General information for g15776.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Putative NAD-dependent protein deacetylase Sirt6.
Parent gene
- The parent gene g15776 is located on chr_4: 6759619..6760564 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g15776 | g15776.t2 | isoform | g15776.t2 | 6759619 | 6760564 |
| chr_4 | g15776 | g15776.t2 | exon | g15776.t2.exon1 | 6759619 | 6760564 |
| chr_4 | g15776 | g15776.t2 | cds | g15776.t2.CDS1 | 6759926 | 6760564 |
| chr_4 | g15776 | g15776.t2 | TTS | g15776.t2 | 6760617 | 6760617 |
| chr_4 | g15776 | g15776.t2 | TSS | g15776.t2 | NA | NA |
Sequences
>g15776.t2 Gene=g15776 Length=946
AGTATTAATTGAAAATTTCTGTGATGATTTTTTGTTTCAATTTTATTTTTAAAAAATTGT
TTTCAATCAAGAAAAAGGCAAAAAAAAATAAAATTTCTAAAAATATTATTTTAGCTCAAC
ATCTTGTGGCATTCCAGACTTCAGAGGCCCAAATGGTGTCTGGACACTCGAACAAAAAGG
AATAAAACCAAAAATTGATGTCAGTTTTAAAGATGCAATCCCATCAAAAACTCATAGAAT
TCTCAAACTTCTCCTCGATCGTGGTTTCATAAAATTTATCATAAGTCAAAACATTGATGG
TCTTCATATGCGTTGTGGAACACCTCGAAAGAATCTCTCTGAACTTCATGGAAACATGTT
CACATCAGAATGTCCAAAATGTAAGCGACAATTTGTAAGATCAAATCCAGTGCCAACGGT
AGGTAGAAAAGCAGTTGGAGTGACTTGTAAAAATAATCAAAGACCATGTCGTGGTCAATT
AATTGACACAATTCTCGATTGGGAAGATAATTTACCTGAAGATGACATTGAAATGGCTAT
AATGCACTCTACATTAGCTGACTTAAACATTGGACTTGGTTCGAGCTTTCAAATTATGCC
AAGCGGAAAATTTCCATTGAGAAGTCAAAAATATGGTGGAAAATTTGCACTAATAAATTT
GCAGCCAATAAAAGTTGAGAAAAAAGCTGACTTAGTAATTCATAGCTATGTAGATGAAGT
CATGGAAAAAATAATAAAACGACTTGGTATTGAAGAAATTCCAGAATATTGTGAAGATGA
AGATCCAACTAGAAAAGAAGATTTAAGCATTAATTGGAACATTCCAAAAGAAACAATCAA
AGAAGTCGAAATTCTTTATAAAGCAAGAACAGAAAGAAACAAAAAACAGAAATTCTCAAC
TGCCGATGAAATTGTTGTTAAGAAAAAAATAAAAAAAGATGAATAA
>g15776.t2 Gene=g15776 Length=212
MRCGTPRKNLSELHGNMFTSECPKCKRQFVRSNPVPTVGRKAVGVTCKNNQRPCRGQLID
TILDWEDNLPEDDIEMAIMHSTLADLNIGLGSSFQIMPSGKFPLRSQKYGGKFALINLQP
IKVEKKADLVIHSYVDEVMEKIIKRLGIEEIPEYCEDEDPTRKEDLSINWNIPKETIKEV
EILYKARTERNKKQKFSTADEIVVKKKIKKDE
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 6 | g15776.t2 | Gene3D | G3DSA:2.20.28.200 | - | 15 | 64 | 0.0000000 |
| 5 | g15776.t2 | Gene3D | G3DSA:3.40.50.1220 | - | 65 | 149 | 0.0000000 |
| 2 | g15776.t2 | PANTHER | PTHR45853 | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-(6/7) FAMILY MEMBER | 1 | 201 | 0.0000000 |
| 3 | g15776.t2 | PANTHER | PTHR45853:SF3 | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-6 | 1 | 201 | 0.0000000 |
| 1 | g15776.t2 | Pfam | PF02146 | Sir2 family | 8 | 98 | 0.0000068 |
| 7 | g15776.t2 | ProSiteProfiles | PS50305 | Sirtuin catalytic domain profile. | 1 | 151 | 19.0220000 |
| 4 | g15776.t2 | SUPERFAMILY | SSF52467 | DHS-like NAD/FAD-binding domain | 2 | 172 | 0.0000000 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0070403 | NAD+ binding | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
