General information for g15131.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Insulin-like receptor.
Parent gene
- The parent gene g15131 is located on chr_4: 4047770..4053255 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g15131 | g15131.t1 | isoform | g15131.t1 | 4047770 | 4053255 |
| chr_4 | g15131 | g15131.t1 | exon | g15131.t1.exon1 | 4047770 | 4048141 |
| chr_4 | g15131 | g15131.t1 | cds | g15131.t1.CDS1 | 4047770 | 4048141 |
| chr_4 | g15131 | g15131.t1 | exon | g15131.t1.exon2 | 4048211 | 4048352 |
| chr_4 | g15131 | g15131.t1 | cds | g15131.t1.CDS2 | 4048211 | 4048352 |
| chr_4 | g15131 | g15131.t1 | exon | g15131.t1.exon3 | 4048517 | 4048994 |
| chr_4 | g15131 | g15131.t1 | cds | g15131.t1.CDS3 | 4048517 | 4048994 |
| chr_4 | g15131 | g15131.t1 | exon | g15131.t1.exon4 | 4049096 | 4050178 |
| chr_4 | g15131 | g15131.t1 | cds | g15131.t1.CDS4 | 4049096 | 4050178 |
| chr_4 | g15131 | g15131.t1 | exon | g15131.t1.exon5 | 4050285 | 4050402 |
| chr_4 | g15131 | g15131.t1 | cds | g15131.t1.CDS5 | 4050285 | 4050402 |
| chr_4 | g15131 | g15131.t1 | exon | g15131.t1.exon6 | 4050701 | 4051789 |
| chr_4 | g15131 | g15131.t1 | cds | g15131.t1.CDS6 | 4050701 | 4051789 |
| chr_4 | g15131 | g15131.t1 | exon | g15131.t1.exon7 | 4052001 | 4052306 |
| chr_4 | g15131 | g15131.t1 | cds | g15131.t1.CDS7 | 4052001 | 4052306 |
| chr_4 | g15131 | g15131.t1 | exon | g15131.t1.exon8 | 4052465 | 4052883 |
| chr_4 | g15131 | g15131.t1 | cds | g15131.t1.CDS8 | 4052465 | 4052883 |
| chr_4 | g15131 | g15131.t1 | exon | g15131.t1.exon9 | 4052946 | 4053255 |
| chr_4 | g15131 | g15131.t1 | cds | g15131.t1.CDS9 | 4052946 | 4053255 |
| chr_4 | g15131 | g15131.t1 | TSS | g15131.t1 | NA | NA |
| chr_4 | g15131 | g15131.t1 | TTS | g15131.t1 | NA | NA |
Sequences
>g15131.t1 Gene=g15131 Length=4317
ATGCAAAAAATCATCAAAAATAAATCACACACAAGAAATTTACCACGTGGATATTACAAA
AGGAAAAAACCACCTGATGAATGTACACCAAGTGTTGAAACATGTCAAACGTCAATAAAA
ATAGATAATTATTTTAGTCTAAGGTGTAAATTTAGTGATAATCGACATGTAAATACAAAA
TTTCATTTATTTTACATAATTTCACTTTTAATTATTGTAAATGCAACTGCTGAAGACTTA
CGATTAAAACGAGAAATTGAAAATTTCTCAAAAACTACACCAACACCATTAACATTGCCT
AATGATGGAATTTGCAAATCAATCGATGTGCGTTTTTATTTTGTAAAAATCCATAGTTTG
ACAGGGTGTCGTGTAGTTGAAGGATCAATAACAATTCTTATGATGGATGAAATTACACCA
AAAGACGTTGCAAATATAACTTTTCCTGAACTAGTCGAAGTTACCGGATTTATTATGCTC
TATCGTGTTGGTGGATTTACAAGTCTAAATCAACTTTTTCCTAATCTTTCTGTCATACGT
GGACGTGATTTATTTAAAGATTATTCACTTGTTATTTATGAAATGATTCATTTAGAAGAA
ATTGGATTAAAAAATTTAATGGCGATTGAAAGAGGAAATGTTAGAATTGAGAAAAATGAG
CTGATGTGCTTTTCAAAGACGATAAATTGGAAAAATATTATTATACAGTATGAAGATCCT
TACATTGAGAAAAATCGTTTACCAGCGCATTGTCCAAACTGCCAAAATGACAAATGCCCA
AAGTCAATTGATGGAAAAAACACTTACTGCTGGAATATTGAGCATTGCCAAAGAACATGC
TCACATTGTCAGCAAAATTCAAAGAAAGGCGAAATGACTTATTGCTCACCAAATCAACAA
ACTTGCTGCGATCACAGTTGTATTGGCGGTTGCGAAGATGACAAACCAAAAAACTGTTTT
GCTTGTAGAAAATTTGCTTATGGAACATATCCAAATATTGAATGTTTAGACAAATGTCCT
AATGGAACTTTTGCTCATCTCGAACGTCGATGTTTAACTAGAGATCAATGTTATGACTTA
AACAACGACAGCGTTTTAAAAGAACATGATGCAACTTTCATACCTTTTGAAAAAGAATGC
CGCAAAGATTGTCCACCAAATTATAGAAAAGTAAATACGGGTAGAAAAATTTTCTGTCAA
AAATGTCAAGGTTCATGCTTAAAAGAATGCAGATTTGGAAATCTTGTTGATTCAATTGAA
GCAGCTCAATCATTAAAAGGATGCAACATTATTGAAGGGCCTTTAGAAATTCAAATTCGT
GGAATTACAAAAAGTCCAGAATCGGGTAGAAATATTGTAAAAGAACTTGAGTCTTCACTT
TCTGACATTCAAGAAATCAAAGGTTATTTAAAAATTGCTCGCTCACATGCAATTCTTTCA
ATGTCATTTCTCAAAAATCTTCGTAAAATTCATGGAAATAGTCTTGAAGGTGGTCGCAAT
GCAATCATGGTTTGGGAAAATCAAAATTTACAAGAACTTTGGGATGAATCGCATCGAATT
GAAATTGTTCGTGGAAAACTTTTCTTTCATTTTAATCCAAAACTTTGTTTTTATAAAATT
GAACAATTGGCAAGAAAAAGTGCAATTCGTGGCTTAAATGCATCGCAAATGATTGAAAAT
TATGAAACAGCAAAAATTTCAAATGGTGATAAAACTCCTTGCAATTTGACACCTTTGAAT
GTCACAGTTGATCAAATTTTTCCACAAGCTGCACTACTCACTTGGGATCCATTGAAACTC
GAAGATGAAAGATCATTGCTTAATTATGTTGTCTATTATATTGCTGCACCATATACAAAT
GTCACATTATGGGATGGACGTGATGCATGTGGTGATGATGGCTGGAGTGTTGAAGATGTC
AATGATTTTAGAAATAATAAAAAAGTCTCACAACCATTGACAAAATTGGAACCATATACA
CAATATGCTTATTATGTCAAAGCTTATACATTGGCTACTGAGAAAACTGGTGCACAGAGT
GAAATTAGCTATTTCACTACAAAACCTGATGTGCCGGAAGTTGTTAAGAAATTTAAACTG
ACAGTTACTGGACCTGATAAAATTGAAGTATCATGGGAGACATTAAAGAAAGTGAATGGA
AGATTAGACCATTACATTTTACGAGCCAATGCAATTCCACAGGATGATAAATTATTATTA
CAAAGAGATTACTGCAAAGAACCAATCGATACTTCACCACCACCATCACCTCCATCAAAA
GATACTTTGCCAATCAGAATTGTACCAAAGAATCCCAATATAGCACCAGATGGTGTTTGT
GATTGTCCAACATGTTCAAAATTATGCAGTGAAGGAAAGCAATTAGCACCACAAAAAGGT
GGATTTGATGAGCGACAATTAGAAAATGATTTTGAAGATGATATTCAGGATTATGTCTAT
GTTCGTACAGATGATAAAACAACAGAATTAAAAGATACAAGAACAAAACGACAAGTTCCA
AATGAAATTGAATTTCCATCACAACCAATTGATCCATCTAATCCTTTTACTGTCGATCGT
GAGACAATGAAAAATACAAGTGATTTTTATTTTGATGAAATTGGCCCTGAAACTACAACT
TTTACCATTACTGGATTAAATCATTATACAACTTACAATATTCGAATTCGAGCATGCAGA
AAACGTGAAGAAGGTGAAAGTTTTTTGGCTGAAATTTGCGGACCTGAAATGAAAGATTTT
GCAACAACATTTAGAGAACTTGCAAATGATAATATTCCAAATTTTTATGCTGAACAATTT
GTGAATAATTCATTGACAAATATTCGAATTACTTGGGAGCAACCAGCAGATCCAAATGGA
CTTTTACTTGCATACACAATCAGACATAAAAGAGTTGATATTGAACACACTCAGCCTGTT
TTACATTGTATTTCAACAAGTATGCTTAATGGAACAAATTATTACATTCTACAGAAAGTT
ACACCAGGAAATTATAGCATTGACATGATGGCAACATCAATGGCTGGCAATGGAAATTAT
ACAAACCCAAAATATGTTTTTATAAAAGAACAAAGTCAATATACAAGCATATGGACAATT
ATTGCTATACTTTTTATAGTTTTCATCATTGGTACAATTGGATTAATTTGGTTCTTTAAG
AAAATGTATTTGTCTAATATTTCAAATATGAAATTAATTGCAAATGTTAATCCTGATTAT
GCTGGTGTAACTTATCGACAAGATGAATGGGAAATTCCAAGGGAAAAAATTATTCAATTG
CAAGAACTGGGTTGTGGAAGTTTTGGTATGGTCTACGAAGGACTCATCAAAGATTTTCAT
CGAAAAGGCGAAGATGTTCGTTGTGCCATAAAAACAGTAAATGAAAGCGCCACTGATAAA
GAACAAATAACTTTCCTAAATGAAGCTTCAGTCATGAAGCAATTTGACACTCATCATGTA
GTTCGACTTCTTGGTGTTGTGTCAATTGGTCAACCAACTTTAGTAGTTATGGAATTAATG
GCAAGTGGCGATTTAAAAAGTTATCTAAGATCTCATCGACCTGAGTATGATACAGTCAGT
ACTGAACCACCACCACAGCCACCAACATTGAGAAGAATTCTACAAATGGCTATTGAAATT
GCTGATGGCATGGCTTATTTGTCAGCTAAGAAGTTTGTACATCGTGATCTTGCTGCGAGA
AATTGTATGGTTGCTGAAGATTTGACAGTAAAAATTGGTGACTTTGGAATGACTCGAGAT
ATTTATGAAACTGACTATTACAGAAAAGGCACAAAAGGACTTTTGCCAGTACGATGGATG
AGCCCTGAATCTTTAAAAGATGGAGTTTTCTCATCAAGTAGTGATGTTTTTAGTTATGGT
GTTGTTGTTTGGGAAATGTCAACACTTGCCCAACAACCTTATGCTGGTCTTTCAAATGAT
CAAGTTTTACGTTACGTTATTGAAGGGGGCGTAATGGAAAGACCAGAAAATTGTCCTGAT
AAACTTTACGATCTTATGCGACGATGTTGGCAACACAGACCTTCAGCACGTCCAACATTT
ATGGATATTATTACAATGCTTTTGGACAGTGTCAGTCCTGAATTTGAAAAAGTCAGTTTC
TTTCATTCACCAGATGGTGTTGAAATTCGACATCAAATGGCATTAAATGAAGTGGCTGTG
TTTACTGATGACGTAACGACACCATTAAGACATGATGAAGATTCAATCATTGATCGAAAT
AATATTCTTATGGAAAACATGAGTAGTCAAAAAAGTCACTACGATGATGACTTGTAA
>g15131.t1 Gene=g15131 Length=1438
MQKIIKNKSHTRNLPRGYYKRKKPPDECTPSVETCQTSIKIDNYFSLRCKFSDNRHVNTK
FHLFYIISLLIIVNATAEDLRLKREIENFSKTTPTPLTLPNDGICKSIDVRFYFVKIHSL
TGCRVVEGSITILMMDEITPKDVANITFPELVEVTGFIMLYRVGGFTSLNQLFPNLSVIR
GRDLFKDYSLVIYEMIHLEEIGLKNLMAIERGNVRIEKNELMCFSKTINWKNIIIQYEDP
YIEKNRLPAHCPNCQNDKCPKSIDGKNTYCWNIEHCQRTCSHCQQNSKKGEMTYCSPNQQ
TCCDHSCIGGCEDDKPKNCFACRKFAYGTYPNIECLDKCPNGTFAHLERRCLTRDQCYDL
NNDSVLKEHDATFIPFEKECRKDCPPNYRKVNTGRKIFCQKCQGSCLKECRFGNLVDSIE
AAQSLKGCNIIEGPLEIQIRGITKSPESGRNIVKELESSLSDIQEIKGYLKIARSHAILS
MSFLKNLRKIHGNSLEGGRNAIMVWENQNLQELWDESHRIEIVRGKLFFHFNPKLCFYKI
EQLARKSAIRGLNASQMIENYETAKISNGDKTPCNLTPLNVTVDQIFPQAALLTWDPLKL
EDERSLLNYVVYYIAAPYTNVTLWDGRDACGDDGWSVEDVNDFRNNKKVSQPLTKLEPYT
QYAYYVKAYTLATEKTGAQSEISYFTTKPDVPEVVKKFKLTVTGPDKIEVSWETLKKVNG
RLDHYILRANAIPQDDKLLLQRDYCKEPIDTSPPPSPPSKDTLPIRIVPKNPNIAPDGVC
DCPTCSKLCSEGKQLAPQKGGFDERQLENDFEDDIQDYVYVRTDDKTTELKDTRTKRQVP
NEIEFPSQPIDPSNPFTVDRETMKNTSDFYFDEIGPETTTFTITGLNHYTTYNIRIRACR
KREEGESFLAEICGPEMKDFATTFRELANDNIPNFYAEQFVNNSLTNIRITWEQPADPNG
LLLAYTIRHKRVDIEHTQPVLHCISTSMLNGTNYYILQKVTPGNYSIDMMATSMAGNGNY
TNPKYVFIKEQSQYTSIWTIIAILFIVFIIGTIGLIWFFKKMYLSNISNMKLIANVNPDY
AGVTYRQDEWEIPREKIIQLQELGCGSFGMVYEGLIKDFHRKGEDVRCAIKTVNESATDK
EQITFLNEASVMKQFDTHHVVRLLGVVSIGQPTLVVMELMASGDLKSYLRSHRPEYDTVS
TEPPPQPPTLRRILQMAIEIADGMAYLSAKKFVHRDLAARNCMVAEDLTVKIGDFGMTRD
IYETDYYRKGTKGLLPVRWMSPESLKDGVFSSSSDVFSYGVVVWEMSTLAQQPYAGLSND
QVLRYVIEGGVMERPENCPDKLYDLMRRCWQHRPSARPTFMDIITMLLDSVSPEFEKVSF
FHSPDGVEIRHQMALNEVAVFTDDVTTPLRHDEDSIIDRNNILMENMSSQKSHYDDDL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 31 | g15131.t1 | CDD | cd00064 | FU | 302 | 352 | 3.67676E-6 |
| 34 | g15131.t1 | CDD | cd00063 | FN3 | 578 | 687 | 1.03476E-7 |
| 35 | g15131.t1 | CDD | cd00063 | FN3 | 876 | 906 | 7.17064E-4 |
| 33 | g15131.t1 | CDD | cd00063 | FN3 | 939 | 1026 | 1.54462E-6 |
| 32 | g15131.t1 | CDD | cd05032 | PTKc_InsR_like | 1090 | 1369 | 9.47222E-172 |
| 24 | g15131.t1 | Gene3D | G3DSA:3.80.20.20 | - | 99 | 333 | 1.4E-65 |
| 25 | g15131.t1 | Gene3D | G3DSA:2.10.220.10 | Hormone Receptor | 334 | 405 | 1.6E-14 |
| 23 | g15131.t1 | Gene3D | G3DSA:3.80.20.20 | - | 406 | 583 | 6.7E-51 |
| 20 | g15131.t1 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins | 584 | 685 | 1.3E-34 |
| 19 | g15131.t1 | Gene3D | G3DSA:2.60.40.10 | Immunoglobulins | 928 | 1037 | 4.2E-16 |
| 21 | g15131.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 1073 | 1178 | 4.6E-32 |
| 22 | g15131.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 1179 | 1391 | 8.8E-64 |
| 5 | g15131.t1 | PANTHER | PTHR24416:SF106 | INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR | 260 | 1385 | 3.0E-272 |
| 6 | g15131.t1 | PANTHER | PTHR24416 | TYROSINE-PROTEIN KINASE RECEPTOR | 260 | 1385 | 3.0E-272 |
| 9 | g15131.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1177 | 1190 | 1.0E-31 |
| 8 | g15131.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1226 | 1244 | 1.0E-31 |
| 10 | g15131.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1275 | 1285 | 1.0E-31 |
| 11 | g15131.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1294 | 1316 | 1.0E-31 |
| 7 | g15131.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 1338 | 1360 | 1.0E-31 |
| 2 | g15131.t1 | Pfam | PF01030 | Receptor L domain | 122 | 233 | 1.8E-22 |
| 1 | g15131.t1 | Pfam | PF00757 | Furin-like cysteine rich region | 252 | 410 | 4.0E-22 |
| 3 | g15131.t1 | Pfam | PF01030 | Receptor L domain | 427 | 542 | 3.2E-25 |
| 4 | g15131.t1 | Pfam | PF07714 | Protein tyrosine and serine/threonine kinase | 1100 | 1367 | 4.8E-93 |
| 27 | g15131.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 60 | - |
| 30 | g15131.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 61 | 77 | - |
| 28 | g15131.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 78 | 1036 | - |
| 29 | g15131.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 1037 | 1059 | - |
| 26 | g15131.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1060 | 1438 | - |
| 46 | g15131.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 1103 | 1131 | - |
| 44 | g15131.t1 | ProSitePatterns | PS00109 | Tyrosine protein kinases specific active-site signature. | 1232 | 1244 | - |
| 45 | g15131.t1 | ProSitePatterns | PS00239 | Receptor tyrosine kinase class II signature. | 1260 | 1268 | - |
| 49 | g15131.t1 | ProSiteProfiles | PS50853 | Fibronectin type-III domain profile. | 577 | 690 | 14.698 |
| 47 | g15131.t1 | ProSiteProfiles | PS50853 | Fibronectin type-III domain profile. | 822 | 920 | 6.785 |
| 48 | g15131.t1 | ProSiteProfiles | PS50853 | Fibronectin type-III domain profile. | 934 | 1031 | 10.564 |
| 50 | g15131.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 1097 | 1375 | 34.548 |
| 43 | g15131.t1 | SMART | SM00261 | furin_3 | 299 | 345 | 3.5E-6 |
| 40 | g15131.t1 | SMART | SM00060 | FN3_2 | 575 | 675 | 8.7E-4 |
| 39 | g15131.t1 | SMART | SM00060 | FN3_2 | 692 | 907 | 7.3E-6 |
| 41 | g15131.t1 | SMART | SM00060 | FN3_2 | 933 | 1018 | 37.0 |
| 42 | g15131.t1 | SMART | SM00219 | tyrkin_6 | 1097 | 1367 | 7.3E-133 |
| 17 | g15131.t1 | SUPERFAMILY | SSF52058 | L domain-like | 103 | 272 | 4.82E-35 |
| 15 | g15131.t1 | SUPERFAMILY | SSF57184 | Growth factor receptor domain | 302 | 411 | 6.46E-8 |
| 16 | g15131.t1 | SUPERFAMILY | SSF52058 | L domain-like | 413 | 575 | 1.87E-35 |
| 14 | g15131.t1 | SUPERFAMILY | SSF49265 | Fibronectin type III | 574 | 689 | 2.76E-27 |
| 12 | g15131.t1 | SUPERFAMILY | SSF49265 | Fibronectin type III | 685 | 906 | 1.23E-12 |
| 13 | g15131.t1 | SUPERFAMILY | SSF49265 | Fibronectin type III | 858 | 1028 | 1.03E-17 |
| 18 | g15131.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 1068 | 1367 | 3.14E-77 |
| 36 | g15131.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 61 | 78 | - |
| 37 | g15131.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 1037 | 1059 | - |
| 38 | g15131.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 1160 | 1182 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0005524 | ATP binding | MF |
| GO:0006468 | protein phosphorylation | BP |
| GO:0004713 | protein tyrosine kinase activity | MF |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | BP |
| GO:0005515 | protein binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K04527 (insulin receptor)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
