General information for g14295.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Atrial natriuretic peptide receptor 1.
Parent gene
- The parent gene g14295 is located on chr_1: 36367454..36380831 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_1 | g14295 | g14295.t1 | isoform | g14295.t1 | 36367454 | 36380831 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon1 | 36367454 | 36367494 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS1 | 36367454 | 36367494 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon2 | 36370311 | 36370476 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS2 | 36370311 | 36370476 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon3 | 36371777 | 36371854 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS3 | 36371777 | 36371854 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon4 | 36371944 | 36372323 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS4 | 36371944 | 36372323 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon5 | 36372386 | 36372437 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS5 | 36372386 | 36372437 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon6 | 36372626 | 36372656 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS6 | 36372626 | 36372656 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon7 | 36372751 | 36372908 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS7 | 36372751 | 36372908 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon8 | 36372973 | 36373023 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS8 | 36372973 | 36373023 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon9 | 36373092 | 36373156 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS9 | 36373092 | 36373156 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon10 | 36373251 | 36373270 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS10 | 36373251 | 36373270 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon11 | 36377547 | 36377667 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS11 | 36377547 | 36377667 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon12 | 36377741 | 36377766 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS12 | 36377741 | 36377766 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon13 | 36377831 | 36377920 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS13 | 36377831 | 36377920 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon14 | 36378218 | 36378296 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS14 | 36378218 | 36378296 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon15 | 36378380 | 36378423 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS15 | 36378380 | 36378423 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon16 | 36378487 | 36378563 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS16 | 36378487 | 36378563 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon17 | 36378784 | 36378927 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS17 | 36378784 | 36378927 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon18 | 36378995 | 36379379 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS18 | 36378995 | 36379379 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon19 | 36379455 | 36379779 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS19 | 36379455 | 36379779 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon20 | 36379830 | 36380384 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS20 | 36379830 | 36380384 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon21 | 36380480 | 36380686 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS21 | 36380480 | 36380686 |
| chr_1 | g14295 | g14295.t1 | exon | g14295.t1.exon22 | 36380756 | 36380831 |
| chr_1 | g14295 | g14295.t1 | cds | g14295.t1.CDS22 | 36380756 | 36380831 |
| chr_1 | g14295 | g14295.t1 | TSS | g14295.t1 | NA | NA |
| chr_1 | g14295 | g14295.t1 | TTS | g14295.t1 | NA | NA |
Sequences
>g14295.t1 Gene=g14295 Length=3171
ATGGCTGGCTGGCTGGCTGGGTCAGTCATAACTCGACAATGCTATAAATTTTGTTCAGGC
TCAAAGTCACCAGGACTAGCGGCCGATATGAAATTTAAACAAAATGTAATTGCATTTATT
GGACCAGCTTGTGCATTTGCTTTAGAACCAGTAGCACGATTAGCAGATTTTTGGAATATA
CCGATAATAACTGGGATGGGTGATCAGCCACCCGAGCAAGGAGAGCTAACAGTCACATCC
GGAATACTTGGGAGAATCACACAAAAATGGAAAAATGAAAGCTCTTTTTTTAAAGATAAA
TCACGGTATGCCACTCTAACTAGGATGTCTTATTGCCAATGCAGATTGAAGCTCGTTTTC
AAAAGCATTTTCAAAGAATTTGGTTTCAAGCATGTCGCGTTACTTCTCGATCGTTCAGAT
TTATTTTCACTGACAGTTGGAAAAAATTTAGAATACGGCTTAAAAGAAGATGGAGTTCTA
AAATTGGTGAAAGAATTGAATGGCAATGAATTACTTTTGCCAGGAGGAAAACTCAACAAG
TCTGAGAGTGACAAGCTAATGAAAGATCTTACGACATATTTGCGTGACGCTTCAATGTAT
GCGCGAGTTATTATTTTGTCAGTTCGAGGACAACTTGTGAGACAATTTATGCTTGCTGCG
TATCACCTTGGCATGACAAAAGGTGATTACACTTTTCTAGATGTCGAGATTTTTCAAAGT
TCTTATTGGTCTGATCATTATTGGGAAGAGGACGATGAGAATGATTTGATAGCGAGAAAA
GCTTTTGAAGCTCTCTTACGAGTTTCGCTTCTTCAACCAACCAGTCCGAAATTCAATCAA
TTTGCTGAGAATGTAAGGGAGCGTGCTAAACGTGACTATGGATATTCCTTTTATGAGGGT
GAAGAGGTAAATTTCTTCATTGGAGCATTTTACGATGGTGTATTATTACTTGGCATGGTT
TTAAATGAGACACTAACTGAAGGAGGTGACATATATAACGGTGGATTGATAACCAAGAAA
ATGTGGAATAGAACATTTCAAGGGATTACTGGAACAGTTCGGATCGATGATAATGGTGAT
AGAGATGCTGATTATTCGCTTCTAGATTTAGATCCTGTTACAGGAAGATTTGAAGTTGTT
TCTCATTATTATGGTTCAAATAGAAGTTTAGTGCCAGTTCAAGGAAAACACATTCATTGG
CCTGGATCACTTGATGGACCTCCAGCTGATGTTCCGGCATGTGGTTTTCTAGGAAACGAT
CCGAATTGTCAAGGAAATGAGACAATAATAATCTATGGACTGTTATCATTCGTTCTCCTC
ACTGGCTTCATATCGTCACTGTCGTATCTATTTTACAAGCAACTACGACTGAATAGTGAA
TTAAACAACATGACATGGAGAGTTAAACCGGATGATGTACTTATTGAAGTTGGAAGACTT
TTTGGATCTAAAATTGGCCTTCAAAAATTAAATTATGAGAATTTTTCAATAAATCAACTT
GGTGTGAGCAGTGGTCGTGGTTCAATAGCAAGTCTTGGCAGTATAGCTCCATCTCAAGAA
TCAATTACAATAGGTGTTTTTAGAGGCGAAAGAGTCGCAATAAAGAAAATTCTTAAGAAA
AAGGTTGTCGTTGATACTACGTTGTTATGGGAGATAAAAAAAACTCGAGATGTTAATCAT
GAAAATACAAATCGATTTATTGGTGCTTGCATTGATTTGCCTTACTCATGTTCTTGCGTT
CTCATATTATCCGAATATTGTCCCAAAACGCTCAAGGAAGTGCTTGAGAATGAAGCCATT
CAACTTGATTGGAATTTTCGAATGTCGCTCATTCATGACCTTGTAAAAGGCATGGCTTAT
TTGCACAATAGTGATGTCTCGGTTCATGGTAAATTGAGGTCGAGTAATTGCCTTATCGAT
GGACGATTTGTTCTCAAAATATCTGATTTTGGTTTAAGAACATTGACATTTCCTTCAGAG
TTTGTCAAGGATCAAACTTATTATCACAAGCTATTATGGGTAGCACCGGAACTTCTTCCA
ATAACCATTATAGCAGGAACGCCTGCAACACAAAAAGGCGATGTTTATTCATTTTCTATA
ATCCTCGAGGAAATAGTTGTGCGTGGAGGTCCTTACGAAACAGTCAAATACATGACAATC
AATCAAATTCTTGATCGTGTAGCTGCTCATGACAATCCACCTTTTAGGCCACTCATTGGA
GAGCGTGATTGCCCATCAGAATTAGTTGATTTAATGGAGAAATGTTGGAATGATAATCCT
GATGAACGTCCATCATTTGCAAATATTAAGACAACTGTCTCATGCATTATGAAAGGTTTT
TGTGAAAATTTAATGGATGATTTATTACGCCGCATGCAACATTACGCAAACAACTTAGAA
AGTCTTGTCGAAGAAAAGACGGAGCAATTGAGCATGGAAAAGCGTCGTACAGAAGAGTTA
CTCTATCAAGTGTTACCAAAGAGTGTCGCATTGACTTTACTCTCGGGAGAAATGGTTCAA
CCAGAACAATTCGAATGCGTGACCATTTATTTCAGTGACATTTGTGGCTTTACTGCTTTG
TGTGCTCAATCAAATCCAATTGAAGTTGTAGACTTTTTGAATGATCTTTATAGTACCTTT
GATAGAATTATTGGTTTTTACGATGTTTATAAAGTAGAGACAATTGGTGATGCTTATATG
TGTGTTTCTGGTTTACCTGAACGAAATGGAGATGACCATGCAAGGGAAATAGGATTAATG
GCGTTATCAATTCTTGATGCAGTAAAAAGTTTTACAATTAAACATAAGCCTGAATATCAA
TTAAAAATTCGAATTGGGATCAATTCTGGCAGTGTTTGTGCAGGCGTTGTAGGACAAAAA
ATGCCTCGCTATTGTCTCTTTGGTGATGTTGTGAACACCGCAAGTCGTCTCGAATCGACA
GGCGAGCCGCTAAAAATACACGTTTCACAGGCAACAAAGATTATTTTTGACAAATTCGGT
ACGTTTCAATTGGAATTACGTGGCGATATTGAGCTGAAAGGAAAGGGAAAAGTTACGACA
TACTGGTTATGTGGTTGCTCTGAAAAAGATCCACGACCACCTACTCCACTCAAGAATCAT
GTTGACACTGAAGCAAATCCATTTCCGATTTTATTTCCATCTATTAAATAA
>g14295.t1 Gene=g14295 Length=1056
MAGWLAGSVITRQCYKFCSGSKSPGLAADMKFKQNVIAFIGPACAFALEPVARLADFWNI
PIITGMGDQPPEQGELTVTSGILGRITQKWKNESSFFKDKSRYATLTRMSYCQCRLKLVF
KSIFKEFGFKHVALLLDRSDLFSLTVGKNLEYGLKEDGVLKLVKELNGNELLLPGGKLNK
SESDKLMKDLTTYLRDASMYARVIILSVRGQLVRQFMLAAYHLGMTKGDYTFLDVEIFQS
SYWSDHYWEEDDENDLIARKAFEALLRVSLLQPTSPKFNQFAENVRERAKRDYGYSFYEG
EEVNFFIGAFYDGVLLLGMVLNETLTEGGDIYNGGLITKKMWNRTFQGITGTVRIDDNGD
RDADYSLLDLDPVTGRFEVVSHYYGSNRSLVPVQGKHIHWPGSLDGPPADVPACGFLGND
PNCQGNETIIIYGLLSFVLLTGFISSLSYLFYKQLRLNSELNNMTWRVKPDDVLIEVGRL
FGSKIGLQKLNYENFSINQLGVSSGRGSIASLGSIAPSQESITIGVFRGERVAIKKILKK
KVVVDTTLLWEIKKTRDVNHENTNRFIGACIDLPYSCSCVLILSEYCPKTLKEVLENEAI
QLDWNFRMSLIHDLVKGMAYLHNSDVSVHGKLRSSNCLIDGRFVLKISDFGLRTLTFPSE
FVKDQTYYHKLLWVAPELLPITIIAGTPATQKGDVYSFSIILEEIVVRGGPYETVKYMTI
NQILDRVAAHDNPPFRPLIGERDCPSELVDLMEKCWNDNPDERPSFANIKTTVSCIMKGF
CENLMDDLLRRMQHYANNLESLVEEKTEQLSMEKRRTEELLYQVLPKSVALTLLSGEMVQ
PEQFECVTIYFSDICGFTALCAQSNPIEVVDFLNDLYSTFDRIIGFYDVYKVETIGDAYM
CVSGLPERNGDDHAREIGLMALSILDAVKSFTIKHKPEYQLKIRIGINSGSVCAGVVGQK
MPRYCLFGDVVNTASRLESTGEPLKIHVSQATKIIFDKFGTFQLELRGDIELKGKGKVTT
YWLCGCSEKDPRPPTPLKNHVDTEANPFPILFPSIK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 22 | g14295.t1 | CDD | cd07302 | CHD | 847 | 1023 | 8.00639E-66 |
| 18 | g14295.t1 | Coils | Coil | Coil | 785 | 816 | - |
| 17 | g14295.t1 | Gene3D | G3DSA:3.40.50.2300 | - | 18 | 362 | 6.6E-95 |
| 16 | g14295.t1 | Gene3D | G3DSA:3.40.50.2300 | - | 112 | 370 | 6.6E-95 |
| 15 | g14295.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 523 | 813 | 1.6E-52 |
| 14 | g14295.t1 | Gene3D | G3DSA:3.30.70.1230 | Adenylyl Cyclase | 833 | 1025 | 9.4E-74 |
| 4 | g14295.t1 | PANTHER | PTHR11920 | GUANYLYL CYCLASE | 12 | 1052 | 0.0 |
| 5 | g14295.t1 | PANTHER | PTHR11920:SF274 | GUANYLATE CYCLASE | 12 | 1052 | 0.0 |
| 7 | g14295.t1 | PRINTS | PR00255 | Natriuretic peptide receptor signature | 40 | 58 | 2.3E-22 |
| 9 | g14295.t1 | PRINTS | PR00255 | Natriuretic peptide receptor signature | 202 | 220 | 2.3E-22 |
| 10 | g14295.t1 | PRINTS | PR00255 | Natriuretic peptide receptor signature | 310 | 328 | 2.3E-22 |
| 8 | g14295.t1 | PRINTS | PR00255 | Natriuretic peptide receptor signature | 348 | 365 | 2.3E-22 |
| 6 | g14295.t1 | PRINTS | PR00255 | Natriuretic peptide receptor signature | 431 | 453 | 2.3E-22 |
| 2 | g14295.t1 | Pfam | PF01094 | Receptor family ligand binding region | 16 | 371 | 1.6E-61 |
| 3 | g14295.t1 | Pfam | PF07714 | Protein tyrosine and serine/threonine kinase | 530 | 771 | 7.4E-36 |
| 1 | g14295.t1 | Pfam | PF00211 | Adenylate and Guanylate cyclase catalytic domain | 840 | 1023 | 6.3E-65 |
| 20 | g14295.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 428 | - |
| 21 | g14295.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 429 | 452 | - |
| 19 | g14295.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 453 | 1056 | - |
| 25 | g14295.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 498 | 780 | 27.651 |
| 24 | g14295.t1 | ProSiteProfiles | PS50125 | Guanylate cyclase domain profile. | 848 | 978 | 49.206 |
| 23 | g14295.t1 | SMART | SM00044 | cyc_6 | 812 | 1006 | 5.7E-103 |
| 11 | g14295.t1 | SUPERFAMILY | SSF53822 | Periplasmic binding protein-like I | 15 | 416 | 5.05E-81 |
| 12 | g14295.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 528 | 817 | 2.95E-48 |
| 13 | g14295.t1 | SUPERFAMILY | SSF55073 | Nucleotide cyclase | 834 | 1023 | 1.73E-63 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0016021 | integral component of membrane | CC |
| GO:0009190 | cyclic nucleotide biosynthetic process | BP |
| GO:0006468 | protein phosphorylation | BP |
| GO:0035556 | intracellular signal transduction | BP |
KEGG
Orthology
- This transcript has been annotated with K12323 (atrial natriuretic peptide receptor A)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed