General information for g2506.t37
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as S-adenosylmethionine synthase.
Parent gene
- The parent gene g2506 is located on chr_3: 18332519..18333574 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2506 | g2506.t37 | isoform | g2506.t37 | 18331182 | 18333028 |
| chr_3 | g2506 | g2506.t37 | exon | g2506.t37.exon1 | 18331182 | 18331308 |
| chr_3 | g2506 | g2506.t37 | cds | g2506.t37.CDS1 | 18331222 | 18331308 |
| chr_3 | g2506 | g2506.t37 | exon | g2506.t37.exon2 | 18331502 | 18331645 |
| chr_3 | g2506 | g2506.t37 | cds | g2506.t37.CDS2 | 18331502 | 18331645 |
| chr_3 | g2506 | g2506.t37 | exon | g2506.t37.exon3 | 18331872 | 18332407 |
| chr_3 | g2506 | g2506.t37 | cds | g2506.t37.CDS3 | 18331872 | 18332407 |
| chr_3 | g2506 | g2506.t37 | exon | g2506.t37.exon4 | 18332477 | 18333028 |
| chr_3 | g2506 | g2506.t37 | cds | g2506.t37.CDS4 | 18332477 | 18332582 |
| chr_3 | g2506 | g2506.t37 | TTS | g2506.t37 | 18333629 | 18333629 |
| chr_3 | g2506 | g2506.t37 | TSS | g2506.t37 | NA | NA |
Sequences
>g2506.t37 Gene=g2506 Length=1359
ACTATTTTTTAAAGGTTTTGATTACAAAACTTGTAGTCTTATGGTATGTCTTGAGCAGCA
AAGTCCAAATATTGCTGACGGGGTGCATGTTAATCGTAATGTCGAGGATATTGGAGCTGG
CGATCAGGGTTTGATGTTTGGATATGCTACAGACGAAACTGAAGAATGCATGCCTCTTAC
AGTCGTCTTAGCACATCGTTTGAACCAAAAGATTGCTGAACTTCGCAGATCTGGAGTTTT
GAGCTGGGCACGTCCAGATTCTAAAACACAAGTTACAGCAGAATACATTTTCCAAAAAGG
AGCTTGCATTCCAAAGCGAGTTCACACGGTTGTCGTCTCTTTACAGCATTCTGAAAAGGT
TACATTGGAAGAATTACGAAAAGAGATTACTGAAAAAGTTGTTCGTGTCGTCATTCCCGA
AAAGTATTTGGATAATGAAACTATTGTTCACATCAATCCATGTGGAAATTTTGTAATTGG
TGGACCACAAGGTGATGCAGGTTTAACTGGACGCAAAATTATTGTCGATACCTATGGCGG
ATGGGGAGCTCATGGTGGTGGAGCATTTTCAGGAAAGGACTTTACAAAGGTCGATCGCTC
TGCTGCTTATGCTGCTCGTTGGGTTGCAAAATCATTGGTCAAAGCTGGTGTTTGCAGAAG
ATGCTTGGTTCAAGTAAGCTACGCCATTGGTGTCGCTGAACCATTGTCAATAACAGTCTT
TGACTATGGAACATCAAGTTATACACAAAAACAACTTTTGGAAATCATTAAAAAGAACTT
TGATCTTCGCCCAGGCAAAATTGTTAATGACTTAAATTTGCGCACACCATTTTACCAACA
AACAAGCACATATGGTCATTTTGGTCGTGAAGGTTTTCCATGGGAAAAACCAAAGACATT
GATTCTTGAATGACTGCCGCAACTTGTTGTTTCAGATGCATCCGAAAGTGATGATGAAAA
TCCCAATTGTTCTAAAAAAATTAAATTAGCATAAGCCCACAAACAACATACTAAAAATTT
TAAAATATGGTTCTTAAAAATTCCCCACATGACGTTTAAAAAAATTAACATAGGACGTGA
CAAAAAGTTTAAATTCCTTTTAGTTTTATCCTCTATAAAAATAGTCCATTTTCATGGGAT
TTTTGAATATTTTTCTTTATCGAGAAATCTACAAACATAACTTTTTAGAAATACTTTTTT
ACTATCTTTAGTTGTTTAAGTAAATGTTCTACTACCTAACTCTTTTTTTTTGTTAGTAGT
TGCTTCTCAAAAAAACTTATAACTTTATCATAAAAGCTATTACATGATTAATGAGAAGAT
AAAAAAAATCAAAAAACCTTTGCTATTAGAGAAAGAGTG
>g2506.t37 Gene=g2506 Length=290
MVCLEQQSPNIADGVHVNRNVEDIGAGDQGLMFGYATDETEECMPLTVVLAHRLNQKIAE
LRRSGVLSWARPDSKTQVTAEYIFQKGACIPKRVHTVVVSLQHSEKVTLEELRKEITEKV
VRVVIPEKYLDNETIVHINPCGNFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKD
FTKVDRSAAYAARWVAKSLVKAGVCRRCLVQVSYAIGVAEPLSITVFDYGTSSYTQKQLL
EIIKKNFDLRPGKIVNDLNLRTPFYQQTSTYGHFGREGFPWEKPKTLILE
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 12 | g2506.t37 | CDD | cd18079 | S-AdoMet_synt | 1 | 285 | 0.0 |
| 10 | g2506.t37 | Gene3D | G3DSA:3.30.300.10 | - | 25 | 146 | 2.4E-47 |
| 9 | g2506.t37 | Gene3D | G3DSA:3.30.300.10 | - | 164 | 290 | 6.1E-53 |
| 3 | g2506.t37 | PANTHER | PTHR11964:SF11 | S-ADENOSYLMETHIONINE SYNTHASE ISOFORM TYPE-1 | 1 | 288 | 1.1E-154 |
| 4 | g2506.t37 | PANTHER | PTHR11964 | S-ADENOSYLMETHIONINE SYNTHETASE | 1 | 288 | 1.1E-154 |
| 1 | g2506.t37 | Pfam | PF02772 | S-adenosylmethionine synthetase, central domain | 24 | 144 | 7.5E-45 |
| 2 | g2506.t37 | Pfam | PF02773 | S-adenosylmethionine synthetase, C-terminal domain | 146 | 283 | 3.0E-68 |
| 7 | g2506.t37 | ProSitePatterns | PS00376 | S-adenosylmethionine synthase signature 1. | 25 | 35 | - |
| 8 | g2506.t37 | ProSitePatterns | PS00377 | S-adenosylmethionine synthase signature 2. | 172 | 180 | - |
| 6 | g2506.t37 | SUPERFAMILY | SSF55973 | S-adenosylmethionine synthetase | 22 | 145 | 8.63E-50 |
| 5 | g2506.t37 | SUPERFAMILY | SSF55973 | S-adenosylmethionine synthetase | 146 | 286 | 1.84E-66 |
| 11 | g2506.t37 | TIGRFAM | TIGR01034 | metK: methionine adenosyltransferase | 2 | 287 | 3.1E-131 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005524 | ATP binding | MF |
| GO:0004478 | methionine adenosyltransferase activity | MF |
| GO:0006556 | S-adenosylmethionine biosynthetic process | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
