Gene loci information

Transcript annotation

  • This transcript has been annotated as Dihydrolipoyl dehydrogenase, mitochondrial.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g2842 g2842.t6 TSS g2842.t6 20511705 20511705
chr_3 g2842 g2842.t6 isoform g2842.t6 20512134 20513635
chr_3 g2842 g2842.t6 exon g2842.t6.exon1 20512134 20513361
chr_3 g2842 g2842.t6 cds g2842.t6.CDS1 20512288 20513361
chr_3 g2842 g2842.t6 exon g2842.t6.exon2 20513423 20513512
chr_3 g2842 g2842.t6 cds g2842.t6.CDS2 20513423 20513512
chr_3 g2842 g2842.t6 exon g2842.t6.exon3 20513570 20513635
chr_3 g2842 g2842.t6 cds g2842.t6.CDS3 20513570 20513635
chr_3 g2842 g2842.t6 TTS g2842.t6 20513825 20513825

Sequences

>g2842.t6 Gene=g2842 Length=1384
AGGTGGTCCAGGAGGATATGTCGCAGCAATTAAGGGCGCTCAAGTTGGACTTAACACAGT
TTGTATTGAAAAGAATGATACACTCGGTGGCACTTGTCTCAATGTTGGATGCATTCCTTC
AAAAGCTCTTCTCAACAACTCGCATTATTATCATATGGCACACTCTGGTGACCTCAATAA
TCGCGGTATCACTGTTGGAAATGTGTCATTAGACTTGGAGAAAATGATGGGTCAAAAGTC
AAACGCCGTAAAGTCACTGACCGGAGGAATTGCACAGTTATTTAAAAAGAACAAAGTTAC
ACATCTCAACGGTTGGGGACAAATCACAGGTCCAAATCAAGTTCAAGCAAAAATGAAGGA
TGGTTCAGTCGAGACAGTAAATACAAAATACATGATCATTGCTAGCGGTTCTGAAGTCAC
ACCTTTCCCAGGAGTAACAATTGATGAGGAAGTTATTGTGTCAAGTACTGGTGCTTTGAG
TTTAAAACAAGTTCCTAAGAAAATGGTCGTAATTGGAGCTGGTGTTATTGGTCTCGAATT
AGGATCAGTTTGGTCACGTCTTGGCGCAGAAGTTATTGCCGTTGAATTCTTAAATAGCAT
TGGAGGAGTTGGAATTGATGGTGAAGTATCAAAAACCTTCCAAAAAGTTCTCACAAAACA
AGGAATGCAATTTAGACTCGGTACAAAAGTGACTGGTGCACAACGTACTGGCAATGGAGC
TGTAGTCTCAGTCGAATCAGTAAAAGACGGTTCAAAGGAAGATATTGAATGTGATGTTCT
TCTTGTTTGTATTGGTCGTCGTCCATTTACAGAAGGATTAGGTCTCGAAAATGTTGGAAT
TGCAACTGACGATCGTGGTAGAATCCCTGTTAATGCAATGCTTCAAACTATTGTACCTAA
TATTCATGCAATCGGCGATGTAATTCATGGACCTATGTTGGCGCACAAAGCTGAAGATGA
GGGAATAATCTGTGTTGAAGGAATTATGGGTGGTCACGTACATCTTGATTATAATTGTGT
GCCCTCAGTTGTATATACACATCCAGAAGTTGCATGGGTTGGAAAATCTGAAGAGGATCT
GAAAAAAGAAGGAGTCGAATACAAAGTTGGCAAATTTCCATACATGGCAAACTCTCGTGC
TAAGACAAATAATGAAACAGACGGATTTGTAAAAGTTCTTGCCGACAAAGCAACAGACCG
CATTTTGGGAACACATATGATCGGACCGGGTGTGGGAGAATTAATAAATGAAGCTGTTTT
GGCTATGGAATATGGTGCATCGGCAGAAGATGTTGCACGAGTGTGTCACGCTCATCCTAC
CTGTGCTGAAGCTCTGAGAGAAGCAAATCTGGCTGCATATATCGGTAAACCAATTAACTT
CTAA

>g2842.t6 Gene=g2842 Length=409
MAHSGDLNNRGITVGNVSLDLEKMMGQKSNAVKSLTGGIAQLFKKNKVTHLNGWGQITGP
NQVQAKMKDGSVETVNTKYMIIASGSEVTPFPGVTIDEEVIVSSTGALSLKQVPKKMVVI
GAGVIGLELGSVWSRLGAEVIAVEFLNSIGGVGIDGEVSKTFQKVLTKQGMQFRLGTKVT
GAQRTGNGAVVSVESVKDGSKEDIECDVLLVCIGRRPFTEGLGLENVGIATDDRGRIPVN
AMLQTIVPNIHAIGDVIHGPMLAHKAEDEGIICVEGIMGGHVHLDYNCVPSVVYTHPEVA
WVGKSEEDLKKEGVEYKVGKFPYMANSRAKTNNETDGFVKVLADKATDRILGTHMIGPGV
GELINEAVLAMEYGASAEDVARVCHAHPTCAEALREANLAAYIGKPINF

Protein features from InterProScan

Transcript Database ID Name Start End E.value
18 g2842.t6 Gene3D G3DSA:3.50.50.60 - 2 271 0
19 g2842.t6 Gene3D G3DSA:3.50.50.60 - 89 213 0
20 g2842.t6 Gene3D G3DSA:3.30.390.30 - 286 409 0
3 g2842.t6 PANTHER PTHR22912:SF151 DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL 2 409 0
4 g2842.t6 PANTHER PTHR22912 DISULFIDE OXIDOREDUCTASE 2 409 0
7 g2842.t6 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 77 95 0
11 g2842.t6 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 80 89 0
6 g2842.t6 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 116 134 0
14 g2842.t6 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 116 141 0
8 g2842.t6 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 206 222 0
9 g2842.t6 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 207 221 0
5 g2842.t6 PRINTS PR00368 FAD-dependent pyridine nucleotide reductase signature 235 257 0
10 g2842.t6 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 250 257 0
13 g2842.t6 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 285 306 0
12 g2842.t6 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 350 365 0
15 g2842.t6 PRINTS PR00411 Pyridine nucleotide disulphide reductase class-I signature 372 392 0
1 g2842.t6 Pfam PF07992 Pyridine nucleotide-disulphide oxidoreductase 25 270 0
2 g2842.t6 Pfam PF02852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain 289 397 0
17 g2842.t6 SUPERFAMILY SSF51905 FAD/NAD(P)-binding domain 17 307 0
16 g2842.t6 SUPERFAMILY SSF55424 FAD/NAD-linked reductases, dimerisation (C-terminal) domain 285 401 0
21 g2842.t6 TIGRFAM TIGR01350 lipoamide_DH: dihydrolipoyl dehydrogenase 6 407 0

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0004148 dihydrolipoyl dehydrogenase activity MF
GO:0050660 flavin adenine dinucleotide binding MF
GO:0055114 NA NA
GO:0045454 cell redox homeostasis BP
GO:0016491 oxidoreductase activity MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.

Raw TPM values