General information for g1826.t7
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Succinate-semialdehyde dehydrogenase, mitochondrial.
Parent gene
- The parent gene g1826 is located on chr_3: 13206485..13210007 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g1826 | g1826.t7 | isoform | g1826.t7 | 13205255 | 13207189 |
| chr_3 | g1826 | g1826.t7 | exon | g1826.t7.exon1 | 13205255 | 13206417 |
| chr_3 | g1826 | g1826.t7 | cds | g1826.t7.CDS1 | 13205471 | 13206417 |
| chr_3 | g1826 | g1826.t7 | exon | g1826.t7.exon2 | 13206479 | 13206553 |
| chr_3 | g1826 | g1826.t7 | cds | g1826.t7.CDS2 | 13206479 | 13206553 |
| chr_3 | g1826 | g1826.t7 | exon | g1826.t7.exon3 | 13206612 | 13206825 |
| chr_3 | g1826 | g1826.t7 | cds | g1826.t7.CDS3 | 13206612 | 13206825 |
| chr_3 | g1826 | g1826.t7 | exon | g1826.t7.exon4 | 13206884 | 13207189 |
| chr_3 | g1826 | g1826.t7 | cds | g1826.t7.CDS4 | 13206884 | 13207189 |
| chr_3 | g1826 | g1826.t7 | TSS | g1826.t7 | 13207183 | 13207183 |
| chr_3 | g1826 | g1826.t7 | TTS | g1826.t7 | NA | NA |
Sequences
>g1826.t7 Gene=g1826 Length=1758
ATGATTAGTCTATCGCAAAGAGTCTTCCAATTTGGAGCAATCAAATTTAATTCTACAAAT
AAGATTCAATTGGTTAGAATGATGCATTCTCTGATTAAAAACCAAGCCTACATTAATGGA
AAGTGGACAAATGCAGCTAACAATAAAACATTTAGTGTAATGAATCCATCAAATCAAGAA
ATAGTTGCACAAGTTCCTGATATGACTAAAATTGATTGTCAAAAAGCAATTGATGCAGCT
AATGATGCATTTTATTCAAAAGAATGGCGTAATGCCACAGCTAAAGATCGATCTACATTA
CTAAAGAAATGGTTTACACTTTTGGAAGCGAATAAACAAGAAATTGCTCAAATAATGACA
ACTGAGAGTGGCAAACCTATTGCTGAAGCGTTAGGAGAAGTAGCTTACGGAAATTCTTTT
GTTGAATGGTTTGCAGAAGAGGCAAGAAGAATTTATGGTGAAATTGTCCCTTCTCCAGTT
GCCAGCAAACAAATTAAAATTGTACGACAACCTATTGGAGTTGCTGGTCTTATCACACCT
TGGAATTTTCCACACGCAATGATAACACGAAAAGCTGCTGCTGCATTAGCTGCAGGTTGC
ACAGTTGTAATGCGTCCTGCTGAAGACACACCACTTACTGCTCTTGCTCTTTGTAAATTA
GCAGAAGATGCCGGCTTTCCAAAGGGAGTCATAAATTGCGTAACTTCGAGTCGATCACAT
GCATCCGAAATTGGTGAACTTTTGTGCAAAAGTCCAAAAGTAGCAGGAATTTCATTTACC
GGTTCGACTCAAGTTGGAAAACTTTTATATAAACAATGTGGAGAAGGAGTCAAAAGAATT
GGATTAGAATTAGGTGGAAATGCGGCATTTATAGTTTTTGAATCTGCTAACATTGATCAA
GCTGTTGCTGGTGCAATGGCATCAAAATTTAGAAATTGTGGTCAAACATGTGTATCATCA
AATCGATTCCTAGTTCAAGAAAAAATTTTTGATCAATTTGTTGAGAAAATTACTGAACAA
GTTAAAGCACTAAAAATCGGTGATGGTACACAATCTGATGTAAAAATTGGACCATTGATT
AATGAAGCACAACTTCATAAAGTATCTGCAATGGTTGATGATGCAAAATCAAAAGGTGCT
AAAGTCATATATGGTGGTCGAGCATTATCTGAAATTGGCTCACTTTTTTATGAACCGACA
ATAATTTCAAATATTCAATCAAATATGGATTTGTATAACGAAGAAGTTTTTGGACCAGTA
ATTTCACTAATTAAATTTAAAACAGAAGAAGAAGCATTAAAAATCGCAAATAGCACACCT
AGAGGTCTTGCAGGTTATTTCTATAGTCAAGATATAAATCAAATTTTCCGTGTCGAAAGA
GATCTAGAAGCTGGAATGATTGGAATTAATGAAGGCATCATATCAACAACTGAGGCGCCT
TTTGGTGGAATAAAAGAATCTGGAATTGGTCGAGAAGGTTCAAAACATGGTATCGATGAA
TACGTTGAAATCAAATATATTTGTTATGGAAATTTAAATTAAATATGTAAATGCATTTAA
ATGAATTCCCTGTATTATATGATTGTTATTGTGCATATAAAAATTATATAAAATTTAAAC
AAATAATTTTTATTAAGAACGAGTCTTCCACTAATTTAATTTTAAAATAAATGTCAAACA
CTTCATGAAAAATTACAATATGACTTTTAAGATAATGATATCTTTATAATATTGTAATCA
TTGTTTTATTTGTTTATA
>g1826.t7 Gene=g1826 Length=513
MISLSQRVFQFGAIKFNSTNKIQLVRMMHSLIKNQAYINGKWTNAANNKTFSVMNPSNQE
IVAQVPDMTKIDCQKAIDAANDAFYSKEWRNATAKDRSTLLKKWFTLLEANKQEIAQIMT
TESGKPIAEALGEVAYGNSFVEWFAEEARRIYGEIVPSPVASKQIKIVRQPIGVAGLITP
WNFPHAMITRKAAAALAAGCTVVMRPAEDTPLTALALCKLAEDAGFPKGVINCVTSSRSH
ASEIGELLCKSPKVAGISFTGSTQVGKLLYKQCGEGVKRIGLELGGNAAFIVFESANIDQ
AVAGAMASKFRNCGQTCVSSNRFLVQEKIFDQFVEKITEQVKALKIGDGTQSDVKIGPLI
NEAQLHKVSAMVDDAKSKGAKVIYGGRALSEIGSLFYEPTIISNIQSNMDLYNEEVFGPV
ISLIKFKTEEEALKIANSTPRGLAGYFYSQDINQIFRVERDLEAGMIGINEGIISTTEAP
FGGIKESGIGREGSKHGIDEYVEIKYICYGNLN
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g1826.t7 | CDD | cd07103 | ALDH_F5_SSADH_GabD | 53 | 508 | 0.0 |
| 6 | g1826.t7 | Gene3D | G3DSA:3.40.605.10 | Aldehyde Dehydrogenase; Chain A | 41 | 502 | 4.5E-178 |
| 7 | g1826.t7 | Gene3D | G3DSA:3.40.309.10 | Aldehyde Dehydrogenase; Chain A | 287 | 477 | 4.5E-178 |
| 2 | g1826.t7 | PANTHER | PTHR43353:SF5 | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL | 28 | 511 | 5.6E-217 |
| 3 | g1826.t7 | PANTHER | PTHR43353 | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL | 28 | 511 | 5.6E-217 |
| 1 | g1826.t7 | Pfam | PF00171 | Aldehyde dehydrogenase family | 42 | 507 | 4.3E-168 |
| 5 | g1826.t7 | ProSitePatterns | PS00687 | Aldehyde dehydrogenases glutamic acid active site. | 282 | 289 | - |
| 4 | g1826.t7 | SUPERFAMILY | SSF53720 | ALDH-like | 22 | 511 | 2.09E-165 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K00139 (succinate-semialdehyde dehydrogenase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
