General information for g2619.t2
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Leishmanolysin-like peptidase.
Parent gene
- The parent gene g2619 is located on chr_3: 19148907..19150306 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2619 | g2619.t2 | TTS | g2619.t2 | 19142145 | 19142145 |
| chr_3 | g2619 | g2619.t2 | isoform | g2619.t2 | 19142572 | 19149730 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon1 | 19142572 | 19143081 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS1 | 19142572 | 19143081 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon2 | 19143141 | 19143323 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS2 | 19143141 | 19143323 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon3 | 19143404 | 19143440 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS3 | 19143404 | 19143440 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon4 | 19143497 | 19143614 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS4 | 19143497 | 19143614 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon5 | 19143687 | 19143794 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS5 | 19143687 | 19143794 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon6 | 19143860 | 19144047 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS6 | 19143860 | 19144047 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon7 | 19144113 | 19144347 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS7 | 19144113 | 19144347 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon8 | 19144412 | 19144609 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS8 | 19144412 | 19144609 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon9 | 19144692 | 19144839 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS9 | 19144692 | 19144839 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon10 | 19144918 | 19144948 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS10 | 19144918 | 19144948 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon11 | 19145248 | 19145351 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS11 | 19145248 | 19145351 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon12 | 19148552 | 19148597 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS12 | 19148552 | 19148597 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon13 | 19148911 | 19149073 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS13 | 19148911 | 19149073 |
| chr_3 | g2619 | g2619.t2 | exon | g2619.t2.exon14 | 19149133 | 19149730 |
| chr_3 | g2619 | g2619.t2 | cds | g2619.t2.CDS14 | 19149133 | 19149730 |
| chr_3 | g2619 | g2619.t2 | TSS | g2619.t2 | 19149957 | 19149957 |
Sequences
>g2619.t2 Gene=g2619 Length=2667
ATGGCAAAGTATCAAATTGTTATGGTCAGACATGGTGAGAGTGAGTGGAATCAACTCAAT
TTGTTTTGCGGTTGGTTCAATGCTGACTTAAGTGATAAGGGTCGACAAGAGGCAATTGAC
GCAGGAAAGGCTATTAAAGAAGCTGGTCTCAAGTTTGATATCGCTCATACATCAGTTTTG
AAGCGTGCAAATTTGACACTCGACTCAATCCTTAAAGAATCTGGTCAAACTGGAATTCCC
ATTTACAAGACATGGCGTTTAAATGAACGTCACTATGGTGGTTTGACTGGCATGAATAAG
GCTGAGACTGCTGAAAAGTATGGTGAGGAACAAGTTAAGATCTGGCGTCGATCTTACGAT
ATTCCACCACCACCAATGGAAGAAGATCATAAATATTATAAAACAATTGTCGAAGATCCA
ATCTATGCTGATGGTCCCTCAAAAGATGAATTCCCTAAATTCGAGTCTTTGAAACTTACT
ATTCAGCGAACACTCCCATATTGGAATGAGACCATTATTCCTCAATTGAAGGAAGGCAAG
AAAATTATTATTGCTGCTCACGGTAACAGCTTGAGAGGCATTGTTAAACATCTTGATCAA
ATGTCTGATGAGGCTATTATGGGTTTGAATTTGCCAACTGGAATTCCATTTGTTTATGAG
CTGGATGAGAACTTCAAACCAGTTGTCTCAATGAAATTCTTGGGTGATGAAGAAACAGTA
AGAAAAGCTATGGAGAGCGTTGCCAACCAAGGCAAAGCTAAATACCAAACATATATTATG
ACGCCTTTTTTCAACATCATTACAAAGGTGATTCATGGAGCGAGTTTAAGTGAACCGGAA
CATATCATTAGAAAACGCAGCATCGATCAAAAATTGCGTATCTTGATGTTTTACGATGAT
TCCGTCTACAGATTGGATGAAGAAAAATTTTCATTAATAAATAATACAATATTACCAGAA
GCAGTGAGTTTCTGGGAGCAAGCGTTGTACGTGCGTGAGACTAAAGAGGCAATAAGACTG
AATCGAAAATGTGAAAGCTCACAAGTTTTCATTAAAAACTCACTGACCCACTGCATAGAC
AGCTGCAAAGCTGTCACCATGTGTGGAGAAATTCAAGTACCAGACGAACACTTGGATGTT
TGCCGTGTATGTAATGCAACCGGTCAAAATTGTCGAATCGATTCAAATTCTCGTGCTGGT
CGTGGTATAAGAAATGCAGATTTTGTATTTTATGTGAGCGCACGTCAAACTGAGCGATGT
CATAAAGGCTTGACAGTTGGTTATGCCGCACATTGTCAGCAAGAATCTTCACTTGATCGT
CCAATCGCAGGTCATGCAAATTTATGCCCAGACTCTATTAGTACTAAACCACAAGAATTG
AGCACGTTGTTGAGCACAGTCAAGCATGAAATTTTGCATGCTCTTGGATTTTCTGTTAGT
CTTTATGCATTCTTTCGTGACGAACACGGAAAACCACGAACGCCTAGAAAGCCGGACACT
AACAAGCCTTATCTAAACGAAAAATTACAAATACATCAATGGAGTGAGGCGACAATAAAA
AGAGTTGTAAGAGATCAATGGGAGGTTAAAGGTGGATTAATCAAAAAAACAATCGATATG
ATGGTCACTCCACGAGTTGTTGAGGAAGTTCGAAAACATTTCAACTGTTCAGAGCTGGAA
GGAGCTGAGTTGGAAGATCAAGGCGGGGAAGGAACTGCTTTGACGCACTGGGAGAAAAGA
GTTTTTGAAAGCGAAGCAATGAGCGGAACACATTCATCGAGACCAGTATTTTCAAGAATC
ACATTGGCGTTAATGGAAGATACTGGTTGGTATAAAGCAAATTATGAGATGGCATCGGAA
TTGACTTGGGGCAAAAATATGGGGTGTGACTTTGTAATGAAAAGCTGCAAATCATGGATT
ACATCACGACATAAAAACGGACATTCTATTCATCCATTTTGCTCTAAAGTGAAGCATGAT
CCACTACAGACTGAATGTACAGATGATCGCAACTCTGTTGCATTGTGTAATTTAGTCAGA
CACGATTATCCACTGCCACGCGAATATCAAAATTTCGATAGCTTAACTCATGTACAAGAT
AATTTAGAGTTCTATGGAGGAAGTGTTTCTTTAGCAGATTATTGTGCTTACGTTCAAGAA
TTCACATGGAGAAGTAAAAATGTGATCGTACGAGGTTCACAATGTAAATTTGAAGAAAAT
AATCCAAATCCAGATAAAAATTTTGCAATGGAGAGATATGGACCACATTCGAAATGTTTT
GAGCACACAAACAAAATGTGGGAAGAAAGATCATGTTTCCAAACGAGAGAATGGCAGCAC
TTCGGAAGTGGATGTTATAAATACTCGTGCCTAAATGGAAGAGTTCACATTCATGTTGGC
AATTATACTTATGAATGTTATAGATCTGGTCAAGAAATACAAGTTAAGATATTTGAGAGT
GGTTGGCTGAAAATGGGAGCTATTGTCTGCCCATCATGCAACGAAATTTGTGGTGAAGAA
CTCGAATCAATTGGTGTTAAATGCAAAGAACCCGAAAACATTCCAATACATTATTCATAT
CCCAAAGATTCACTTCATTGCAATACAGTTGCCATTTTACCAAGTGTTTTGATTATTATA
GCTGCCTACATTTTTACAAAACTGTAA
>g2619.t2 Gene=g2619 Length=888
MAKYQIVMVRHGESEWNQLNLFCGWFNADLSDKGRQEAIDAGKAIKEAGLKFDIAHTSVL
KRANLTLDSILKESGQTGIPIYKTWRLNERHYGGLTGMNKAETAEKYGEEQVKIWRRSYD
IPPPPMEEDHKYYKTIVEDPIYADGPSKDEFPKFESLKLTIQRTLPYWNETIIPQLKEGK
KIIIAAHGNSLRGIVKHLDQMSDEAIMGLNLPTGIPFVYELDENFKPVVSMKFLGDEETV
RKAMESVANQGKAKYQTYIMTPFFNIITKVIHGASLSEPEHIIRKRSIDQKLRILMFYDD
SVYRLDEEKFSLINNTILPEAVSFWEQALYVRETKEAIRLNRKCESSQVFIKNSLTHCID
SCKAVTMCGEIQVPDEHLDVCRVCNATGQNCRIDSNSRAGRGIRNADFVFYVSARQTERC
HKGLTVGYAAHCQQESSLDRPIAGHANLCPDSISTKPQELSTLLSTVKHEILHALGFSVS
LYAFFRDEHGKPRTPRKPDTNKPYLNEKLQIHQWSEATIKRVVRDQWEVKGGLIKKTIDM
MVTPRVVEEVRKHFNCSELEGAELEDQGGEGTALTHWEKRVFESEAMSGTHSSRPVFSRI
TLALMEDTGWYKANYEMASELTWGKNMGCDFVMKSCKSWITSRHKNGHSIHPFCSKVKHD
PLQTECTDDRNSVALCNLVRHDYPLPREYQNFDSLTHVQDNLEFYGGSVSLADYCAYVQE
FTWRSKNVIVRGSQCKFEENNPNPDKNFAMERYGPHSKCFEHTNKMWEERSCFQTREWQH
FGSGCYKYSCLNGRVHIHVGNYTYECYRSGQEIQVKIFESGWLKMGAIVCPSCNEICGEE
LESIGVKCKEPENIPIHYSYPKDSLHCNTVAILPSVLIIIAAYIFTKL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 15 | g2619.t2 | CDD | cd07067 | HP_PGM_like | 5 | 229 | 1.53751E-41 |
| 8 | g2619.t2 | Gene3D | G3DSA:3.40.50.1240 | - | 1 | 263 | 1.2E-83 |
| 11 | g2619.t2 | Gene3D | G3DSA:3.10.170.20 | - | 363 | 474 | 1.3E-15 |
| 10 | g2619.t2 | Gene3D | G3DSA:3.90.132.10 | Leishmanolysin | 513 | 636 | 5.0E-43 |
| 9 | g2619.t2 | Gene3D | G3DSA:2.10.55.10 | Leishmanolysin domain 3 | 645 | 719 | 6.3E-7 |
| 5 | g2619.t2 | Hamap | MF_01039 | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [gpmA]. | 3 | 234 | 41.557571 |
| 3 | g2619.t2 | PANTHER | PTHR11931:SF8 | PHOSPHOGLYCERATE MUTASE 2 | 2 | 254 | 8.5E-119 |
| 4 | g2619.t2 | PANTHER | PTHR11931 | PHOSPHOGLYCERATE MUTASE | 2 | 254 | 8.5E-119 |
| 1 | g2619.t2 | Pfam | PF00300 | Histidine phosphatase superfamily (branch 1) | 6 | 128 | 1.5E-24 |
| 2 | g2619.t2 | Pfam | PF01457 | Leishmanolysin | 367 | 839 | 7.4E-62 |
| 13 | g2619.t2 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 1 | 868 | - |
| 14 | g2619.t2 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 869 | 886 | - |
| 12 | g2619.t2 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 887 | 888 | - |
| 16 | g2619.t2 | ProSitePatterns | PS00175 | Phosphoglycerate mutase family phosphohistidine signature. | 8 | 17 | - |
| 17 | g2619.t2 | SMART | SM00855 | PGAM_5 | 5 | 194 | 1.9E-18 |
| 6 | g2619.t2 | SUPERFAMILY | SSF53254 | Phosphoglycerate mutase-like | 4 | 242 | 3.46E-71 |
| 7 | g2619.t2 | SUPERFAMILY | SSF55486 | Metalloproteases (zincins), catalytic domain | 283 | 842 | 8.07E-139 |
| 18 | g2619.t2 | TIGRFAM | TIGR01258 | pgm_1: phosphoglycerate mutase 1 family | 5 | 252 | 2.0E-110 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0016020 | membrane | CC |
| GO:0004222 | metalloendopeptidase activity | MF |
| GO:0006096 | glycolytic process | BP |
| GO:0003824 | catalytic activity | MF |
| GO:0016868 | intramolecular transferase activity, phosphotransferases | MF |
| GO:0007155 | cell adhesion | BP |
| GO:0004619 | phosphoglycerate mutase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
- This transcript has been annotated with K13539 (leishmanolysin-like peptidase [EC:3.4.24.-])
Pathway
This gene does not belong to any pathways.
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
