General information for g15785.t10
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Lactoylglutathione lyase.
Parent gene
- The parent gene g15785 is located on chr_4: 6775310..6776119 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g15785 | g15785.t10 | isoform | g15785.t10 | 6774847 | 6776119 |
| chr_4 | g15785 | g15785.t10 | exon | g15785.t10.exon1 | 6774847 | 6775015 |
| chr_4 | g15785 | g15785.t10 | cds | g15785.t10.CDS1 | 6774987 | 6775015 |
| chr_4 | g15785 | g15785.t10 | exon | g15785.t10.exon2 | 6775090 | 6775309 |
| chr_4 | g15785 | g15785.t10 | cds | g15785.t10.CDS2 | 6775090 | 6775309 |
| chr_4 | g15785 | g15785.t10 | exon | g15785.t10.exon3 | 6775368 | 6775645 |
| chr_4 | g15785 | g15785.t10 | cds | g15785.t10.CDS3 | 6775368 | 6775634 |
| chr_4 | g15785 | g15785.t10 | exon | g15785.t10.exon4 | 6775929 | 6776119 |
| chr_4 | g15785 | g15785.t10 | TSS | g15785.t10 | 6775951 | 6775951 |
| chr_4 | g15785 | g15785.t10 | TTS | g15785.t10 | NA | NA |
Sequences
>g15785.t10 Gene=g15785 Length=858
TTTAAAATATTTTTTTAACTTTTCGTGATTTTAAAATTGAAAAATTTTCTTTTTTGTAAA
CAAACCGAGATGATAAAATTTCTGTTGAATTTAGAAACTTCGAAAACAGCTGATTAGATA
AAAATAAAAACTTTTTGCCGACAATTGTTAGTTTTTTGTCTTATCAATATTCTTCATTTG
GATTTTGATCGAAACATAAAAAATGTCAGGCTTAACGGATGCTGAAGCAAATGCACTTTG
CCGTCCATTTGATGGCTCAACTAAGGATTTTCTCTTCCAACAAACAATGTATCGCATCAA
AGATCCAAGAAAAACACTTCCATTTTACTCTGAAGTGCTTGGCATGACACTTTTAGTCAA
ATTGGATTTTCCTGAAGCTAAATTTTCTCTCTATTTTATGGGATATGAAAATCCTGCTGA
TGTTCCAAGTGATCCAGCTAAAAGAAAAGTTTGGGCAATGTCAAGAAAGGCAACTGTTGA
ATTGACTCACAATTGGGGAACTGAAGATGATCCAAATCAAAGTTATCATAATGGCAATAA
TGATCCACGTGGATTTGGACACATTGGCATTATGGTTCCAAATGTTGAAGAAGCTTGTGC
ACGATTTGAGAAATTTGGTGTTGAATTTGTTAAGAAACCAAACGATGGTCGCATGAAAGG
ACTTGCTTTTATTAAAGATCCAGATGGCTTATCCACATCTGTTGATTTCTATTTTTAGAC
AAACAACACTGAAAACATATTTGAGAAAAAATAAACAAATCAAAGAAAATATTGGGAAAA
TTGATTTTTCTTTACTTCGGCGCTATTGAATTTTCATTAAAAGATTTACTTTTTCTTTAA
TATTTAAATTTATTTTAT
>g15785.t10 Gene=g15785 Length=171
MSGLTDAEANALCRPFDGSTKDFLFQQTMYRIKDPRKTLPFYSEVLGMTLLVKLDFPEAK
FSLYFMGYENPADVPSDPAKRKVWAMSRKATVELTHNWGTEDDPNQSYHNGNNDPRGFGH
IGIMVPNVEEACARFEKFGVEFVKKPNDGRMKGLAFIKDPDGLSTSVDFYF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 6 | g15785.t10 | CDD | cd07233 | GlxI_Zn | 25 | 162 | 3.45485E-90 |
| 5 | g15785.t10 | Gene3D | G3DSA:3.10.180.10 | 2 | 1 | 167 | 7.8E-62 |
| 2 | g15785.t10 | PANTHER | PTHR10374:SF30 | LACTOYLGLUTATHIONE LYASE | 12 | 164 | 2.1E-74 |
| 3 | g15785.t10 | PANTHER | PTHR10374 | LACTOYLGLUTATHIONE LYASE GLYOXALASE I | 12 | 164 | 2.1E-74 |
| 1 | g15785.t10 | Pfam | PF00903 | Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily | 27 | 163 | 1.2E-16 |
| 7 | g15785.t10 | ProSitePatterns | PS00934 | Glyoxalase I signature 1. | 27 | 48 | - |
| 8 | g15785.t10 | ProSiteProfiles | PS51819 | Vicinal oxygen chelate (VOC) domain profile. | 24 | 170 | 20.685 |
| 4 | g15785.t10 | SUPERFAMILY | SSF54593 | Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase | 24 | 163 | 1.03E-30 |
| 9 | g15785.t10 | TIGRFAM | TIGR00068 | glyox_I: lactoylglutathione lyase | 16 | 163 | 9.1E-51 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004462 | lactoylglutathione lyase activity | MF |
| GO:0046872 | metal ion binding | MF |
KEGG
Orthology
- This transcript has been annotated with K01759 (lactoylglutathione lyase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
