Gene loci information

Transcript annotation

  • This transcript has been annotated as Protein unc-13 homolog 4B.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g1826 g1826.t1 TTS g1826.t1 13199737 13199737
chr_3 g1826 g1826.t1 isoform g1826.t1 13199976 13207189
chr_3 g1826 g1826.t1 exon g1826.t1.exon1 13199976 13200073
chr_3 g1826 g1826.t1 cds g1826.t1.CDS1 13199976 13200073
chr_3 g1826 g1826.t1 exon g1826.t1.exon2 13200139 13200332
chr_3 g1826 g1826.t1 cds g1826.t1.CDS2 13200139 13200332
chr_3 g1826 g1826.t1 exon g1826.t1.exon3 13200389 13202896
chr_3 g1826 g1826.t1 cds g1826.t1.CDS3 13200389 13202896
chr_3 g1826 g1826.t1 exon g1826.t1.exon4 13202968 13203308
chr_3 g1826 g1826.t1 cds g1826.t1.CDS4 13202968 13203308
chr_3 g1826 g1826.t1 exon g1826.t1.exon5 13204968 13205245
chr_3 g1826 g1826.t1 cds g1826.t1.CDS5 13204968 13205245
chr_3 g1826 g1826.t1 exon g1826.t1.exon6 13205536 13206417
chr_3 g1826 g1826.t1 cds g1826.t1.CDS6 13205536 13206417
chr_3 g1826 g1826.t1 exon g1826.t1.exon7 13206479 13206553
chr_3 g1826 g1826.t1 cds g1826.t1.CDS7 13206479 13206553
chr_3 g1826 g1826.t1 exon g1826.t1.exon8 13206612 13206825
chr_3 g1826 g1826.t1 cds g1826.t1.CDS8 13206612 13206825
chr_3 g1826 g1826.t1 exon g1826.t1.exon9 13206884 13207189
chr_3 g1826 g1826.t1 cds g1826.t1.CDS9 13206884 13207189
chr_3 g1826 g1826.t1 TSS g1826.t1 13207183 13207183

Sequences

>g1826.t1 Gene=g1826 Length=4896
ATGATTAGTCTATCGCAAAGAGTCTTCCAATTTGGAGCAATCAAATTTAATTCTACAAAT
AAGATTCAATTGGTTAGAATGATGCATTCTCTGATTAAAAACCAAGCCTACATTAATGGA
AAGTGGACAAATGCAGCTAACAATAAAACATTTAGTGTAATGAATCCATCAAATCAAGAA
ATAGTTGCACAAGTTCCTGATATGACTAAAATTGATTGTCAAAAAGCAATTGATGCAGCT
AATGATGCATTTTATTCAAAAGAATGGCGTAATGCCACAGCTAAAGATCGATCTACATTA
CTAAAGAAATGGTTTACACTTTTGGAAGCGAATAAACAAGAAATTGCTCAAATAATGACA
ACTGAGAGTGGCAAACCTATTGCTGAAGCGTTAGGAGAAGTAGCTTACGGAAATTCTTTT
GTTGAATGGTTTGCAGAAGAGGCAAGAAGAATTTATGGTGAAATTGTCCCTTCTCCAGTT
GCCAGCAAACAAATTAAAATTGTACGACAACCTATTGGAGTTGCTGGTCTTATCACACCT
TGGAATTTTCCACACGCAATGATAACACGAAAAGCTGCTGCTGCATTAGCTGCAGGTTGC
ACAGTTGTAATGCGTCCTGCTGAAGACACACCACTTACTGCTCTTGCTCTTTGTAAATTA
GCAGAAGATGCCGGCTTTCCAAAGGGAGTCATAAATTGCGTAACTTCGAGTCGATCACAT
GCATCCGAAATTGGTGAACTTTTGTGCAAAAGTCCAAAAGTAGCAGGAATTTCATTTACC
GGTTCGACTCAAGTTGGAAAACTTTTATATAAACAATGTGGAGAAGGAGTCAAAAGAATT
GGATTAGAATTAGGTGGAAATGCGGCATTTATAGTTTTTGAATCTGCTAACATTGATCAA
GCTGTTGCTGGTGCAATGGCATCAAAATTTAGAAATTGTGGTCAAACATGTGTATCATCA
AATCGATTCCTAGTTCAAGAAAAAATTTTTGATCAATTTGTTGAGAAAATTACTGAACAA
GTTAAAGCACTAAAAATCGGTGATGGTACACAATCTGATGTAAAAATTGGACCATTGATT
AATGAAGCACAACTTCATAAAGTATCTGCAATGGTTGATGATGCAAAATCAAAAGGTGCT
AAAGTCATATATGGTGGTCGAGCATTATCTGAAATTGGCTCACTTTTTTATGAACCGACA
ATAATTTCAAATATTCAATCAAATATGGATTTGTATAACGAAGAAGTTTTTGGACCAGTA
ATTTCACTAATTAAATTTAAAACAGAAGAAGAAGCATTAAAAATCGCAAATAGCACACCT
AGAGGTCTTGCAGGTTATTTCTATAGTCAAGATATAAATCAAATTTTCCGTGTCGAAAGA
GATCTAGAAGCTGGAATGATTGGAATTAATGAAGGCATCATATCAACAACTGAGGCGCCT
TTTGGTGGAATAAAAGAATCTGGAATTGGTCGAGAAGATTCAGATGGTGGTTTCTTCGAA
AGATTTGGCTCATTGTTGCATGCAAGAGGTGAAAACAATGAGGAGAAGCTATTTGAAACA
GCAACAGTATCAGTTAGTCAAGAAGCTCCTAGATTACGAGAAGAACCAATTGCTGATATA
CAAATCGAGTCTCGAATGCTTGCCGATGACGAAGGCAAAGATAGTGGAAATGAGTCGGCA
GAAGCTGATAGTGATGCCGAAGATAAGAGAGAAGAAAATTTTAGAAAATTGCAGAACTCA
CTTGTTGGAATGAATATTGAAGAACTCTATGAAGAAATTCTTTACGAAATCATTCATAAT
GTTGGGAGTGATGAATCAAAACTCTCACGCGATAAAATTTTCGAATTTATGCAAGAAGCA
TTCAAACTTCCCGAAGAAACACATTTTGAATTGCTTGAGAAAGCAAAAATCAAAGAACCT
CCTGAACTTCGTCTCAACATTGAAATAATTGAAGCTAAAGATCTTAATTCAAAAGATCCG
AATGGTTTGGCTGATCCATTTGTGACACTTTATATTGCATCAGCACCAAGTATTCGATAT
ACAAGCAGTGTAAAATCAGGAACATTAAATCCGAAATATGAAGAACATTTTTCATTACCA
ATATCTGAAAATCCAAATGAAGACACGCTCATCATAGAAGTTTGGGATTTCGATCCAGCA
GAGACACTTAGTGAAAAAATGAATAAATTATTTGATGTGAAGGGTGCAAAAGGTTTTCGT
AAATTGATGAAAGAAATAGCCAGCACTGCTTCATCTGGAAAGCATGACAATGAATTTGTT
GGTTCATCAAAAGTTCCTTTAAAAACAGTTCCTGCTAGTGGCCTTACAATGTGGTATAAT
CTTGATAAGAAAGGGAAAATGAAAACTCAAGGAACAATCAAAGTTCGTCTTAACTTCAGT
AGTGAAAAGAATGATCAAGTCGCTTCACAAGAACATCGACATTTATTGAAAATTCTTCTT
TATCATGAACTTGAATCATCGAAAGTTGCACCGTATTGGTGGGCAGGAAAATTTAATCAA
GTGGCTGAAATGATCATTACTCAGCATCAAGCACAGAGTGGATTAACTGATATTGATGTT
GCATTTGCGCAATGGAGCGTTTTTTCTGAAGTTCATCAACAGCATCCTTTGTCATTTGAA
TTATTTGAAAATATTCTTGAAACTTTAATAAGACCAATTCAAACGAATAGTGTAAGTCAT
TCAGAAGAACTATCATTATTTTGGGAAGCTACAAAACGACTTTTACCAACGTGCTTTGGA
ATAATTCGTAAATTGAGAAAGAAGCTTGCTGGTGATGCAAATGCATTAAAGCATTTATCT
AAATCTCTCAGCATCATTTCAAAAGTCGCTATGCTTGAACCACCAGATCAATTTGATCTA
TTTCCTGAACAATATTATGGATGGTTAAAGAAAAATAATTCTGCAACTTCATGGGATATT
CGTGAAGCTATTGATCAAGCTGTCACTATTGGAACCGAAGAATATTATGAGAGCATTATT
GATCATAACGAATTAAATAGTGATGACAGTGATCAACGATTACAACAATTGATTAAAATT
ATTCAACTTGTAAGATCAGACTTACAAAGAGGCATTGAACATCATGATAAAATTTTTCAA
GAGACACTAAACTATCAATACGCTGGCATGCTTTATAAAGTATATGACAGGAAACTTATG
AATCAAGTTAATCCTATTGTTGTTGATATTTGTAGTAAAAAAATTGAGCGATTAGATTTA
CTTGAGCGACCAGATATGAAGCACAATCGATATGAAGAAATCAACATGTTAACGACTCTT
TTCGAACTGTATCTATTATTAAAAAGATTTTCAGTGCTTGGAACAGCATTATGTCCTGGT
GTGACTGAATTTTGTATGAAAGATTATTACGAGTGGTTTGCTAATGGTGTTGCACATTGG
CTAGATATTTCAGTTTATAAAGCATTAACAAGAATTCAAAAGGCAATAGAACTTGATTCA
TTGATTGCTGTTGATGCTACTGTGAAATATAGTAGTTCTGCAGTCGATACCCTTGCTATT
TTCTATCAAATTCGCATATTTTGGCAACAATTAGCATGGCCCAGTGCTGAAGGTGCTTTT
ATTTTTGTGAGCAAAATTGTTGATGACATTTGCAGATGTTGTACATTCTATGGTGACACA
ATGGCTGAAAGAGTTGATAAATTAGGAATGGTAGAGACAGTTTACGAAAAGAAATTTCAA
GTTACTCCTGAATGGTGTCTTGCAATTAATAATATTGATTATATTCGTCAAAGCATTCAT
TCATTTGTGAAAGAATTGGGCGTTGATGAGATAATAAGAAATATGAGTGACTTTAGAGGA
CCACTTGATGCACAAAGATGCTCTGATACATTACAGAATGTTATTGAAAATGCCATAGAT
ACGGGTAAAAACAAAATTTTCGAATTAACAGCAAAACTTGCACGTAAAATGAGTCCAGCA
ATGCGTCGATTCCTAGTGGAAGGTGCAGAACTGTTTGAAACAGATTCAAATTCGATGGAT
CGACTTATGATGTACATGGAAGATTCACTTAAGACACTTCATACTGAATTAAATGATGAT
AATTTCATGAGAATGTTGGATTGCATTTGGGAAGAAATTGCAAGTATTCTCTATGACCTT
GTTCACAGTAGCTTGGACAAGAGGCGTCCGCCTGCATTTTATGCCAATTTGCGTGCAACT
TTGCAAGTTATGGTGGAAAATTTCAAGTGCCAAAATACAACTGAGCCTGTCAAGTCAAGC
GATAAAGAGACGTTAGAGAAAATAGACAGACTTCTTGAAATTCACAGCTTAGAAACAACT
GATCTCATTCATCAGTATTATAAAGATCGATATGCAATGCAGCAAGCCATGGGAGATTCA
ATGCCTTATGGCATTCTCACAATTCAATGTTATTTTCAACGCAATACATTAGAAATTGAA
GTGATGAATGCAAAACATTTATTGCCGATGAATGCTGATGGAACATGTGATCCTTTCGTT
AGAATACATTTTTATCCAGAAGATAAATTTATTGGCATTTCACCACCCAAGACTAAAGTC
CATCAAAAGACACTTTTTCCGCTTTTCGATGAAAAGTTTACAATTCAATTGAATGATGAT
CAGCGTAAAATGGACGAAGCTATAATTTTGTTTAGTGTTAAAGATCATGATTATTTTGGA
ATGGCAAACCAATATGTTGCTGAGGCTTTTCTTATGTTCAAAGACATAGCTGATATTACT
GGTGAAACTGGAAGCATCAAACAGTTGCATTTAACACTTACACGACCACAAAATGACGAT
ATGGAGACAGTTAAAGCATTACAACATCGAGTTGGTGACAAATTGGCTAAAGAATTTTTA
AAGAAGCTTAAGACAAAAAAAACGGAAGCAAAATGA

>g1826.t1 Gene=g1826 Length=1631
MISLSQRVFQFGAIKFNSTNKIQLVRMMHSLIKNQAYINGKWTNAANNKTFSVMNPSNQE
IVAQVPDMTKIDCQKAIDAANDAFYSKEWRNATAKDRSTLLKKWFTLLEANKQEIAQIMT
TESGKPIAEALGEVAYGNSFVEWFAEEARRIYGEIVPSPVASKQIKIVRQPIGVAGLITP
WNFPHAMITRKAAAALAAGCTVVMRPAEDTPLTALALCKLAEDAGFPKGVINCVTSSRSH
ASEIGELLCKSPKVAGISFTGSTQVGKLLYKQCGEGVKRIGLELGGNAAFIVFESANIDQ
AVAGAMASKFRNCGQTCVSSNRFLVQEKIFDQFVEKITEQVKALKIGDGTQSDVKIGPLI
NEAQLHKVSAMVDDAKSKGAKVIYGGRALSEIGSLFYEPTIISNIQSNMDLYNEEVFGPV
ISLIKFKTEEEALKIANSTPRGLAGYFYSQDINQIFRVERDLEAGMIGINEGIISTTEAP
FGGIKESGIGREDSDGGFFERFGSLLHARGENNEEKLFETATVSVSQEAPRLREEPIADI
QIESRMLADDEGKDSGNESAEADSDAEDKREENFRKLQNSLVGMNIEELYEEILYEIIHN
VGSDESKLSRDKIFEFMQEAFKLPEETHFELLEKAKIKEPPELRLNIEIIEAKDLNSKDP
NGLADPFVTLYIASAPSIRYTSSVKSGTLNPKYEEHFSLPISENPNEDTLIIEVWDFDPA
ETLSEKMNKLFDVKGAKGFRKLMKEIASTASSGKHDNEFVGSSKVPLKTVPASGLTMWYN
LDKKGKMKTQGTIKVRLNFSSEKNDQVASQEHRHLLKILLYHELESSKVAPYWWAGKFNQ
VAEMIITQHQAQSGLTDIDVAFAQWSVFSEVHQQHPLSFELFENILETLIRPIQTNSVSH
SEELSLFWEATKRLLPTCFGIIRKLRKKLAGDANALKHLSKSLSIISKVAMLEPPDQFDL
FPEQYYGWLKKNNSATSWDIREAIDQAVTIGTEEYYESIIDHNELNSDDSDQRLQQLIKI
IQLVRSDLQRGIEHHDKIFQETLNYQYAGMLYKVYDRKLMNQVNPIVVDICSKKIERLDL
LERPDMKHNRYEEINMLTTLFELYLLLKRFSVLGTALCPGVTEFCMKDYYEWFANGVAHW
LDISVYKALTRIQKAIELDSLIAVDATVKYSSSAVDTLAIFYQIRIFWQQLAWPSAEGAF
IFVSKIVDDICRCCTFYGDTMAERVDKLGMVETVYEKKFQVTPEWCLAINNIDYIRQSIH
SFVKELGVDEIIRNMSDFRGPLDAQRCSDTLQNVIENAIDTGKNKIFELTAKLARKMSPA
MRRFLVEGAELFETDSNSMDRLMMYMEDSLKTLHTELNDDNFMRMLDCIWEEIASILYDL
VHSSLDKRRPPAFYANLRATLQVMVENFKCQNTTEPVKSSDKETLEKIDRLLEIHSLETT
DLIHQYYKDRYAMQQAMGDSMPYGILTIQCYFQRNTLEIEVMNAKHLLPMNADGTCDPFV
RIHFYPEDKFIGISPPKTKVHQKTLFPLFDEKFTIQLNDDQRKMDEAIILFSVKDHDYFG
MANQYVAEAFLMFKDIADITGETGSIKQLHLTLTRPQNDDMETVKALQHRVGDKLAKEFL
KKLKTKKTEAK

Protein features from InterProScan

Transcript Database ID Name Start End E.value
18 g1826.t1 CDD cd07103 ALDH_F5_SSADH_GabD 53 500 0.0
17 g1826.t1 CDD cd04009 C2B_Munc13-like 1462 1594 3.82091E-50
16 g1826.t1 Coils Coil Coil 1616 1631 -
13 g1826.t1 Gene3D G3DSA:3.40.605.10 Aldehyde Dehydrogenase; Chain A 41 497 7.1E-174
14 g1826.t1 Gene3D G3DSA:3.40.309.10 Aldehyde Dehydrogenase; Chain A 287 477 7.1E-174
12 g1826.t1 Gene3D G3DSA:1.10.357.50 - 1125 1302 2.4E-16
15 g1826.t1 Gene3D G3DSA:2.60.40.150 - 1459 1594 2.3E-19
22 g1826.t1 MobiDBLite mobidb-lite consensus disorder prediction 547 571 -
4 g1826.t1 PANTHER PTHR45999:SF2 PROTEIN UNC-13 HOMOLOG 4B 490 1627 0.0
5 g1826.t1 PANTHER PTHR45999 UNC-13-4A, ISOFORM B 490 1627 0.0
8 g1826.t1 PRINTS PR00360 C2 domain signature 660 672 4.3E-5
7 g1826.t1 PRINTS PR00360 C2 domain signature 687 700 4.3E-5
6 g1826.t1 PRINTS PR00360 C2 domain signature 710 718 4.3E-5
1 g1826.t1 Pfam PF00171 Aldehyde dehydrogenase family 42 496 1.2E-162
2 g1826.t1 Pfam PF00168 C2 domain 644 769 1.4E-15
3 g1826.t1 Pfam PF00168 C2 domain 1476 1583 2.7E-11
21 g1826.t1 ProSitePatterns PS00687 Aldehyde dehydrogenases glutamic acid active site. 282 289 -
24 g1826.t1 ProSiteProfiles PS50004 C2 domain profile. 630 731 13.816
26 g1826.t1 ProSiteProfiles PS51258 Munc13-homology domain 1 (MHD1) profile. 1101 1221 19.703
25 g1826.t1 ProSiteProfiles PS51259 Munc13-homology domain 2 (MHD2) profile. 1336 1446 15.184
23 g1826.t1 ProSiteProfiles PS50004 C2 domain profile. 1475 1570 13.949
20 g1826.t1 SMART SM00239 C2_3c 644 779 4.6E-17
19 g1826.t1 SMART SM00239 C2_3c 1476 1585 2.2E-12
9 g1826.t1 SUPERFAMILY SSF53720 ALDH-like 21 497 5.5E-158
11 g1826.t1 SUPERFAMILY SSF49562 C2 domain (Calcium/lipid-binding domain, CaLB) 639 798 7.74E-24
10 g1826.t1 SUPERFAMILY SSF49562 C2 domain (Calcium/lipid-binding domain, CaLB) 1465 1576 1.13E-16

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor MF
GO:0055114 NA NA
GO:0016491 oxidoreductase activity MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values