General information for g14808.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as GATOR complex protein WDR24.
Parent gene
- The parent gene g14808 is located on chr_4: 2429496..2432182 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g14808 | g14808.t1 | TTS | g14808.t1 | 2429327 | 2429327 |
| chr_4 | g14808 | g14808.t1 | isoform | g14808.t1 | 2429496 | 2432182 |
| chr_4 | g14808 | g14808.t1 | exon | g14808.t1.exon1 | 2429496 | 2430503 |
| chr_4 | g14808 | g14808.t1 | cds | g14808.t1.CDS1 | 2429496 | 2430503 |
| chr_4 | g14808 | g14808.t1 | exon | g14808.t1.exon2 | 2430587 | 2431822 |
| chr_4 | g14808 | g14808.t1 | cds | g14808.t1.CDS2 | 2430587 | 2431822 |
| chr_4 | g14808 | g14808.t1 | exon | g14808.t1.exon3 | 2431882 | 2432012 |
| chr_4 | g14808 | g14808.t1 | cds | g14808.t1.CDS3 | 2431882 | 2432012 |
| chr_4 | g14808 | g14808.t1 | exon | g14808.t1.exon4 | 2432071 | 2432182 |
| chr_4 | g14808 | g14808.t1 | cds | g14808.t1.CDS4 | 2432071 | 2432182 |
| chr_4 | g14808 | g14808.t1 | TSS | g14808.t1 | 2432251 | 2432251 |
Sequences
>g14808.t1 Gene=g14808 Length=2487
ATGGAAGAACAAGTGAGATCGTCATCATTACGTTATGTTTCACTCGATGGACATGCAAAT
TCATTTGCACTCAACAAAGACAACAATTGCATTGCTGTTGCTGGACGATCTTTATTGAAA
GTTTTTTCTTTTGAAAATGATGGTTTCACAGAAATTCATAATATGCGGCAACAACCGAGT
AACAATAAAAATCATAATTTATCATTCAGCTCTAATGCAATTGATTGGAGCAAAATTGAT
ACTAATATTCTCGCAACAGCTGCAACAAATGGATGCATAGCAATTTGGGATCTCAATAAA
TTTGGTCGTCAAAAACAACTCAATGTTTATCATGACCATGAACGTACAACACATGCCGTT
TCTTTTCATCATCAAGATGCAAATTTTCTTCTTTCTGCCTCACAAGATTCAACAATTAAA
CTTTTTGATTTACGTGAAAAAAATTCGTGTGTTTCAACATTTCAAAGTACAGAATCAGTC
AGAGATGTCAAATTTAATCCTTTTAATTGCAATTCATTTGCATCAGTTAGTGAAAATGGC
TGTGTTCATTCATGGGATGTAAGAAGACCTGAAAAATTTGTGCAACAATTTACAGCACAT
TCAGGTCCAATTTATTGCCTCGATTGGCATCCAACAAATCAATGGCTTGCAACTGGCAGT
CGTGACAAACTCATTAAAGTCTGGAATATGTCAAATCCAAAACCACAACTTGAATATACA
ATTTATACAATTGCAGTTGTTGGCAGAGTTCGATGGAGACCAGAAAGGAAATTTCATATT
GCAAGTTGTTCTTTAGTTGTTGATTACTCAATTTATATTTGGGATGTTCGTCGACCTTTT
ATACCTTATGCGAGTTTTAATGAACACACAAATGTAACAACAGATATTGCATTTAAGGGC
GCACCTGATACTTTGATTTCAACTTCCAAAGATTCAACAATTTATAAACATATTACAAAA
GATGCTCATCATCCTGCATTAAGTGCTAATCCACAAGCAACTACAATTTCACCTCGTGGT
GATATTTTGTTTGTTTGCAAGGCAAAAATCAAAAGCCAACCTCAAGTCATGACCACATCA
AGCACAATACCGAAATTATTTAAGAAAACAACAAATGACACGGTTGATGGTGTTATTAAT
GCTATACCATCGTCACCATCACTTCATGAACAATTTCATTTAGCAAAATCATCATTGCAT
TATTTCTCAGATGATGGCAGTAATAATAGAAAAATTTCAGTTGGTCAACATGCGAAAATT
GATGACAGTGCATTGACAAAAACTTTACAAAAAGATTACAATTTCTTTACTGGTTGTGCT
AAAGAATATCGGTTGAAAAGTGACGAAAAAAATTTCCTTGAAATGTTGGAGCATAATGCA
AATGTAGCTAGAAAATATGGACGACCAAATGTGTCAATGTTGTGGAACTTAGTTAAAATG
ATTTATCGTTCAACACCTTTGAGGGAGCCGACTTCTAATCCAAGTCTAAATGTAGTAAAT
TTCACAACACAAAATTCTAATGACAGCTCAATATCACGTGTAGGATCATTCGGTACATCA
GGACTAACAACAAATGAAAATAATAACATCAACATCCTCGATCAAATTGGTTCTAGAGAA
AATATTTCATCAACTGATGAACTCTTAAATGACCCAAATGAATTTCAAATACCAAAAGCA
ATTGTAAGTTCAGATTTGGAAGTTGAAGTTTTTAATGATGGTGAAAGTCAAGTTCATCAG
AATGCAATTGATAGTAAACATCTTAGAAATGGATTTCTTTTTACTGGTCCAGCTCATGAT
AAAGAATTTCCAATGGTTATGTGTTCATCATCATTAATTAATCATGAATTGATGCATTAT
AATCATAATCGAAGTAAAGAAATGGAAATGATGATTGCTGACCAAATGCAAACATCACAA
ATAATGCCTACAAATGATCAAGTTGTCAGTCAAAGTTTTCTCTCTATAAATATGCCAGAA
TTTCAATCAAATAATTGGAAACCAAATCAAGTTTTGGCTGATTGTCTTGTGCTACAGTCA
GAAATTGGTGATGTACAAACACCAACTTGCATTTTACTCTGTCTTGGTAAAAGACGTCGT
GATGATTTGCCAATTGATCGAATGATACAAGAAAATTTTTTACAATCATATATTGACATG
TTGCATCGACATCAAATGTGGAATGAAGCAACAGAAGTTATAAATATGTCAGCAACATGG
ATACCAAATATTGGTGAAATGAATGAACAATCGACAACAATTCATACATCATGTGGTGAA
TGTGGAAGAGTTATAAATAAAGGCTGGTATTGTAAACATTGTAAATCATCAGATCCATCA
AGATGTGTTGTCTGTAATGAAATTGTTAAAGGAATGTTTACTTTCTGCAATCATTGTTGT
CATGGCGGTCATTTGCAGCATATGATTGAATGGTTCTCACAAAATCCAAGGTGTCCTAAA
TGTAATCATCTTTGTGAATATGACTGA
>g14808.t1 Gene=g14808 Length=828
MEEQVRSSSLRYVSLDGHANSFALNKDNNCIAVAGRSLLKVFSFENDGFTEIHNMRQQPS
NNKNHNLSFSSNAIDWSKIDTNILATAATNGCIAIWDLNKFGRQKQLNVYHDHERTTHAV
SFHHQDANFLLSASQDSTIKLFDLREKNSCVSTFQSTESVRDVKFNPFNCNSFASVSENG
CVHSWDVRRPEKFVQQFTAHSGPIYCLDWHPTNQWLATGSRDKLIKVWNMSNPKPQLEYT
IYTIAVVGRVRWRPERKFHIASCSLVVDYSIYIWDVRRPFIPYASFNEHTNVTTDIAFKG
APDTLISTSKDSTIYKHITKDAHHPALSANPQATTISPRGDILFVCKAKIKSQPQVMTTS
STIPKLFKKTTNDTVDGVINAIPSSPSLHEQFHLAKSSLHYFSDDGSNNRKISVGQHAKI
DDSALTKTLQKDYNFFTGCAKEYRLKSDEKNFLEMLEHNANVARKYGRPNVSMLWNLVKM
IYRSTPLREPTSNPSLNVVNFTTQNSNDSSISRVGSFGTSGLTTNENNNINILDQIGSRE
NISSTDELLNDPNEFQIPKAIVSSDLEVEVFNDGESQVHQNAIDSKHLRNGFLFTGPAHD
KEFPMVMCSSSLINHELMHYNHNRSKEMEMMIADQMQTSQIMPTNDQVVSQSFLSINMPE
FQSNNWKPNQVLADCLVLQSEIGDVQTPTCILLCLGKRRRDDLPIDRMIQENFLQSYIDM
LHRHQMWNEATEVINMSATWIPNIGEMNEQSTTIHTSCGECGRVINKGWYCKHCKSSDPS
RCVVCNEIVKGMFTFCNHCCHGGHLQHMIEWFSQNPRCPKCNHLCEYD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g14808.t1 | CDD | cd00200 | WD40 | 15 | 314 | 3.79829E-41 |
| 6 | g14808.t1 | CDD | cd16693 | mRING-H2-C3H3C2_WDR24 | 782 | 825 | 3.49885E-18 |
| 4 | g14808.t1 | Gene3D | G3DSA:2.130.10.10 | - | 3 | 244 | 2.6E-45 |
| 5 | g14808.t1 | Gene3D | G3DSA:2.130.10.10 | - | 245 | 346 | 4.1E-7 |
| 2 | g14808.t1 | PANTHER | PTHR46200 | GATOR COMPLEX PROTEIN WDR24 | 10 | 826 | 9.1E-193 |
| 1 | g14808.t1 | Pfam | PF00400 | WD domain, G-beta repeat | 193 | 229 | 6.2E-10 |
| 9 | g14808.t1 | ProSitePatterns | PS00678 | Trp-Asp (WD) repeats signature. | 84 | 98 | - |
| 8 | g14808.t1 | ProSitePatterns | PS00678 | Trp-Asp (WD) repeats signature. | 216 | 230 | - |
| 10 | g14808.t1 | ProSitePatterns | PS00678 | Trp-Asp (WD) repeats signature. | 262 | 276 | - |
| 18 | g14808.t1 | ProSiteProfiles | PS50294 | Trp-Asp (WD) repeats circular profile. | 62 | 314 | 27.078 |
| 20 | g14808.t1 | ProSiteProfiles | PS50082 | Trp-Asp (WD) repeats profile. | 110 | 152 | 9.64 |
| 19 | g14808.t1 | ProSiteProfiles | PS50082 | Trp-Asp (WD) repeats profile. | 197 | 238 | 15.187 |
| 11 | g14808.t1 | SMART | SM00320 | WD40_4 | 8 | 43 | 110.0 |
| 15 | g14808.t1 | SMART | SM00320 | WD40_4 | 60 | 97 | 0.67 |
| 17 | g14808.t1 | SMART | SM00320 | WD40_4 | 103 | 143 | 3.1E-5 |
| 13 | g14808.t1 | SMART | SM00320 | WD40_4 | 147 | 186 | 4.4E-4 |
| 12 | g14808.t1 | SMART | SM00320 | WD40_4 | 190 | 229 | 2.9E-12 |
| 14 | g14808.t1 | SMART | SM00320 | WD40_4 | 234 | 275 | 28.0 |
| 16 | g14808.t1 | SMART | SM00320 | WD40_4 | 279 | 318 | 43.0 |
| 3 | g14808.t1 | SUPERFAMILY | SSF50978 | WD40 repeat-like | 16 | 315 | 1.7E-54 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
| GO:0032008 | positive regulation of TOR signaling | BP |
KEGG
Orthology
- This transcript has been annotated with K20408 (SEA/GATOR complex protein SEA2/WDR24)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
