General information for g2225.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Histone acetyltransferase KAT2A.
Parent gene
- The parent gene g2225 is located on chr_3: 16117145..16118544 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2225 | g2225.t1 | TTS | g2225.t1 | 16115588 | 16115588 |
| chr_3 | g2225 | g2225.t1 | isoform | g2225.t1 | 16115783 | 16118544 |
| chr_3 | g2225 | g2225.t1 | exon | g2225.t1.exon1 | 16115783 | 16115939 |
| chr_3 | g2225 | g2225.t1 | cds | g2225.t1.CDS1 | 16115783 | 16115939 |
| chr_3 | g2225 | g2225.t1 | exon | g2225.t1.exon2 | 16115998 | 16117228 |
| chr_3 | g2225 | g2225.t1 | cds | g2225.t1.CDS2 | 16115998 | 16117228 |
| chr_3 | g2225 | g2225.t1 | exon | g2225.t1.exon3 | 16117291 | 16117436 |
| chr_3 | g2225 | g2225.t1 | cds | g2225.t1.CDS3 | 16117291 | 16117436 |
| chr_3 | g2225 | g2225.t1 | exon | g2225.t1.exon4 | 16117496 | 16117913 |
| chr_3 | g2225 | g2225.t1 | cds | g2225.t1.CDS4 | 16117496 | 16117913 |
| chr_3 | g2225 | g2225.t1 | exon | g2225.t1.exon5 | 16118147 | 16118327 |
| chr_3 | g2225 | g2225.t1 | cds | g2225.t1.CDS5 | 16118147 | 16118327 |
| chr_3 | g2225 | g2225.t1 | exon | g2225.t1.exon6 | 16118416 | 16118544 |
| chr_3 | g2225 | g2225.t1 | cds | g2225.t1.CDS6 | 16118416 | 16118544 |
| chr_3 | g2225 | g2225.t1 | TSS | g2225.t1 | 16118638 | 16118638 |
Sequences
>g2225.t1 Gene=g2225 Length=2262
ATGGCTTCAGCAGTCATCAACCACGAAACGAGCGGCAGTGGTATGAGCGAAAATGTTGCC
AGAAAGCAAATTAAAGTGGATTCGAGTCGTCAAACAAATATTTTGAGAATAAAAGCCAGG
AAAGCCAAAATATATCAATTGCCACGGTCGCAAAAGCTAGCTAAAATTTCGATGTATTCA
CAATGCAATCAGCAGTGTGGATGCAAAGGTTGGCGTTTACCAGAAGAGTCGAGACATAAA
GATGTTGAAATTGATCATTGTCCAAACATCAATGATTTGTGTCGTAATGCAAATTGTAAA
CACCCATTAGAATCACATTTTGCTCATATTAAAAATATTTCAAATGAACAAATGGATCAG
CTTCTCTCAATTATTGTTGATGCTGAAGTACTTTATACAACACTTGGTCTTCAAAAAGAT
AAATTTATCAAAAAGATTTACTCATTTCTGTTTACATTCTTACATCAATGTGTTGCTGAA
CGTAAACCAGCGATAATTCAAGGTCCCTTGGGTGATCCAGAAAAGAGCTTTGAAAAACCA
TCAATACAGAAAATAATTAAAAATTTTGTGGTTTTGAAGTATGATAAATTACGCGAGAAT
AATGAACCAGAATTTAAAGTTATCATGGAAGTTGCAAGAACATTTCTGAATTGTTATAAT
AACTGGGACTTTGAAATACCAAATGACTGTAAAGATGCAAATGCTGAAGAAAATTTTTAT
AAAATTGATTACACACGTTGGCTAGTTTTTTGTTATGTTCCATCATTCTGTAATAGTTTA
AAATACTACAATTGCAGTGAAATCTTTGGAAAGAGATTTTTGTTTTATACATTTCCTTTT
CTTTCACAACAATTTCTCTCACATTATGAGATTGAAAAGGAAAGTTTACCGCTTGAAAAA
CAAATTTTACTCGAACGTTTGCCAAAATTCCTTGAAACACTTCGTGAAGAGCTAAAAAAT
GACAAATCAGAAATTTTCAATCCTTCATTTAAACCACAAGCAACAACAGCTGGATATCCA
AGAACAAAAAGATTTGCAGACAACAGCAATGAAGTGAGAATTGCAAAACGAATGCGAAGA
GAAGTTGAAGATTTGCCTGATGATGTTGTGCTGAAGGCAATTAATCGAGTTAATGATCCA
AATGTAAATTCCACTGATGTTATGAATCCAGTTGTCTCCTCAGCACGTGATGACATCCCA
AAATCAGAAGAGAGACGTGGTGTGATTGAGTTTCATGTCGTTGGTAATTCCATGATAAAT
AAAGTCTCACAATTGCAGAAAAAGTGGTTGCTTGATATTAAAAATGTTTTTGCACATCGT
CTCCCACGAATGCCAAAAGAATATATTACTCAGCAAGTTTTTGATGGTAATCACAAGACT
TTGGCTTTGATCAAATATGGAAGACCAATTGGAGGAATTTGTTTCCGTTCATTTCCAACA
CAAGGTTTCATAGAAATAGTCTTCTGTGCAGTAGAAGATAAGGAACAAATTAAGGGTTAT
GGATCTCATTTGATGAACCATCTCAAAGATTATAGCATTTCAAAGCGCATTAGACATTTT
CTCACATATGCAGATGAAAATGCAGTTGAATTTTTCAAGAAGCAGGGCTTCTCAAATGAC
ATAAAACTTCCAAGATCAGAATATTTTGGTTATATTAAAGATTATGAAGGAGCTTATTTG
ATGCATTGTGAATTGCATCCTGGAATTATTTACACACAATTTAGTAGTGTAGTAAGAAAG
CAAAAAGAAATTGTTAAAGAATTATTTAAACAACGGCAGCAAGAAATGGAAAAGGTTCAT
CCTGGATTGACATGTTTTAAAGAAGGTTTTCGAAGAACAATTCCCTTCGAAGCAATTCCA
GGATTGAGAGACATTTATGGCTGGAAATTGCCAAGAAATACTCCAAAACATTTGAGATAT
TCAGAAGAATTGAATGATCCAGAAGTTTTGGCAATGCAATTTAGTAATATTTTGCAATTG
GTGAAAAATCATAAATGTGCATGGCCTTTCTTAAAACCAGTGTCTGCAGCAGAAGTTCCA
GATTATTATGATCATATAAAATATGCAATGGATTTGAAGACAATGAGTGATCGATTGAAA
GCAAGATATTACGTTACGAGACATTTATTCAAAGCAGATATGAACAGAATTTTCACCAAT
TGTAAAATTTACAATTCACCTGAAACTGAATATTATCAATGTGCAGAAAAACTTGAAATT
TATTTTAATAATAAGATGAAAGAAGCAGGATTAATGGAGTAA
>g2225.t1 Gene=g2225 Length=753
MASAVINHETSGSGMSENVARKQIKVDSSRQTNILRIKARKAKIYQLPRSQKLAKISMYS
QCNQQCGCKGWRLPEESRHKDVEIDHCPNINDLCRNANCKHPLESHFAHIKNISNEQMDQ
LLSIIVDAEVLYTTLGLQKDKFIKKIYSFLFTFLHQCVAERKPAIIQGPLGDPEKSFEKP
SIQKIIKNFVVLKYDKLRENNEPEFKVIMEVARTFLNCYNNWDFEIPNDCKDANAEENFY
KIDYTRWLVFCYVPSFCNSLKYYNCSEIFGKRFLFYTFPFLSQQFLSHYEIEKESLPLEK
QILLERLPKFLETLREELKNDKSEIFNPSFKPQATTAGYPRTKRFADNSNEVRIAKRMRR
EVEDLPDDVVLKAINRVNDPNVNSTDVMNPVVSSARDDIPKSEERRGVIEFHVVGNSMIN
KVSQLQKKWLLDIKNVFAHRLPRMPKEYITQQVFDGNHKTLALIKYGRPIGGICFRSFPT
QGFIEIVFCAVEDKEQIKGYGSHLMNHLKDYSISKRIRHFLTYADENAVEFFKKQGFSND
IKLPRSEYFGYIKDYEGAYLMHCELHPGIIYTQFSSVVRKQKEIVKELFKQRQQEMEKVH
PGLTCFKEGFRRTIPFEAIPGLRDIYGWKLPRNTPKHLRYSEELNDPEVLAMQFSNILQL
VKNHKCAWPFLKPVSAAEVPDYYDHIKYAMDLKTMSDRLKARYYVTRHLFKADMNRIFTN
CKIYNSPETEYYQCAEKLEIYFNNKMKEAGLME
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 16 | g2225.t1 | CDD | cd04301 | NAT_SF | 467 | 520 | 4.49304E-4 |
| 17 | g2225.t1 | CDD | cd05509 | Bromo_gcn5_like | 653 | 748 | 1.40114E-47 |
| 15 | g2225.t1 | Gene3D | G3DSA:3.40.630.30 | - | 405 | 572 | 3.9E-67 |
| 14 | g2225.t1 | Gene3D | G3DSA:1.20.920.10 | Histone Acetyltransferase; Chain A | 637 | 753 | 5.1E-36 |
| 20 | g2225.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 21 | - |
| 21 | g2225.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1 | 18 | - |
| 5 | g2225.t1 | PANTHER | PTHR45750:SF2 | HISTONE ACETYLTRANSFERASE KAT2B | 15 | 333 | 1.4E-219 |
| 7 | g2225.t1 | PANTHER | PTHR45750 | GH11602P | 15 | 333 | 1.4E-219 |
| 4 | g2225.t1 | PANTHER | PTHR45750:SF2 | HISTONE ACETYLTRANSFERASE KAT2B | 328 | 753 | 1.4E-219 |
| 6 | g2225.t1 | PANTHER | PTHR45750 | GH11602P | 328 | 753 | 1.4E-219 |
| 11 | g2225.t1 | PRINTS | PR00503 | Bromodomain signature | 665 | 678 | 5.9E-15 |
| 10 | g2225.t1 | PRINTS | PR00503 | Bromodomain signature | 679 | 695 | 5.9E-15 |
| 9 | g2225.t1 | PRINTS | PR00503 | Bromodomain signature | 695 | 713 | 5.9E-15 |
| 8 | g2225.t1 | PRINTS | PR00503 | Bromodomain signature | 713 | 732 | 5.9E-15 |
| 1 | g2225.t1 | Pfam | PF06466 | PCAF (P300/CBP-associated factor) N-terminal domain | 36 | 286 | 2.6E-73 |
| 3 | g2225.t1 | Pfam | PF00583 | Acetyltransferase (GNAT) family | 454 | 537 | 8.8E-9 |
| 2 | g2225.t1 | Pfam | PF00439 | Bromodomain | 655 | 737 | 4.9E-21 |
| 19 | g2225.t1 | ProSitePatterns | PS00633 | Bromodomain signature. | 667 | 724 | - |
| 22 | g2225.t1 | ProSiteProfiles | PS51186 | Gcn5-related N-acetyltransferase (GNAT) domain profile. | 420 | 566 | 15.92 |
| 23 | g2225.t1 | ProSiteProfiles | PS50014 | Bromodomain profile. | 662 | 732 | 19.068 |
| 18 | g2225.t1 | SMART | SM00297 | bromo_6 | 643 | 751 | 6.2E-38 |
| 13 | g2225.t1 | SUPERFAMILY | SSF55729 | Acyl-CoA N-acyltransferases (Nat) | 429 | 568 | 1.98E-17 |
| 12 | g2225.t1 | SUPERFAMILY | SSF47370 | Bromodomain | 634 | 748 | 3.66E-35 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005634 | nucleus | CC |
| GO:0005515 | protein binding | MF |
| GO:0006355 | regulation of transcription, DNA-templated | BP |
| GO:0004402 | histone acetyltransferase activity | MF |
| GO:0008080 | N-acetyltransferase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K06062 (histone acetyltransferase)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
