General information for g2384.t9
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Suppressor of cytokine signaling 5.
Parent gene
- The parent gene g2384 is located on chr_3: 17494195..17495803 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2384 | g2384.t9 | TSS | g2384.t9 | 17492739 | 17492739 |
| chr_3 | g2384 | g2384.t9 | isoform | g2384.t9 | 17493323 | 17495232 |
| chr_3 | g2384 | g2384.t9 | exon | g2384.t9.exon1 | 17493323 | 17493841 |
| chr_3 | g2384 | g2384.t9 | cds | g2384.t9.CDS1 | 17493377 | 17493835 |
| chr_3 | g2384 | g2384.t9 | exon | g2384.t9.exon2 | 17493911 | 17495232 |
| chr_3 | g2384 | g2384.t9 | TTS | g2384.t9 | 17495189 | 17495189 |
Sequences
>g2384.t9 Gene=g2384 Length=1841
TATCTAGTGCCAGACCTTGAGAAAATCACTTCATGCTGCTATTATTGGGGAAAAATGGAC
CGATATGAAGCGGAAAAGTTACTCGATGGCAAGCCCGAGGGAACATTTCTGCTACGTGAT
TCAGCGCAGGATGATTTTCTATTCAGTGTTTCATTCCGCAAATATGGTCGATCATTGCAT
GCGCGCATCGAGCAATTTAATCACAAATTCAGTTTTGATTCACATGATCCAAGTGTATTC
ATGGCATCTACAGTTACTGGTCTAGTAGAACATTATAAAGATCCTACATCAGTAATGTTC
TTTGAACCTATGCTAACAAGTCCATTGCATCGAAATTTTGTCTTCTCATTACAACAATTA
TGTAGAGCAAATATTGTCAGTAAAACCACATATGATGGAATCAATAAGCTATGCTTACCA
TTAGCAATGAAAAATTATCTAAAAGAATATCATTACAAGCTTCGAGTACGTGTCAAGCAT
TTTCCTGAGGGTGTAACTTTTAGAAACTCTTAGTGCCAGGTAATAACTTGTACATTACCT
TCATCATCGTCATCCTCAAGTAGTAATTCATCATCATCGAGTAATTTATTTTGGCATACA
ACAGCGACAACATCATCGCCATTTCGTTTGAATTTTCGTCAATTTTTCGAAATTGCAAGC
ACAACGTTAAATAATGAGATCGAACAACCTTCAACATCGTCAGCTGCTGCTTTGTCAATT
GACACAGATGACAATGCTAAAAAGTGTTGCAATAAGAAGAAATTGACAAAAAAATTACAA
AATTTCTTTAGTAAATTTTGGTAAATACAGTGACACACAGAAATGTACTAAGCTAAGTAG
TGATAATTATTTGAGCTTTCTGTAATGCATTAATTTATTGAATAACTAGTGGAGAGATAA
AAAAAGTTAAGAAAATTGTGGTACTACAATGAAAGAAATTATTTAATCAAAAAAAAAACA
TAATCAAGCTAAAACAGACTACGAAGATACAAATTATAATGAATCATGTAGTTTAGTTAG
ATTTAAATGTTTATAAATAATAATGTTAAATGTTATTAAAAAACAAAAATATATATAATG
AGAAGAAGAAAGGTTTAATATGAATCTCAATTGACTGGCCAGAAAAAATAAGAGAAACAA
TAGCTTCGTGATTTATATTTTTTAACAAATTTATTTTTTTCTGTTAAGAAGACGATTGTA
GGAACGTGAGATTTGTGAAAGCAGAGAATTCAAAAAGTATTATAAAAGAGTAGAAAAAAA
TTTCTTTTCCAAAAAATACATACACACACGTGGTTATTTTAGATGTTTTCAAATTAGACT
TTAATGAACTATAAATGCTAAAAAAGAATTAATTTATATTTAAAATTAAATGAGAGTGAA
TGCTGAATTATAATTGAATGATTTATAAACAGACGAATTCGTCACTTTTTATTATTTTTG
TTTCGACAATAAATGTAATGTCATATTATAAAAAAGCAAGAAAAGAAGAATTCCACTCAA
TCAAAAATTTTTTCAAATCCTGTATATAGCCGGTTGGTTAATTATCACACAGTTTCTAAT
ATTGCCACAGACTTTATAGTCGAGTGGATTTCTTTACGCGTTGTTAAATCTTATTTCGAC
CAAAATAAATTTTTTTCATAGAACCAAAATTAAAGAAGAAAAGGAAAGAATGTGATGAAG
TTTAACTGATTCTGTTTTATGACTACAAATATAGAATTATCATATAATATGTAAAAATCA
AAAACATAATGTGTAAATTAAATTATACTTAACTATAAAAAGAAAGAATAAAAAAAATCA
AAATTTAATTAATTGAAAAAAGAATTCAATTTTTATTTTTT
>g2384.t9 Gene=g2384 Length=152
MDRYEAEKLLDGKPEGTFLLRDSAQDDFLFSVSFRKYGRSLHARIEQFNHKFSFDSHDPS
VFMASTVTGLVEHYKDPTSVMFFEPMLTSPLHRNFVFSLQQLCRANIVSKTTYDGINKLC
LPLAMKNYLKEYHYKLRVRVKHFPEGVTFRNS
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 10 | g2384.t9 | Gene3D | G3DSA:3.30.505.10 | SHC Adaptor Protein | 1 | 146 | 0.0000000 |
| 3 | g2384.t9 | PANTHER | PTHR10155 | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT | 1 | 142 | 0.0000000 |
| 4 | g2384.t9 | PANTHER | PTHR10155:SF18 | SUPPRESSOR OF CYTOKINE-SIGNALING 9 | 1 | 142 | 0.0000000 |
| 2 | g2384.t9 | Pfam | PF00017 | SH2 domain | 2 | 74 | 0.0000000 |
| 1 | g2384.t9 | Pfam | PF07525 | SOCS box | 96 | 132 | 0.0000001 |
| 11 | g2384.t9 | ProSiteProfiles | PS50001 | Src homology 2 (SH2) domain profile. | 1 | 91 | 13.5040000 |
| 12 | g2384.t9 | ProSiteProfiles | PS50225 | SOCS box domain profile. | 86 | 135 | 15.3420000 |
| 9 | g2384.t9 | SMART | SM00252 | SH2_5 | 1 | 80 | 0.0000001 |
| 7 | g2384.t9 | SMART | SM00253 | socs_2 | 90 | 133 | 0.0000000 |
| 8 | g2384.t9 | SMART | SM00969 | SOCS_box_2 | 96 | 132 | 0.0000000 |
| 6 | g2384.t9 | SUPERFAMILY | SSF55550 | SH2 domain | 1 | 93 | 0.0000000 |
| 5 | g2384.t9 | SUPERFAMILY | SSF158235 | SOCS box-like | 96 | 138 | 0.0000000 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0035556 | intracellular signal transduction | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
