General information for g17114.t11
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Lysosomal aspartic protease.
Parent gene
- The parent gene g17114 is located on chr_4: 12519041..12520450 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g17114 | g17114.t11 | TTS | g17114.t11 | 12518088 | 12518088 |
| chr_4 | g17114 | g17114.t11 | isoform | g17114.t11 | 12518210 | 12518952 |
| chr_4 | g17114 | g17114.t11 | exon | g17114.t11.exon1 | 12518210 | 12518297 |
| chr_4 | g17114 | g17114.t11 | cds | g17114.t11.CDS1 | 12518210 | 12518297 |
| chr_4 | g17114 | g17114.t11 | exon | g17114.t11.exon2 | 12518554 | 12518952 |
| chr_4 | g17114 | g17114.t11 | cds | g17114.t11.CDS2 | 12518554 | 12518876 |
| chr_4 | g17114 | g17114.t11 | TSS | g17114.t11 | NA | NA |
Sequences
>g17114.t11 Gene=g17114 Length=487
TGGAAGTGATCCAGATCATTATGAAGGTGATTTCACTTATCTCCCAGTCAATCGCAAAGC
ATACTGGCAATTCAAAATGGATGGAGTGAAAATTGGTGACAAAACTTTCTGTAATGGTGG
ATGCCAAGCAATTGCTGACACTGGAACATCACTCATTGCTGGACCAACTGATGAAGTTAC
AGCAATTAACAAAGCCATCGGTGGAACACCAATTTTAAATGGACAATACATGGTTAATTG
TGACATGATACCAAATTTGCCTACAATTAAATTCACTTTGGGTGGCAAGGAATTTGCACT
TGATGGATCTGATTATATTTTAAGAATCGCTCAAATGGGTAAAACTATTTGCTTGTCTGG
TTTCATGGGAATTAATATTCCACCACCAAATGGACCACTATGGATTCTCGGTGATGTTTT
TATTGGAAAATACTACACAGAATTTGATTTTGGCAATGACCGTGTTGGTTTTGCTGTCAC
AAAATAG
>g17114.t11 Gene=g17114 Length=136
MDGVKIGDKTFCNGGCQAIADTGTSLIAGPTDEVTAINKAIGGTPILNGQYMVNCDMIPN
LPTIKFTLGGKEFALDGSDYILRIAQMGKTICLSGFMGINIPPPNGPLWILGDVFIGKYY
TEFDFGNDRVGFAVTK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g17114.t11 | Gene3D | G3DSA:2.40.70.10 | Acid Proteases | 1 | 136 | 3.0E-45 |
| 2 | g17114.t11 | PANTHER | PTHR47966:SF17 | ZGC:63831 | 1 | 136 | 1.0E-54 |
| 3 | g17114.t11 | PANTHER | PTHR47966 | BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED | 1 | 136 | 1.0E-54 |
| 4 | g17114.t11 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 18 | 29 | 1.2E-10 |
| 5 | g17114.t11 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 109 | 124 | 1.2E-10 |
| 1 | g17114.t11 | Pfam | PF00026 | Eukaryotic aspartyl protease | 1 | 133 | 1.4E-40 |
| 7 | g17114.t11 | ProSitePatterns | PS00141 | Eukaryotic and viral aspartyl proteases active site. | 18 | 29 | - |
| 9 | g17114.t11 | ProSiteProfiles | PS51767 | Peptidase family A1 domain profile. | 1 | 133 | 31.487 |
| 6 | g17114.t11 | SUPERFAMILY | SSF50630 | Acid proteases | 1 | 133 | 8.02E-42 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006508 | proteolysis | BP |
| GO:0004190 | aspartic-type endopeptidase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
