General information for g17554.t4
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Ferrochelatase, mitochondrial.
Parent gene
- The parent gene g17554 is located on chr_4: 13854639..13855949 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g17554 | g17554.t4 | TSS | g17554.t4 | 13854161 | 13854161 |
| chr_4 | g17554 | g17554.t4 | isoform | g17554.t4 | 13854164 | 13855949 |
| chr_4 | g17554 | g17554.t4 | exon | g17554.t4.exon1 | 13854164 | 13854192 |
| chr_4 | g17554 | g17554.t4 | exon | g17554.t4.exon2 | 13854367 | 13854626 |
| chr_4 | g17554 | g17554.t4 | cds | g17554.t4.CDS1 | 13854389 | 13854626 |
| chr_4 | g17554 | g17554.t4 | exon | g17554.t4.exon3 | 13854683 | 13855949 |
| chr_4 | g17554 | g17554.t4 | cds | g17554.t4.CDS2 | 13854683 | 13855557 |
| chr_4 | g17554 | g17554.t4 | TTS | g17554.t4 | 13855928 | 13855928 |
Sequences
>g17554.t4 Gene=g17554 Length=1556
CTTATTTGCACACAAATCTTCACAGGCAAAAATTTTTCCTTATCAGCAACGATGTGTGAT
AACCCTAAGCCAAAAACAGGAATTTTGATGTTAAACATGGGTGGACCGCAGACTACAGAT
CAAGTTGGCGATTACCTTCGGCGCATTATGACTGACCGTGATATGATGCAATTACCATTC
CAAGATACTTTAGGACCATTTATTGCAAAAAGAAGAACATCAGAAGTGCAAAAGAAATAT
CAAGAAATAGGAGGCGGAAGTCCAATTTTAAAATGGACTAAATTACAAGGTGAACTAATG
TGCAAAAAACTCGATCAACTTTCACCTGAAACTGCTCCTCATAAAAGTTATGTTGGTTTT
CGTTACGTTGATCCATTCACTGAAGATACTATCAAACAAATTGAAGCTGATGGACCAGAG
CGTGTTGTTATTTTCTCTCAATATCCACAATATAGTTGTGCAACATCAGGTTCAAGTTTT
AATTCAATATATACTCATTTCAATGGACAAAAACCTAAGAGTAGTATCAAGTGGAGTATG
ATTGACAGATGGCCAACTCATCAACTTCTTGTTAAAACATTTGCAGAGAGAATTAAGGAA
AAACTTGTTGAATTTGATGAAAATGATAGAAAAGATGTAATTTTACTTTTCTCAGCTCAC
TCACTGCCATTAAAATCAGTAAGACGAGGTGATCCATATCCAAATGAAGTAGGAGCAACT
GTTAACGCTGTAATGGCTGAACTTGATTACTGTAATCCATACAGTCTCGTTTGGCAATCG
AAGGTGGGACCTCTGCCCTGGCTTGAGCCATTCACTGACGATGCCATCAAAATGTATGTC
GCTAAGGGCAAGAAACATTTTATTCTTGTTCCCATAGCTTTTGTAAACGAGCACATTGAG
ACACTTCATGAATTGGACATTGAATACTGTAAAGATCTTGCTAAAGAAATCAGAGCAGAG
AAAATATTGCGAGCAGCAGCACCTAACGATCATCCAATCTTTATCGATGCAATTAGTGAT
ATTGTAAACAAGCATTTAAAGAGCGATCAAAGAGTTAATCCGAAATTTTTGACTCGCTGT
CCTCACTGTGTTAGCGAGAAATGTCACAAGAGCAAGAAATTCTTTAAAGAGTTGTGTGAG
GCCAGTGTGAATCTCTCAATTTGATTTTTTAATCTAAATATTTTTACACTTCTTTGAAAA
CAATACCTCATACAAAAAACGGGTCAAATTTATGTTTCTTTTTCTGTTAGAATTCTAAAA
ATTCATCAGTTTACAAACGCTCTTTAAAGAATTTCTTTTTATTTCAAATCGAATTTGTAA
AACAAATGACAAATGATCAACTCAACTCATAGCATTCTAGAAATTTCTGTGTTAATTTTT
TTCCTTTAGAAATAGACAATTTAATTGTCCCTTGATTTTTTTTTATATCTGTTCCTTACG
CAAGCAGCTTGCATTTTTTTGTTAGAAAATTTTTATTTTGTTTTATGAACACACACCATG
AAAAGACCATATAAATAAATTTTTATGAAAAATGTACCCGATTATTTTTTTTTACT
>g17554.t4 Gene=g17554 Length=370
MCDNPKPKTGILMLNMGGPQTTDQVGDYLRRIMTDRDMMQLPFQDTLGPFIAKRRTSEVQ
KKYQEIGGGSPILKWTKLQGELMCKKLDQLSPETAPHKSYVGFRYVDPFTEDTIKQIEAD
GPERVVIFSQYPQYSCATSGSSFNSIYTHFNGQKPKSSIKWSMIDRWPTHQLLVKTFAER
IKEKLVEFDENDRKDVILLFSAHSLPLKSVRRGDPYPNEVGATVNAVMAELDYCNPYSLV
WQSKVGPLPWLEPFTDDAIKMYVAKGKKHFILVPIAFVNEHIETLHELDIEYCKDLAKEI
RAEKILRAAAPNDHPIFIDAISDIVNKHLKSDQRVNPKFLTRCPHCVSEKCHKSKKFFKE
LCEASVNLSI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 9 | g17554.t4 | CDD | cd03411 | Ferrochelatase_N | 9 | 170 | 1.03605E-61 |
| 8 | g17554.t4 | CDD | cd00419 | Ferrochelatase_C | 175 | 312 | 2.81466E-53 |
| 6 | g17554.t4 | Gene3D | G3DSA:3.40.50.1400 | - | 8 | 331 | 1.2E-137 |
| 7 | g17554.t4 | Gene3D | G3DSA:3.40.50.1400 | - | 168 | 310 | 1.2E-137 |
| 4 | g17554.t4 | Hamap | MF_00323 | Coproporphyrin III ferrochelatase [cpfC]. | 7 | 329 | 32.361618 |
| 2 | g17554.t4 | PANTHER | PTHR11108:SF1 | FERROCHELATASE, MITOCHONDRIAL | 6 | 359 | 5.8E-131 |
| 3 | g17554.t4 | PANTHER | PTHR11108 | FERROCHELATASE | 6 | 359 | 5.8E-131 |
| 1 | g17554.t4 | Pfam | PF00762 | Ferrochelatase | 8 | 329 | 1.1E-103 |
| 10 | g17554.t4 | ProSitePatterns | PS00534 | Ferrochelatase signature. | 198 | 216 | - |
| 5 | g17554.t4 | SUPERFAMILY | SSF53800 | Chelatase | 6 | 359 | 1.8E-111 |
| 11 | g17554.t4 | TIGRFAM | TIGR00109 | hemH: ferrochelatase | 6 | 329 | 3.0E-98 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0004325 | ferrochelatase activity | MF |
| GO:0006783 | heme biosynthetic process | BP |
KEGG
Orthology
- This transcript has been annotated with K01772 (protoporphyrin/coproporphyrin ferrochelatase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
