General information for g2619.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Leishmanolysin-like peptidase.
Parent gene
- The parent gene g2619 is located on chr_3: 19148907..19150306 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2619 | g2619.t1 | TTS | g2619.t1 | 19142145 | 19142145 |
| chr_3 | g2619 | g2619.t1 | isoform | g2619.t1 | 19142572 | 19148118 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon1 | 19142572 | 19143081 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS1 | 19142572 | 19143081 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon2 | 19143141 | 19143323 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS2 | 19143141 | 19143323 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon3 | 19143404 | 19143440 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS3 | 19143404 | 19143440 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon4 | 19143497 | 19143614 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS4 | 19143497 | 19143614 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon5 | 19143687 | 19143794 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS5 | 19143687 | 19143794 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon6 | 19143860 | 19144047 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS6 | 19143860 | 19144047 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon7 | 19144113 | 19144347 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS7 | 19144113 | 19144347 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon8 | 19144412 | 19144609 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS8 | 19144412 | 19144609 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon9 | 19144692 | 19144839 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS9 | 19144692 | 19144839 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon10 | 19144918 | 19144948 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS10 | 19144918 | 19144948 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon11 | 19145248 | 19145351 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS11 | 19145248 | 19145351 |
| chr_3 | g2619 | g2619.t1 | exon | g2619.t1.exon12 | 19147969 | 19148118 |
| chr_3 | g2619 | g2619.t1 | cds | g2619.t1.CDS12 | 19147969 | 19148118 |
| chr_3 | g2619 | g2619.t1 | TSS | g2619.t1 | 19148288 | 19148288 |
Sequences
>g2619.t1 Gene=g2619 Length=2010
ATGGAAAAATATCAAATTAGAAAATTGTGCAATTTAAATTTGTGGATTTTAGTGCTGTGT
ATTGAGTTCATAAGTTTCAATAATGTAGTATCTCTGACAGTAGATCATTCTCATCAACAT
TGCAATCATCAACATCCAAAAGCTCATGAGGTGATTCATGGAGCGAGTTTAAGTGAACCG
GAACATATCATTAGAAAACGCAGCATCGATCAAAAATTGCGTATCTTGATGTTTTACGAT
GATTCCGTCTACAGATTGGATGAAGAAAAATTTTCATTAATAAATAATACAATATTACCA
GAAGCAGTGAGTTTCTGGGAGCAAGCGTTGTACGTGCGTGAGACTAAAGAGGCAATAAGA
CTGAATCGAAAATGTGAAAGCTCACAAGTTTTCATTAAAAACTCACTGACCCACTGCATA
GACAGCTGCAAAGCTGTCACCATGTGTGGAGAAATTCAAGTACCAGACGAACACTTGGAT
GTTTGCCGTGTATGTAATGCAACCGGTCAAAATTGTCGAATCGATTCAAATTCTCGTGCT
GGTCGTGGTATAAGAAATGCAGATTTTGTATTTTATGTGAGCGCACGTCAAACTGAGCGA
TGTCATAAAGGCTTGACAGTTGGTTATGCCGCACATTGTCAGCAAGAATCTTCACTTGAT
CGTCCAATCGCAGGTCATGCAAATTTATGCCCAGACTCTATTAGTACTAAACCACAAGAA
TTGAGCACGTTGTTGAGCACAGTCAAGCATGAAATTTTGCATGCTCTTGGATTTTCTGTT
AGTCTTTATGCATTCTTTCGTGACGAACACGGAAAACCACGAACGCCTAGAAAGCCGGAC
ACTAACAAGCCTTATCTAAACGAAAAATTACAAATACATCAATGGAGTGAGGCGACAATA
AAAAGAGTTGTAAGAGATCAATGGGAGGTTAAAGGTGGATTAATCAAAAAAACAATCGAT
ATGATGGTCACTCCACGAGTTGTTGAGGAAGTTCGAAAACATTTCAACTGTTCAGAGCTG
GAAGGAGCTGAGTTGGAAGATCAAGGCGGGGAAGGAACTGCTTTGACGCACTGGGAGAAA
AGAGTTTTTGAAAGCGAAGCAATGAGCGGAACACATTCATCGAGACCAGTATTTTCAAGA
ATCACATTGGCGTTAATGGAAGATACTGGTTGGTATAAAGCAAATTATGAGATGGCATCG
GAATTGACTTGGGGCAAAAATATGGGGTGTGACTTTGTAATGAAAAGCTGCAAATCATGG
ATTACATCACGACATAAAAACGGACATTCTATTCATCCATTTTGCTCTAAAGTGAAGCAT
GATCCACTACAGACTGAATGTACAGATGATCGCAACTCTGTTGCATTGTGTAATTTAGTC
AGACACGATTATCCACTGCCACGCGAATATCAAAATTTCGATAGCTTAACTCATGTACAA
GATAATTTAGAGTTCTATGGAGGAAGTGTTTCTTTAGCAGATTATTGTGCTTACGTTCAA
GAATTCACATGGAGAAGTAAAAATGTGATCGTACGAGGTTCACAATGTAAATTTGAAGAA
AATAATCCAAATCCAGATAAAAATTTTGCAATGGAGAGATATGGACCACATTCGAAATGT
TTTGAGCACACAAACAAAATGTGGGAAGAAAGATCATGTTTCCAAACGAGAGAATGGCAG
CACTTCGGAAGTGGATGTTATAAATACTCGTGCCTAAATGGAAGAGTTCACATTCATGTT
GGCAATTATACTTATGAATGTTATAGATCTGGTCAAGAAATACAAGTTAAGATATTTGAG
AGTGGTTGGCTGAAAATGGGAGCTATTGTCTGCCCATCATGCAACGAAATTTGTGGTGAA
GAACTCGAATCAATTGGTGTTAAATGCAAAGAACCCGAAAACATTCCAATACATTATTCA
TATCCCAAAGATTCACTTCATTGCAATACAGTTGCCATTTTACCAAGTGTTTTGATTATT
ATAGCTGCCTACATTTTTACAAAACTGTAA
>g2619.t1 Gene=g2619 Length=669
MEKYQIRKLCNLNLWILVLCIEFISFNNVVSLTVDHSHQHCNHQHPKAHEVIHGASLSEP
EHIIRKRSIDQKLRILMFYDDSVYRLDEEKFSLINNTILPEAVSFWEQALYVRETKEAIR
LNRKCESSQVFIKNSLTHCIDSCKAVTMCGEIQVPDEHLDVCRVCNATGQNCRIDSNSRA
GRGIRNADFVFYVSARQTERCHKGLTVGYAAHCQQESSLDRPIAGHANLCPDSISTKPQE
LSTLLSTVKHEILHALGFSVSLYAFFRDEHGKPRTPRKPDTNKPYLNEKLQIHQWSEATI
KRVVRDQWEVKGGLIKKTIDMMVTPRVVEEVRKHFNCSELEGAELEDQGGEGTALTHWEK
RVFESEAMSGTHSSRPVFSRITLALMEDTGWYKANYEMASELTWGKNMGCDFVMKSCKSW
ITSRHKNGHSIHPFCSKVKHDPLQTECTDDRNSVALCNLVRHDYPLPREYQNFDSLTHVQ
DNLEFYGGSVSLADYCAYVQEFTWRSKNVIVRGSQCKFEENNPNPDKNFAMERYGPHSKC
FEHTNKMWEERSCFQTREWQHFGSGCYKYSCLNGRVHIHVGNYTYECYRSGQEIQVKIFE
SGWLKMGAIVCPSCNEICGEELESIGVKCKEPENIPIHYSYPKDSLHCNTVAILPSVLII
IAAYIFTKL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 7 | g2619.t1 | Gene3D | G3DSA:3.10.170.20 | - | 144 | 255 | 9.0E-16 |
| 6 | g2619.t1 | Gene3D | G3DSA:3.90.132.10 | Leishmanolysin | 294 | 417 | 3.3E-43 |
| 5 | g2619.t1 | Gene3D | G3DSA:2.10.55.10 | Leishmanolysin domain 3 | 426 | 500 | 4.3E-7 |
| 2 | g2619.t1 | PANTHER | PTHR10942 | LEISHMANOLYSIN-LIKE PEPTIDASE | 32 | 628 | 7.9E-98 |
| 1 | g2619.t1 | Pfam | PF01457 | Leishmanolysin | 148 | 620 | 3.8E-62 |
| 8 | g2619.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 1 | 11 | - |
| 11 | g2619.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 12 | 34 | - |
| 10 | g2619.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 35 | 649 | - |
| 12 | g2619.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 650 | 667 | - |
| 9 | g2619.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 668 | 669 | - |
| 4 | g2619.t1 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 37 | 623 | 4.55E-139 |
| 3 | g2619.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 12 | 34 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0007155 | cell adhesion | BP |
| GO:0006508 | proteolysis | BP |
| GO:0004222 | metalloendopeptidase activity | MF |
KEGG
Orthology
- This transcript has been annotated with K13539 (leishmanolysin-like peptidase [EC:3.4.24.-])
Pathway
This gene does not belong to any pathways.
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
