General information for g15422.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Serine/threonine-protein kinase pelle.
Parent gene
- The parent gene g15422 is located on chr_4: 5406718..5408570 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g15422 | g15422.t1 | TSS | g15422.t1 | 5406214 | 5406214 |
| chr_4 | g15422 | g15422.t1 | isoform | g15422.t1 | 5406718 | 5408570 |
| chr_4 | g15422 | g15422.t1 | exon | g15422.t1.exon1 | 5406718 | 5406867 |
| chr_4 | g15422 | g15422.t1 | cds | g15422.t1.CDS1 | 5406718 | 5406867 |
| chr_4 | g15422 | g15422.t1 | exon | g15422.t1.exon2 | 5407177 | 5407910 |
| chr_4 | g15422 | g15422.t1 | cds | g15422.t1.CDS2 | 5407177 | 5407910 |
| chr_4 | g15422 | g15422.t1 | exon | g15422.t1.exon3 | 5407977 | 5408101 |
| chr_4 | g15422 | g15422.t1 | cds | g15422.t1.CDS3 | 5407977 | 5408101 |
| chr_4 | g15422 | g15422.t1 | exon | g15422.t1.exon4 | 5408158 | 5408570 |
| chr_4 | g15422 | g15422.t1 | cds | g15422.t1.CDS4 | 5408158 | 5408570 |
| chr_4 | g15422 | g15422.t1 | TTS | g15422.t1 | 5408832 | 5408832 |
Sequences
>g15422.t1 Gene=g15422 Length=1422
ATGACAACCTCAACTGCACAACAAGTAGACCATATAGATTTGACAAAATTACCAGTACAT
GAAAAGACAAAATTATGTGCAATCCTGGATCAAAATGAAACATGGGCTGAACTAGGAAAG
CTAATGATGTTTAATGCTTTTGAAATCATGGAAATGCAAACCGAAGCTGATCGCAAACGA
AAATCTCCTTCGGAAGTTCTCATCACAAAATGGTCACGTCATGGTCACATTGTCACAGAA
CTTTTCAAATTACTCTCAATTATGCAACATTATCAAGCAATGGAAGCAATCAAACATTCA
GTTCCATCAGCATATCATATTTGGATCAAACCAGTGCAACCTCACATTAGCCGACTTATA
AATGGTCAGCAAATTTCATCAAAACTTCAAAATATACATGAAAATGTTCAACAAAGTCAA
ATTTTTCAATCACGTCAAGATCGACCGAATGTTGTGACTAAAAATGATATTAAAGACAGC
TTACGAGAATTATTGAACATTCCAGAAATCCCAATTGATGAATTAGCTTTTGCAACCAAC
AATTGGTCAGAAGAGAATGTCTTAGGTAAAGGAGGTTTTGGAACAGTCTACAAAGGTGAA
TGGTTGTCAACAAAAGTTGCCATAAAAAAGCTCGAATATCGTGAAAGTAGATCAGGAACT
TCTCGTGATTATTTGTTACAAAGTTTGAATGAATTGCGACATTTAAATCACTGCAGACAT
GACAATATTTTACCAATTTATGGATATTCCTTAAAAGATGAAACTTGCTTGGTTGTTTAT
CAATTAATGCCTGGTGGAAGCTTGGAAGAAAGATTATCAAGAAAGAATGGAAGTGAAGCA
TTAACTTGGCCTCAAAGATGGACTGTTTCGAAAGGAACTGCAAGAGGACTTCAATATCTC
CATCGCTTTAGTCAGAAACCTTTAATTCACGGTGACATTAAACCAGCAAATATTCTTCTA
GACACATGTGGTGAACCAAAAATTGGAGATTTCGGTCTTTCACGTGAAGGTCACATAAAA
GATGATTATCAAGAATTGTCAAGAGTTTTCGGTACAAAGCCTTACCTTCCAAAAGAATTT
TTAAATTCGCATTTGTTTTCAACAAAAGTTGATGTTTTTAGTTTTGGTGTTGTTTTATTT
GAACTTGCAACAGGATTTAAAGCTTATGATAAATCAAGAAAATTGCCATTTTTGTATGAT
CATTTATCGAAGTTGGATGAGTCTTTGTTGGAAAATATTACAAGAGTTATTGACAAATCA
ACAGTTAGTGATGGAGCTTGTTTGAATTTATGTCAATTGATGATTTACTTAGGAAAGAAA
TGTTGTGATCATAATCCAAATTATAGACCTGATATGGCAAGCGTATTGAAAGCTCTTGAA
ACATTCAATCCAGTTATTGTGATGAATACTAATGGAAATTAA
>g15422.t1 Gene=g15422 Length=473
MTTSTAQQVDHIDLTKLPVHEKTKLCAILDQNETWAELGKLMMFNAFEIMEMQTEADRKR
KSPSEVLITKWSRHGHIVTELFKLLSIMQHYQAMEAIKHSVPSAYHIWIKPVQPHISRLI
NGQQISSKLQNIHENVQQSQIFQSRQDRPNVVTKNDIKDSLRELLNIPEIPIDELAFATN
NWSEENVLGKGGFGTVYKGEWLSTKVAIKKLEYRESRSGTSRDYLLQSLNELRHLNHCRH
DNILPIYGYSLKDETCLVVYQLMPGGSLEERLSRKNGSEALTWPQRWTVSKGTARGLQYL
HRFSQKPLIHGDIKPANILLDTCGEPKIGDFGLSREGHIKDDYQELSRVFGTKPYLPKEF
LNSHLFSTKVDVFSFGVVLFELATGFKAYDKSRKLPFLYDHLSKLDESLLENITRVIDKS
TVSDGACLNLCQLMIYLGKKCCDHNPNYRPDMASVLKALETFNPVIVMNTNGN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g15422.t1 | CDD | cd14066 | STKc_IRAK | 188 | 460 | 5.23737E-89 |
| 8 | g15422.t1 | Gene3D | G3DSA:1.10.533.10 | Death Domain | 6 | 109 | 8.0E-21 |
| 7 | g15422.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 151 | 262 | 1.2E-21 |
| 9 | g15422.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 263 | 469 | 2.7E-48 |
| 3 | g15422.t1 | PANTHER | PTHR24419:SF33 | SERINE/THREONINE-PROTEIN KINASE PELLE | 14 | 462 | 2.8E-156 |
| 4 | g15422.t1 | PANTHER | PTHR24419 | INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE | 14 | 462 | 2.8E-156 |
| 1 | g15422.t1 | Pfam | PF00531 | Death domain | 24 | 100 | 5.3E-7 |
| 2 | g15422.t1 | Pfam | PF00069 | Protein kinase domain | 184 | 457 | 2.1E-43 |
| 12 | g15422.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 188 | 210 | - |
| 11 | g15422.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 308 | 320 | - |
| 14 | g15422.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 182 | 466 | 38.025 |
| 13 | g15422.t1 | SMART | SM00220 | serkin_6 | 182 | 462 | 3.7E-35 |
| 6 | g15422.t1 | SUPERFAMILY | SSF47986 | DEATH domain | 10 | 115 | 7.06E-20 |
| 5 | g15422.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 162 | 460 | 5.13E-70 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0007165 | signal transduction | BP |
| GO:0005524 | ATP binding | MF |
| GO:0005515 | protein binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K04730 (interleukin-1 receptor-associated kinase 1)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
