Gene loci information

Transcript annotation

  • This transcript has been annotated as Insulin-degrading enzyme.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_4 g17566 g17566.t1 isoform g17566.t1 13890116 13893435
chr_4 g17566 g17566.t1 exon g17566.t1.exon1 13890116 13890519
chr_4 g17566 g17566.t1 cds g17566.t1.CDS1 13890116 13890519
chr_4 g17566 g17566.t1 exon g17566.t1.exon2 13890581 13891145
chr_4 g17566 g17566.t1 cds g17566.t1.CDS2 13890581 13891145
chr_4 g17566 g17566.t1 exon g17566.t1.exon3 13891200 13891359
chr_4 g17566 g17566.t1 cds g17566.t1.CDS3 13891200 13891359
chr_4 g17566 g17566.t1 exon g17566.t1.exon4 13891412 13892587
chr_4 g17566 g17566.t1 cds g17566.t1.CDS4 13891412 13892587
chr_4 g17566 g17566.t1 exon g17566.t1.exon5 13892657 13893159
chr_4 g17566 g17566.t1 cds g17566.t1.CDS5 13892657 13893159
chr_4 g17566 g17566.t1 exon g17566.t1.exon6 13893214 13893435
chr_4 g17566 g17566.t1 cds g17566.t1.CDS6 13893214 13893435
chr_4 g17566 g17566.t1 TSS g17566.t1 NA NA
chr_4 g17566 g17566.t1 TTS g17566.t1 NA NA

Sequences

>g17566.t1 Gene=g17566 Length=3030
ATGTTAACAACTGAGTTAAAAAATCAATTTCGTCACAAACTTCGTTTTAAAAAACGTCCA
ATTAAAAGCCTTGAATCGAAAGAATCAATACCACCACCGATTCATCCCAAATCTAAAGTA
AAACCATTATTTCCAGAAATTACTTATAACTTTATTAAAAAATCTCAACAAGATCCAAAA
AATTATCGTGCAATTGTTCTTCCAAATGAAATAAAAGTCACACTCATTTCTGATCCAACA
ACTTCAAAATCTGCGGCATGTATGAGCATTGAAGTAGGTCATATGAGTGATCCTGTTGAT
ACTCCAGGCCTTGCACATCTTTGTGAACATGCGCTCTTTTTAGGAAGTGAAAAATTTCCT
ACTAACAATGATTTTCGATTATTTTTAAATGAAAATGGTGGCAGTTGTAATGCACAAACT
TTTGCTGATGTGACGAAATATTTTTTTGATGTTTTGCCAGATCAATTAGAGGCAGCAATT
GAACGCTTTTCTCAAATGTTTATTGCACCATTATTTGAAAATGAAAATGTGATTCGTGAG
ATATCAGCTGTGAATAACGAACATGAAAAAAATTTGGCTTCAGACGCATGGCGATTAAGA
ATGGTGAATAAACGTCTAGCAGTTCAAAGTCATGATTATACAAAATTTGGTACAGGAAAT
AAATCAACTCTATTAAAACCTGATATTTGCAAAGAATTAAAAGAATTTCATAAAAAGTTT
TATAAAACTGGAAATTTGATGAATTTGACAATTCTTGGAACTGAAACTCTTGATAGATTA
GAGGCAATGGCAAAGAAATATTTTATGGAAGATATTGAAAATTTTGGAGTGGAAATTCCT
CGCTGGGATGATAAAATTTATGATGAAGAAATGATGAGGACAGTTACTTATGTTGTACCT
ATTAAAGATGTGAGAACTATGACTTTACAGTTTCAAACACCATGTTTGTTAGAATATTTT
AGAGCTAAACCTGAACAATATATAATTAATTGTTTAGCATATGAAAGTCGTGGTTCTGTA
CTTTATGAACTTAGAAAATTAAGATGGTGTACAACATTAAATTGTGACCATGTGAAATAT
GCAAAAGGATTCGGATTCTTTGAAATTAAAGTTGATTTGACTGATGAAGGTTATATTTAT
ATGAATGATATTATAAAATTAATATTTCAATATCTTAATCTCATTAAACGTGTTGGTATA
AAAAATTGGATATTTGAAGAACTTAAAAATCTCGCAGTAATTGAATTTCGTTTTGAAGAT
GAAAAATCTCCAATAAATTTAGTATCAAAAATTTCAAGTTACATGCGTCATTATCCATTG
ACAGAAATTCTTACTGGCCCAACATTAATTAATGAATTCAGAATTGATTTAATTGAATAT
GTTCTTGATATGCTAGTACCTGATAATCTTCGTGTTATAGTCGTTGACCAAACACCTTAC
TATAAATGTAATTGTATTGAATCAATATATGAAACGAAATACGGTGTTGAAAAAATTCGC
TCTTCAGTTATTCGTGAATGGAAAATTTGTGGATCAAATCCAAATTTTAAATTACCTGAG
CCTAATATTTTCATTCCATCAGATTTTTTATGGTTACCGATAGAAAATTGGAGTCAAACT
TATCCAAAAATAATCAAAGATACTTCTCTAATAAGAGTTTGGTTCAAACAAGATGAACAC
TTTCGATCTCCCAAAACAATCCTCACTGTTGAACTTAAAAATCCAACAATTAATTGTGAT
CCTTTAAATTGGAATATGACACATATTTTTGTGTGGATGCTTCAAGATTACCTAAGAGAA
AAATTTTATGGTGCTACTTTAGCAGGAATTGATTTGCAGTTATGCATTACAAAAGCTGGA
ATAAGAATTTTTATTGAAGGGTTTTCAGATAAACTCGGTTTATTTTTAGAAACAATTTTG
CGTGAAATTTTTAAATTTAAAATTGATCTTCGACATTTTGAAGACACTTATGATGCATAT
TTAGCTGATTTGAAAGGTTTTGAGGGTGAAAAACCGCAACATATGGGAATTTACTATTTG
GAAATAATTTTAAATGAACAGACATGGTCAAATGAAGAACTTTTATTAGCAATGAAAGTG
TTAACATTGGGTAGACTCAAAACATTTGCAAAAGAAGTGTTGACACAAACTAATGCAGAT
TGTTTGATTTTCGGAAATGTCAATGAAGAAAAAGCAATAGAATTGACTGATATTGTGGAA
GATAGATTAGAAAAAGCGAGTCGAAATGAAAGACAAATAATTATTCTTGCATCACACAGT
GTTAGAGAAAGAAAAATTAATGAAGGTGATTTTTATACATTTCAAACAATTAATGAGTAT
CATAAATATAATTGTATAAGCTATTTCATTCAATGCGGTTTACAAGATGATAAATCAAAT
GTTATTCTTGATTTAATTTTACAAATCATTCGAGCATCATTTTTTGATGTGTTAAGAACT
CAAGAGCAACAAGGATATTTAGTTGATTGCATTGTTAGAAGAGTGAATGGAACGCAAGGT
ATTAAATTTGTTGTTGAATCAAGTAAACATCCAGAATATATTGAGGAAAGAATAAAAATA
TTTTTAATTACTATGCACAAGGAAATTGAAGAAATGTGTGAAGAAAAATTTCTAAATCAT
AAGACTGCATTGAAATCCAAAAAGAAACAAAAACCTCTAACGCTAGCTGGTCAATTTTGG
CAATATCATAAAGAAATTGTTATTCAAAACTATCATTTCAATAGACATCAAGTTGAAGCT
TCAATATTGAAAGAAATAAGTTTAAAAGATATTTGTGAATTTTATGAGGCTCATATTTCT
CCTGATTCTGCATCACAGAAAATAATTTCAATACATATAATTTCAAAAGAAACAATGAAA
AAAACTCGTCATCTGCCATCATCGGTTATAAACAAGATAGAAAATCTTATTGATTTCAAA
AACACTCTTCAACTTAATCCAAGAAAGAAACTAAAAAGTCTTCGACAATTTTATAGCAGA
AATATCAACAAAAAAACTAAAAGACATTAA

>g17566.t1 Gene=g17566 Length=1009
MLTTELKNQFRHKLRFKKRPIKSLESKESIPPPIHPKSKVKPLFPEITYNFIKKSQQDPK
NYRAIVLPNEIKVTLISDPTTSKSAACMSIEVGHMSDPVDTPGLAHLCEHALFLGSEKFP
TNNDFRLFLNENGGSCNAQTFADVTKYFFDVLPDQLEAAIERFSQMFIAPLFENENVIRE
ISAVNNEHEKNLASDAWRLRMVNKRLAVQSHDYTKFGTGNKSTLLKPDICKELKEFHKKF
YKTGNLMNLTILGTETLDRLEAMAKKYFMEDIENFGVEIPRWDDKIYDEEMMRTVTYVVP
IKDVRTMTLQFQTPCLLEYFRAKPEQYIINCLAYESRGSVLYELRKLRWCTTLNCDHVKY
AKGFGFFEIKVDLTDEGYIYMNDIIKLIFQYLNLIKRVGIKNWIFEELKNLAVIEFRFED
EKSPINLVSKISSYMRHYPLTEILTGPTLINEFRIDLIEYVLDMLVPDNLRVIVVDQTPY
YKCNCIESIYETKYGVEKIRSSVIREWKICGSNPNFKLPEPNIFIPSDFLWLPIENWSQT
YPKIIKDTSLIRVWFKQDEHFRSPKTILTVELKNPTINCDPLNWNMTHIFVWMLQDYLRE
KFYGATLAGIDLQLCITKAGIRIFIEGFSDKLGLFLETILREIFKFKIDLRHFEDTYDAY
LADLKGFEGEKPQHMGIYYLEIILNEQTWSNEELLLAMKVLTLGRLKTFAKEVLTQTNAD
CLIFGNVNEEKAIELTDIVEDRLEKASRNERQIIILASHSVRERKINEGDFYTFQTINEY
HKYNCISYFIQCGLQDDKSNVILDLILQIIRASFFDVLRTQEQQGYLVDCIVRRVNGTQG
IKFVVESSKHPEYIEERIKIFLITMHKEIEEMCEEKFLNHKTALKSKKKQKPLTLAGQFW
QYHKEIVIQNYHFNRHQVEASILKEISLKDICEFYEAHISPDSASQKIISIHIISKETMK
KTRHLPSSVINKIENLIDFKNTLQLNPRKKLKSLRQFYSRNINKKTKRH

Protein features from InterProScan

Transcript Database ID Name Start End E.value
13 g17566.t1 Gene3D G3DSA:3.30.830.10 Cytochrome Bc1 Complex; Chain A 41 274 4.8E-74
15 g17566.t1 Gene3D G3DSA:3.30.830.10 Cytochrome Bc1 Complex; Chain A 280 508 9.5E-69
14 g17566.t1 Gene3D G3DSA:3.30.830.10 Cytochrome Bc1 Complex; Chain A 537 759 8.3E-57
12 g17566.t1 Gene3D G3DSA:3.30.830.10 Cytochrome Bc1 Complex; Chain A 764 995 1.0E-61
5 g17566.t1 PANTHER PTHR43690:SF18 INSULIN-DEGRADING ENZYME-RELATED 51 988 2.6E-253
6 g17566.t1 PANTHER PTHR43690 NARDILYSIN 51 988 2.6E-253
1 g17566.t1 Pfam PF00675 Insulinase (Peptidase family M16) 72 206 8.3E-35
3 g17566.t1 Pfam PF05193 Peptidase M16 inactive domain 232 410 1.1E-8
2 g17566.t1 Pfam PF16187 Middle or third domain of peptidase_M16 416 695 5.2E-77
4 g17566.t1 Pfam PF05193 Peptidase M16 inactive domain 701 884 8.1E-8
11 g17566.t1 ProSitePatterns PS00143 Insulinase family, zinc-binding region signature. 93 116 -
7 g17566.t1 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase 52 268 1.83E-44
10 g17566.t1 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase 282 521 5.6E-62
8 g17566.t1 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase 522 744 4.89E-41
9 g17566.t1 SUPERFAMILY SSF63411 LuxS/MPP-like metallohydrolase 764 960 4.77E-32

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0046872 metal ion binding MF
GO:0006508 proteolysis BP

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed