General information for g14174.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Uroporphyrinogen decarboxylase.
Parent gene
- The parent gene g14174 is located on chr_1: 35236950..35240093 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g14174 | g14174.t1 | TSS | g14174.t1 | 35236699 | 35236699 |
| chr_1 | g14174 | g14174.t1 | isoform | g14174.t1 | 35236794 | 35238042 |
| chr_1 | g14174 | g14174.t1 | exon | g14174.t1.exon1 | 35236794 | 35236811 |
| chr_1 | g14174 | g14174.t1 | cds | g14174.t1.CDS1 | 35236794 | 35236811 |
| chr_1 | g14174 | g14174.t1 | exon | g14174.t1.exon2 | 35236981 | 35238042 |
| chr_1 | g14174 | g14174.t1 | cds | g14174.t1.CDS2 | 35236981 | 35238042 |
| chr_1 | g14174 | g14174.t1 | TTS | g14174.t1 | 35238155 | 35238155 |
Sequences
>g14174.t1 Gene=g14174 Length=1080
ATGCAATATCAACCGAAGAACTTTCCTGTGCTCAAAAATGACAATCTATTGCGTGCGGCT
CGTGGTGATAAAGTTGATCGAGTGCCGGTTTGGGTGATGAGACAAGCTGGAAGATATCTA
CCTGAATTTCGTGAAGTTCGCGCTGAAAGTGATTTCTTCAAAGTCTGTCGTACACCTGAA
CTTGCTGTTGAAGTCACTATGCAACCTATTCGACGATTCGATCTTGATGCATCGATTATC
TTTTCTGATATTCTCGTCATTCCACAAGCTCTTGGTATGGAAGTTGAAATGAGACCAGGT
CACGGACCGGTTTTTCCTGAGCCATTGCAAGATATTAAAGATGTGTCACGATTGAATGCT
GATGGCGCTATCGATAGATTAAAATACGTTGGTGATGCAATTACACTCATGAGACATACA
CTCGAAGGAAAAGTTCCACTCTTTGGATTTACTGGTGCTCCATGGACACTTATGGGTTAC
ATGATTGAAGGAGGTGGCAGCAAAACAATGTCAAAGGCTCGTAGTTGGCTTAAAGATCAT
TCCGAAGAATCTCGCAATCTTCTTTCTCTTCTCACTGATGTTATTGTTGATTATTTAGTG
ATGCAAGTGAAAGCTGGTGCACAAATTTTACAAGTGTTCGAATCAAGTGCTGAATATATC
AGCAAAGAAGAATTTATTGAATTTGCACTGCCATACCTAAAAGAAATTCGAATTAAAACA
CAAGAGAAACTCAATAAACAAGACATTGAGCTCGTTCCAATGGTTGTATTTGCAAAAGGT
GCCATGCATTCACTAGCTGAAATGTCTGATTTGGGATACGATGTCATCGGACTTGACTGG
ACAGTTGATCCTGAAGAAGCAAGAAAAATTGTTGGACCAAATGTCACACTTCAAGGAAAT
TTGAATCCACAAGATCTTTATAAATCGCAAGAGGAAATTCGTGAATTGACAAGAACTATG
GTGAGAAAGTTTGGAAAAGATCGTTACATTGCTAATCTTGGACATGGAATTACGCCTCAA
ACACCAATTGAGAGCATGACAACTTTTGTTGATACCGTTCATTCCGCTTTTGACGATTAA
>g14174.t1 Gene=g14174 Length=359
MQYQPKNFPVLKNDNLLRAARGDKVDRVPVWVMRQAGRYLPEFREVRAESDFFKVCRTPE
LAVEVTMQPIRRFDLDASIIFSDILVIPQALGMEVEMRPGHGPVFPEPLQDIKDVSRLNA
DGAIDRLKYVGDAITLMRHTLEGKVPLFGFTGAPWTLMGYMIEGGGSKTMSKARSWLKDH
SEESRNLLSLLTDVIVDYLVMQVKAGAQILQVFESSAEYISKEEFIEFALPYLKEIRIKT
QEKLNKQDIELVPMVVFAKGAMHSLAEMSDLGYDVIGLDWTVDPEEARKIVGPNVTLQGN
LNPQDLYKSQEEIRELTRTMVRKFGKDRYIANLGHGITPQTPIESMTTFVDTVHSAFDD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g14174.t1 | CDD | cd00717 | URO-D | 17 | 355 | 0.0 |
| 6 | g14174.t1 | Gene3D | G3DSA:3.20.20.210 | - | 1 | 358 | 1.8E-156 |
| 4 | g14174.t1 | Hamap | MF_00218 | Uroporphyrinogen decarboxylase [hemE]. | 13 | 357 | 43.50943 |
| 2 | g14174.t1 | PANTHER | PTHR21091:SF169 | UROPORPHYRINOGEN DECARBOXYLASE | 6 | 355 | 9.1E-174 |
| 3 | g14174.t1 | PANTHER | PTHR21091 | METHYLTETRAHYDROFOLATE:HOMOCYSTEINE METHYLTRANSFERASE RELATED | 6 | 355 | 9.1E-174 |
| 1 | g14174.t1 | Pfam | PF01208 | Uroporphyrinogen decarboxylase (URO-D) | 12 | 355 | 3.4E-130 |
| 9 | g14174.t1 | ProSitePatterns | PS00906 | Uroporphyrinogen decarboxylase signature 1. | 29 | 38 | - |
| 8 | g14174.t1 | ProSitePatterns | PS00907 | Uroporphyrinogen decarboxylase signature 2. | 148 | 164 | - |
| 5 | g14174.t1 | SUPERFAMILY | SSF51726 | UROD/MetE-like | 8 | 355 | 2.27E-111 |
| 10 | g14174.t1 | TIGRFAM | TIGR01464 | hemE: uroporphyrinogen decarboxylase | 16 | 355 | 9.1E-133 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004853 | uroporphyrinogen decarboxylase activity | MF |
| GO:0006779 | porphyrin-containing compound biosynthetic process | BP |
KEGG
Orthology
- This transcript has been annotated with K01599 (uroporphyrinogen decarboxylase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
