General information for g166.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Adenosine deaminase 2.
Parent gene
- The parent gene g166 is located on chr_3: 1459224..1461090 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g166 | g166.t1 | TSS | g166.t1 | 1456964 | 1456964 |
| chr_3 | g166 | g166.t1 | isoform | g166.t1 | 1457047 | 1459224 |
| chr_3 | g166 | g166.t1 | exon | g166.t1.exon1 | 1457047 | 1457128 |
| chr_3 | g166 | g166.t1 | cds | g166.t1.CDS1 | 1457047 | 1457128 |
| chr_3 | g166 | g166.t1 | exon | g166.t1.exon2 | 1457237 | 1457317 |
| chr_3 | g166 | g166.t1 | cds | g166.t1.CDS2 | 1457237 | 1457317 |
| chr_3 | g166 | g166.t1 | exon | g166.t1.exon3 | 1457525 | 1457807 |
| chr_3 | g166 | g166.t1 | cds | g166.t1.CDS3 | 1457525 | 1457807 |
| chr_3 | g166 | g166.t1 | exon | g166.t1.exon4 | 1457898 | 1458037 |
| chr_3 | g166 | g166.t1 | cds | g166.t1.CDS4 | 1457898 | 1458037 |
| chr_3 | g166 | g166.t1 | exon | g166.t1.exon5 | 1458096 | 1458250 |
| chr_3 | g166 | g166.t1 | cds | g166.t1.CDS5 | 1458096 | 1458250 |
| chr_3 | g166 | g166.t1 | exon | g166.t1.exon6 | 1458312 | 1458549 |
| chr_3 | g166 | g166.t1 | cds | g166.t1.CDS6 | 1458312 | 1458549 |
| chr_3 | g166 | g166.t1 | exon | g166.t1.exon7 | 1458609 | 1458919 |
| chr_3 | g166 | g166.t1 | cds | g166.t1.CDS7 | 1458609 | 1458919 |
| chr_3 | g166 | g166.t1 | exon | g166.t1.exon8 | 1458979 | 1459224 |
| chr_3 | g166 | g166.t1 | cds | g166.t1.CDS8 | 1458979 | 1459224 |
| chr_3 | g166 | g166.t1 | TTS | g166.t1 | NA | NA |
Sequences
>g166.t1 Gene=g166 Length=1536
ATGAGAACTATTTCCACTATCTTTATTGCAATATCGTTTTTTCATTATTCACGAAGTGCA
ACAATTTTCAACAATCAACTCAACTATAAAGATGTGAGGAATAATATCATTGCTGCGGAA
GAAAGTATTCGAACTGGTGGAAATATTTATCTTAGTCCAAAAGAACATGAGGCTGATAAA
ATACTTCTTACAATGAAGGAAAAATCTATCAATAGAGGAATAATCGATCCTTCTTCATAT
GCACCATCTTTGCATTTCTTTCATGCGAAACCACTTATTGAAAAGGATCCAATATTTGAT
ATTATTAAACGACTGCCTAAAGGAGGTGTTTTACATCTTCACAATAGTGCTGGCGTATCT
AGTGAATGGGTTATTAAAAATTTAACATACCGTAATGATGTGAAGCTTTGCAATTCAACT
GATGGGGAAAAAATTTTTACTACAGTACCTACAAAAGCATGTCAATCAGAACCAATTCCA
ATACCAAAACTGCGTGCACAAGCTCAAGATGTGAAAGAATTTGATAAATCACTTGAACTT
ATGATAAACCTTTACACTAAATATCCTGAATTAGATTATCCTGATGTCAACACCGTATGG
AAAAAGTTTCAAAATATATTTTCAATAATTGGTGGTATTTTTGATTATCTACCAACATAT
AAAGCTTTTCATAGACGACTTTTGGAAGAATTGTATGAGGATAACGTTATGTACTTAGAG
ATGAGAACTGGTATGGGTGGATTAATTGACGAAAATGGAAATAAGTTGAATAGTGATGAT
GTCGCTTTAGTGCTATTAAACCTTGTTGATGAATTTAAAAAAGATCATCCATTGTTTCTT
GGGTTAAAAGTCATTTTAGCGATTCCAAGAAATTCTGACACACAATCATTAGAGCTAAAA
ATGCAAAGATTTGTTGAACTTCGAAAGAAATATCCAAATTTTGTTATTGGGTTTGATCTT
GTCGGACAAGAAGATATAGGTCGCCCTCTGTCACAATATGTGGAGAAGCTGAAAGAAATT
TCTCAGAATGGTCGCTTCTTCTTTCATGCTGGTGAAACAAATTGGTTTAATACAGACGCA
GATCACAATTTGATTGACGCAATTTTAATGAACACAAAAAGAATTGGCCACGGTTATTCA
CTATATAAGCATCCAGTATTATGGGAAGCTTTCAAAGAGAAGGACATTGCCTTAGAAATC
AGTCCAATTTCAAATCAAGTTTTGCATCTCGTACAAGATTTACGAAATCATCCTGCATCA
TTTTATATTTCAGAAAACATTCCAATTGTGATTGCAAATGATGATCCTGGATTTTGGAAT
GCAAAAGGACTAAGTTATGATTTTTACTATGCATTTATGGCTTTTGCACCATCTGATACA
GGACTTCAAATTCTTAAACAACTTGCATGGAATTCATTAAAATATAGTGCAATGTCACAA
AAAGAAAGAAGTGATGCGGCAGTTGTTTTTAAAGCTTCATGGGACAAGTTTATTGACTCG
ATTCTGCTCATGGAAAATAAAAATACATCAACTTAA
>g166.t1 Gene=g166 Length=511
MRTISTIFIAISFFHYSRSATIFNNQLNYKDVRNNIIAAEESIRTGGNIYLSPKEHEADK
ILLTMKEKSINRGIIDPSSYAPSLHFFHAKPLIEKDPIFDIIKRLPKGGVLHLHNSAGVS
SEWVIKNLTYRNDVKLCNSTDGEKIFTTVPTKACQSEPIPIPKLRAQAQDVKEFDKSLEL
MINLYTKYPELDYPDVNTVWKKFQNIFSIIGGIFDYLPTYKAFHRRLLEELYEDNVMYLE
MRTGMGGLIDENGNKLNSDDVALVLLNLVDEFKKDHPLFLGLKVILAIPRNSDTQSLELK
MQRFVELRKKYPNFVIGFDLVGQEDIGRPLSQYVEKLKEISQNGRFFFHAGETNWFNTDA
DHNLIDAILMNTKRIGHGYSLYKHPVLWEAFKEKDIALEISPISNQVLHLVQDLRNHPAS
FYISENIPIVIANDDPGFWNAKGLSYDFYYAFMAFAPSDTGLQILKQLAWNSLKYSAMSQ
KERSDAAVVFKASWDKFIDSILLMENKNTST
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g166.t1 | CDD | cd01321 | ADGF | 82 | 494 | 2.81169E-167 |
| 7 | g166.t1 | Gene3D | G3DSA:3.20.20.140 | - | 27 | 502 | 3.0E-159 |
| 3 | g166.t1 | PANTHER | PTHR11409 | ADENOSINE DEAMINASE | 49 | 502 | 1.4E-163 |
| 4 | g166.t1 | PANTHER | PTHR11409:SF47 | ADENOSINE DEAMINASE-RELATED GROWTH FACTOR C | 49 | 502 | 1.4E-163 |
| 1 | g166.t1 | Pfam | PF08451 | Adenosine/AMP deaminase N-terminal | 16 | 102 | 4.9E-19 |
| 2 | g166.t1 | Pfam | PF00962 | Adenosine/AMP deaminase | 301 | 484 | 8.7E-22 |
| 9 | g166.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 19 | - |
| 10 | g166.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 2 | - |
| 11 | g166.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 3 | 14 | - |
| 12 | g166.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 15 | 19 | - |
| 8 | g166.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 20 | 511 | - |
| 5 | g166.t1 | SUPERFAMILY | SSF51556 | Metallo-dependent hydrolases | 75 | 502 | 2.95E-81 |
| 6 | g166.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 19 | - |
| 14 | g166.t1 | TIGRFAM | TIGR01431 | adm_rel: adenosine deaminase-related growth factor | 29 | 502 | 1.2E-171 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0019239 | deaminase activity | MF |
| GO:0005615 | extracellular space | CC |
| GO:0004000 | adenosine deaminase activity | MF |
| GO:0006154 | adenosine catabolic process | BP |
KEGG
Orthology
- This transcript has been annotated with K19572 (adenosine deaminase CECR1)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed