Gene loci information

Transcript annotation

  • This transcript has been annotated as NAD-dependent protein deacetylase Sirt6.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_4 g15776 g15776.t1 isoform g15776.t1 6759384 6760564
chr_4 g15776 g15776.t1 exon g15776.t1.exon1 6759384 6759449
chr_4 g15776 g15776.t1 cds g15776.t1.CDS1 6759384 6759449
chr_4 g15776 g15776.t1 exon g15776.t1.exon2 6759517 6759614
chr_4 g15776 g15776.t1 cds g15776.t1.CDS2 6759517 6759614
chr_4 g15776 g15776.t1 exon g15776.t1.exon3 6759733 6760564
chr_4 g15776 g15776.t1 cds g15776.t1.CDS3 6759733 6760564
chr_4 g15776 g15776.t1 TTS g15776.t1 6760617 6760617
chr_4 g15776 g15776.t1 TSS g15776.t1 NA NA

Sequences

>g15776.t1 Gene=g15776 Length=996
ATGTCATGCAATTATGCTGATAATTTATCACCTTATGATGACAAAGGAATATTAGGAACA
CCAGAAATTTTTGACACACAAGATGAAGTAAATAAAAAAGTTGAGCAACTTGTTGATTTA
ATTTTGACTTCTAAACACATTGTTGTCCACACTGGAGCTGGAATCTCAACATCTTGTGGC
ATTCCAGACTTCAGAGGCCCAAATGGTGTCTGGACACTCGAACAAAAAGGAATAAAACCA
AAAATTGATGTCAGTTTTAAAGATGCAATCCCATCAAAAACTCATAGAATTCTCAAACTT
CTCCTCGATCGTGGTTTCATAAAATTTATCATAAGTCAAAACATTGATGGTCTTCATATG
CGTTGTGGAACACCTCGAAAGAATCTCTCTGAACTTCATGGAAACATGTTCACATCAGAA
TGTCCAAAATGTAAGCGACAATTTGTAAGATCAAATCCAGTGCCAACGGTAGGTAGAAAA
GCAGTTGGAGTGACTTGTAAAAATAATCAAAGACCATGTCGTGGTCAATTAATTGACACA
ATTCTCGATTGGGAAGATAATTTACCTGAAGATGACATTGAAATGGCTATAATGCACTCT
ACATTAGCTGACTTAAACATTGGACTTGGTTCGAGCTTTCAAATTATGCCAAGCGGAAAA
TTTCCATTGAGAAGTCAAAAATATGGTGGAAAATTTGCACTAATAAATTTGCAGCCAATA
AAAGTTGAGAAAAAAGCTGACTTAGTAATTCATAGCTATGTAGATGAAGTCATGGAAAAA
ATAATAAAACGACTTGGTATTGAAGAAATTCCAGAATATTGTGAAGATGAAGATCCAACT
AGAAAAGAAGATTTAAGCATTAATTGGAACATTCCAAAAGAAACAATCAAAGAAGTCGAA
ATTCTTTATAAAGCAAGAACAGAAAGAAACAAAAAACAGAAATTCTCAACTGCCGATGAA
ATTGTTGTTAAGAAAAAAATAAAAAAAGATGAATAA

>g15776.t1 Gene=g15776 Length=331
MSCNYADNLSPYDDKGILGTPEIFDTQDEVNKKVEQLVDLILTSKHIVVHTGAGISTSCG
IPDFRGPNGVWTLEQKGIKPKIDVSFKDAIPSKTHRILKLLLDRGFIKFIISQNIDGLHM
RCGTPRKNLSELHGNMFTSECPKCKRQFVRSNPVPTVGRKAVGVTCKNNQRPCRGQLIDT
ILDWEDNLPEDDIEMAIMHSTLADLNIGLGSSFQIMPSGKFPLRSQKYGGKFALINLQPI
KVEKKADLVIHSYVDEVMEKIIKRLGIEEIPEYCEDEDPTRKEDLSINWNIPKETIKEVE
ILYKARTERNKKQKFSTADEIVVKKKIKKDE

Protein features from InterProScan

Transcript Database ID Name Start End E.value
6 g15776.t1 Gene3D G3DSA:3.40.50.1220 - 37 265 0.000000
7 g15776.t1 Gene3D G3DSA:2.20.28.200 - 134 185 0.000000
3 g15776.t1 PANTHER PTHR45853 NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-(6/7) FAMILY MEMBER 1 320 0.000000
4 g15776.t1 PANTHER PTHR45853:SF3 NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6 1 320 0.000000
1 g15776.t1 Pfam PF02146 Sir2 family 52 73 0.000013
2 g15776.t1 Pfam PF02146 Sir2 family 86 217 0.000000
8 g15776.t1 ProSiteProfiles PS50305 Sirtuin catalytic domain profile. 35 270 39.751000
5 g15776.t1 SUPERFAMILY SSF52467 DHS-like NAD/FAD-binding domain 3 289 0.000000

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0070403 NAD+ binding MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values