General information for g2627.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Probable multidrug resistance-associated protein lethal(2)03659.
Parent gene
- The parent gene g2627 is located on chr_3: 19176518..19180530 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2627 | g2627.t1 | TTS | g2627.t1 | 19175104 | 19175104 |
| chr_3 | g2627 | g2627.t1 | isoform | g2627.t1 | 19176106 | 19180530 |
| chr_3 | g2627 | g2627.t1 | exon | g2627.t1.exon1 | 19176106 | 19177025 |
| chr_3 | g2627 | g2627.t1 | cds | g2627.t1.CDS1 | 19176106 | 19177025 |
| chr_3 | g2627 | g2627.t1 | exon | g2627.t1.exon2 | 19178416 | 19178581 |
| chr_3 | g2627 | g2627.t1 | cds | g2627.t1.CDS2 | 19178416 | 19178581 |
| chr_3 | g2627 | g2627.t1 | exon | g2627.t1.exon3 | 19178648 | 19178920 |
| chr_3 | g2627 | g2627.t1 | cds | g2627.t1.CDS3 | 19178648 | 19178920 |
| chr_3 | g2627 | g2627.t1 | exon | g2627.t1.exon4 | 19178981 | 19179140 |
| chr_3 | g2627 | g2627.t1 | cds | g2627.t1.CDS4 | 19178981 | 19179140 |
| chr_3 | g2627 | g2627.t1 | exon | g2627.t1.exon5 | 19179200 | 19180530 |
| chr_3 | g2627 | g2627.t1 | cds | g2627.t1.CDS5 | 19179200 | 19180530 |
| chr_3 | g2627 | g2627.t1 | TSS | g2627.t1 | NA | NA |
Sequences
>g2627.t1 Gene=g2627 Length=2850
ATGTCTATGGTTCACTTTTGGCCTCTAGCCATAACATTCTGTGCTGAGGGCTATGTTTCA
GCAAAACGTCTTCAAGAATTTTTATTAATGCCTGAACACAAGAAGCGACCATTAATGTTA
TTGAATAAGAATGAAAAAGAGAAAGAAGAATCGAAAATTTCTTCAGCAGCAAAAAGAATT
CACAATGAAATCTCGAGCAACACAAATGCAATAATTTTCAAAGACCTCTCAGCTGACTGG
ATAAATGGTGATCTTGAGTGTGTAACGGGTTTGAAGGAAATTAATTACAAGTTTAAGCGT
GGTAACACTTATGCAGTGATTGGATCTGTTGGTTCTGGCAAGAGTTCATTGTTGCAAGCA
ATTCTTGGAGAATTAGAAATTGACTCAGGCACAATTGAAATTTTTGGAACTATTAGTTAT
GCAAATCAAGAAGCTTTTCTATTCGAAGGTACTGTACGTAGCAACATCTTGTTCAAAGAA
AGCTTTGATGAGAACAAATATGCTAAAGTAACTGCAGCGTGTGGGTTGCTAAAAGATTTT
GAACAACTCGAGAAAGGCGACTTGACTGTCGTGGGTGAAAAAGGAGTTTCGTTAAGTGGC
GGACAGAAGGCGAGAATAAACCTTGCAAGAGCAGTGTATAGAGAAGCTGACATATATTTG
CTTGACGACATTCTCAGTGCTGTTGATGCTCATGTAGGTTCACATATTTTCAATGAGTGC
ATAATGGAATATTTAAAAAATAAAACAGTTATTCTTGTGAGCCACCAACTTCAATATTTG
CATAAAATTGAAGATATCATTGTACTTGCAGATGGGCAAATTAAAGCTAGTGGAAGTTAT
AATGAATTAAAACATAAAGAAATTGCTAATCTGTTGCCAGTTGAAAGTAATAACGATAAG
AATGAAAATGAAAGTGAAAAATTCTTTGAAGAACTAACAAAACATCTCAATCAAAAACCA
GAAGAATCTGAATCTTATAATGAAAAAGAATCACAAGAAATCGGAACTGTTCGATTTGAA
ATATATAAAAACTATATGAAAGCAATTCAAAATGTACCACTTGTGATTTTTGTACTTTTC
CTTCGAGTGCTCAACCAGTCGATTGCATCATTTATCGATTATTTTGTCTCACAATGGGTC
AATTGGGAAGAATCTGTGGCAAGAGTATCCAATACGACGACAATTGTAAATGATACGCAG
ATAGAGAATTATGAAGAAAATGAAATTAATGATAAACGACAGTGGTTCATTAATGTCTAT
ATTGGAATCATCTGCATTTTTATTGTTGTCATTTTAAAGGCAGAATTTTCATTCTTTTAC
TCTTTGCTGAGAGCATCACAAAATCTGCATAATATGATGTTTAATGGCTTAATCAATACT
TATACACAATTTTTCAATCAAAATCCTTCAGGAAGAATTCTCAATCGATTTTCAAAGGAT
ATTGGTAGTATTGACACACAATTGCCTAATGTCATGTTTGAATGTATTTGTTTTGTGCTT
GAATTTTTCGCTATTATGATTCTTGTGTCACTTGTCAATGTTTATTTTGTAATTCCTACC
TTAATTATGGTAGTTATTCTTATTGGTATGCGACATATTTATGTAAGTACATCGAGAAAC
ATTAAGAGAGTTGAGAGCATCTCTAAATCACCAATTTTCGCACATACAAATGCAACTTTG
CAAGGTTTAAGTACAATAAGAGCTTTAAAGGCAGAAAATGCAGTTATCGAGAATTTCAAT
TACTATGTCGATCATAATACCTCAGCATGGTTCTCTTATTGGACAGTTACGAGAGCATTC
GCTTTTTGGCTCGACATCGTTTGTATACTTTATATTGCAATCATCACTTTCTCATTTGTT
GAAATGAATGTCGAAAATGTACCTGGAGGAAATGTGGGACTTGCAATTACACAAATTATC
GGATTAATTGGAATGCTACAATGGGGCATCCGTCAGACCAGTGAACTTGAAAATCAAATG
GTCTGTGTAGAACGAGTTATGGAGTATGCAAATTTGCCATCAGAAATGAAAAATGAAAAA
GCTCCACCGGCAAATTGGCCATCAAATGGTGAAGTTGAGTTTGATAATCTTTCACTTTAT
TATAAAAATGAAGAATGCAAGGCTTCAATTAGTAACTTGAGCATTAAGATTAAACCACAA
GAAAAAGTTGGCATAGTTGGTCGTACAGGCAGCGGAAAATCGTCAATAATTCAAGCACTT
TTTAGAATGACAAGAATTGAAGGTAGCATAAAAATTGATGGAATCGACACTCAACAAATT
GACCTCTACAACCTTCGCAAAAACATTTCAATAATTCCTCAAGAACCAGTACTTTTCAGC
GGTTCGTTACGTTTTAATTTGGATGCTTTTAACGAAAATTCAGACGATGCAATTTGGAAA
GCACTCGAACTAGTTGAACTGAAAGAGACAATAAAAGCGTTAACTGGTGGATTGGAATGT
AAAATTTCTGATGGTGGCAGCAATTTCTCTGTTGGTCAGCGACAACTTATTTGCCTAGCT
CGAGCTTTATTACGAAAGAATAAAATTTTAGTTTTGGATGAAGCGACAGCAAATGTAGAT
TATGAAACGGACAAACTTATTCAAAAAACAATTAGCACAGAATTCGCAGACTGCACTTTA
ATTGTTATCGCACATCGATTAAATACTGTCATACATTCAGATAAAATTCTCGTCATGGAG
GGCGGCAATCTTGTTGAATTTGATCATCCTTATAATCTACTTAAAAATGAAAATGGATTC
TTGCGGAAACTTGTCAATCAGACGTCTCTATCATTAATAGATGAAGCTGAAAAAAGCTAT
CAGGAACAAGAATCAAAAAAACTTAAATAG
>g2627.t1 Gene=g2627 Length=949
MSMVHFWPLAITFCAEGYVSAKRLQEFLLMPEHKKRPLMLLNKNEKEKEESKISSAAKRI
HNEISSNTNAIIFKDLSADWINGDLECVTGLKEINYKFKRGNTYAVIGSVGSGKSSLLQA
ILGELEIDSGTIEIFGTISYANQEAFLFEGTVRSNILFKESFDENKYAKVTAACGLLKDF
EQLEKGDLTVVGEKGVSLSGGQKARINLARAVYREADIYLLDDILSAVDAHVGSHIFNEC
IMEYLKNKTVILVSHQLQYLHKIEDIIVLADGQIKASGSYNELKHKEIANLLPVESNNDK
NENESEKFFEELTKHLNQKPEESESYNEKESQEIGTVRFEIYKNYMKAIQNVPLVIFVLF
LRVLNQSIASFIDYFVSQWVNWEESVARVSNTTTIVNDTQIENYEENEINDKRQWFINVY
IGIICIFIVVILKAEFSFFYSLLRASQNLHNMMFNGLINTYTQFFNQNPSGRILNRFSKD
IGSIDTQLPNVMFECICFVLEFFAIMILVSLVNVYFVIPTLIMVVILIGMRHIYVSTSRN
IKRVESISKSPIFAHTNATLQGLSTIRALKAENAVIENFNYYVDHNTSAWFSYWTVTRAF
AFWLDIVCILYIAIITFSFVEMNVENVPGGNVGLAITQIIGLIGMLQWGIRQTSELENQM
VCVERVMEYANLPSEMKNEKAPPANWPSNGEVEFDNLSLYYKNEECKASISNLSIKIKPQ
EKVGIVGRTGSGKSSIIQALFRMTRIEGSIKIDGIDTQQIDLYNLRKNISIIPQEPVLFS
GSLRFNLDAFNENSDDAIWKALELVELKETIKALTGGLECKISDGGSNFSVGQRQLICLA
RALLRKNKILVLDEATANVDYETDKLIQKTISTEFADCTLIVIAHRLNTVIHSDKILVME
GGNLVEFDHPYNLLKNENGFLRKLVNQTSLSLIDEAEKSYQEQESKKLK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 29 | g2627.t1 | CDD | cd03250 | ABCC_MRP_domain1 | 71 | 273 | 1.10314E-100 |
| 27 | g2627.t1 | CDD | cd18580 | ABC_6TM_ABCC_D2 | 355 | 670 | 1.47119E-94 |
| 28 | g2627.t1 | CDD | cd03244 | ABCC_MRP_domain2 | 690 | 910 | 1.48064E-124 |
| 10 | g2627.t1 | Gene3D | G3DSA:3.40.50.300 | - | 39 | 319 | 2.1E-72 |
| 11 | g2627.t1 | Gene3D | G3DSA:1.20.1560.10 | - | 321 | 676 | 1.6E-30 |
| 9 | g2627.t1 | Gene3D | G3DSA:3.40.50.300 | - | 677 | 929 | 2.6E-82 |
| 4 | g2627.t1 | PANTHER | PTHR24223 | ATP-BINDING CASSETTE SUB-FAMILY C | 3 | 928 | 0.0 |
| 5 | g2627.t1 | PANTHER | PTHR24223:SF324 | LD17001P | 3 | 928 | 0.0 |
| 2 | g2627.t1 | Pfam | PF00005 | ABC transporter | 91 | 223 | 4.6E-20 |
| 1 | g2627.t1 | Pfam | PF00664 | ABC transporter transmembrane region | 355 | 617 | 3.2E-28 |
| 3 | g2627.t1 | Pfam | PF00005 | ABC transporter | 711 | 857 | 2.9E-31 |
| 18 | g2627.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 21 | - |
| 19 | g2627.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 3 | - |
| 20 | g2627.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 4 | 15 | - |
| 26 | g2627.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 16 | 21 | - |
| 16 | g2627.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 22 | 414 | - |
| 25 | g2627.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 415 | 443 | - |
| 14 | g2627.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 444 | 490 | - |
| 23 | g2627.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 491 | 509 | - |
| 17 | g2627.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 510 | 514 | - |
| 22 | g2627.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 515 | 534 | - |
| 12 | g2627.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 535 | 599 | - |
| 24 | g2627.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 600 | 620 | - |
| 15 | g2627.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 621 | 631 | - |
| 21 | g2627.t1 | Phobius | TRANSMEMBRANE | Region of a membrane-bound protein predicted to be embedded in the membrane. | 632 | 650 | - |
| 13 | g2627.t1 | Phobius | CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm. | 651 | 949 | - |
| 34 | g2627.t1 | ProSitePatterns | PS00211 | ABC transporters family signature. | 198 | 212 | - |
| 35 | g2627.t1 | ProSitePatterns | PS00211 | ABC transporters family signature. | 829 | 843 | - |
| 40 | g2627.t1 | ProSiteProfiles | PS50893 | ATP-binding cassette, ABC transporter-type domain profile. | 71 | 296 | 22.909 |
| 38 | g2627.t1 | ProSiteProfiles | PS50929 | ABC transporter integral membrane type-1 fused domain profile. | 356 | 658 | 27.354 |
| 39 | g2627.t1 | ProSiteProfiles | PS50893 | ATP-binding cassette, ABC transporter-type domain profile. | 692 | 926 | 15.406 |
| 37 | g2627.t1 | SMART | SM00382 | AAA_5 | 100 | 281 | 1.2E-10 |
| 36 | g2627.t1 | SMART | SM00382 | AAA_5 | 719 | 903 | 8.7E-14 |
| 8 | g2627.t1 | SUPERFAMILY | SSF52540 | P-loop containing nucleoside triphosphate hydrolases | 69 | 286 | 3.2E-51 |
| 6 | g2627.t1 | SUPERFAMILY | SSF90123 | ABC transporter transmembrane region | 352 | 675 | 1.31E-46 |
| 7 | g2627.t1 | SUPERFAMILY | SSF52540 | P-loop containing nucleoside triphosphate hydrolases | 683 | 922 | 4.48E-69 |
| 31 | g2627.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 420 | 442 | - |
| 32 | g2627.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 507 | 529 | - |
| 30 | g2627.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 599 | 621 | - |
| 33 | g2627.t1 | TMHMM | TMhelix | Region of a membrane-bound protein predicted to be embedded in the membrane. | 628 | 650 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0055085 | transmembrane transport | BP |
| GO:0005524 | ATP binding | MF |
| GO:0042626 | ATPase-coupled transmembrane transporter activity | MF |
| GO:0016021 | integral component of membrane | CC |
| GO:0016887 | ATP hydrolysis activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
