General information for g2770.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Venom carboxylesterase-6.
Parent gene
- The parent gene g2770 is located on chr_3: 20091461..20093885 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2770 | g2770.t1 | TSS | g2770.t1 | 20091419 | 20091419 |
| chr_3 | g2770 | g2770.t1 | isoform | g2770.t1 | 20091461 | 20093885 |
| chr_3 | g2770 | g2770.t1 | exon | g2770.t1.exon1 | 20091461 | 20091661 |
| chr_3 | g2770 | g2770.t1 | cds | g2770.t1.CDS1 | 20091461 | 20091661 |
| chr_3 | g2770 | g2770.t1 | exon | g2770.t1.exon2 | 20092129 | 20093450 |
| chr_3 | g2770 | g2770.t1 | cds | g2770.t1.CDS2 | 20092129 | 20093450 |
| chr_3 | g2770 | g2770.t1 | exon | g2770.t1.exon3 | 20093645 | 20093885 |
| chr_3 | g2770 | g2770.t1 | cds | g2770.t1.CDS3 | 20093645 | 20093885 |
| chr_3 | g2770 | g2770.t1 | TTS | g2770.t1 | 20093958 | 20093958 |
Sequences
>g2770.t1 Gene=g2770 Length=1764
ATGGTTAAGTTGTTTTTATTATTAACATTATGTGGTTTCATTATATTGACTTACGGTCGT
ACATCTGAAAATCTTAAAGTGCAGTTACCTGATGGAAGTAGAATAATAGGAAGATATTTG
ACATCAGACAGTGGAAAAGGTATAAGAGCATTTTTAGGTGTTCCTTATGCAGAACCACCG
CTTGGAGATTTAAGATTCAAGGCTCCACAAAAGAAAAAACCATGGAATTTTGAACTCAAA
GCACATAATGATCCACCAATTTGTATTCAACGTGATCCATTTAGAAGAGATTATGAAATT
AGTGGAAGTGATGACTGTCTTTATATTAATATCTACACGCCAGAAAAAATTGAGAAACTA
CTGCCTGTAATGGTATTTTTCCACGGTGGTGGATTTATGTGTGGAAGTGGAATTAAACCA
TTCTATGGTCCTGATTATTTATTAGAACATGATGTGATTTATATTGGTGCAAATTACCGA
GTTGGGCCTCTTGGATTTCTTTCAACTGGTGATGATAATAGTCCTGGTAATTTTGGTTTA
AAAGATCAGGTATTTATATTAAAATGGATTAATGAAAATATTGAAGTTTTTGGTGGAGAT
AAGAATTTAGTGACAATATTTGGTGAATCTGCAGGAGGTGCTAGCGTCACATACCACATG
CATTCTCACCTATCTAAAGGTTTATTTCATCGAGGAATTGCTCAATCGGGAACAAATTTA
GCTCCTTGGGGAGCTGTTGCTCATCGTAATGTTGCTCAAGAAAGAGCAAAAATAATGGGT
GAAAAAATGAATTGCCCAACTCATGATAATAGCGAAATGATGGCTTGTCTTAGAAAAGCA
TCGCCTCAGAAAATTACTGAAGCATTTTATGATTACTTTAAATGGGATACTGATCCTATG
GTTCCATTTCCACCTGTCATTGAACATGAGCATGAAGGTGCATTCTTAACTGAGAATCCT
CGTTTTAAATTTGATATGCATGGAAATGATGTTCCTTTAATGACTGGAGTTACTAGTGAA
GAGGGAGTTTTAAAAACAGGTGCTTTAATTTATAATAAAGATCTCACAGCCGATTTGCTG
AAAAATTGGGAAAGAGCACTTCCAATTTCTCTCTACTATGATCATCATAATCAACAGAAA
CAAGATGAAATCACTAAAAAAATTGATGAATTTTATTTCAATAATCAAAAACTGACCTTA
GACACTCAAAAAAATTTTACGGACTTATGGACCGATGGTTGGTTCTTCCATGCGATGATT
GATTATCTTAAATTGAGATTCTCGAATGAAAAACGAGCTCCAACTTATATCTACTTATTC
ACACATAAAGGTGCAGCAAGTTTCAGTGAAATCTTCAAAGCCGGAAGTGAAACTTATTAC
GGAACAGCTCATGCTGAAGAGCTTCAATATATTTTTCCAATTAGGAAAGATCTTCATTAT
TTCTTTAATTCAATTCCTACTGAGCAAGACAAAAAAATAAGCAAAATATTAACTAAACTG
TGGGTCAACTTTGCGTATACTGGTAATCCGACACCAACAGAAGTTGAAGGTTTGATATGG
AAAGAGGCAAATGCTTTTCCATTAGATTATATGCGAATTGGTAATGAAATGAAGACAGAA
ACTAAAGGTCAAATTTTGATGTCGATAGAAAAAGACCTTAATCCTGAAAGGGCAAATTTT
TGGAATGAATTAAAAGCACATTACCCTGCTGATGATGATGATATAGAAGTTACAACACGC
AAAACAATGAAAGGAGAGCTGTAA
>g2770.t1 Gene=g2770 Length=587
MVKLFLLLTLCGFIILTYGRTSENLKVQLPDGSRIIGRYLTSDSGKGIRAFLGVPYAEPP
LGDLRFKAPQKKKPWNFELKAHNDPPICIQRDPFRRDYEISGSDDCLYINIYTPEKIEKL
LPVMVFFHGGGFMCGSGIKPFYGPDYLLEHDVIYIGANYRVGPLGFLSTGDDNSPGNFGL
KDQVFILKWINENIEVFGGDKNLVTIFGESAGGASVTYHMHSHLSKGLFHRGIAQSGTNL
APWGAVAHRNVAQERAKIMGEKMNCPTHDNSEMMACLRKASPQKITEAFYDYFKWDTDPM
VPFPPVIEHEHEGAFLTENPRFKFDMHGNDVPLMTGVTSEEGVLKTGALIYNKDLTADLL
KNWERALPISLYYDHHNQQKQDEITKKIDEFYFNNQKLTLDTQKNFTDLWTDGWFFHAMI
DYLKLRFSNEKRAPTYIYLFTHKGAASFSEIFKAGSETYYGTAHAEELQYIFPIRKDLHY
FFNSIPTEQDKKISKILTKLWVNFAYTGNPTPTEVEGLIWKEANAFPLDYMRIGNEMKTE
TKGQILMSIEKDLNPERANFWNELKAHYPADDDDIEVTTRKTMKGEL
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 8 | g2770.t1 | Gene3D | G3DSA:3.40.50.1820 | - | 10 | 569 | 1.1E-156 |
| 2 | g2770.t1 | PANTHER | PTHR11559:SF395 | CARBOXYLIC ESTER HYDROLASE | 6 | 572 | 2.2E-225 |
| 3 | g2770.t1 | PANTHER | PTHR11559 | CARBOXYLESTERASE | 6 | 572 | 2.2E-225 |
| 1 | g2770.t1 | Pfam | PF00135 | Carboxylesterase family | 27 | 561 | 8.0E-135 |
| 10 | g2770.t1 | Phobius | SIGNAL_PEPTIDE | Signal peptide region | 1 | 19 | - |
| 11 | g2770.t1 | Phobius | SIGNAL_PEPTIDE_N_REGION | N-terminal region of a signal peptide. | 1 | 3 | - |
| 12 | g2770.t1 | Phobius | SIGNAL_PEPTIDE_H_REGION | Hydrophobic region of a signal peptide. | 4 | 15 | - |
| 13 | g2770.t1 | Phobius | SIGNAL_PEPTIDE_C_REGION | C-terminal region of a signal peptide. | 16 | 19 | - |
| 9 | g2770.t1 | Phobius | NON_CYTOPLASMIC_DOMAIN | Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region. | 20 | 587 | - |
| 5 | g2770.t1 | ProSitePatterns | PS00941 | Carboxylesterases type-B signature 2. | 104 | 114 | - |
| 6 | g2770.t1 | ProSitePatterns | PS00122 | Carboxylesterases type-B serine active site. | 197 | 212 | - |
| 4 | g2770.t1 | SUPERFAMILY | SSF53474 | alpha/beta-Hydrolases | 27 | 563 | 3.17E-123 |
| 7 | g2770.t1 | SignalP_EUK | SignalP-noTM | SignalP-noTM | 1 | 19 | - |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
There are no GO annotations for this transcript.
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
