General information for g2224.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Histone acetyltransferase KAT2A.
Parent gene
- The parent gene g2224 is located on chr_3: 16113856..16119710 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2224 | g2224.t1 | TTS | g2224.t1 | 16111721 | 16111721 |
| chr_3 | g2224 | g2224.t1 | isoform | g2224.t1 | 16112735 | 16115285 |
| chr_3 | g2224 | g2224.t1 | exon | g2224.t1.exon1 | 16112735 | 16112897 |
| chr_3 | g2224 | g2224.t1 | cds | g2224.t1.CDS1 | 16112735 | 16112897 |
| chr_3 | g2224 | g2224.t1 | exon | g2224.t1.exon2 | 16112961 | 16114334 |
| chr_3 | g2224 | g2224.t1 | cds | g2224.t1.CDS2 | 16112961 | 16114334 |
| chr_3 | g2224 | g2224.t1 | exon | g2224.t1.exon3 | 16114402 | 16114846 |
| chr_3 | g2224 | g2224.t1 | cds | g2224.t1.CDS3 | 16114402 | 16114846 |
| chr_3 | g2224 | g2224.t1 | exon | g2224.t1.exon4 | 16114940 | 16115060 |
| chr_3 | g2224 | g2224.t1 | cds | g2224.t1.CDS4 | 16114940 | 16115060 |
| chr_3 | g2224 | g2224.t1 | exon | g2224.t1.exon5 | 16115127 | 16115285 |
| chr_3 | g2224 | g2224.t1 | cds | g2224.t1.CDS5 | 16115127 | 16115285 |
| chr_3 | g2224 | g2224.t1 | TSS | g2224.t1 | 16115506 | 16115506 |
Sequences
>g2224.t1 Gene=g2224 Length=2262
ATGTCTGAGGAAAATAATAATCAGAGTAATGATTCATCTAGTGCTGGAGCGACAAGAGCG
AGCAATATTCAAAAAATTATTGACAGGAAGCAAAAGATTTTTAGTTTGCCAAGAAATTCA
AAGCTCTTCAAGATATCTACTTACAGTTTATGCCAATATGAGAAAGGATGTAAGTGTGTT
GGATTTAAATTAAGTGAAGAACAGCGAAAAAGAGATGAAGCGAGTTATATGCCGCAAAAC
AAAGACCTCTGCTCTAATCCAAATTGCAATCATCCTTTTTCAAAACATGTGTGCCATTTA
AATAGCTTAACTGATCCAGAACTTAATAGACTTTTGAATTTAATTGTGGATATGGAAAAC
CTTTACATCTCAATCTCTCGCCAAAATGATTCTGACATTAAAAAAGTTTATATTTATTTA
TCAAAATTATTAAGACACCAAGTTTTGATGAAGCAAACATCGGTAGTAATACCAACTAAT
GCGAGCATGATCGGTTCACCACCATTCGAAGACCCATCAATACAAAGAATAATTTCAAAT
TTTGTATTTCTCAAATATGGTCACTTTAGAGATCATCCCTCTTCAAAAATTCAATTTCAA
ATTTTCACTGAATTAGCAAAGAATTTTCTTCATTGCGTGTGTACATGGGATTTTGAAAGT
CCAAATGATCGCAAAGAGTGTTCAACACCGGAAGAAGCGTCTGCATATAAAGTTAACTAT
ACAAGATGGTTAATATTTTCTTGGGTCCCAGCGTTCTGCAGCAGTTTACGTCAATATAAA
ACATCAAATATTTTCGGGAAAACTTTTCTCAAGTCCATTTACAATTTCGTTTCATCTTTG
ATGCTTCAAAAATACAAAGCAGATAAAGATCGAGAGAAATTACCAACTGAAAAGTTAATT
GTTTTTGATTCACTTCCAAAATTTTTGGATGATCTTCGAGAGGAAATTTCAAATGATAAT
TCTCTCATTTTTGATCCAACATTTAAGCCGGTGTTTCCACAGAATGCAATTGGAATAAAA
AGAGAGCTCGATGCAAATTCGAATGATGATGGTCGTGTGAAAAAATTAAAGCGTGAAAAT
ACATGTGAAGATTTGTCAGATTTTACTGTTATCAATATTCTCGATCGCATTAATGATGAC
GATTATAAAATTAATGCTGAAGTACTAAGTTCAGTAAAATTGACAGCACGGGATGATGTA
GCAAAAGCAGAGCAATCGAGAAATGAGATATCTTTTCATATTATTGCTAATTCATTTAAA
AAACAACCGTCCACTGAGAATTTGGCGTGGTTATTAACATGCAAAAATGTATTTGCACAT
CAGCTACCAAGAATGCCAAAGGAATATATAACGCAATTGGTTTTTGACGGTAAACATAAA
ACACTTGCGCTAATTAAAAATCAAAAGCCAATAGGAGGAATTTGTTTTCGTTCATTTCCA
TCTCAAGGCTTTATAGAAATAGTTTTTTGCGCAGTTACAAGTAGTGAACAGGTTAAAGGA
TATGGAACACATTTAATGAATCATTTGAAAGATTATAGCAATCAGCAGAAAATTCGACAC
TTTTTAACATATGCTGATGAATTCGCTCTCGGTTACTTTAAAAAGCAAGGATTTTCTGAT
GAAATAAAACTTGCTCCATCAATTTATAGTGGTTATATTAAAGAATATGAAGGTGCTACA
CTAATGCACTGTGAATTGCATCCAGAAATAGTTTACACACAATTTAGTAACGTAATTAGA
AAGCAAAAAGAAATTATTAAGGAATTAATACTTCAAAGACAGCAAGAGATGCAAAAAGTA
TATCCTGGAATAACATGTTTCAAAGATGGTTCAAAGTGCATATCGTTAGAATCTATACCA
GGGATAAAAGATATTAATTGGAAAGCATTTAGAGCTTTAAAGCAAATTAAAATAAATGAA
GAAGATGAAGATTTAGAGAAGCTTACAATGCAATTAACTTCAATATTAAGTGCTGTTCGT
CAACATCAAGCAGCATGGCCATTTTTACAGCCAGTATCTGTTCAAGAAGTTCCAGACTAT
TATAATGTCATTAAATTGCCTATGGATCTAAAAACAATAAGCGATAGATTGAAAGCTAGG
TATTATCGAAATAGTCGACTCTTTCAAGCTGACATGAATAGAATATTCATCAACTGCAAG
ATTTATAATTCACCAGAAACTGAATATGTTGCATTGGCAAATAAGCTCGAAAGTTACTTT
CAAACAAAAATGAGAAGGCTTGGTCTTTGGGTTGAAATATAA
>g2224.t1 Gene=g2224 Length=753
MSEENNNQSNDSSSAGATRASNIQKIIDRKQKIFSLPRNSKLFKISTYSLCQYEKGCKCV
GFKLSEEQRKRDEASYMPQNKDLCSNPNCNHPFSKHVCHLNSLTDPELNRLLNLIVDMEN
LYISISRQNDSDIKKVYIYLSKLLRHQVLMKQTSVVIPTNASMIGSPPFEDPSIQRIISN
FVFLKYGHFRDHPSSKIQFQIFTELAKNFLHCVCTWDFESPNDRKECSTPEEASAYKVNY
TRWLIFSWVPAFCSSLRQYKTSNIFGKTFLKSIYNFVSSLMLQKYKADKDREKLPTEKLI
VFDSLPKFLDDLREEISNDNSLIFDPTFKPVFPQNAIGIKRELDANSNDDGRVKKLKREN
TCEDLSDFTVINILDRINDDDYKINAEVLSSVKLTARDDVAKAEQSRNEISFHIIANSFK
KQPSTENLAWLLTCKNVFAHQLPRMPKEYITQLVFDGKHKTLALIKNQKPIGGICFRSFP
SQGFIEIVFCAVTSSEQVKGYGTHLMNHLKDYSNQQKIRHFLTYADEFALGYFKKQGFSD
EIKLAPSIYSGYIKEYEGATLMHCELHPEIVYTQFSNVIRKQKEIIKELILQRQQEMQKV
YPGITCFKDGSKCISLESIPGIKDINWKAFRALKQIKINEEDEDLEKLTMQLTSILSAVR
QHQAAWPFLQPVSVQEVPDYYNVIKLPMDLKTISDRLKARYYRNSRLFQADMNRIFINCK
IYNSPETEYVALANKLESYFQTKMRRLGLWVEI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 17 | g2224.t1 | CDD | cd04301 | NAT_SF | 462 | 521 | 8.77811E-5 |
| 18 | g2224.t1 | CDD | cd05509 | Bromo_gcn5_like | 647 | 747 | 1.07408E-39 |
| 16 | g2224.t1 | Coils | Coil | Coil | 579 | 599 | - |
| 15 | g2224.t1 | Gene3D | G3DSA:3.40.630.30 | - | 407 | 573 | 4.5E-72 |
| 14 | g2224.t1 | Gene3D | G3DSA:1.20.920.10 | Histone Acetyltransferase; Chain A | 636 | 751 | 1.2E-36 |
| 5 | g2224.t1 | PANTHER | PTHR45750:SF2 | HISTONE ACETYLTRANSFERASE KAT2B | 10 | 331 | 1.8E-220 |
| 7 | g2224.t1 | PANTHER | PTHR45750 | GH11602P | 10 | 331 | 1.8E-220 |
| 4 | g2224.t1 | PANTHER | PTHR45750:SF2 | HISTONE ACETYLTRANSFERASE KAT2B | 357 | 749 | 1.8E-220 |
| 6 | g2224.t1 | PANTHER | PTHR45750 | GH11602P | 357 | 749 | 1.8E-220 |
| 11 | g2224.t1 | PRINTS | PR00503 | Bromodomain signature | 663 | 676 | 6.6E-18 |
| 9 | g2224.t1 | PRINTS | PR00503 | Bromodomain signature | 677 | 693 | 6.6E-18 |
| 8 | g2224.t1 | PRINTS | PR00503 | Bromodomain signature | 693 | 711 | 6.6E-18 |
| 10 | g2224.t1 | PRINTS | PR00503 | Bromodomain signature | 711 | 730 | 6.6E-18 |
| 1 | g2224.t1 | Pfam | PF06466 | PCAF (P300/CBP-associated factor) N-terminal domain | 25 | 283 | 1.3E-78 |
| 3 | g2224.t1 | Pfam | PF00583 | Acetyltransferase (GNAT) family | 460 | 538 | 5.5E-8 |
| 2 | g2224.t1 | Pfam | PF00439 | Bromodomain | 654 | 735 | 6.0E-21 |
| 20 | g2224.t1 | ProSitePatterns | PS00633 | Bromodomain signature. | 665 | 722 | - |
| 21 | g2224.t1 | ProSiteProfiles | PS51186 | Gcn5-related N-acetyltransferase (GNAT) domain profile. | 419 | 567 | 14.753 |
| 22 | g2224.t1 | ProSiteProfiles | PS50014 | Bromodomain profile. | 660 | 730 | 20.406 |
| 19 | g2224.t1 | SMART | SM00297 | bromo_6 | 641 | 749 | 3.8E-37 |
| 13 | g2224.t1 | SUPERFAMILY | SSF55729 | Acyl-CoA N-acyltransferases (Nat) | 428 | 568 | 2.84E-18 |
| 12 | g2224.t1 | SUPERFAMILY | SSF47370 | Bromodomain | 643 | 747 | 8.11E-35 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005634 | nucleus | CC |
| GO:0005515 | protein binding | MF |
| GO:0006355 | regulation of transcription, DNA-templated | BP |
| GO:0004402 | histone acetyltransferase activity | MF |
| GO:0008080 | N-acetyltransferase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K06062 (histone acetyltransferase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
