General information for g15557.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Palmitoyl-protein thioesterase 1.
Parent gene
- The parent gene g15557 is located on chr_4: 5852783..5854008 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g15557 | g15557.t1 | TTS | g15557.t1 | 5852679 | 5852679 |
| chr_4 | g15557 | g15557.t1 | isoform | g15557.t1 | 5852783 | 5853868 |
| chr_4 | g15557 | g15557.t1 | exon | g15557.t1.exon1 | 5852783 | 5853436 |
| chr_4 | g15557 | g15557.t1 | cds | g15557.t1.CDS1 | 5852783 | 5853436 |
| chr_4 | g15557 | g15557.t1 | exon | g15557.t1.exon2 | 5853547 | 5853714 |
| chr_4 | g15557 | g15557.t1 | cds | g15557.t1.CDS2 | 5853547 | 5853714 |
| chr_4 | g15557 | g15557.t1 | exon | g15557.t1.exon3 | 5853779 | 5853868 |
| chr_4 | g15557 | g15557.t1 | cds | g15557.t1.CDS3 | 5853779 | 5853868 |
| chr_4 | g15557 | g15557.t1 | TSS | g15557.t1 | 5854030 | 5854030 |
Sequences
>g15557.t1 Gene=g15557 Length=912
ATGAGATCAACACCAATTTTGTTGCTCATCATAGTGCTGATCTCAACAATTTATGGTAAT
AATGTGACACAGAATTACACTCCAATTGTGATGTGGCATGGTATGGGTGACTCATGTTGC
TTTCCATTCTCACTTGGTTCAATTAAAAAACTATTGGAGAGGTCATTAGAAAATAAAGTT
TATGTCACATCGTTGGAAATTGGTGGGAGTTATGTGAGAGATTATGAATCAGGCTATTTT
ATTCATCCTGATAAGCAACTTCAAGATGCATGCAACCAAATAGCAAACAATAAAATTCTT
TCAAACGGCTTCAATGCAATTGGTTTCTCACAAGGTTCACAATTTTTACGTGCTTTAGTG
CAAAGATGTCCAGCTGCAAAAGTCAAAAATTTGATCTCACTTGGTGGTCAGCATCAAGGT
GTTTATGGACTTCCAAACTGTCCATCATTGACCACAAAATCATGTGAATACTTTCGTGAA
ATGTTAAATTATGCTGCTTATACTGGTTGGGTTCAAAAGCGACTCGTGCAAGCCACTTAT
TGGCATGATCCAATGAATGAAAATTTGTATAAAAGTAAAAGTACTTTTTTGGCTGAAATT
AATAATGAAAGAAAAATCAATCAAAAATATATTGATAGACTACAGAAGCTTGAAAATTTT
GTGATGGTTAAATTTTGGAATGACACAATTGTTCAACCAGTTGATACACAATGGTTTGGT
TTTTATAAGCCAGGCAGTGACAGTGAAACATTGACAATGGAAGAGAGCGATATTTACACC
AAAGATCGACTTGGATTGAAGAAAATGAAAGAGGACGGAAAGATCAAGTTCATTGCGGTT
GAAGGCAATCATTTGCAAATTAAGAACGATTGGTTTATTGCTAATATCATTGATGTTTAT
TTGAAGAACTAA
>g15557.t1 Gene=g15557 Length=303
MRSTPILLLIIVLISTIYGNNVTQNYTPIVMWHGMGDSCCFPFSLGSIKKLLERSLENKV
YVTSLEIGGSYVRDYESGYFIHPDKQLQDACNQIANNKILSNGFNAIGFSQGSQFLRALV
QRCPAAKVKNLISLGGQHQGVYGLPNCPSLTTKSCEYFREMLNYAAYTGWVQKRLVQATY
WHDPMNENLYKSKSTFLAEINNERKINQKYIDRLQKLENFVMVKFWNDTIVQPVDTQWFG
FYKPGSDSETLTMEESDIYTKDRLGLKKMKEDGKIKFIAVEGNHLQIKNDWFIANIIDVY
LKN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g15557.t1 | Gene3D | G3DSA:3.40.50.1820 | - | 18 | 303 | 1.8E-107 |
| 2 | g15557.t1 | PANTHER | PTHR11247 | PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 | 9 | 302 | 5.8E-98 |
| 3 | g15557.t1 | PANTHER | PTHR11247:SF8 | PALMITOYL-PROTEIN THIOESTERASE 1 | 9 | 302 | 5.8E-98 |
| 6 | g15557.t1 | PRINTS | PR00414 | Palmitoyl protein thioesterase signature | 20 | 42 | 1.1E-44 |
| 8 | g15557.t1 | PRINTS | PR00414 | Palmitoyl protein thioesterase signature | 61 | 80 | 1.1E-44 |
| 7 | g15557.t1 | PRINTS | PR00414 | Palmitoyl protein thioesterase signature | 101 | 117 | 1.1E-44 |
| 9 | g15557.t1 | PRINTS | PR00414 | Palmitoyl protein thioesterase signature | 146 | 165 | 1.1E-44 |
| 10 | g15557.t1 | PRINTS | PR00414 | Palmitoyl protein thioesterase signature | 180 | 199 | 1.1E-44 |
| 5 | g15557.t1 | PRINTS | PR00414 | Palmitoyl protein thioesterase signature | 232 | 250 | 1.1E-44 |
| 4 | g15557.t1 | PRINTS | PR00414 | Palmitoyl protein thioesterase signature | 277 | 295 | 1.1E-44 |
| 1 | g15557.t1 | Pfam | PF02089 | Palmitoyl protein thioesterase | 28 | 284 | 1.3E-82 |
| 15 | g15557.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 19 | - |
| 16 | g15557.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 5 | - |
| 17 | g15557.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 6 | 14 | - |
| 18 | g15557.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 15 | 19 | - |
| 14 | g15557.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 20 | 303 | - |
| 11 | g15557.t1 | SUPERFAMILY | SSF53474 | alpha/beta-Hydrolases | 24 | 298 | 6.22E-87 |
| 12 | g15557.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 19 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0098599 | palmitoyl hydrolase activity | MF |
| GO:0008474 | palmitoyl-(protein) hydrolase activity | MF |
| GO:0002084 | protein depalmitoylation | BP |
KEGG
Orthology
- This transcript has been annotated with K01074 (palmitoyl-protein thioesterase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
