General information for g14391.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative Dihydroorotate dehydrogenase (quinone), mitochondrial.
Parent gene
- The parent gene g14391 is located on chr_4: 247362..248632 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g14391 | g14391.t2 | isoform | g14391.t2 | 247084 | 248333 |
| chr_4 | g14391 | g14391.t2 | exon | g14391.t2.exon1 | 247084 | 248333 |
| chr_4 | g14391 | g14391.t2 | TTS | g14391.t2 | 247228 | 247228 |
| chr_4 | g14391 | g14391.t2 | cds | g14391.t2.CDS1 | 247362 | 248024 |
| chr_4 | g14391 | g14391.t2 | TSS | g14391.t2 | 248711 | 248711 |
Sequences
>g14391.t2 Gene=g14391 Length=1250
AGTACTGAGATTTGTAACATTGCATTAAAAAATCCAGTCGGTATTGCAGCCGGTTTTGAC
AAAAACGCAGAAGCAATTGAAGGTCTCGATCATCTTGGTTTTGGATTTATTGAAGTTGGG
AGTGTAACACCATTGGCTCAAGTCGGTAATCAAAAGCCAAGAGTTTTTCGTCTTACTGAA
GATGAAGCGATTATAAATCGTTATGGATTTAATAGTGATGGACATGAAAAAGTTTGGCAT
CGAATTCAACAATTGAGAGCGAGTGGAAAATTTAATGGCGTTCTTGGAGTAAATTTGGGA
AAAAATAAAATGTCTGAGGATGCAGTTAATGATTATCTTGAAGGTTTAAAGTTATTTTCA
CCTGTTGCTGATTATTTAGTCATAAATGTGAGCAGTCCTAATACTCCAGGTTTGAGAGAT
TTGCAGCAAAAAGATAGCTTAAAGACATTGTTGTGTAAAATAAATGAAACAAAAAAGCAA
ATTGAAACTCCAAAACCAATTTTTGTTAAGCTTGCTCCAGACCTTACACAGTCAGAACTT
AAAGATATTTGTAATACAATTCAGCGCAAAGATTGTCATGTTGATGGTTTAATTATTTCA
AACACAACAATTGATCGATCTGTGGCACTTAACAGTAGCAACGCATTTGAAGTTGGTGGA
CTAAGTGGTAAACCATTGAAAGAAAAAAGTCGAAGAATGATTGAAGATGTTTATAAAATG
ACAAATGGAAAAATCCCGATAATTGGGGTTGGTGGTATTGGCAGTGGTCAAGATGCTTAT
GAAAAAATCATTGCTGGTGCAAGTGCAATTCAACTTTATTCAAGTTTTGTTTTTCACGGA
CCACCATTGGTTACAAAAGTCAAAAAAGAACTTGATGACATTTTAAAATCAAATGGTTAT
CAAAATGTTCAACAGGCTGTCGGCAAAGGAGTTCAAATGGATAAAAAATCTTTCTTATCT
TACTTTTTTTAAATTTTTAAGATTTTTGATCAAATATGGTGATGTTAATTTGTACCTTTA
AAAAAAAATAATGGCTATGTAAAAACCATCATTTACTTTTCATTTTTGTAAATTCTGCAC
AAATAAATTTTTTTTAAATATCACACAAAAAATCTTATTGTTTTGATCTTATCAGAAAAA
AAATTTCTAAGAGAAAGAGAGAAGTAAATTTCCTACAGTGAGAGTAAATGAGAAAAGAAA
GAGAAATTTTTATGCGGCTCTATGATCAGTTGTAATTTGAACTCCAACAA
>g14391.t2 Gene=g14391 Length=220
MSEDAVNDYLEGLKLFSPVADYLVINVSSPNTPGLRDLQQKDSLKTLLCKINETKKQIET
PKPIFVKLAPDLTQSELKDICNTIQRKDCHVDGLIISNTTIDRSVALNSSNAFEVGGLSG
KPLKEKSRRMIEDVYKMTNGKIPIIGVGGIGSGQDAYEKIIAGASAIQLYSSFVFHGPPL
VTKVKKELDDILKSNGYQNVQQAVGKGVQMDKKSFLSYFF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g14391.t2 | CDD | cd04738 | DHOD_2_like | 3 | 188 | 1.53109E-84 |
| 6 | g14391.t2 | Gene3D | G3DSA:3.20.20.70 | Aldolase class I | 1 | 215 | 1.7E-80 |
| 2 | g14391.t2 | PANTHER | PTHR48109 | DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED | 3 | 206 | 3.9E-71 |
| 3 | g14391.t2 | PANTHER | PTHR48109:SF4 | DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL | 3 | 206 | 3.9E-71 |
| 1 | g14391.t2 | Pfam | PF01180 | Dihydroorotate dehydrogenase | 2 | 192 | 1.3E-61 |
| 5 | g14391.t2 | ProSitePatterns | PS00912 | Dihydroorotate dehydrogenase signature 2. | 144 | 164 | - |
| 4 | g14391.t2 | SUPERFAMILY | SSF51395 | FMN-linked oxidoreductases | 3 | 207 | 4.89E-59 |
| 7 | g14391.t2 | TIGRFAM | TIGR01036 | pyrD_sub2: dihydroorotate dehydrogenase (fumarate) | 2 | 206 | 3.6E-74 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016627 | oxidoreductase activity, acting on the CH-CH group of donors | MF |
| GO:0016020 | membrane | CC |
| GO:0004152 | dihydroorotate dehydrogenase activity | MF |
| GO:0006207 | ‘de novo’ pyrimidine nucleobase biosynthetic process | BP |
| GO:0003824 | catalytic activity | MF |
| GO:0055114 | NA | NA |
| GO:0005737 | cytoplasm | CC |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
