General information for g14930.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Kynureninase.
Parent gene
- The parent gene g14930 is located on chr_4: 3094974..3100046 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g14930 | g14930.t1 | TTS | g14930.t1 | 3094911 | 3094911 |
| chr_4 | g14930 | g14930.t1 | isoform | g14930.t1 | 3094974 | 3100046 |
| chr_4 | g14930 | g14930.t1 | exon | g14930.t1.exon1 | 3094974 | 3096226 |
| chr_4 | g14930 | g14930.t1 | cds | g14930.t1.CDS1 | 3094974 | 3096226 |
| chr_4 | g14930 | g14930.t1 | exon | g14930.t1.exon2 | 3096692 | 3096942 |
| chr_4 | g14930 | g14930.t1 | cds | g14930.t1.CDS2 | 3096692 | 3096942 |
| chr_4 | g14930 | g14930.t1 | exon | g14930.t1.exon3 | 3097001 | 3097747 |
| chr_4 | g14930 | g14930.t1 | cds | g14930.t1.CDS3 | 3097001 | 3097747 |
| chr_4 | g14930 | g14930.t1 | exon | g14930.t1.exon4 | 3097888 | 3098011 |
| chr_4 | g14930 | g14930.t1 | cds | g14930.t1.CDS4 | 3097888 | 3098011 |
| chr_4 | g14930 | g14930.t1 | exon | g14930.t1.exon5 | 3098709 | 3098841 |
| chr_4 | g14930 | g14930.t1 | cds | g14930.t1.CDS5 | 3098709 | 3098841 |
| chr_4 | g14930 | g14930.t1 | exon | g14930.t1.exon6 | 3098990 | 3099073 |
| chr_4 | g14930 | g14930.t1 | cds | g14930.t1.CDS6 | 3098990 | 3099073 |
| chr_4 | g14930 | g14930.t1 | exon | g14930.t1.exon7 | 3099546 | 3099679 |
| chr_4 | g14930 | g14930.t1 | cds | g14930.t1.CDS7 | 3099546 | 3099679 |
| chr_4 | g14930 | g14930.t1 | exon | g14930.t1.exon8 | 3099782 | 3100046 |
| chr_4 | g14930 | g14930.t1 | cds | g14930.t1.CDS8 | 3099782 | 3100046 |
| chr_4 | g14930 | g14930.t1 | TSS | g14930.t1 | NA | NA |
Sequences
>g14930.t1 Gene=g14930 Length=2991
ATGTCATCAATAGATGTTAATACTTTAAGCGAGTCGATGCGGCATTTTGGAACAGCTGAT
TATACAGTATTCGTAGCGATGCTTCTTTTTTCATCTTTAGTCGGTCTTTATTTTGGTTAT
AAAGATCATAAAACTAGTAAAGAAAATAAAAGAAACGGAATTGATGATGATACTGCAAAT
TATTTAGTTGGTGGTCGAAATATGCAAGTTATACCCGTTGCACTTTCTTTAGTTGCCTCA
TTTGTATCTGGAATAACTTTATTAGGAACTAGCACAGAAATTTATCTTTATGGTTCGCAA
TATTCCATCTTTTTAATTGCAATTGTCATTGCCGCTTTTATTGTTCACCATACAATTATA
CCCGTCCTTCATGAGCTAGAAATAACTTCAACTTATCAGTATTTAGAAGCTAGATTTAAT
CGTGAGCTTCGTCTTTATGGATCAATTTCTTATATGATGATACAAATGATGTGGTTGCCA
ATTATCATTTATGTGCCTGCTTTGGCATTTAATCAAACAACTGGAGTTAATATTCACATT
ATAACACCGATATCAATGTTTATTTGCATTGTTTATACATCAATTGGTGGAATTAAAGCT
GTTATATGGACTGATGTTCTACAAATAACATTGATGTATGGAACATTAACATTAATTGCT
GTCAAAGGAACAATTGCAATTGGTGGATTAGAAGTTTTGATTGAAAGAAATATTAAAGGT
GAACGCTTTGAACCTGTCATCTTCGACCTTGATCCAACAATTCGTCATTCATTTTGGACA
TTAGTTGTTGGTGGATCGATTTGGTATCTCAACATTAATGGTATCAATCAATCAATGGTA
CAAAGATATTTAAGTTTAAGAACAATAAAAAGAGCACAAATTGGTGCAGCATTATTTTCA
GCTGGTGTTATGTTGATGATTTCATTGTGCATTTATAATGGTTTTGTTCTTTTCGCTATG
TATCATGATTGTGATCCATTGAAAACAAAATTAGCAAAAGCAAAAGATCAATTACTGCCA
TTACTTGCTATTGAAACATTAAAAGATTTCCCTGGATTAACTGGAGTTTTTGTAGCTGGT
GTTTTTAGTGCTGCACTTTCATCTGCTTCTACTGGATTAAATTCAATGGCTGCAGTAATT
TTAGTTGATTTTTGTGGACATTTTAATCTTTCGAAAACTCAAACTGCCGTAATACTTCGT
GGAACTGTTATTGTGCTTGGCGTAATTGCGGTTTTGCTTGTTTATGTCGTTGAACGTCTT
GGAACAGTTCTACAGCTTGCAATGATCATTCCTAGTGCAACTAATGGGCCACTTTTGGGG
GTTTTCTTTATTGGAAGTTTAATTCCATGGATTGGTGGAAAAGCGACACTTTGGGGCGTA
ATTACTGGTGCTGTAACAATGACATCAATTATTGTCAAAGCACAAATTGAATCAATGAGG
GGAAAAATTAAATTTCCATTAAAACCTGTTTTTACTGATGGTTGCACTTATAATTTTACT
GCCACAAATATTACATCAGAAGTCGTTGAGACTGGCAGCAAGCATATTTATCACATGTCT
TATCTTTATTATACAATTTTTGGTACAATTTTAGTTATTATTGTTTCTTCACTTTTAAGT
TTAGTTTTTGGCTTTCAAGATCCTAGAAAAGTAGATAGACGACTTGTTGCACCATTTATG
AGAAAATATATTGAGTTTGAAAATCAAAATGTTAGAAATGAAAATTTAGAATACGAAGCT
ACAAAGAAAAATTTAAAAATTGAAAACTTCACAACACGTCAAGATTTTGAAAAAGCAGAT
GAAATTGATGAATTGAAAGATTTTCGAGAAAAGTTTCAACTTCCATCTGATGTGATTTAT
TTCATTGGAAATTCACTCGGCCCATGTGCAGTAAACACTCAAGAAATCATCAGTAAATTC
ATCACTGACAATTGGATAAAAAATTCAAGTTCAGCTGAATTTCATCAAACACCATTAAAA
GTTGGTGAAAAAATTGGAAAAATTATTGGTGCTGAAAAGGATGAAACAATTGTTTGTGAT
TCAACTTCTGTCAATATTTTTAAAGCACTTGGAACAGCTTTGAAAATTCAAAAACTCAAA
AATCCAAACAGACGTGTGATTTTGCTTGAAAAACAAAATTTTCCATCAGATAATTACATT
GTGCAAGGTCTTGTAAATTTTCTATCAGCTGAAAATTATAAAATTGAAAAGTTTGAAGAT
GAGAAAGAACTTGAAAAAATTTTAAGTACTGAAATTACAGTTTTATTGTTATCACATGTC
AGTTATCGCACTGGAAAATTGTTTGATATGAAAATTATCACAAAAATGGCACATGATTTT
GGTGTTCTTATAATTTGGGATTTATGTCATTCAGTTGGTGCTGTACCAATTAATTTAACT
GAATCAAATGTTGATTTTGCAGTTGGTTGTACTTATAAATACTTAAATTGTGGTCCAGGA
GCTCCTGCATTTTTTTATGTCAATAAAAGGCATCAAAATGTTGTTTGGCAGCCATTAGCA
GGCTGGTATGGACATGAAGAACCTTTTAAAATGAAATCAAATTATGAACCTGCAAGAAAT
ATTCAACAATTTTTAACAGGAACTGGGGAAATTTTTCATATGTCAATTGTTGAAAACAGC
ATTGAAATTTTACTTAAAGCAGACATAAAAAAGATGAGAAAAAAGTCATTACTTTTGGGT
GATCTTTTCATAAATCTTTTAAATGAAAAATGTTCAAGTTTAAAACTTTTAACACCATTA
GAGCATGAAAAACGTGGAAGTCATTTGAGTTTTGAACATGAAAATGCTTACAATATCAGT
GTGATGATTAATAAGCGTGGAATTTGTGGAAATTTCCGTTTTCCTAATATTTTACGATTT
GCTATGACTTCTTTATATTTGAGATTTGTTGACATTTGGGATACAGTTGAAATTATTTCT
GATATTGTTAATAATTTTGAGATTTATAAAAATCTTGCTGAAAAGTTGTGA
>g14930.t1 Gene=g14930 Length=996
MSSIDVNTLSESMRHFGTADYTVFVAMLLFSSLVGLYFGYKDHKTSKENKRNGIDDDTAN
YLVGGRNMQVIPVALSLVASFVSGITLLGTSTEIYLYGSQYSIFLIAIVIAAFIVHHTII
PVLHELEITSTYQYLEARFNRELRLYGSISYMMIQMMWLPIIIYVPALAFNQTTGVNIHI
ITPISMFICIVYTSIGGIKAVIWTDVLQITLMYGTLTLIAVKGTIAIGGLEVLIERNIKG
ERFEPVIFDLDPTIRHSFWTLVVGGSIWYLNINGINQSMVQRYLSLRTIKRAQIGAALFS
AGVMLMISLCIYNGFVLFAMYHDCDPLKTKLAKAKDQLLPLLAIETLKDFPGLTGVFVAG
VFSAALSSASTGLNSMAAVILVDFCGHFNLSKTQTAVILRGTVIVLGVIAVLLVYVVERL
GTVLQLAMIIPSATNGPLLGVFFIGSLIPWIGGKATLWGVITGAVTMTSIIVKAQIESMR
GKIKFPLKPVFTDGCTYNFTATNITSEVVETGSKHIYHMSYLYYTIFGTILVIIVSSLLS
LVFGFQDPRKVDRRLVAPFMRKYIEFENQNVRNENLEYEATKKNLKIENFTTRQDFEKAD
EIDELKDFREKFQLPSDVIYFIGNSLGPCAVNTQEIISKFITDNWIKNSSSAEFHQTPLK
VGEKIGKIIGAEKDETIVCDSTSVNIFKALGTALKIQKLKNPNRRVILLEKQNFPSDNYI
VQGLVNFLSAENYKIEKFEDEKELEKILSTEITVLLLSHVSYRTGKLFDMKIITKMAHDF
GVLIIWDLCHSVGAVPINLTESNVDFAVGCTYKYLNCGPGAPAFFYVNKRHQNVVWQPLA
GWYGHEEPFKMKSNYEPARNIQQFLTGTGEIFHMSIVENSIEILLKADIKKMRKKSLLLG
DLFINLLNEKCSSLKLLTPLEHEKRGSHLSFEHENAYNISVMINKRGICGNFRFPNILRF
AMTSLYLRFVDIWDTVEIISDIVNNFEIYKNLAEKL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 37 | g14930.t1 | CDD | cd11492 | SLC5sbd_NIS-SMVT | 19 | 542 | 0.0 |
| 9 | g14930.t1 | Coils | Coil | Coil | 564 | 588 | - |
| 8 | g14930.t1 | Gene3D | G3DSA:1.20.1730.10 | - | 51 | 550 | 3.6E-106 |
| 6 | g14930.t1 | Gene3D | G3DSA:3.90.1150.10 | Aspartate Aminotransferase | 600 | 982 | 1.8E-131 |
| 7 | g14930.t1 | Gene3D | G3DSA:3.40.640.10 | - | 630 | 889 | 1.8E-131 |
| 3 | g14930.t1 | PANTHER | PTHR42985 | SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER | 12 | 571 | 1.1E-215 |
| 4 | g14930.t1 | PANTHER | PTHR42985:SF5 | LP24461P | 12 | 571 | 1.1E-215 |
| 1 | g14930.t1 | Pfam | PF00474 | Sodium:solute symporter family | 61 | 463 | 3.1E-32 |
| 2 | g14930.t1 | Pfam | PF00266 | Aminotransferase class-V | 651 | 948 | 4.7E-17 |
| 18 | g14930.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 20 | - |
| 29 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 21 | 40 | - |
| 14 | g14930.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 41 | 69 | - |
| 27 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 70 | 89 | - |
| 19 | g14930.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 90 | 100 | - |
| 24 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 101 | 124 | - |
| 16 | g14930.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 125 | 144 | - |
| 34 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 145 | 170 | - |
| 17 | g14930.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 171 | 175 | - |
| 35 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 176 | 198 | - |
| 12 | g14930.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 199 | 209 | - |
| 30 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 210 | 234 | - |
| 20 | g14930.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 235 | 253 | - |
| 36 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 254 | 275 | - |
| 10 | g14930.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 276 | 295 | - |
| 32 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 296 | 321 | - |
| 22 | g14930.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 322 | 355 | - |
| 26 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 356 | 385 | - |
| 11 | g14930.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 386 | 396 | - |
| 31 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 397 | 417 | - |
| 23 | g14930.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 418 | 422 | - |
| 33 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 423 | 448 | - |
| 13 | g14930.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 449 | 454 | - |
| 25 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 455 | 476 | - |
| 21 | g14930.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 477 | 520 | - |
| 28 | g14930.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 521 | 545 | - |
| 15 | g14930.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 546 | 996 | - |
| 52 | g14930.t1 | ProSiteProfiles | PS50283 | Sodium:solute symporter family profile. | 17 | 477 | 46.415 |
| 5 | g14930.t1 | SUPERFAMILY | SSF53383 | PLP-dependent transferases | 592 | 986 | 1.23E-66 |
| 51 | g14930.t1 | TIGRFAM | TIGR00813 | sss: transporter, solute:sodium symporter (SSS) family | 61 | 463 | 4.7E-73 |
| 50 | g14930.t1 | TIGRFAM | TIGR01814 | kynureninase: kynureninase | 598 | 983 | 7.6E-89 |
| 39 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 18 | 40 | - |
| 44 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 70 | 92 | - |
| 47 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 102 | 124 | - |
| 40 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 145 | 167 | - |
| 48 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 182 | 204 | - |
| 49 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 211 | 233 | - |
| 42 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 253 | 275 | - |
| 43 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 296 | 318 | - |
| 45 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 395 | 417 | - |
| 41 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 429 | 451 | - |
| 38 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 455 | 472 | - |
| 46 | g14930.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 521 | 543 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0055085 | transmembrane transport | BP |
| GO:0030429 | kynureninase activity | MF |
| GO:0006569 | tryptophan catabolic process | BP |
| GO:0003824 | catalytic activity | MF |
| GO:0005737 | cytoplasm | CC |
| GO:0030170 | pyridoxal phosphate binding | MF |
| GO:0009435 | NAD biosynthetic process | BP |
| GO:0022857 | transmembrane transporter activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed