General information for g15831.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Mitogen-activated protein kinase kinase kinase 7.
Parent gene
- The parent gene g15831 is located on chr_4: 6960734..6961859 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g15831 | g15831.t1 | TTS | g15831.t1 | 6953958 | 6953958 |
| chr_4 | g15831 | g15831.t1 | isoform | g15831.t1 | 6954784 | 6961859 |
| chr_4 | g15831 | g15831.t1 | exon | g15831.t1.exon1 | 6954784 | 6954891 |
| chr_4 | g15831 | g15831.t1 | cds | g15831.t1.CDS1 | 6954784 | 6954891 |
| chr_4 | g15831 | g15831.t1 | exon | g15831.t1.exon2 | 6955341 | 6955451 |
| chr_4 | g15831 | g15831.t1 | cds | g15831.t1.CDS2 | 6955341 | 6955451 |
| chr_4 | g15831 | g15831.t1 | exon | g15831.t1.exon3 | 6955506 | 6955789 |
| chr_4 | g15831 | g15831.t1 | cds | g15831.t1.CDS3 | 6955506 | 6955789 |
| chr_4 | g15831 | g15831.t1 | exon | g15831.t1.exon4 | 6959477 | 6960004 |
| chr_4 | g15831 | g15831.t1 | cds | g15831.t1.CDS4 | 6959477 | 6960004 |
| chr_4 | g15831 | g15831.t1 | exon | g15831.t1.exon5 | 6960180 | 6960495 |
| chr_4 | g15831 | g15831.t1 | cds | g15831.t1.CDS5 | 6960180 | 6960495 |
| chr_4 | g15831 | g15831.t1 | exon | g15831.t1.exon6 | 6960549 | 6960734 |
| chr_4 | g15831 | g15831.t1 | cds | g15831.t1.CDS6 | 6960549 | 6960734 |
| chr_4 | g15831 | g15831.t1 | exon | g15831.t1.exon7 | 6961567 | 6961674 |
| chr_4 | g15831 | g15831.t1 | cds | g15831.t1.CDS7 | 6961567 | 6961674 |
| chr_4 | g15831 | g15831.t1 | exon | g15831.t1.exon8 | 6961773 | 6961859 |
| chr_4 | g15831 | g15831.t1 | cds | g15831.t1.CDS8 | 6961773 | 6961859 |
| chr_4 | g15831 | g15831.t1 | TSS | g15831.t1 | 6962094 | 6962094 |
Sequences
>g15831.t1 Gene=g15831 Length=1728
ATGGCAGAAAGAAGACGTGATTATGATGGAATTAGTGAAGAAATTCATTGCGAAGAAATT
GATCACAATGAAATTGAAATCATTCAGCTGATCGGCAAAGGAAGTTTCGGAAGTGTTTAT
AAAGCAAATTGGAAGACTAATGTGGTTGCAGTTAAGGCACTTGCTATGCCACCAGAAAAA
GGACCTTTAGTAGAAGTTCGCTATCTTTCACGAGTTCAACACCAAAACATAATTGGACTT
TATGGAACAGTAATTAAAGGACCGTTAGTGAGTTTAGTTATGGAATATGCCGAAGGTGGA
TCACTTTACAATCTTCTTCACTGTTCAAGAATTGAATACACAGCAAGTCATGCAATGTCT
TGGTGTCGACAAACTGCTGATGGTGTCGCTTACCTTCATGCAATGCGTCCAAAGCCTCTA
ATCCATCGTGATTTGAAGCCACCAAATTTGTTACTAGTCAAAAATGGTCTTGTGTTGAAA
ATTTGTGATTTTGGCACTGTGACTGATAAAAGTACATTGATGACAAATAATAAAGGAAGT
GCTGCATGGATGGCGCCAGAAGTTTTTGAGGGTTCAATTTATTCAGAAAGATGCGATGTT
TTCAGTTGGAGTATCATTTTATGGGAATGTTTGGCACGTGAATTGCCTTTTAAAGAAATT
GAATTGACTTACTCAATTATGTGGTGTGTTCATAAAGGTCAACGCCCACATAAAATAGAA
GGCCTTCCAAAGCCAATAAATCAATTAATGACACAATGTTGGGATCCTTTACCCCAAAAT
CGTCCATCAATGGAAGAAGTTCATGAAAGAATGAAAACACTTTGTGAATTTTTCCCTGAA
TGTGAACCACTCAATATGGATGAAACATATGACGATGAAACCTCAAATATTGACACATAT
GATTCCATAATTTGGCCTACAGAGCAAACAGAAATGCCACAAATTAGAGTCAGTGCCAAT
ACTTATGATTCAAGTTATCACAATACCTCACGGACACCAACTGCACAACAATATCTTCTT
AATGTTTCATCAGTTGATGCAGCACGATGGTCAAGTGGTGATTCTGGTAATCCAAAAATT
GTCTCATCAACTTTTCACAATGAACCACCTATGGTTAGAAGTGTCAGCACTGGCAGTGGC
ATGATGACACCACTCAATATCGATGTTGATCCAAATGCTTGGGATTTAAAGAATTACGAA
CTGCAACGACTCATTGGCGGCAACTCCAAAAATCAGGGCATCGCAATAACAAAAAACACA
GCATCAACGACACTTCATCCCGATCATTCACATCATCCCGCATATACGTCATCACATTCA
CCACAGTCAAGCACGAGAGTCAGCGTGGAGTCGACATCGATCAATGGCTTTCAAACAAAT
CGCAGTGAGCTTGACATGGCGATGCTGCAAATTTTAGATCCGCACTTGAGACCCATTCCA
CCTGCCAATGATCCAACATCACAGAGAATTTACAAAGAACATCTTGATTTGGCTCAAGAA
TATTTCAAAACACAGACAGATATGGCATATTTGGCTGAAAATAAAAAGAAAATTCTTCAA
AAAATGACACCAGAAGAACAAAAAAATCGATTAGAAATTTGTAATAAATTAAGAGAAAAA
GAATCACTATTGAAATTAGAAGCTACTTTAAGGCAACAACTTGAAATGGTAAAAAATCAA
CAAAATAATCATGATAATGTTAATGAAGAAGGTTTTTGTATGCTATGA
>g15831.t1 Gene=g15831 Length=575
MAERRRDYDGISEEIHCEEIDHNEIEIIQLIGKGSFGSVYKANWKTNVVAVKALAMPPEK
GPLVEVRYLSRVQHQNIIGLYGTVIKGPLVSLVMEYAEGGSLYNLLHCSRIEYTASHAMS
WCRQTADGVAYLHAMRPKPLIHRDLKPPNLLLVKNGLVLKICDFGTVTDKSTLMTNNKGS
AAWMAPEVFEGSIYSERCDVFSWSIILWECLARELPFKEIELTYSIMWCVHKGQRPHKIE
GLPKPINQLMTQCWDPLPQNRPSMEEVHERMKTLCEFFPECEPLNMDETYDDETSNIDTY
DSIIWPTEQTEMPQIRVSANTYDSSYHNTSRTPTAQQYLLNVSSVDAARWSSGDSGNPKI
VSSTFHNEPPMVRSVSTGSGMMTPLNIDVDPNAWDLKNYELQRLIGGNSKNQGIAITKNT
ASTTLHPDHSHHPAYTSSHSPQSSTRVSVESTSINGFQTNRSELDMAMLQILDPHLRPIP
PANDPTSQRIYKEHLDLAQEYFKTQTDMAYLAENKKKILQKMTPEEQKNRLEICNKLREK
ESLLKLEATLRQQLEMVKNQQNNHDNVNEEGFCML
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g15831.t1 | Coils | Coil | Coil | 540 | 570 | - |
| 9 | g15831.t1 | Gene3D | G3DSA:3.30.200.20 | Phosphorylase Kinase; domain 1 | 16 | 98 | 4.7E-20 |
| 10 | g15831.t1 | Gene3D | G3DSA:1.10.510.10 | Transferase(Phosphotransferase) domain 1 | 99 | 303 | 1.0E-54 |
| 15 | g15831.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 426 | 448 | - |
| 2 | g15831.t1 | PANTHER | PTHR46716 | MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7 | 15 | 565 | 3.4E-139 |
| 5 | g15831.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 94 | 107 | 4.9E-10 |
| 6 | g15831.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 134 | 152 | 4.9E-10 |
| 4 | g15831.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 179 | 189 | 4.9E-10 |
| 3 | g15831.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 198 | 220 | 4.9E-10 |
| 7 | g15831.t1 | PRINTS | PR00109 | Tyrosine kinase catalytic domain signature | 242 | 264 | 4.9E-10 |
| 1 | g15831.t1 | Pfam | PF07714 | Protein tyrosine and serine/threonine kinase | 26 | 270 | 4.3E-53 |
| 14 | g15831.t1 | ProSitePatterns | PS00107 | Protein kinases ATP-binding region signature. | 31 | 52 | - |
| 13 | g15831.t1 | ProSitePatterns | PS00108 | Serine/Threonine protein kinases active-site signature. | 140 | 152 | - |
| 16 | g15831.t1 | ProSiteProfiles | PS50011 | Protein kinase domain profile. | 25 | 278 | 40.979 |
| 12 | g15831.t1 | SMART | SM00220 | serkin_6 | 25 | 274 | 9.7E-53 |
| 8 | g15831.t1 | SUPERFAMILY | SSF56112 | Protein kinase-like (PK-like) | 19 | 300 | 2.29E-69 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0000287 | magnesium ion binding | MF |
| GO:0004709 | MAP kinase kinase kinase activity | MF |
| GO:0007165 | signal transduction | BP |
| GO:0005524 | ATP binding | MF |
| GO:0004672 | protein kinase activity | MF |
| GO:0006468 | protein phosphorylation | BP |
KEGG
Orthology
- This transcript has been annotated with K04427 (mitogen-activated protein kinase kinase kinase 7)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
