Gene loci information

Transcript annotation

  • This transcript has been annotated as Leukotriene A-4 hydrolase.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_4 g15894 g15894.t4 TTS g15894.t4 7199965 7199965
chr_4 g15894 g15894.t4 isoform g15894.t4 7200004 7203778
chr_4 g15894 g15894.t4 exon g15894.t4.exon1 7200004 7200503
chr_4 g15894 g15894.t4 cds g15894.t4.CDS1 7200004 7200503
chr_4 g15894 g15894.t4 exon g15894.t4.exon2 7200557 7200963
chr_4 g15894 g15894.t4 cds g15894.t4.CDS2 7200557 7200963
chr_4 g15894 g15894.t4 exon g15894.t4.exon3 7201453 7201591
chr_4 g15894 g15894.t4 cds g15894.t4.CDS3 7201453 7201591
chr_4 g15894 g15894.t4 exon g15894.t4.exon4 7201659 7202292
chr_4 g15894 g15894.t4 cds g15894.t4.CDS4 7201659 7202292
chr_4 g15894 g15894.t4 exon g15894.t4.exon5 7202348 7202515
chr_4 g15894 g15894.t4 cds g15894.t4.CDS5 7202348 7202506
chr_4 g15894 g15894.t4 exon g15894.t4.exon6 7203766 7203778
chr_4 g15894 g15894.t4 TSS g15894.t4 7203793 7203793

Sequences

>g15894.t4 Gene=g15894 Length=1861
TCTAATAAATTAGACTTCAAACATGCCACGTCTTGGAACAGATCCATCATCTTATTCTCA
ACCTGATCTTGTAAAGATCAAACATATTGATTTGGACTGGACTGTTGATTTTAGTCAGAA
AATTATCAGTGGAAGTGCTCAAATTCAATTCATCATTTTAACGAAATTCATTGAGGAAAT
TCTTCTTGATGTCAGTGATATAACAATTGATTCTGTTAATGTTCTCAATGAAGGCTGTGA
AATTCCTTTGAAATTTGATATTTCTGGATTGGTTCCTGATATTGGTTCAAAACTTACAAT
TACTTTGCCAACAAAAACTGATGGCAAATTGACCTTGAAAATTTACTACAAAACATCCAG
CAGTGCAAGCGCTTTACAATGGCTCACACCTGAACAAACTCTTGGCAAAAAACATCCATT
CATGTTCAGTCAATGTCAAGCAATTCATGCTCGAAGTATTCTTCCATGTCAAGACTCACC
ATCAGTTAAATTCACTTACAATGCGACACTTAGACATTCACCAGAATTGACTGGTTTAAT
GAGTGCAATTCGTCAAGGAAGTGAAAATGGTGTAACCAAATATGTGCAAAAAGTTCCAAT
TCCAAGTTATTTGCTTGCTATTGCAGTTGGTGATTTGTATTCGAAAAAAATTGGACCAAG
ATCACATGTATGGGCTGAAAAAGACATTGTTGATGAAGCTGCTGAGGAATATAGTGACAC
TGAAAAGTTTTTGAAAACAGCTGAAGATATTTGCGGACCTTATTTATGGCAGCAATATGA
TTTGCTTGTTATGCCACCTTCTTTCCCATTTGGAGGCATGGAAAATCCATCATTGACTTT
TATCACTCCTACAACAATTGCTGGTGATAAATCACTTGTAGATGTTGTTGCACATGAAAT
TTCTCATTCATGGACTGGAAATCTTGTAACAAATGCAAACTTTGAACATTTCTGGCTCAA
TGAAGGTTTCACAGTATTTGTCGAACAAAAAATCATCGGACGTCTTCGTGGTGATGAATA
TCGTGATTTCCATGCCCTTCACGGTCTCTCAGACTTGAAAGACACGATCAAAAATCAATT
GAAAAATGAACCAGAATTAACAAAACTTGTTGTTGATTTGAGCAATGTTGGTCCAGATGA
TGCTTTTAGTTCTGTTCCATATATGAAAGGAAGCACATTCTTGAGATATTTGGAAGATCT
TTTCGGTGGTCCAGGAATTTTTGAGCCATTTTTGAGATCGTATTTGGATCAATTTAAATA
TCAATCAATTTTGACAAAAGATTTTAAGAAATATTTGTATGATTATTTCAAAGATAAAAT
TCCTGAAAAATTGGAACAAGTTGATTGGGATAAATGGCTTTATTCTGAAGGAATGCCACT
TGTAATTCCAAATTATGACACAAAAGTTTATGATACATGCAAGAAACATGCAGATTTGTG
GGCATCGCAACCAACCAGTGCTATAAAAACTTCATCAATCATTAAAGAAAAATTGACAAG
CATTCAAAAAATTGAGCTTCTTTCTGAGCTTCTCGATAAGCCAGAAATTGTTGATTTAAC
AGCAGAAAAAGTTGATCTTTTGACTGAAACTTATGAAATGTCACGAAATGTTACTAAAAA
TTCTGAAATTCGTTTCCGTCTCATGCGATTGGTAATCAAAGCGCGTTTGGAACGTTTTGA
TGAAATTTTTGAATTTGCAAATAGCAATTTTAGAATGAAATTTGTGCGACCAATTTATCG
TGATTTAGCTGGATGGGATGTTGGAAAACCATTGGCAATTGAGAATTTCAAGAAAGTTCG
CGATGAAATGATGAAAGTTTGTGCTTATGCTGTTGCTAAAGATTTGGGAATTGAAAATTG
A

>g15894.t4 Gene=g15894 Length=612
MPRLGTDPSSYSQPDLVKIKHIDLDWTVDFSQKIISGSAQIQFIILTKFIEEILLDVSDI
TIDSVNVLNEGCEIPLKFDISGLVPDIGSKLTITLPTKTDGKLTLKIYYKTSSSASALQW
LTPEQTLGKKHPFMFSQCQAIHARSILPCQDSPSVKFTYNATLRHSPELTGLMSAIRQGS
ENGVTKYVQKVPIPSYLLAIAVGDLYSKKIGPRSHVWAEKDIVDEAAEEYSDTEKFLKTA
EDICGPYLWQQYDLLVMPPSFPFGGMENPSLTFITPTTIAGDKSLVDVVAHEISHSWTGN
LVTNANFEHFWLNEGFTVFVEQKIIGRLRGDEYRDFHALHGLSDLKDTIKNQLKNEPELT
KLVVDLSNVGPDDAFSSVPYMKGSTFLRYLEDLFGGPGIFEPFLRSYLDQFKYQSILTKD
FKKYLYDYFKDKIPEKLEQVDWDKWLYSEGMPLVIPNYDTKVYDTCKKHADLWASQPTSA
IKTSSIIKEKLTSIQKIELLSELLDKPEIVDLTAEKVDLLTETYEMSRNVTKNSEIRFRL
MRLVIKARLERFDEIFEFANSNFRMKFVRPIYRDLAGWDVGKPLAIENFKKVRDEMMKVC
AYAVAKDLGIEN

Protein features from InterProScan

Transcript Database ID Name Start End E.value
18 g15894.t4 CDD cd09599 M1_LTA4H 7 447 0
15 g15894.t4 Gene3D G3DSA:2.60.40.1730 tricorn interacting facor f3 domain 16 203 0
17 g15894.t4 Gene3D G3DSA:1.10.1740.60 - 204 300 0
16 g15894.t4 Gene3D G3DSA:1.10.390.10 Neutral Protease Domain 2 301 459 0
14 g15894.t4 Gene3D G3DSA:1.25.40.320 - 461 611 0
4 g15894.t4 PANTHER PTHR45726 - 6 608 0
5 g15894.t4 PANTHER PTHR45726:SF3 LEUKOTRIENE A-4 HYDROLASE 6 608 0
6 g15894.t4 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 144 159 0
7 g15894.t4 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 187 202 0
8 g15894.t4 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 261 271 0
9 g15894.t4 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 288 303 0
10 g15894.t4 PRINTS PR00756 Membrane alanyl dipeptidase (M1) family signature 307 319 0
3 g15894.t4 Pfam PF17900 Peptidase M1 N-terminal domain 21 197 0
2 g15894.t4 Pfam PF01433 Peptidase family M1 domain 235 445 0
1 g15894.t4 Pfam PF09127 Leukotriene A4 hydrolase, C-terminal 492 608 0
19 g15894.t4 SMART SM01263 Leuk_A4_hydro_C_2 461 608 0
13 g15894.t4 SUPERFAMILY SSF63737 Leukotriene A4 hydrolase N-terminal domain 4 204 0
12 g15894.t4 SUPERFAMILY SSF55486 Metalloproteases (zincins), catalytic domain 209 456 0
11 g15894.t4 SUPERFAMILY SSF48371 ARM repeat 462 610 0
20 g15894.t4 TIGRFAM TIGR02411 leuko_A4_hydro: leukotriene A-4 hydrolase/aminopeptidase 7 608 0

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0008237 metallopeptidase activity MF
GO:0006508 proteolysis BP
GO:0008270 zinc ion binding MF

KEGG

Orthology

Pathway

  • This transcript belongs to the following pathways

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values