General information for g17114.t25
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Lysosomal aspartic protease.
Parent gene
- The parent gene g17114 is located on chr_4: 12519041..12520450 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g17114 | g17114.t25 | TTS | g17114.t25 | 12518088 | 12518088 |
| chr_4 | g17114 | g17114.t25 | isoform | g17114.t25 | 12518210 | 12520362 |
| chr_4 | g17114 | g17114.t25 | exon | g17114.t25.exon1 | 12518210 | 12518297 |
| chr_4 | g17114 | g17114.t25 | cds | g17114.t25.CDS1 | 12518210 | 12518297 |
| chr_4 | g17114 | g17114.t25 | exon | g17114.t25.exon2 | 12518554 | 12518963 |
| chr_4 | g17114 | g17114.t25 | cds | g17114.t25.CDS2 | 12518554 | 12518963 |
| chr_4 | g17114 | g17114.t25 | exon | g17114.t25.exon3 | 12519024 | 12519251 |
| chr_4 | g17114 | g17114.t25 | cds | g17114.t25.CDS3 | 12519024 | 12519251 |
| chr_4 | g17114 | g17114.t25 | exon | g17114.t25.exon4 | 12519796 | 12519986 |
| chr_4 | g17114 | g17114.t25 | cds | g17114.t25.CDS4 | 12519796 | 12519930 |
| chr_4 | g17114 | g17114.t25 | exon | g17114.t25.exon5 | 12520047 | 12520196 |
| chr_4 | g17114 | g17114.t25 | exon | g17114.t25.exon6 | 12520270 | 12520362 |
| chr_4 | g17114 | g17114.t25 | TSS | g17114.t25 | 12520391 | 12520391 |
Sequences
>g17114.t25 Gene=g17114 Length=1160
ATGTCAAAAAAGTTTAGTGCAACAATTTTTCTTCTCCTTCAGCTTTTGCTGATTGTAAAT
GGAAAACTATTGAGGTAAATTGCTCAAATTATCCAAGACGCCATTTTCAAACCGTAGGAA
CAGATCTCACACAAGTTCGTCTTGCAAATGTTCAAGGACCAACACCAGAACCATTGTCAA
ATTATCTTGATGCCCAATATTATGGACCAATTACAATTGGAAGTCCACCACAAAGTTTCA
AAGTTGTTTTTGACACTGGAAGTTCAAATTTATGGGTTCCATCAAAATCTTGTTCACTTA
TGAACATTGCCTGTCTTATGCATAACAAATATGATTCGAAAAAAAGTTCAACATACGAGA
AAAATGGAACAAAATTTCATATCGAATACGGTAGCGGTTCACTAAGTGGCTTCTTGTCAA
CTGATACTGTCGGTATTGGTGATTTAAAAATTCAAAAGCAAACATTTGCAGAAGCAGTTT
CAGAACCCGGTTTAGTTTTTGTTGCTGCTAAATTTGATGGAATTCTTGGATTAGGCTACA
AATCAATTTCAGTTGATGGAGTTGAACCAGTTTTCTATAACATGTACAATCAAGGACTCA
TTTCAGAGCCAATTTTCTCATTTTATTTGAATCGTGATCCAAATGGCAAAGAAGGTGGAG
AAATTATTTTTGGTGGAAGTGATCCAGATCATTATGAAGGTGATTTCACTTATCTCCCAG
TCAATCGCAAAGCATACTGGCAATTCAAAATGGATGGAGTGAAAATTGGTGACAAAACTT
TCTGTAATGGTGGATGCCAAGCAATTGCTGACACTGGAACATCACTCATTGCTGGACCAA
CTGATGAAGTTACAGCAATTAACAAAGCCATCGGTGGAACACCAATTTTAAATGGACAAT
ACATGGTTAATTGTGACATGATACCAAATTTGCCTACAATTAAATTCACTTTGGGTGGCA
AGGAATTTGCACTTGATGGATCTGATTATATTTTAAGAATCGCTCAAATGGGTAAAACTA
TTTGCTTGTCTGGTTTCATGGGAATTAATATTCCACCACCAAATGGACCACTATGGATTC
TCGGTGATGTTTTTATTGGAAAATACTACACAGAATTTGATTTTGGCAATGACCGTGTTG
GTTTTGCTGTCACAAAATAG
>g17114.t25 Gene=g17114 Length=286
MNIACLMHNKYDSKKSSTYEKNGTKFHIEYGSGSLSGFLSTDTVGIGDLKIQKQTFAEAV
SEPGLVFVAAKFDGILGLGYKSISVDGVEPVFYNMYNQGLISEPIFSFYLNRDPNGKEGG
EIIFGGSDPDHYEGDFTYLPVNRKAYWQFKMDGVKIGDKTFCNGGCQAIADTGTSLIAGP
TDEVTAINKAIGGTPILNGQYMVNCDMIPNLPTIKFTLGGKEFALDGSDYILRIAQMGKT
ICLSGFMGINIPPPNGPLWILGDVFIGKYYTEFDFGNDRVGFAVTK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g17114.t25 | Gene3D | G3DSA:2.40.70.10 | Acid Proteases | 3 | 99 | 6.0E-105 |
| 11 | g17114.t25 | Gene3D | G3DSA:2.60.40.1960 | - | 100 | 282 | 6.0E-105 |
| 10 | g17114.t25 | Gene3D | G3DSA:2.40.70.10 | Acid Proteases | 146 | 267 | 6.0E-105 |
| 2 | g17114.t25 | PANTHER | PTHR47966:SF42 | CATHEPSIN D | 2 | 284 | 5.6E-124 |
| 3 | g17114.t25 | PANTHER | PTHR47966 | BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED | 2 | 284 | 5.6E-124 |
| 5 | g17114.t25 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 120 | 133 | 6.5E-17 |
| 4 | g17114.t25 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 168 | 179 | 6.5E-17 |
| 6 | g17114.t25 | PRINTS | PR00792 | Pepsin (A1) aspartic protease family signature | 259 | 274 | 6.5E-17 |
| 1 | g17114.t25 | Pfam | PF00026 | Eukaryotic aspartyl protease | 2 | 283 | 6.4E-107 |
| 8 | g17114.t25 | ProSitePatterns | PS00141 | Eukaryotic and viral aspartyl proteases active site. | 168 | 179 | - |
| 12 | g17114.t25 | ProSiteProfiles | PS51767 | Peptidase family A1 domain profile. | 1 | 283 | 65.747 |
| 7 | g17114.t25 | SUPERFAMILY | SSF50630 | Acid proteases | 3 | 283 | 3.9E-102 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0006508 | proteolysis | BP |
| GO:0004190 | aspartic-type endopeptidase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed