General information for g17114.t23
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Lysosomal aspartic protease.
Parent gene
- The parent gene g17114 is located on chr_4: 12519041..12520450 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g17114 | g17114.t23 | TTS | g17114.t23 | 12518088 | 12518088 |
| chr_4 | g17114 | g17114.t23 | isoform | g17114.t23 | 12518210 | 12520362 |
| chr_4 | g17114 | g17114.t23 | exon | g17114.t23.exon1 | 12518210 | 12518963 |
| chr_4 | g17114 | g17114.t23 | cds | g17114.t23.CDS1 | 12518550 | 12518963 |
| chr_4 | g17114 | g17114.t23 | exon | g17114.t23.exon2 | 12519024 | 12519251 |
| chr_4 | g17114 | g17114.t23 | cds | g17114.t23.CDS2 | 12519024 | 12519251 |
| chr_4 | g17114 | g17114.t23 | exon | g17114.t23.exon3 | 12519796 | 12519986 |
| chr_4 | g17114 | g17114.t23 | cds | g17114.t23.CDS3 | 12519796 | 12519930 |
| chr_4 | g17114 | g17114.t23 | exon | g17114.t23.exon4 | 12520047 | 12520362 |
| chr_4 | g17114 | g17114.t23 | TSS | g17114.t23 | 12520391 | 12520391 |
Sequences
>g17114.t23 Gene=g17114 Length=1489
ATGTCAAAAAAGTTTAGTGCAACAATTTTTCTTCTCCTTCAGCTTTTGCTGATTGTAAAT
GGAAAACTATTGAGGTAAATTGCTCAAATTATCGATTTTGAAAAATTTATTTCATTTTAC
GTCTTAATTTTTATTCTCAGAATTCCTTTGTATAAATTTGAATCAGCAAGACGCCATTTT
CAAACCGTAGGAACAGATCTCACACAAGTTCGTCTTGCAAATGTTCAAGGACCAACACCA
GAACCATTGTCAAATTATCTTGATGCCCAATATTATGGACCAATTACAATTGGAAGTCCA
CCACAAAGTTTCAAAGTTGTTTTTGACACTGGAAGTTCAAATTTATGGGTTCCATCAAAA
TCTTGTTCACTTATGAACATTGCCTGTCTTATGCATAACAAATATGATTCGAAAAAAAGT
TCAACATACGAGAAAAATGGAACAAAATTTCATATCGAATACGGTAGCGGTTCACTAAGT
GGCTTCTTGTCAACTGATACTGTCGGTATTGGTGATTTAAAAATTCAAAAGCAAACATTT
GCAGAAGCAGTTTCAGAACCCGGTTTAGTTTTTGTTGCTGCTAAATTTGATGGAATTCTT
GGATTAGGCTACAAATCAATTTCAGTTGATGGAGTTGAACCAGTTTTCTATAACATGTAC
AATCAAGGACTCATTTCAGAGCCAATTTTCTCATTTTATTTGAATCGTGATCCAAATGGC
AAAGAAGGTGGAGAAATTATTTTTGGTGGAAGTGATCCAGATCATTATGAAGGTGATTTC
ACTTATCTCCCAGTCAATCGCAAAGCATACTGGCAATTCAAAATGGATGGAGTGAAAATT
GGTGACAAAACTTTCTGTAATGGTGGATGCCAAGCAATTGCTGACACTGGAACATCACTC
ATTGCTGGACCAACTGATGAAGTTACAGCAATTAACAAAGCCATCGGTGGAACACCAATT
TTAAATGGACAATACATGGTTAATTGTGACATGATACCAAATTTGCCTACAATTAAATTC
ACTTTGGGTGGCAAGGAATTTGCACTTGATGGATCTGATTATATTTTAAGAATCGCTCAA
ATGGGTAAAACTATTTGCTTGTCTGGTTTCATGGGAATTAATATTCCACCACCAAATGGA
CCACTGTAAGTTTTTAAGAATTTTTATTGAAAATTTTTTGAATTTGTTTTTAAATTTTCT
GAAAGGTTTCTTTATAAGATTTAAAAAAATTGAATTTTTAAAAATTTTCTTTATGAGTTT
TTGAATTTTTTGGTAAATTTTTTGACAATTTTTCTCAATTAATTTTTGTCTCAAATTTCA
AAATTTGCTTCAAATTCTCTACAAAATCTTAAATTGCAATAATCAAAATTTCACTAAATT
TATTTTCTATTTTATTTCCAGATGGATTCTCGGTGATGTTTTTATTGGAAAATACTACAC
AGAATTTGATTTTGGCAATGACCGTGTTGGTTTTGCTGTCACAAAATAG
>g17114.t23 Gene=g17114 Length=258
MNIACLMHNKYDSKKSSTYEKNGTKFHIEYGSGSLSGFLSTDTVGIGDLKIQKQTFAEAV
SEPGLVFVAAKFDGILGLGYKSISVDGVEPVFYNMYNQGLISEPIFSFYLNRDPNGKEGG
EIIFGGSDPDHYEGDFTYLPVNRKAYWQFKMDGVKIGDKTFCNGGCQAIADTGTSLIAGP
TDEVTAINKAIGGTPILNGQYMVNCDMIPNLPTIKFTLGGKEFALDGSDYILRIAQMGKT
ICLSGFMGINIPPPNGPL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g17114.t23 | Gene3D | G3DSA:2.40.70.10 | Acid Proteases | 1 | 47 | 2.7E-13 |
| 9 | g17114.t23 | Gene3D | G3DSA:2.40.70.10 | Acid Proteases | 48 | 258 | 8.6E-73 |
| 2 | g17114.t23 | PANTHER | PTHR47966:SF42 | CATHEPSIN D | 2 | 258 | 4.1E-110 |
| 3 | g17114.t23 | PANTHER | PTHR47966 | BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED | 2 | 258 | 4.1E-110 |
| 5 | g17114.t23 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 120 | 133 | 1.0E-7 |
| 4 | g17114.t23 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 168 | 179 | 1.0E-7 |
| 1 | g17114.t23 | Pfam | PF00026 | Eukaryotic aspartyl protease | 2 | 255 | 4.8E-92 |
| 7 | g17114.t23 | ProSitePatterns | PS00141 | Eukaryotic and viral aspartyl proteases active site. | 168 | 179 | - |
| 10 | g17114.t23 | ProSiteProfiles | PS51767 | Peptidase family A1 domain profile. | 1 | 258 | 54.691 |
| 6 | g17114.t23 | SUPERFAMILY | SSF50630 | Acid proteases | 3 | 257 | 2.38E-88 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006508 | proteolysis | BP |
| GO:0004190 | aspartic-type endopeptidase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
