAGTACAGAAAGCTCAACATGTTGTTCATAGCACATCATACCTTA
ATCAAAACAATTCACAATCAATGAATGCAATGAATAATATTAGTACCACAGGTTTAGACC
TTAATGATAGCGGAAGAACTCATTCACCTCTGCCCGTCTTGGAAAATTCATCATCGCGAC
ATGCATCTACAAATGTTTTGGCAACGCCGCGTGCCGTCAGTCATGAAGATATCACAAGAG
AACCGCGAACTATAGTGATTCATAAAGGCAAGACGGCATCAAAAGCTTTAGGCTTGAATA
TTGTCGGCGGCGAAGATGGCCAGGGAATTTATGTATCATTTATACTGGCTGGTGGTCCTG
CTGATCTTAGTGGTGACTTGAAACGTGGCGATCAATTGCTATCGGTTAATGGTATTAATT
TGCGAAATGCAACGCATGAAGAAGCAGCGGCTGCACTTAAAAATTCTGGTGATACAGTTA
CACTCGTGGCTCAATATCGACCCGAAGACTATAATCGATTTGAGGCACGAATTCATGAAT
TAAAGCAGCAAGCGGCAGCAGCTGTACAATCTGGCACAGGAACACTCTTGCGTACATCAC
AAAAACGTTCACTCTATGTGAGAGCTTTGTTCGACTATGATCCAAATCGAGATGACGGAT
TACCAACACGTGGTCTGCCATTTAAGCATGGCGATATTTTACATGTAACGAATGCATCCG
ATGATGAGTGGTGGCAAGCGAGACGCGTCATTGGAGATGGTGAAGAAGATAATATGGGTA
TTGTGCCATCAAAAAGACGCTGGGAGAGAAAACAAAGAGCGAGGGATCGTAGTGTTAAAT
TTCAAGGATACCAAGCACCCGCAAATGTTGCAGAAAAG

>g13718.t5 Gene=g13718 Length=517
MTTRKKNKNQQKETGGFIKKVSSLFNLDTASAGTDAKVNGDDQWVHEEIALSRGSSGLGF
SIAGGTDNPHIGTDTSIYITKIIPGGAAYSDGRIQVNDIIVSVNDVSVVDVTHALAVEAL
KSAGDRVKLNVKRKRPPAVPQTAEIDLVKGDKTLGFSIAGGIGNQHIPGDNGIYVTKIMD
GGAAAVDGRLSIGDKLLNVKTKTMNKNLENVSHEDAVATLKAITDRVVLTVQKAQHVVHS
TSYLNQNNSQSMNAMNNISTTGLDLNDSGRTHSPLPVLENSSSRHASTNVLATPRAVSHE
DITREPRTIVIHKGKTASKALGLNIVGGEDGQGIYVSFILAGGPADLSGDLKRGDQLLSV
NGINLRNATHEEAAAALKNSGDTVTLVAQYRPEDYNRFEARIHELKQQAAAAVQSGTGTL
LRTSQKRSLYVRALFDYDPNRDDGLPTRGLPFKHGDILHVTNASDDEWWQARRVIGDGEE
DNMGIVPSKRRWERKQRARDRSVKFQGYQAPANVAEK

Protein features from InterProScan

Transcript Database ID Name Start End E.value
18 g13718.t5 CDD cd00992 PDZ_signaling 48 132 1.3585E-11
19 g13718.t5 CDD cd00992 PDZ_signaling 144 232 1.91395E-15
17 g13718.t5 CDD cd00992 PDZ_signaling 306 387 9.19986E-24
16 g13718.t5 CDD cd11861 SH3_DLG-like 430 490 1.25789E-39
15 g13718.t5 Coils Coil Coil 395 415 -
14 g13718.t5 Gene3D G3DSA:2.30.42.10 - 30 138 6.1E-32
13 g13718.t5 Gene3D G3DSA:2.30.42.10 - 141 244 2.6E-27
12 g13718.t5 Gene3D G3DSA:2.30.42.10 - 303 421 1.5E-36
11 g13718.t5 Gene3D G3DSA:2.30.30.40 SH3 Domains 422 515 3.9E-34
24 g13718.t5 MobiDBLite mobidb-lite consensus disorder prediction 491 517 -
5 g13718.t5 PANTHER PTHR23119 DISCS LARGE 28 507 2.5E-183
6 g13718.t5 PANTHER PTHR23119:SF5 DISKS LARGE HOMOLOG 1 28 507 2.5E-183
4 g13718.t5 Pfam PF00595 PDZ domain 49 131 1.7E-21
2 g13718.t5 Pfam PF00595 PDZ domain 145 232 3.3E-16
3 g13718.t5 Pfam PF00595 PDZ domain 317 388 2.0E-19
1 g13718.t5 Pfam PF00018 SH3 domain 432 488 1.8E-8
28 g13718.t5 ProSiteProfiles PS50106 PDZ domain profile. 48 135 22.898
26 g13718.t5 ProSiteProfiles PS50106 PDZ domain profile. 144 235 21.129
27 g13718.t5 ProSiteProfiles PS50106 PDZ domain profile. 308 392 23.139
25 g13718.t5 ProSiteProfiles PS50002 Src homology 3 (SH3) domain profile. 426 496 18.476
20 g13718.t5 SMART SM00228 pdz_new 56 135 1.8E-23
22 g13718.t5 SMART SM00228 pdz_new 152 235 2.3E-15
21 g13718.t5 SMART SM00228 pdz_new 319 392 9.1E-23
23 g13718.t5 SMART SM00326 SH3_2 429 495 5.4E-6
9 g13718.t5 SUPERFAMILY SSF50156 PDZ domain-like 41 136 2.1E-27
8 g13718.t5 SUPERFAMILY SSF50156 PDZ domain-like 138 236 6.97E-21
7 g13718.t5 SUPERFAMILY SSF50156 PDZ domain-like 295 398 4.47E-31
10 g13718.t5 SUPERFAMILY SSF50044 SH3-domain 423 508 7.61E-25

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0005515 protein binding MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values