General information for g17114.t10
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Lysosomal aspartic protease.
Parent gene
- The parent gene g17114 is located on chr_4: 12519041..12520450 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g17114 | g17114.t10 | TTS | g17114.t10 | 12518088 | 12518088 |
| chr_4 | g17114 | g17114.t10 | isoform | g17114.t10 | 12518100 | 12520362 |
| chr_4 | g17114 | g17114.t10 | exon | g17114.t10.exon1 | 12518100 | 12518181 |
| chr_4 | g17114 | g17114.t10 | cds | g17114.t10.CDS1 | 12518159 | 12518181 |
| chr_4 | g17114 | g17114.t10 | exon | g17114.t10.exon2 | 12518236 | 12518297 |
| chr_4 | g17114 | g17114.t10 | cds | g17114.t10.CDS2 | 12518236 | 12518297 |
| chr_4 | g17114 | g17114.t10 | exon | g17114.t10.exon3 | 12518554 | 12518963 |
| chr_4 | g17114 | g17114.t10 | cds | g17114.t10.CDS3 | 12518554 | 12518963 |
| chr_4 | g17114 | g17114.t10 | exon | g17114.t10.exon4 | 12519024 | 12519251 |
| chr_4 | g17114 | g17114.t10 | cds | g17114.t10.CDS4 | 12519024 | 12519251 |
| chr_4 | g17114 | g17114.t10 | exon | g17114.t10.exon5 | 12519796 | 12519986 |
| chr_4 | g17114 | g17114.t10 | cds | g17114.t10.CDS5 | 12519796 | 12519986 |
| chr_4 | g17114 | g17114.t10 | exon | g17114.t10.exon6 | 12520047 | 12520222 |
| chr_4 | g17114 | g17114.t10 | cds | g17114.t10.CDS6 | 12520047 | 12520222 |
| chr_4 | g17114 | g17114.t10 | exon | g17114.t10.exon7 | 12520289 | 12520362 |
| chr_4 | g17114 | g17114.t10 | cds | g17114.t10.CDS7 | 12520289 | 12520362 |
| chr_4 | g17114 | g17114.t10 | TSS | g17114.t10 | 12520391 | 12520391 |
Sequences
>g17114.t10 Gene=g17114 Length=1223
ATGTCAAAAAAGTTTAGTGCAACAATTTTTCTTCTCCTTCAGCTTTTGCTGATTGTAAAT
GGAAAACTATTGAGAATTCCTTTGTATAAATTTGAATCAGCAAGACGCCATTTTCAAACC
GTAGGAACAGATCTCACACAAGTTCGTCTTGCAAATGTTCAAGGACCAACACCAGAACCA
TTGTCAAATTATCTTGATGCCCAATATTATGGACCAATTACAATTGGAAGTCCACCACAA
AGTTTCAAAGTTGTTTTTGACACTGGAAGTTCAAATTTATGGGTTCCATCAAAATCTTGT
TCACTTATGAACATTGCCTGTCTTATGCATAACAAATATGATTCGAAAAAAAGTTCAACA
TACGAGAAAAATGGAACAAAATTTCATATCGAATACGGTAGCGGTTCACTAAGTGGCTTC
TTGTCAACTGATACTGTCGGTATTGGTGATTTAAAAATTCAAAAGCAAACATTTGCAGAA
GCAGTTTCAGAACCCGGTTTAGTTTTTGTTGCTGCTAAATTTGATGGAATTCTTGGATTA
GGCTACAAATCAATTTCAGTTGATGGAGTTGAACCAGTTTTCTATAACATGTACAATCAA
GGACTCATTTCAGAGCCAATTTTCTCATTTTATTTGAATCGTGATCCAAATGGCAAAGAA
GGTGGAGAAATTATTTTTGGTGGAAGTGATCCAGATCATTATGAAGGTGATTTCACTTAT
CTCCCAGTCAATCGCAAAGCATACTGGCAATTCAAAATGGATGGAGTGAAAATTGGTGAC
AAAACTTTCTGTAATGGTGGATGCCAAGCAATTGCTGACACTGGAACATCACTCATTGCT
GGACCAACTGATGAAGTTACAGCAATTAACAAAGCCATCGGTGGAACACCAATTTTAAAT
GGACAATACATGGTTAATTGTGACATGATACCAAATTTGCCTACAATTAAATTCACTTTG
GGTGGCAAGGAATTTGCACTTGATGGATCTGATTATATTTTAAGAATCGCTCAAATGGGT
AAAACTATTTGCTTGTCTGGTTTCATGGGAATTAATATTCCACCACCAAATGGACCACTA
TGGATTCTCGGTGATGTTTTTATTGGAAAATACTACACAGAATTTGATTTTGGCAATGAC
CAGGCTAAAAATCTCTCTCTATAAAAATATCAAAATATTTTTTTAATTTTGTGCCAGATG
ATCAAAAAAAGAAATAAAAATTA
>g17114.t10 Gene=g17114 Length=387
MSKKFSATIFLLLQLLLIVNGKLLRIPLYKFESARRHFQTVGTDLTQVRLANVQGPTPEP
LSNYLDAQYYGPITIGSPPQSFKVVFDTGSSNLWVPSKSCSLMNIACLMHNKYDSKKSST
YEKNGTKFHIEYGSGSLSGFLSTDTVGIGDLKIQKQTFAEAVSEPGLVFVAAKFDGILGL
GYKSISVDGVEPVFYNMYNQGLISEPIFSFYLNRDPNGKEGGEIIFGGSDPDHYEGDFTY
LPVNRKAYWQFKMDGVKIGDKTFCNGGCQAIADTGTSLIAGPTDEVTAINKAIGGTPILN
GQYMVNCDMIPNLPTIKFTLGGKEFALDGSDYILRIAQMGKTICLSGFMGINIPPPNGPL
WILGDVFIGKYYTEFDFGNDQAKNLSL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g17114.t10 | Gene3D | G3DSA:2.40.70.10 | Acid Proteases | 51 | 149 | 2.3E-41 |
| 12 | g17114.t10 | Gene3D | G3DSA:2.40.70.10 | Acid Proteases | 150 | 383 | 4.5E-83 |
| 3 | g17114.t10 | PANTHER | PTHR47966:SF42 | CATHEPSIN D | 15 | 381 | 1.2E-152 |
| 4 | g17114.t10 | PANTHER | PTHR47966 | BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED | 15 | 381 | 1.2E-152 |
| 8 | g17114.t10 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 75 | 95 | 8.6E-29 |
| 7 | g17114.t10 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 222 | 235 | 8.6E-29 |
| 6 | g17114.t10 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 270 | 281 | 8.6E-29 |
| 5 | g17114.t10 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 361 | 376 | 8.6E-29 |
| 1 | g17114.t10 | Pfam | PF07966 | A1 Propeptide | 23 | 49 | 2.2E-4 |
| 2 | g17114.t10 | Pfam | PF00026 | Eukaryotic aspartyl protease | 68 | 381 | 1.5E-125 |
| 14 | g17114.t10 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 21 | - |
| 15 | g17114.t10 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 5 | - |
| 16 | g17114.t10 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 6 | 17 | - |
| 17 | g17114.t10 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 18 | 21 | - |
| 13 | g17114.t10 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 22 | 387 | - |
| 19 | g17114.t10 | ProSitePatterns | PS00141 | Eukaryotic and viral aspartyl proteases active site. | 84 | 95 | - |
| 20 | g17114.t10 | ProSitePatterns | PS00141 | Eukaryotic and viral aspartyl proteases active site. | 270 | 281 | - |
| 21 | g17114.t10 | ProSiteProfiles | PS51767 | Peptidase family A1 domain profile. | 69 | 387 | 78.682 |
| 9 | g17114.t10 | SUPERFAMILY | SSF50630 | Acid proteases | 9 | 381 | 2.82E-126 |
| 10 | g17114.t10 | SignalP_EUK | SignalP-TM | SignalP-TM | 1 | 21 | - |
| 18 | g17114.t10 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 7 | 29 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006508 | proteolysis | BP |
| GO:0004190 | aspartic-type endopeptidase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K01379 (cathepsin D)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed