General information for g2377.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Endophilin-A.
Parent gene
- The parent gene g2377 is located on chr_3: 17454645..17458120 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2377 | g2377.t1 | isoform | g2377.t1 | 17454645 | 17458120 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon1 | 17454645 | 17454689 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS1 | 17454645 | 17454689 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon2 | 17454941 | 17455229 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS2 | 17454941 | 17455229 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon3 | 17455356 | 17455489 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS3 | 17455356 | 17455489 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon4 | 17455558 | 17455624 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS4 | 17455558 | 17455624 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon5 | 17455681 | 17455766 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS5 | 17455681 | 17455766 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon6 | 17455856 | 17455959 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS6 | 17455856 | 17455959 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon7 | 17456024 | 17456100 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS7 | 17456024 | 17456100 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon8 | 17457086 | 17457175 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS8 | 17457086 | 17457175 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon9 | 17457816 | 17457937 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS9 | 17457816 | 17457937 |
| chr_3 | g2377 | g2377.t1 | exon | g2377.t1.exon10 | 17458001 | 17458120 |
| chr_3 | g2377 | g2377.t1 | cds | g2377.t1.CDS10 | 17458001 | 17458120 |
| chr_3 | g2377 | g2377.t1 | TSS | g2377.t1 | NA | NA |
| chr_3 | g2377 | g2377.t1 | TTS | g2377.t1 | NA | NA |
Sequences
>g2377.t1 Gene=g2377 Length=1134
ATGGCATTTGCAGGACTTAAAAAGCAAATTAACAAAGCTAATCAGTTTGTAACTGAAAAG
ATGGGTGGTGCTGAGGGCACCAAACTTGATCTTGATTTCTTAGAAATGGAAAGAAAAACT
GACGTCACAGTTGAGCTCATTGAAGAATTACAAGCAAAAACAAAAGAATATCTTCAGCCA
AATCCAACAGCACGTGCAAAGATGATTGCTGTCAAGGGAATTTCAAAACTCTCTGGACAG
GCAAAGAGTAATACTTATCCACAGGCTGAAGGTGTTCTTGCTGATACAATGCTCATTTAT
GGAAAACGATTGGGTGAAGATCAGAGTGTCTTTGCACAAGCACTTGTTGAATTTGGTGAT
ACATTAAAGCAAATGGCTGATGTAAAATACGCACTTGATGACAATGTAAAGCAAAACTTC
TTGGAGCCATTGCATCAATTACAAATGAAAGATTTAAAGGAGGTTATGCATCATCGTAAG
AAATTGCAAGGACGACGTTTGGACTTTGACTGTAAGAGACGTCGCCAAGCAAGGGATGAT
GAAATCAAGAGTGCCGAGGAAAAGTTTGCCGAGTCATTGCAACAAGCTCAAATTGGAATG
TATCATTTGCTAGAAAACGATGTCGAGCAAGTTTCGCAGCTTGCATACTTTGCCGAAGCC
ATGTTAGATTATCACACACAATGCACAGAAATTCTTCGCGGTCTTGTAGAGAATATGCAA
TTAAAGCGAGAAGAAGCAGCATCTCGTCCTAAATCGGAATTAGTTTTAAAGACCTTGTCC
GATTTAGTAATTGAGGGTGATGATGGATTAACCGGATCAGGATCCGGCACGCCCGTAAAA
CCCAATCATTTGGAAATAATGGGTAATGGCAGTGCTGCTCGTTCAACAAATGCGTCACCA
CTTCCCAGTCCAATGAAATCGCCAGCAAAACCACCGGCACCAGCACAACAACAGCCTTGC
TGCGTGGCTATTTATGACTTTGATCCTGAAAATCCCGGAGAGTTAGGCTTTAAAGAAAAT
GATGTGATTCAACTTTTACAACGCATTGATGAGAACTGGTTTGAAGGAAAACTAAATGGC
AAGACAGGTTACTTTCCGCAGACATACGTTGAAGTTAAAGTTCCACTATCTTAA
>g2377.t1 Gene=g2377 Length=377
MAFAGLKKQINKANQFVTEKMGGAEGTKLDLDFLEMERKTDVTVELIEELQAKTKEYLQP
NPTARAKMIAVKGISKLSGQAKSNTYPQAEGVLADTMLIYGKRLGEDQSVFAQALVEFGD
TLKQMADVKYALDDNVKQNFLEPLHQLQMKDLKEVMHHRKKLQGRRLDFDCKRRRQARDD
EIKSAEEKFAESLQQAQIGMYHLLENDVEQVSQLAYFAEAMLDYHTQCTEILRGLVENMQ
LKREEAASRPKSELVLKTLSDLVIEGDDGLTGSGSGTPVKPNHLEIMGNGSAARSTNASP
LPSPMKSPAKPPAPAQQQPCCVAIYDFDPENPGELGFKENDVIQLLQRIDENWFEGKLNG
KTGYFPQTYVEVKVPLS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g2377.t1 | CDD | cd07592 | BAR_Endophilin_A | 25 | 246 | 5.05571E-124 |
| 14 | g2377.t1 | CDD | cd11803 | SH3_Endophilin_A | 319 | 372 | 6.85033E-34 |
| 12 | g2377.t1 | Gene3D | G3DSA:1.20.1270.60 | Arfaptin | 1 | 245 | 4.7E-75 |
| 11 | g2377.t1 | Gene3D | G3DSA:2.30.30.40 | SH3 Domains | 307 | 377 | 6.0E-26 |
| 17 | g2377.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 292 | 315 | - |
| 3 | g2377.t1 | PANTHER | PTHR14167:SF45 | ENDOPHILIN-A3 | 1 | 376 | 7.4E-115 |
| 4 | g2377.t1 | PANTHER | PTHR14167 | SH3 DOMAIN-CONTAINING | 1 | 376 | 7.4E-115 |
| 7 | g2377.t1 | PRINTS | PR00452 | SH3 domain signature | 319 | 329 | 9.9E-8 |
| 6 | g2377.t1 | PRINTS | PR00452 | SH3 domain signature | 333 | 348 | 9.9E-8 |
| 8 | g2377.t1 | PRINTS | PR00452 | SH3 domain signature | 350 | 359 | 9.9E-8 |
| 5 | g2377.t1 | PRINTS | PR00452 | SH3 domain signature | 361 | 373 | 9.9E-8 |
| 2 | g2377.t1 | Pfam | PF03114 | BAR domain | 6 | 240 | 3.6E-68 |
| 1 | g2377.t1 | Pfam | PF00018 | SH3 domain | 322 | 366 | 1.3E-14 |
| 19 | g2377.t1 | ProSiteProfiles | PS51021 | BAR domain profile. | 18 | 248 | 26.004 |
| 18 | g2377.t1 | ProSiteProfiles | PS50002 | Src homology 3 (SH3) domain profile. | 316 | 375 | 28.302 |
| 15 | g2377.t1 | SMART | SM00721 | 5bar | 5 | 241 | 4.3E-76 |
| 16 | g2377.t1 | SMART | SM00326 | SH3_2 | 319 | 374 | 5.4E-22 |
| 9 | g2377.t1 | SUPERFAMILY | SSF103657 | BAR/IMD domain-like | 11 | 240 | 4.19E-62 |
| 10 | g2377.t1 | SUPERFAMILY | SSF50044 | SH3-domain | 309 | 372 | 2.36E-23 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
| GO:0005737 | cytoplasm | CC |
KEGG
Orthology
- This transcript has been annotated with K11247 (endophilin-A)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed