General information for g248.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Uricase .
Parent gene
- The parent gene g248 is located on chr_3: 2011792..2013796 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g248 | g248.t2 | isoform | g248.t2 | 2010992 | 2013796 |
| chr_3 | g248 | g248.t2 | exon | g248.t2.exon1 | 2010992 | 2011082 |
| chr_3 | g248 | g248.t2 | exon | g248.t2.exon2 | 2011784 | 2011891 |
| chr_3 | g248 | g248.t2 | cds | g248.t2.CDS1 | 2011792 | 2011891 |
| chr_3 | g248 | g248.t2 | exon | g248.t2.exon3 | 2012246 | 2012599 |
| chr_3 | g248 | g248.t2 | cds | g248.t2.CDS2 | 2012246 | 2012599 |
| chr_3 | g248 | g248.t2 | exon | g248.t2.exon4 | 2012660 | 2012786 |
| chr_3 | g248 | g248.t2 | cds | g248.t2.CDS3 | 2012660 | 2012786 |
| chr_3 | g248 | g248.t2 | exon | g248.t2.exon5 | 2012840 | 2013796 |
| chr_3 | g248 | g248.t2 | cds | g248.t2.CDS4 | 2012840 | 2013170 |
| chr_3 | g248 | g248.t2 | TTS | g248.t2 | 2014168 | 2014168 |
| chr_3 | g248 | g248.t2 | TSS | g248.t2 | NA | NA |
Sequences
>g248.t2 Gene=g248 Length=1637
ATGTGTTTGTGTGGTTTCATCATTGCGGATGTGATAAAAACTACTATAGAAGTTTTATTA
TAACAGTAAGAATATGGTTATGTCATAGAAATTTAAAAAATGTCATGTGATGATTTTCAA
GATGGTCCAAATAAATATAAAATTAGTGGTAGAAAATATGGCAAGAATGAAATTAGAATC
TTTTATGTTAATAAAGATGGTCCATGCCATATAATAAAAGAACTCCTAATCAACACTCGT
CTAACGCTTGAAACAAATAAAGAATACATCTCAGATGATAACACTGGAATTATTGATACA
AAATCGCAAAGAAATTCAGTTTATATTTTGGCTAAAAAGCATGGCATAAAAACAACAGAA
GATTTTGGAACTCTTGTGTGTTCTTATTATCTTTCAACTTATTCTCATGTTAAAACAGCT
TCTTTGTATATTGAAGAAGAAAATTGGGAGAGATTGAGTTATGATGATGAGACGAAAGGA
AAATTACATAATCATGCTTTCATGCTTACACCAAAATATGTTCGTACTACTGTAATTGTT
TTTAACCGTGGAGACGAATTTCCAACAATTTCAAATGGCATTAAAAATTTGCGTATTATA
AAAACTACTCAAAATAGTTTCAAAAATTTTTCTCAAAATGAACATCGATCAATAGCTGAT
GCTGAAGAAAGAACTCTTTGCCTTCTTTTGACTTTTTCTTGGACCTACAAGCAAAATCCA
CAAATTGATTTCTGTAAAACTTTCAATTCAATTTTGCATGTTGTTTTGTATAATTTTGCA
GGAGATTTAGAAAAAGGAACAATGTTGACAAGTGTTCAAAACACAATTTTTATGGCAGCA
AAAAAGATTCTTGATAAAGTTGAAGAAATTGAATTTGTTGAAGTCGTTTGTAAAAATTTT
CATTATGACTTATTTGATTTCGAAATTTTTAAAATTCCGAATGAAGTTAATGATGTCTTC
TATCCTCAGGAAAACCCATCAGAAGTTCATATTAGATTGGATAGAAAATGAAAAATTGTG
ATGAAAATGTAAAGCCTGGAGAGATCAATAGGAAAAAATGGCTGTTGGTTGTGTTTAGAA
ACTTTTTAAAAATAAATCAAAATTTTTGAACGCACTCCAAAGCAAAATATCGGTAAATTC
ATAAACATTTTTTTTTTTAAATAAGAATAATATTTTAAAGATTCATAGAAGCAAATCTAA
CAAACAAAAGTAAAGTTATTAAAAATTTACAAAGATTCAATTAAAAATAAACATACCGGT
TTTTTTAAATGGAGAGCAGAAAACGCGCTCCAGTTTAAAATATCGACTAATAACGGTAAA
AAAACTATTGATCTCAACAGGGTTTAAATTTTTTTGGGATTTTTTTATCTTAAGATATTA
AAATTCTTTGTAAAAATAAAAAAGCTTTGTCATTATCAAAGCCTGAGAATTCTTCTGATA
TTTTTGATTTTTTTGTTATTTTTGATATTGTGATTTTCTCTTTAATCAAAGACCATAAAA
ATTTTATTGATAGCCTAAAAGAAAGCTATGAGCATAAGGAATGAAAATCAGAAAGGTCTG
CATAATTTCATGTTATCGTTTTAAAACTGAACTCATTTAAAAAAAGTCCATTCCTTGGTC
ATTATTTAATCTCTAAA
>g248.t2 Gene=g248 Length=303
MSCDDFQDGPNKYKISGRKYGKNEIRIFYVNKDGPCHIIKELLINTRLTLETNKEYISDD
NTGIIDTKSQRNSVYILAKKHGIKTTEDFGTLVCSYYLSTYSHVKTASLYIEEENWERLS
YDDETKGKLHNHAFMLTPKYVRTTVIVFNRGDEFPTISNGIKNLRIIKTTQNSFKNFSQN
EHRSIADAEERTLCLLLTFSWTYKQNPQIDFCKTFNSILHVVLYNFAGDLEKGTMLTSVQ
NTIFMAAKKILDKVEEIEFVEVVCKNFHYDLFDFEIFKIPNEVNDVFYPQENPSEVHIRL
DRK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 11 | g248.t2 | Gene3D | G3DSA:3.10.270.10 | Urate Oxidase; | 3 | 303 | 0 |
| 3 | g248.t2 | PANTHER | PTHR42874 | URICASE | 13 | 294 | 0 |
| 13 | g248.t2 | PIRSF | PIRSF000241 | Urate_oxidase | 4 | 303 | 0 |
| 5 | g248.t2 | PRINTS | PR00093 | Uricase signature | 21 | 32 | 0 |
| 8 | g248.t2 | PRINTS | PR00093 | Uricase signature | 60 | 74 | 0 |
| 4 | g248.t2 | PRINTS | PR00093 | Uricase signature | 96 | 109 | 0 |
| 7 | g248.t2 | PRINTS | PR00093 | Uricase signature | 164 | 180 | 0 |
| 6 | g248.t2 | PRINTS | PR00093 | Uricase signature | 180 | 192 | 0 |
| 1 | g248.t2 | Pfam | PF01014 | Uricase | 19 | 146 | 0 |
| 2 | g248.t2 | Pfam | PF01014 | Uricase | 158 | 294 | 0 |
| 10 | g248.t2 | SUPERFAMILY | SSF55620 | Tetrahydrobiopterin biosynthesis enzymes-like | 17 | 148 | 0 |
| 9 | g248.t2 | SUPERFAMILY | SSF55620 | Tetrahydrobiopterin biosynthesis enzymes-like | 155 | 294 | 0 |
| 12 | g248.t2 | TIGRFAM | TIGR03383 | urate_oxi: urate oxidase | 17 | 294 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
There are no GO annotations for this transcript.
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
