General information for g2424.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Angiotensin-converting enzyme.
Parent gene
- The parent gene g2424 is located on chr_3: 17892328..17895558 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2424 | g2424.t1 | isoform | g2424.t1 | 17892328 | 17895558 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon1 | 17892328 | 17892430 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS1 | 17892328 | 17892430 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon2 | 17892674 | 17892777 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS2 | 17892674 | 17892777 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon3 | 17892837 | 17892973 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS3 | 17892837 | 17892973 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon4 | 17893260 | 17893384 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS4 | 17893260 | 17893384 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon5 | 17893447 | 17893657 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS5 | 17893447 | 17893657 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon6 | 17893711 | 17893956 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS6 | 17893711 | 17893956 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon7 | 17894014 | 17894146 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS7 | 17894014 | 17894146 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon8 | 17894202 | 17894309 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS8 | 17894202 | 17894309 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon9 | 17894369 | 17894527 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS9 | 17894369 | 17894527 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon10 | 17894769 | 17895140 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS10 | 17894769 | 17895140 |
| chr_3 | g2424 | g2424.t1 | exon | g2424.t1.exon11 | 17895199 | 17895558 |
| chr_3 | g2424 | g2424.t1 | cds | g2424.t1.CDS11 | 17895199 | 17895558 |
| chr_3 | g2424 | g2424.t1 | TSS | g2424.t1 | NA | NA |
| chr_3 | g2424 | g2424.t1 | TTS | g2424.t1 | NA | NA |
Sequences
>g2424.t1 Gene=g2424 Length=2058
ATGAATTTTAAAGTAACTTTGAGTTTATTTTTGGCAATATCTTTAGTAAATTGTGATCCT
CAGTTAGATATACCAAATGTGCAAACAACAGATGAATCAAAAGAAAAAAATGGAATAAAA
GTGCTTGTGTTACCAAATAGCTATACAAATGATAAGTTTGATGATCAACCGAAAAGTGAC
TCAAATAATAATCGATTTGATAGTGACAGAAGCCAAAGGTATGGTCCACCATATTCTAGC
AATGAAAATGATGAATATCCACAAAATATAAGAGATAATGAGAGATTACGTTATGGTGAC
CCAAATTCAAACCGCGATAATTTTAAATTTCCTCAAAACGACTTTAATGAACGTTCTCAA
CAGTCATATCCTGTCAACAATAATAATAATAATAATGAACAGAGATATGGAAATGTTGAA
CCTCGATATAGATATGAAAATAACCAAAGAAATGGCTACAATGTAAATGAACAATATGAT
GACAGATATGGAAATAATTTTAATTCCAATTATGGTTTTGTTAATAATCAAAATTATAAT
TATAACAACAATTATAATGATTATCAAAATCTCTATGATATTGAAAATGAAAAAAGAATT
CGTCTTGAGACTGAAAAACTTCGTCAACTATTAATTGAAATCGACAAGAAGCATTCATCT
GAATGTACATTAAATGTTGCAGCTCAATGGAATTTTGAGACAAATGTAAATGAAGCAACA
CAACTTGAAGCTTTGACTGCGCAGCAACGTTATTCAGATTTTATGCGGTACATTTTTGAC
CAAACAAAAAGCATAGACCAAAATTACATATTTGATGAGAAACTTTATCGACAGTTAAAA
TTGTTGAAATCAGCTGGACCTGCTGCACTTCCTGCTGATCAATTAGACAGATATAATAGA
ATCATCAATGATATGCTCACAATTTACAATGGAGCGACAATTTGTGCATATGAGCAACCA
TTTCAATGTTCGTTGAGACTTCAACCACATTTAAGAGATATTATGGTTAAATCTCGAGAT
TGGGATGAATTGACTTGGGTGTGGACTGAATGGAGACGAAAAGCAGGAAAACCAATGAGA
GATCTTTTTGAACAATTGGTTGATTTAACTAATGATGCTGCTAAATATAATAATTTTTCA
AATGCAGCTGACTATTTTAGTTCACAATTTGATTCGCCAAATTTCCGATATGAAATGGAA
AATGTTTGGCAAGAAATACTTCCACTTTATGAGCTCATTCATGCTTATGTGCGTAGAAAA
CTTCGAGAATTTTATGGACCAGATAAAATTAATCGAAATGCACCACTACCAGCGCATATT
TTAGGCAATATGTATGCACAAACTTGGAATATTCTTGATCTTACAATTCCCTATCCAGGT
CGAACTTATCTCGATGTTACACCAACAATGCGTGCACAAGGTTACAATCCATTGATTATG
TTTCAAATAGCCGAAGAGTTTTTCGTCTCAATGAATATGTCAGCAATGCCACCAGAGTTT
TGGGCTCATTCGATACTTGAAGAGCCGGTTGATCGACCTATTTTGTGTCAACCAAGTGCT
TGGGACTTTTGTAATGGAATTGACTATCGTATCAAAATGTGCACGGATGTTACGCACAAA
GACTTCATAACTGTTCATCACGAATTGGCACACATTCAATATTTTTTGAATTATCGTAAT
AATCCGAAAATTTTTCGTGATGGCTCAAATCCAGGATTTCATGACGCGATTGGTGACGCA
ATTACTCTCTCATTAACACCTAAACATTTGCAAGGACTTGGACTGATTCAAAAATCAGTC
GATGACACTGCTCACGACATCAATTTCCTGTTTACACTTGCCATGGACAAGGTTGTGTTT
TTACCTTACGCATTAGCATTAGAACAATGGAGATATGACATTTATACAAAGAAGATTCGT
AAGGAACAATTTAATTGTCATTGGTGGCTTCTGAGGGAGCAATATGGAGGCATTAAACCA
CCAGTACTTCGTTCGGAATTTGATTTCGATCCAGGTGCAAAATATCATATTCCAGCTAAT
GTTCCATATATGAAGTAA
>g2424.t1 Gene=g2424 Length=685
MNFKVTLSLFLAISLVNCDPQLDIPNVQTTDESKEKNGIKVLVLPNSYTNDKFDDQPKSD
SNNNRFDSDRSQRYGPPYSSNENDEYPQNIRDNERLRYGDPNSNRDNFKFPQNDFNERSQ
QSYPVNNNNNNNEQRYGNVEPRYRYENNQRNGYNVNEQYDDRYGNNFNSNYGFVNNQNYN
YNNNYNDYQNLYDIENEKRIRLETEKLRQLLIEIDKKHSSECTLNVAAQWNFETNVNEAT
QLEALTAQQRYSDFMRYIFDQTKSIDQNYIFDEKLYRQLKLLKSAGPAALPADQLDRYNR
IINDMLTIYNGATICAYEQPFQCSLRLQPHLRDIMVKSRDWDELTWVWTEWRRKAGKPMR
DLFEQLVDLTNDAAKYNNFSNAADYFSSQFDSPNFRYEMENVWQEILPLYELIHAYVRRK
LREFYGPDKINRNAPLPAHILGNMYAQTWNILDLTIPYPGRTYLDVTPTMRAQGYNPLIM
FQIAEEFFVSMNMSAMPPEFWAHSILEEPVDRPILCQPSAWDFCNGIDYRIKMCTDVTHK
DFITVHHELAHIQYFLNYRNNPKIFRDGSNPGFHDAIGDAITLSLTPKHLQGLGLIQKSV
DDTAHDINFLFTLAMDKVVFLPYALALEQWRYDIYTKKIRKEQFNCHWWLLREQYGGIKP
PVLRSEFDFDPGAKYHIPANVPYMK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 21 | g2424.t1 | CDD | cd06461 | M2_ACE | 213 | 685 | 0.0 |
| 15 | g2424.t1 | Coils | Coil | Coil | 185 | 205 | - |
| 26 | g2424.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 47 | 89 | - |
| 24 | g2424.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 53 | 67 | - |
| 22 | g2424.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 68 | 86 | - |
| 23 | g2424.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 120 | 139 | - |
| 25 | g2424.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 120 | 137 | - |
| 2 | g2424.t1 | PANTHER | PTHR10514 | ANGIOTENSIN-CONVERTING ENZYME | 4 | 685 | 0.0 |
| 3 | g2424.t1 | PANTHER | PTHR10514:SF40 | ANGIOTENSIN-CONVERTING ENZYME | 4 | 685 | 0.0 |
| 4 | g2424.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 399 | 426 | 9.2E-66 |
| 8 | g2424.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 434 | 455 | 9.2E-66 |
| 7 | g2424.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 510 | 535 | 9.2E-66 |
| 9 | g2424.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 542 | 558 | 9.2E-66 |
| 11 | g2424.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 570 | 590 | 9.2E-66 |
| 10 | g2424.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 610 | 635 | 9.2E-66 |
| 6 | g2424.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 645 | 672 | 9.2E-66 |
| 5 | g2424.t1 | PRINTS | PR00791 | Peptidyl-dipeptidase A (M2) metalloprotease family signature | 673 | 685 | 9.2E-66 |
| 1 | g2424.t1 | Pfam | PF01401 | Angiotensin-converting enzyme | 204 | 685 | 3.6E-176 |
| 17 | g2424.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 18 | - |
| 18 | g2424.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 4 | - |
| 19 | g2424.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 5 | 13 | - |
| 20 | g2424.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 14 | 18 | - |
| 16 | g2424.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 19 | 685 | - |
| 12 | g2424.t1 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 205 | 684 | 2.66E-162 |
| 14 | g2424.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 18 | - |
| 13 | g2424.t1 | SignalP_GRAM_POSITIVE | SignalP-TM | SignalP-TM | 1 | 22 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0008241 | peptidyl-dipeptidase activity | MF |
| GO:0008237 | metallopeptidase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
- This transcript has been annotated with K01283 (peptidyl-dipeptidase A)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed