General information for g17527.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Lipase 3.
Parent gene
- The parent gene g17527 is located on chr_4: 13785842..13787201 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g17527 | g17527.t1 | isoform | g17527.t1 | 13785842 | 13787201 |
| chr_4 | g17527 | g17527.t1 | exon | g17527.t1.exon1 | 13785842 | 13786172 |
| chr_4 | g17527 | g17527.t1 | cds | g17527.t1.CDS1 | 13785842 | 13786172 |
| chr_4 | g17527 | g17527.t1 | exon | g17527.t1.exon2 | 13786222 | 13786597 |
| chr_4 | g17527 | g17527.t1 | cds | g17527.t1.CDS2 | 13786222 | 13786597 |
| chr_4 | g17527 | g17527.t1 | exon | g17527.t1.exon3 | 13786651 | 13787050 |
| chr_4 | g17527 | g17527.t1 | cds | g17527.t1.CDS3 | 13786651 | 13787050 |
| chr_4 | g17527 | g17527.t1 | exon | g17527.t1.exon4 | 13787115 | 13787201 |
| chr_4 | g17527 | g17527.t1 | cds | g17527.t1.CDS4 | 13787115 | 13787201 |
| chr_4 | g17527 | g17527.t1 | TSS | g17527.t1 | NA | NA |
| chr_4 | g17527 | g17527.t1 | TTS | g17527.t1 | NA | NA |
Sequences
>g17527.t1 Gene=g17527 Length=1194
ATGAACATTGTGCACGTTTTTATTGGCATTTTAGCATTGTCTTCTGTTGTACTTGGTGAT
GTTTGGGAAGATACACAATTAAATACAATTCAACTTTTAAGAAAATATGGTTATACAGCA
GACGAATTTACAGTAACAACATCAGATGGTTATCGTTTAGGTATTCATCGTTGTTCTGGT
GGTCCAGTTTCACCACCAGCTCCTAATAAGCCAGTAGCATTTCTTATGCATGGACAACTC
AGTTCATCTGCTGATTGGGTAATTATGGGTCCACATGTGTCACTTGCTTATATGTTATCT
GACCTTGGATATGATGTATGGATGGGAAATTCCCGTGGCAACAGATATTCAAACACGCAT
GTATCGCTCAATAATCAAACAAGAGCTTATTGGGATTTTTCATGGCATGAAATTGGTACA
ATTGATGTTCCTACAATGATTGACTTTATTTTGTCACGAACAGGACAAAGAAATTTGCAT
TACATAGGTCACTCAATGGGAACAACAGTTTATTTGGTAATGATTAGTGAAAGACCAACT
TATGCTTCAAGATTGAGAAGTGTCAATTTGCTGGCTCCTGCAGCTTATATGACATACATT
TTAACACCGTATGTACGTTGGATTGCAGCATTTGCTTACACATGGGATTTAATGTTCCGA
ATGATGGGAACATATTATTTTGCACCAACAAGTGAAATGGACAGACAGGCTGCTTATGAT
GATTGTCGTGATGGTGCACCTTTCCAAGAAATGTGCGCAATACAAATTTTCCTTATTGCT
GGATGGAATTCTCAAGAAACTAATAGAACAATGTTGCCAGTTATTCATGCACATTCACCT
GCAGGAGCCAGCATGATGAATATGTTACATTATGCTCAAATTGTGAGAAGCAGAACTTTC
CAACAATATGATCATGGTGCTAATAATATCTTCAGATATGGTCAACTTCGACCTCCATTA
TATAGGTTTACTGGTCACACTGCACCATTGCATATGTTTTGGTCAACGAATGATTGGATG
GCAACACCAGCTGATGTAGCGACACTTTTTAATAGATTAGGAGGTTCACGTGTTGTTGAC
TTGTTCTATCGTGTGCCACAAATTGAATGGAATCACATGGACTTTGTTTGGGGTATTAAT
GTTAGAACATTAGTTTATGACAGAATGATTGAAGAAATGAGAAAATATGATTGA
>g17527.t1 Gene=g17527 Length=397
MNIVHVFIGILALSSVVLGDVWEDTQLNTIQLLRKYGYTADEFTVTTSDGYRLGIHRCSG
GPVSPPAPNKPVAFLMHGQLSSSADWVIMGPHVSLAYMLSDLGYDVWMGNSRGNRYSNTH
VSLNNQTRAYWDFSWHEIGTIDVPTMIDFILSRTGQRNLHYIGHSMGTTVYLVMISERPT
YASRLRSVNLLAPAAYMTYILTPYVRWIAAFAYTWDLMFRMMGTYYFAPTSEMDRQAAYD
DCRDGAPFQEMCAIQIFLIAGWNSQETNRTMLPVIHAHSPAGASMMNMLHYAQIVRSRTF
QQYDHGANNIFRYGQLRPPLYRFTGHTAPLHMFWSTNDWMATPADVATLFNRLGGSRVVD
LFYRVPQIEWNHMDFVWGINVRTLVYDRMIEEMRKYD
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 6 | g17527.t1 | Gene3D | G3DSA:3.40.50.1820 | - | 19 | 395 | 5.9E-127 |
| 2 | g17527.t1 | PANTHER | PTHR11005:SF127 | LIPASE-RELATED | 22 | 396 | 3.0E-131 |
| 3 | g17527.t1 | PANTHER | PTHR11005 | LYSOSOMAL ACID LIPASE-RELATED | 22 | 396 | 3.0E-131 |
| 12 | g17527.t1 | PIRSF | PIRSF000862 | Steryl_ester_lip | 3 | 397 | 8.3E-122 |
| 1 | g17527.t1 | Pfam | PF04083 | Partial alpha/beta-hydrolase lipase region | 31 | 89 | 3.1E-17 |
| 8 | g17527.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 19 | - |
| 9 | g17527.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 2 | - |
| 10 | g17527.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 3 | 14 | - |
| 11 | g17527.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 15 | 19 | - |
| 7 | g17527.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 20 | 397 | - |
| 4 | g17527.t1 | SUPERFAMILY | SSF53474 | alpha/beta-Hydrolases | 24 | 393 | 1.97E-55 |
| 5 | g17527.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 19 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016788 | hydrolase activity, acting on ester bonds | MF |
| GO:0006629 | lipid metabolic process | BP |
KEGG
Orthology
- This transcript has been annotated with K01052 (lysosomal acid lipase/cholesteryl ester hydrolase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
