General information for g17554.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Ferrochelatase, mitochondrial.
Parent gene
- The parent gene g17554 is located on chr_4: 13854639..13855949 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g17554 | g17554.t1 | TSS | g17554.t1 | 13854161 | 13854161 |
| chr_4 | g17554 | g17554.t1 | isoform | g17554.t1 | 13854247 | 13855557 |
| chr_4 | g17554 | g17554.t1 | exon | g17554.t1.exon1 | 13854247 | 13854283 |
| chr_4 | g17554 | g17554.t1 | cds | g17554.t1.CDS1 | 13854247 | 13854283 |
| chr_4 | g17554 | g17554.t1 | exon | g17554.t1.exon2 | 13854351 | 13854626 |
| chr_4 | g17554 | g17554.t1 | cds | g17554.t1.CDS2 | 13854351 | 13854626 |
| chr_4 | g17554 | g17554.t1 | exon | g17554.t1.exon3 | 13854683 | 13855557 |
| chr_4 | g17554 | g17554.t1 | cds | g17554.t1.CDS3 | 13854683 | 13855557 |
| chr_4 | g17554 | g17554.t1 | TTS | g17554.t1 | 13855928 | 13855928 |
Sequences
>g17554.t1 Gene=g17554 Length=1188
ATGATGCGCCACACTATTCAAAAATTCCCAATAAATGGATGGATGATTAGTAGAAATTTT
TCCTTATCAGCAACGATGTGTGATAACCCTAAGCCAAAAACAGGAATTTTGATGTTAAAC
ATGGGTGGACCGCAGACTACAGATCAAGTTGGCGATTACCTTCGGCGCATTATGACTGAC
CGTGATATGATGCAATTACCATTCCAAGATACTTTAGGACCATTTATTGCAAAAAGAAGA
ACATCAGAAGTGCAAAAGAAATATCAAGAAATAGGAGGCGGAAGTCCAATTTTAAAATGG
ACTAAATTACAAGGTGAACTAATGTGCAAAAAACTCGATCAACTTTCACCTGAAACTGCT
CCTCATAAAAGTTATGTTGGTTTTCGTTACGTTGATCCATTCACTGAAGATACTATCAAA
CAAATTGAAGCTGATGGACCAGAGCGTGTTGTTATTTTCTCTCAATATCCACAATATAGT
TGTGCAACATCAGGTTCAAGTTTTAATTCAATATATACTCATTTCAATGGACAAAAACCT
AAGAGTAGTATCAAGTGGAGTATGATTGACAGATGGCCAACTCATCAACTTCTTGTTAAA
ACATTTGCAGAGAGAATTAAGGAAAAACTTGTTGAATTTGATGAAAATGATAGAAAAGAT
GTAATTTTACTTTTCTCAGCTCACTCACTGCCATTAAAATCAGTAAGACGAGGTGATCCA
TATCCAAATGAAGTAGGAGCAACTGTTAACGCTGTAATGGCTGAACTTGATTACTGTAAT
CCATACAGTCTCGTTTGGCAATCGAAGGTGGGACCTCTGCCCTGGCTTGAGCCATTCACT
GACGATGCCATCAAAATGTATGTCGCTAAGGGCAAGAAACATTTTATTCTTGTTCCCATA
GCTTTTGTAAACGAGCACATTGAGACACTTCATGAATTGGACATTGAATACTGTAAAGAT
CTTGCTAAAGAAATCAGAGCAGAGAAAATATTGCGAGCAGCAGCACCTAACGATCATCCA
ATCTTTATCGATGCAATTAGTGATATTGTAAACAAGCATTTAAAGAGCGATCAAAGAGTT
AATCCGAAATTTTTGACTCGCTGTCCTCACTGTGTTAGCGAGAAATGTCACAAGAGCAAG
AAATTCTTTAAAGAGTTGTGTGAGGCCAGTGTGAATCTCTCAATTTGA
>g17554.t1 Gene=g17554 Length=395
MMRHTIQKFPINGWMISRNFSLSATMCDNPKPKTGILMLNMGGPQTTDQVGDYLRRIMTD
RDMMQLPFQDTLGPFIAKRRTSEVQKKYQEIGGGSPILKWTKLQGELMCKKLDQLSPETA
PHKSYVGFRYVDPFTEDTIKQIEADGPERVVIFSQYPQYSCATSGSSFNSIYTHFNGQKP
KSSIKWSMIDRWPTHQLLVKTFAERIKEKLVEFDENDRKDVILLFSAHSLPLKSVRRGDP
YPNEVGATVNAVMAELDYCNPYSLVWQSKVGPLPWLEPFTDDAIKMYVAKGKKHFILVPI
AFVNEHIETLHELDIEYCKDLAKEIRAEKILRAAAPNDHPIFIDAISDIVNKHLKSDQRV
NPKFLTRCPHCVSEKCHKSKKFFKELCEASVNLSI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g17554.t1 | CDD | cd03411 | Ferrochelatase_N | 34 | 195 | 2.0856E-61 |
| 8 | g17554.t1 | CDD | cd00419 | Ferrochelatase_C | 200 | 337 | 3.34615E-53 |
| 7 | g17554.t1 | Gene3D | G3DSA:3.40.50.1400 | - | 33 | 356 | 1.6E-137 |
| 6 | g17554.t1 | Gene3D | G3DSA:3.40.50.1400 | - | 193 | 335 | 1.6E-137 |
| 4 | g17554.t1 | Hamap | MF_00323 | Coproporphyrin III ferrochelatase [cpfC]. | 32 | 354 | 32.361618 |
| 2 | g17554.t1 | PANTHER | PTHR11108:SF1 | FERROCHELATASE, MITOCHONDRIAL | 29 | 384 | 4.0E-131 |
| 3 | g17554.t1 | PANTHER | PTHR11108 | FERROCHELATASE | 29 | 384 | 4.0E-131 |
| 1 | g17554.t1 | Pfam | PF00762 | Ferrochelatase | 33 | 354 | 1.4E-103 |
| 10 | g17554.t1 | ProSitePatterns | PS00534 | Ferrochelatase signature. | 223 | 241 | - |
| 5 | g17554.t1 | SUPERFAMILY | SSF53800 | Chelatase | 31 | 384 | 2.29E-111 |
| 11 | g17554.t1 | TIGRFAM | TIGR00109 | hemH: ferrochelatase | 31 | 354 | 3.8E-98 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004325 | ferrochelatase activity | MF |
| GO:0006783 | heme biosynthetic process | BP |
KEGG
Orthology
- This transcript has been annotated with K01772 (protoporphyrin/coproporphyrin ferrochelatase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
