General information for g2224.t8
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Histone acetyltransferase KAT2A.
Parent gene
- The parent gene g2224 is located on chr_3: 16113856..16119710 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2224 | g2224.t8 | TTS | g2224.t8 | 16111721 | 16111721 |
| chr_3 | g2224 | g2224.t8 | isoform | g2224.t8 | 16112735 | 16114404 |
| chr_3 | g2224 | g2224.t8 | exon | g2224.t8.exon1 | 16112735 | 16112897 |
| chr_3 | g2224 | g2224.t8 | cds | g2224.t8.CDS1 | 16112735 | 16112897 |
| chr_3 | g2224 | g2224.t8 | exon | g2224.t8.exon2 | 16112961 | 16114334 |
| chr_3 | g2224 | g2224.t8 | cds | g2224.t8.CDS2 | 16112961 | 16114219 |
| chr_3 | g2224 | g2224.t8 | exon | g2224.t8.exon3 | 16114402 | 16114404 |
| chr_3 | g2224 | g2224.t8 | TSS | g2224.t8 | NA | NA |
Sequences
>g2224.t8 Gene=g2224 Length=1540
AAGATGGTTAATATTTTCTTGGGTCCCAGCGTTCTGCAGCAGTTTACGTCAATATAAAAC
ATCAAATATTTTCGGGAAAACTTTTCTCAAGTCCATTTACAATTTCGTTTCATCTTTGAT
GCTTCAAAAATACAAAGCAGATAAAGATCGAGAGAAATTACCAACTGAAAAGTTAATTGT
TTTTGATTCACTTCCAAAATTTTTGGATGATCTTCGAGAGGAAATTTCAAATGATAATTC
TCTCATTTTTGATCCAACATTTAAGCCGGTGTTTCCACAGAATGCAATTGGAATAAAAAG
AGAGCTCGATGCAAATTCGAATGATGATGGTCGTGTGAAAAAATTAAAGCGTGAAAATAC
ATGTGAAGATTTGTCAGATTTTACTGTTATCAATATTCTCGATCGCATTAATGATGACGA
TTATAAAATTAATGCTGAAGTACTAAGTTCAGTAAAATTGACAGCACGGGATGATGTAGC
AAAAGCAGAGCAATCGAGAAATGAGATATCTTTTCATATTATTGCTAATTCATTTAAAAA
ACAACCGTCCACTGAGAATTTGGCGTGGTTATTAACATGCAAAAATGTATTTGCACATCA
GCTACCAAGAATGCCAAAGGAATATATAACGCAATTGGTTTTTGACGGTAAACATAAAAC
ACTTGCGCTAATTAAAAATCAAAAGCCAATAGGAGGAATTTGTTTTCGTTCATTTCCATC
TCAAGGCTTTATAGAAATAGTTTTTTGCGCAGTTACAAGTAGTGAACAGGTTAAAGGATA
TGGAACACATTTAATGAATCATTTGAAAGATTATAGCAATCAGCAGAAAATTCGACACTT
TTTAACATATGCTGATGAATTCGCTCTCGGTTACTTTAAAAAGCAAGGATTTTCTGATGA
AATAAAACTTGCTCCATCAATTTATAGTGGTTATATTAAAGAATATGAAGGTGCTACACT
AATGCACTGTGAATTGCATCCAGAAATAGTTTACACACAATTTAGTAACGTAATTAGAAA
GCAAAAAGAAATTATTAAGGAATTAATACTTCAAAGACAGCAAGAGATGCAAAAAGTATA
TCCTGGAATAACATGTTTCAAAGATGGTTCAAAGTGCATATCGTTAGAATCTATACCAGG
GATAAAAGATATTAATTGGAAAGCATTTAGAGCTTTAAAGCAAATTAAAATAAATGAAGA
AGATGAAGATTTAGAGAAGCTTACAATGCAATTAACTTCAATATTAAGTGCTGTTCGTCA
ACATCAAGCAGCATGGCCATTTTTACAGCCAGTATCTGTTCAAGAAGTTCCAGACTATTA
TAATGTCATTAAATTGCCTATGGATCTAAAAACAATAAGCGATAGATTGAAAGCTAGGTA
TTATCGAAATAGTCGACTCTTTCAAGCTGACATGAATAGAATATTCATCAACTGCAAGAT
TTATAATTCACCAGAAACTGAATATGTTGCATTGGCAAATAAGCTCGAAAGTTACTTTCA
AACAAAAATGAGAAGGCTTGGTCTTTGGGTTGAAATATAA
>g2224.t8 Gene=g2224 Length=473
MLQKYKADKDREKLPTEKLIVFDSLPKFLDDLREEISNDNSLIFDPTFKPVFPQNAIGIK
RELDANSNDDGRVKKLKRENTCEDLSDFTVINILDRINDDDYKINAEVLSSVKLTARDDV
AKAEQSRNEISFHIIANSFKKQPSTENLAWLLTCKNVFAHQLPRMPKEYITQLVFDGKHK
TLALIKNQKPIGGICFRSFPSQGFIEIVFCAVTSSEQVKGYGTHLMNHLKDYSNQQKIRH
FLTYADEFALGYFKKQGFSDEIKLAPSIYSGYIKEYEGATLMHCELHPEIVYTQFSNVIR
KQKEIIKELILQRQQEMQKVYPGITCFKDGSKCISLESIPGIKDINWKAFRALKQIKINE
EDEDLEKLTMQLTSILSAVRQHQAAWPFLQPVSVQEVPDYYNVIKLPMDLKTISDRLKAR
YYRNSRLFQADMNRIFINCKIYNSPETEYVALANKLESYFQTKMRRLGLWVEI
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 14 | g2224.t8 | CDD | cd04301 | NAT_SF | 182 | 241 | 5.4275E-5 |
| 13 | g2224.t8 | Coils | Coil | Coil | 299 | 319 | - |
| 12 | g2224.t8 | Gene3D | G3DSA:3.40.630.30 | - | 127 | 293 | 1.9E-72 |
| 11 | g2224.t8 | Gene3D | G3DSA:1.20.920.10 | Histone Acetyltransferase; Chain A | 356 | 471 | 5.8E-37 |
| 3 | g2224.t8 | PANTHER | PTHR45750:SF2 | HISTONE ACETYLTRANSFERASE KAT2B | 76 | 469 | 1.6E-157 |
| 4 | g2224.t8 | PANTHER | PTHR45750 | GH11602P | 76 | 469 | 1.6E-157 |
| 6 | g2224.t8 | PRINTS | PR00503 | Bromodomain signature | 383 | 396 | 1.3E-18 |
| 5 | g2224.t8 | PRINTS | PR00503 | Bromodomain signature | 397 | 413 | 1.3E-18 |
| 8 | g2224.t8 | PRINTS | PR00503 | Bromodomain signature | 413 | 431 | 1.3E-18 |
| 7 | g2224.t8 | PRINTS | PR00503 | Bromodomain signature | 431 | 450 | 1.3E-18 |
| 2 | g2224.t8 | Pfam | PF00583 | Acetyltransferase (GNAT) family | 180 | 258 | 2.7E-8 |
| 1 | g2224.t8 | Pfam | PF00439 | Bromodomain | 374 | 455 | 3.0E-21 |
| 16 | g2224.t8 | ProSitePatterns | PS00633 | Bromodomain signature. | 385 | 442 | - |
| 17 | g2224.t8 | ProSiteProfiles | PS51186 | Gcn5-related N-acetyltransferase (GNAT) domain profile. | 139 | 287 | 14.753 |
| 18 | g2224.t8 | ProSiteProfiles | PS50014 | Bromodomain profile. | 380 | 450 | 20.406 |
| 15 | g2224.t8 | SMART | SM00297 | bromo_6 | 361 | 469 | 3.8E-37 |
| 10 | g2224.t8 | SUPERFAMILY | SSF55729 | Acyl-CoA N-acyltransferases (Nat) | 148 | 288 | 1.24E-18 |
| 9 | g2224.t8 | SUPERFAMILY | SSF47370 | Bromodomain | 363 | 467 | 3.53E-35 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
| GO:0004402 | histone acetyltransferase activity | MF |
| GO:0008080 | N-acetyltransferase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K06062 (histone acetyltransferase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
