General information for g2439.t7
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as ADAM 17-like protease.
Parent gene
- The parent gene g2439 is located on chr_3: 18005856..18007019 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2439 | g2439.t7 | isoform | g2439.t7 | 18005856 | 18006761 |
| chr_3 | g2439 | g2439.t7 | exon | g2439.t7.exon1 | 18005856 | 18006761 |
| chr_3 | g2439 | g2439.t7 | cds | g2439.t7.CDS1 | 18006050 | 18006760 |
| chr_3 | g2439 | g2439.t7 | TTS | g2439.t7 | 18007090 | 18007090 |
| chr_3 | g2439 | g2439.t7 | TSS | g2439.t7 | NA | NA |
Sequences
>g2439.t7 Gene=g2439 Length=906
AATATTTTAAAAATGGCTACACTCTCTATCTGAATTCTGGTCTTAGTTCATCAAGAAATC
ATTATGGTCAACGTGTGATCACAAGAGAAGCTGATTTAGTCACAGCACATGAATTTGGGC
ACAATTGGGGAAGTGAACATGATCCTGACATTGCTGAATGTTCTCCTTCAGCTTCACAAG
GAGGAAGTTTCTTGATGTATACATATTCAGTTAGTGGTTATGATGTCAATAACAAGAAAT
TTTCACCATGTTCGTTACGTTCAATAAGAAAAGTATTACAAGCAAAAAGTGGACGTTGTT
TCTCAGAACCTGAAGAATCATTTTGTGGAAATTTGCGTGTTGAGGGTGATGAGCAGTGTG
ATGCTGGTTTATTAGGCACAGAAGATAATGATCAATGCTGCGATAAAAACTGTAAATTAC
GAAAAAATCAGGGAGCAGTTTGCAGTGATAAAAATTCTCCATGTTGTCAAAATTGTCAAT
TTATGCCAGCTGGAGTTAAGTGTCGAGAGGCAGCATATAGTACTTGTGAACAAGAAGCGC
GATGTACTGGAAACAGTGCTGATTGCCCTAAATCTCCTGCAATGCAAGATGGAACAATTT
GTCAGGAACGTGGACAATGTCGAAGTGGAAAATGTGTTCCTTTCTGCGAAACTCAAGGAC
TACAAAGTTGTATGTGCGATGTTATTGCAGATGCATGCAAACGATGCTGCCGAATGTCCA
TTAATGAGACATGCTTTGCCGTTGAACCACCTGATATTTTGCCAGATGGTACACCTTGCA
TTCAAGGCTTCTGTAATAAAGGTGTTTGTGAAAAAACAATTCAAGATGTTGTTGAACGCT
TCTGGGATATCATTGAAGAAATTAATATTAACAAAGTATTGAGATTTTTACGTGACAACA
TAGTTA
>g2439.t7 Gene=g2439 Length=237
MYTYSVSGYDVNNKKFSPCSLRSIRKVLQAKSGRCFSEPEESFCGNLRVEGDEQCDAGLL
GTEDNDQCCDKNCKLRKNQGAVCSDKNSPCCQNCQFMPAGVKCREAAYSTCEQEARCTGN
SADCPKSPAMQDGTICQERGQCRSGKCVPFCETQGLQSCMCDVIADACKRCCRMSINETC
FAVEPPDILPDGTPCIQGFCNKGVCEKTIQDVVERFWDIIEEININKVLRFLRDNIV
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g2439.t7 | CDD | cd14246 | ADAM17_MPD | 149 | 206 | 0.0000000 |
| 9 | g2439.t7 | Gene3D | G3DSA:3.40.390.10 | Collagenase (Catalytic Domain) | 1 | 39 | 0.0000000 |
| 8 | g2439.t7 | Gene3D | G3DSA:4.10.70.10 | Echistatin | 40 | 127 | 0.0000000 |
| 3 | g2439.t7 | PANTHER | PTHR45702:SF6 | DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 17 | 1 | 237 | 0.0000000 |
| 4 | g2439.t7 | PANTHER | PTHR45702 | ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER | 1 | 237 | 0.0000000 |
| 2 | g2439.t7 | Pfam | PF00200 | Disintegrin | 50 | 126 | 0.0000000 |
| 1 | g2439.t7 | Pfam | PF16698 | Membrane-proximal domain, switch, for ADAM17 | 150 | 206 | 0.0000000 |
| 10 | g2439.t7 | ProSiteProfiles | PS50214 | Disintegrin domain profile. | 41 | 132 | 13.6110000 |
| 7 | g2439.t7 | SMART | SM00050 | DISIN_2 | 50 | 131 | 0.0000000 |
| 6 | g2439.t7 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 1 | 38 | 0.0000042 |
| 5 | g2439.t7 | SUPERFAMILY | SSF57552 | Blood coagulation inhibitor (disintegrin) | 50 | 129 | 0.0000000 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008237 | metallopeptidase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
