General information for g15894.t3
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Leukotriene A-4 hydrolase.
Parent gene
- The parent gene g15894 is located on chr_4: 7201690..7203778 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g15894 | g15894.t3 | TTS | g15894.t3 | 7199965 | 7199965 |
| chr_4 | g15894 | g15894.t3 | isoform | g15894.t3 | 7200004 | 7201690 |
| chr_4 | g15894 | g15894.t3 | exon | g15894.t3.exon1 | 7200004 | 7200503 |
| chr_4 | g15894 | g15894.t3 | cds | g15894.t3.CDS1 | 7200004 | 7200503 |
| chr_4 | g15894 | g15894.t3 | exon | g15894.t3.exon2 | 7200557 | 7200963 |
| chr_4 | g15894 | g15894.t3 | cds | g15894.t3.CDS2 | 7200557 | 7200963 |
| chr_4 | g15894 | g15894.t3 | exon | g15894.t3.exon3 | 7201453 | 7201591 |
| chr_4 | g15894 | g15894.t3 | cds | g15894.t3.CDS3 | 7201453 | 7201591 |
| chr_4 | g15894 | g15894.t3 | exon | g15894.t3.exon4 | 7201659 | 7201690 |
| chr_4 | g15894 | g15894.t3 | cds | g15894.t3.CDS4 | 7201659 | 7201683 |
| chr_4 | g15894 | g15894.t3 | TSS | g15894.t3 | 7202527 | 7202527 |
Sequences
>g15894.t3 Gene=g15894 Length=1078
GCTTGTTATGCCACCTTCTTTCCCATTTGGAGGCATGGAAAATCCATCATTGACTTTTAT
CACTCCTACAACAATTGCTGGTGATAAATCACTTGTAGATGTTGTTGCACATGAAATTTC
TCATTCATGGACTGGAAATCTTGTAACAAATGCAAACTTTGAACATTTCTGGCTCAATGA
AGGTTTCACAGTATTTGTCGAACAAAAAATCATCGGACGTCTTCGTGGTGATGAATATCG
TGATTTCCATGCCCTTCACGGTCTCTCAGACTTGAAAGACACGATCAAAAATCAATTGAA
AAATGAACCAGAATTAACAAAACTTGTTGTTGATTTGAGCAATGTTGGTCCAGATGATGC
TTTTAGTTCTGTTCCATATATGAAAGGAAGCACATTCTTGAGATATTTGGAAGATCTTTT
CGGTGGTCCAGGAATTTTTGAGCCATTTTTGAGATCGTATTTGGATCAATTTAAATATCA
ATCAATTTTGACAAAAGATTTTAAGAAATATTTGTATGATTATTTCAAAGATAAAATTCC
TGAAAAATTGGAACAAGTTGATTGGGATAAATGGCTTTATTCTGAAGGAATGCCACTTGT
AATTCCAAATTATGACACAAAAGTTTATGATACATGCAAGAAACATGCAGATTTGTGGGC
ATCGCAACCAACCAGTGCTATAAAAACTTCATCAATCATTAAAGAAAAATTGACAAGCAT
TCAAAAAATTGAGCTTCTTTCTGAGCTTCTCGATAAGCCAGAAATTGTTGATTTAACAGC
AGAAAAAGTTGATCTTTTGACTGAAACTTATGAAATGTCACGAAATGTTACTAAAAATTC
TGAAATTCGTTTCCGTCTCATGCGATTGGTAATCAAAGCGCGTTTGGAACGTTTTGATGA
AATTTTTGAATTTGCAAATAGCAATTTTAGAATGAAATTTGTGCGACCAATTTATCGTGA
TTTAGCTGGATGGGATGTTGGAAAACCATTGGCAATTGAGAATTTCAAGAAAGTTCGCGA
TGAAATGATGAAAGTTTGTGCTTATGCTGTTGCTAAAGATTTGGGAATTGAAAATTGA
>g15894.t3 Gene=g15894 Length=356
MPPSFPFGGMENPSLTFITPTTIAGDKSLVDVVAHEISHSWTGNLVTNANFEHFWLNEGF
TVFVEQKIIGRLRGDEYRDFHALHGLSDLKDTIKNQLKNEPELTKLVVDLSNVGPDDAFS
SVPYMKGSTFLRYLEDLFGGPGIFEPFLRSYLDQFKYQSILTKDFKKYLYDYFKDKIPEK
LEQVDWDKWLYSEGMPLVIPNYDTKVYDTCKKHADLWASQPTSAIKTSSIIKEKLTSIQK
IELLSELLDKPEIVDLTAEKVDLLTETYEMSRNVTKNSEIRFRLMRLVIKARLERFDEIF
EFANSNFRMKFVRPIYRDLAGWDVGKPLAIENFKKVRDEMMKVCAYAVAKDLGIEN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g15894.t3 | Gene3D | G3DSA:1.10.1740.60 | - | 1 | 44 | 0 |
| 12 | g15894.t3 | Gene3D | G3DSA:1.10.390.10 | Neutral Protease Domain 2 | 45 | 203 | 0 |
| 11 | g15894.t3 | Gene3D | G3DSA:1.25.40.320 | - | 205 | 355 | 0 |
| 3 | g15894.t3 | PANTHER | PTHR45726 | - | 1 | 352 | 0 |
| 4 | g15894.t3 | PANTHER | PTHR45726:SF3 | LEUKOTRIENE A-4 HYDROLASE | 1 | 352 | 0 |
| 7 | g15894.t3 | PRINTS | PR00756 | Membrane alanyl dipeptidase (M1) family signature | 5 | 15 | 0 |
| 6 | g15894.t3 | PRINTS | PR00756 | Membrane alanyl dipeptidase (M1) family signature | 32 | 47 | 0 |
| 5 | g15894.t3 | PRINTS | PR00756 | Membrane alanyl dipeptidase (M1) family signature | 51 | 63 | 0 |
| 2 | g15894.t3 | Pfam | PF01433 | Peptidase family M1 domain | 3 | 189 | 0 |
| 1 | g15894.t3 | Pfam | PF09127 | Leukotriene A4 hydrolase, C-terminal | 236 | 352 | 0 |
| 10 | g15894.t3 | SMART | SM01263 | Leuk_A4_hydro_C_2 | 205 | 352 | 0 |
| 9 | g15894.t3 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 2 | 200 | 0 |
| 8 | g15894.t3 | SUPERFAMILY | SSF48371 | ARM repeat | 206 | 354 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008237 | metallopeptidase activity | MF |
| GO:0006508 | proteolysis | BP |
| GO:0008270 | zinc ion binding | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
