General information for g17577.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Potassium voltage-gated channel protein Shal.
Parent gene
- The parent gene g17577 is located on chr_4: 13985847..13998771 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_4 | g17577 | g17577.t1 | isoform | g17577.t1 | 13985847 | 13998771 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon1 | 13985847 | 13985978 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS1 | 13985847 | 13985978 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon2 | 13987833 | 13987988 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS2 | 13987833 | 13987988 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon3 | 13988063 | 13988411 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS3 | 13988063 | 13988411 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon4 | 13988538 | 13988567 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS4 | 13988538 | 13988567 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon5 | 13988632 | 13988681 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS5 | 13988632 | 13988681 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon6 | 13988737 | 13988793 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS6 | 13988737 | 13988793 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon7 | 13989576 | 13989880 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS7 | 13989576 | 13989880 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon8 | 13989944 | 13990174 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS8 | 13989944 | 13990174 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon9 | 13990250 | 13990587 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS9 | 13990250 | 13990587 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon10 | 13990644 | 13990767 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS10 | 13990644 | 13990767 |
| chr_4 | g17577 | g17577.t1 | exon | g17577.t1.exon11 | 13998579 | 13998771 |
| chr_4 | g17577 | g17577.t1 | cds | g17577.t1.CDS11 | 13998579 | 13998771 |
| chr_4 | g17577 | g17577.t1 | TSS | g17577.t1 | NA | NA |
| chr_4 | g17577 | g17577.t1 | TTS | g17577.t1 | NA | NA |
Sequences
>g17577.t1 Gene=g17577 Length=1965
ATGAGCAAGAGTGGTGGTGGTATTGTAGATTGTCCAACATCTGAGAATGTGTGCAGCAAT
AATAATGGCTTCAGTAGTGATGAGTCAAATGATGGTGATAAGCAAATTATGATGCCAGTT
GTAGGTACTGATGATGAAGATGACGATCATCAATCAGATGATGATTATATTGGACTATAT
AAGTATGATAATGAGATTTTAATAACCGACCGCAAACTGCCGCCATACGACATAACGTCA
TCGCGCTGCCATAAACCGCTGTCGATGGCTTCTGTAACTGCTTTTCTTCCGTTAGCAAGA
GCTTCTGCGGTTGGATGGATTCCAATCGCAGCTAACCCTCTGCCACCGCCTCCATTGCTG
AAGAAAGATAGACGCAAAGCAGAAGATGAAAAGATGATGATAAATGTGTCGGGACGACGT
TTTGAAACATGGCGTAATACATTAGAGAAACATCCCGACACACTTCTGGGTAGTACTGAG
CGTGAATTTTTTTATGATGAAGAAACTTGCGAGTATTTTTTTGATCGAGATCCTGAAATT
TTTCGTCATATACTAAATTACTATCATACCGGCAAATTACATTATCCGCGACATGAATGT
CTACTTTCGTATGATGAGGAACTTTCATTTTTTGGGATTCTTCCCGATGTCATAGGGGAC
TGTTGCTATGAAGATTATCGTGATCGCAAAAGAGAAAACACTGAACGTCTGATGGATGAT
AAATTGAGTGAGAATGGTGAAGCTAATAAGGTAGTGCTTACTAATAGGCGAGAGAAAATG
TGGAGAGCATTTGAGAATCCACATACCAGCACTAGTGCATTAGTTTTTTATTACGTTACG
GGATTTTTCATTGCTGTATCCGTGATGGCTAATGTTATTGAAACTGTTCCATGCGGTCAT
CGTCCAGGGAGAGCAGGATCAATAAGTTGCGGAGAACGTTATAAGGTTGTCTTTTTCTGT
CTCGACACTGCTTGCGTCATGATCTTCACAGCTGAATATTTACTACGACTCTTTGCTGCA
CCTGATCGATTACGCTTTATTAGATCAGTCATGTCTGTTATTGATGTTGTGGCTATTATG
CCGTACTATATTGGATTATTCATGACTGACAATGATGACGTTTCGGGAGCTTTTGTTACA
CTGCGAGTCTTCCGTGTTTTTCGAATTTTTAAATTTTCGAGGCATTCACAGGGTCTTCGC
ATTTTGGGCTATACACTTAAGAGTTGTGCAAGCGAGCTTGGCTTTCTTAGAAAGAATGTT
GACGGTACCAATTTCACATCTATTCCAGCAGCATTTTGGTATACAATTGTCACAATGACA
ACTTTGGGGTATGGTGATATGGTACCAGAAACAATAGCAGGCAAAATTGTTGGCGGTGTT
TGCTCTTTGAGTGGAGTGTTGGTCATCGCTCTTCCCGTTCCCGTCATTGTGTCAAACTTT
TCACGTATATATCATCAGAATCAAAGAGCAGATAAAAGAAAAGCACAAAGAAAAGCTAGA
CTAGCACGAATCCGGCTAGCAAAAGCAAGTTCTTCAGCTGCATTTGCAAATAAGAAAAGA
TTAGCTGAATCTCGAATGCTGAGACACCAACAAGGACTTGATTCAGAAGATTTGAGTGAT
GAAGATATATTTGAGATGCAACACCATCATTTGCTTAAATGTCTTGAAAAGGCTACTGAT
AGAGAATTTGCTGATCTAGATGCATTTAATGGTGCAACAAAAAGACCTGGCTCTCCATCT
CCACTTGCAACAAGTCCATTGCATGCTCGTATAAGTAAACTTGGATTTTTGCAAGCATGT
TGTGGTCGGTGTTGTAATGGAAAGCGCTATAAGGGCTACGGCAAATATGTTCCAGCAAGA
ACAAGTAGTCGCGTAGTGATTCATAATAATCGAAATAATGACAGCAATGACAACAGTAAT
CAGAATGAAGAAAGCATGGATTATTTAGTTGAAGAGACTTTCTAA
>g17577.t1 Gene=g17577 Length=654
MSKSGGGIVDCPTSENVCSNNNGFSSDESNDGDKQIMMPVVGTDDEDDDHQSDDDYIGLY
KYDNEILITDRKLPPYDITSSRCHKPLSMASVTAFLPLARASAVGWIPIAANPLPPPPLL
KKDRRKAEDEKMMINVSGRRFETWRNTLEKHPDTLLGSTEREFFYDEETCEYFFDRDPEI
FRHILNYYHTGKLHYPRHECLLSYDEELSFFGILPDVIGDCCYEDYRDRKRENTERLMDD
KLSENGEANKVVLTNRREKMWRAFENPHTSTSALVFYYVTGFFIAVSVMANVIETVPCGH
RPGRAGSISCGERYKVVFFCLDTACVMIFTAEYLLRLFAAPDRLRFIRSVMSVIDVVAIM
PYYIGLFMTDNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLRKNV
DGTNFTSIPAAFWYTIVTMTTLGYGDMVPETIAGKIVGGVCSLSGVLVIALPVPVIVSNF
SRIYHQNQRADKRKAQRKARLARIRLAKASSSAAFANKKRLAESRMLRHQQGLDSEDLSD
EDIFEMQHHHLLKCLEKATDREFADLDAFNGATKRPGSPSPLATSPLHARISKLGFLQAC
CGRCCNGKRYKGYGKYVPARTSSRVVIHNNRNNDSNDNSNQNEESMDYLVEETF
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 28 | g17577.t1 | Gene3D | G3DSA:3.30.710.10 | Potassium Channel Kv1.1; Chain A | 87 | 233 | 3.1E-50 |
| 27 | g17577.t1 | Gene3D | G3DSA:1.20.120.350 | - | 246 | 395 | 1.1E-36 |
| 26 | g17577.t1 | Gene3D | G3DSA:1.10.287.70 | - | 399 | 491 | 9.0E-23 |
| 48 | g17577.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 624 | 648 | - |
| 6 | g17577.t1 | PANTHER | PTHR11537:SF265 | POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 2 | 112 | 604 | 3.2E-242 |
| 7 | g17577.t1 | PANTHER | PTHR11537 | VOLTAGE-GATED POTASSIUM CHANNEL | 112 | 604 | 3.2E-242 |
| 17 | g17577.t1 | PRINTS | PR01497 | Shal voltage-gated K+ channel family signature | 157 | 170 | 6.8E-48 |
| 9 | g17577.t1 | PRINTS | PR01491 | Voltage-gated potassium channel family signature | 171 | 181 | 1.9E-12 |
| 13 | g17577.t1 | PRINTS | PR00169 | Potassium channel signature | 171 | 190 | 5.4E-52 |
| 16 | g17577.t1 | PRINTS | PR01497 | Shal voltage-gated K+ channel family signature | 232 | 248 | 6.8E-48 |
| 19 | g17577.t1 | PRINTS | PR01497 | Shal voltage-gated K+ channel family signature | 250 | 264 | 6.8E-48 |
| 12 | g17577.t1 | PRINTS | PR00169 | Potassium channel signature | 267 | 295 | 5.4E-52 |
| 18 | g17577.t1 | PRINTS | PR01497 | Shal voltage-gated K+ channel family signature | 269 | 283 | 6.8E-48 |
| 21 | g17577.t1 | PRINTS | PR01497 | Shal voltage-gated K+ channel family signature | 309 | 325 | 6.8E-48 |
| 11 | g17577.t1 | PRINTS | PR00169 | Potassium channel signature | 320 | 343 | 5.4E-52 |
| 15 | g17577.t1 | PRINTS | PR00169 | Potassium channel signature | 346 | 366 | 5.4E-52 |
| 14 | g17577.t1 | PRINTS | PR00169 | Potassium channel signature | 383 | 409 | 5.4E-52 |
| 8 | g17577.t1 | PRINTS | PR01491 | Voltage-gated potassium channel family signature | 388 | 396 | 1.9E-12 |
| 10 | g17577.t1 | PRINTS | PR01491 | Voltage-gated potassium channel family signature | 465 | 476 | 1.9E-12 |
| 22 | g17577.t1 | PRINTS | PR01497 | Shal voltage-gated K+ channel family signature | 486 | 497 | 6.8E-48 |
| 23 | g17577.t1 | PRINTS | PR01497 | Shal voltage-gated K+ channel family signature | 500 | 516 | 6.8E-48 |
| 20 | g17577.t1 | PRINTS | PR01497 | Shal voltage-gated K+ channel family signature | 545 | 559 | 6.8E-48 |
| 4 | g17577.t1 | Pfam | PF11601 | Shal-type voltage-gated potassium channels, N-terminal | 90 | 117 | 6.3E-8 |
| 1 | g17577.t1 | Pfam | PF02214 | BTB/POZ domain | 133 | 221 | 7.9E-27 |
| 2 | g17577.t1 | Pfam | PF00520 | Ion transport protein | 275 | 414 | 1.7E-20 |
| 3 | g17577.t1 | Pfam | PF00520 | Ion transport protein | 419 | 487 | 2.0E-14 |
| 5 | g17577.t1 | Pfam | PF11879 | Domain of unknown function (DUF3399) | 538 | 608 | 5.3E-13 |
| 29 | g17577.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 273 | - |
| 38 | g17577.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 274 | 293 | - |
| 35 | g17577.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 294 | 312 | - |
| 36 | g17577.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 313 | 334 | - |
| 32 | g17577.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 335 | 345 | - |
| 41 | g17577.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 346 | 368 | - |
| 34 | g17577.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 369 | 373 | - |
| 40 | g17577.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 374 | 390 | - |
| 30 | g17577.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 391 | 424 | - |
| 39 | g17577.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 425 | 444 | - |
| 33 | g17577.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 445 | 455 | - |
| 37 | g17577.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 456 | 477 | - |
| 31 | g17577.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 478 | 654 | - |
| 47 | g17577.t1 | SMART | SM00225 | BTB_4 | 130 | 229 | 2.2E-17 |
| 25 | g17577.t1 | SUPERFAMILY | SSF54695 | POZ domain | 130 | 233 | 9.03E-31 |
| 24 | g17577.t1 | SUPERFAMILY | SSF81324 | Voltage-gated potassium channels | 270 | 482 | 1.83E-48 |
| 44 | g17577.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 274 | 296 | - |
| 46 | g17577.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 316 | 338 | - |
| 42 | g17577.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 345 | 367 | - |
| 43 | g17577.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 425 | 444 | - |
| 45 | g17577.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 456 | 478 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0055085 | transmembrane transport | BP |
| GO:0006813 | potassium ion transport | BP |
| GO:0005249 | voltage-gated potassium channel activity | MF |
| GO:0051260 | protein homooligomerization | BP |
| GO:0006811 | ion transport | BP |
| GO:0005216 | ion channel activity | MF |
| GO:0005515 | protein binding | MF |
| GO:0008076 | voltage-gated potassium channel complex | CC |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed