Gene loci information

Transcript annotation

  • This transcript has been annotated as Hexokinase type 2.

Parent gene

Gene structure

  • The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.

Chromosome Gene Transcript Category ID Start End
chr_3 g2925 g2925.t11 TSS g2925.t11 21264718 21264718
chr_3 g2925 g2925.t11 isoform g2925.t11 21264957 21272795
chr_3 g2925 g2925.t11 exon g2925.t11.exon1 21264957 21264995
chr_3 g2925 g2925.t11 cds g2925.t11.CDS1 21264957 21264995
chr_3 g2925 g2925.t11 exon g2925.t11.exon2 21271023 21271185
chr_3 g2925 g2925.t11 cds g2925.t11.CDS2 21271023 21271185
chr_3 g2925 g2925.t11 exon g2925.t11.exon3 21271251 21271435
chr_3 g2925 g2925.t11 cds g2925.t11.CDS3 21271251 21271435
chr_3 g2925 g2925.t11 exon g2925.t11.exon4 21271497 21271670
chr_3 g2925 g2925.t11 cds g2925.t11.CDS4 21271497 21271670
chr_3 g2925 g2925.t11 exon g2925.t11.exon5 21272698 21272795
chr_3 g2925 g2925.t11 cds g2925.t11.CDS5 21272698 21272793
chr_3 g2925 g2925.t11 TTS g2925.t11 NA NA

Sequences

>g2925.t11 Gene=g2925 Length=659
ATGTCCAAAGGTGTAGTAATGACTAAACCAACAAAAGAGATCAAGGAAGCCTGTCAGGAG
TTGATATTGGATGACAAAACAATGAGAGAAATCATGAAGAGATTTCTTCATGAAATTCAA
CTTGGGTTAAAGAAAGAGACACATCCAGCAGCTGACATTAAGTGCTTCATAACTTACGTT
CAAGATTTGCCAAATGGAAAAGAAAAAGGCAGATTCCTTGCATTGGATTTAGGTGGTACG
AATTTCCGTGTCCTTCTTATTCATCTCAAAGGTGACAGTGAGTTCGAAATGCAATCAAAG
ATTTACGCCATCCCACAAAGTATTATGATTGGTTCGGGAACACAATTGTTTGACCATATT
GCTGAATGTCTTGCAAATTTCATCAAGGAACATAAACTTCAAAATGAACGGCTGCCATTA
GGTTTTACTTTCTCCTTCCCTCTTAAACAGTTAGGTTTAACAAAGGGTATTTTAATCAGA
TGGACTAAAGGTTTCAATTGTGAGGGAGTTGTTGATCGTGATGTCGTTGAACTGTTAGAA
GAGGCATTAAAAAGACGTGGAGATGTTTCTATTGAAATTTGTGCTATTCTTAATGATACA
ACTGGAACTCTTATGTCATGTGCCTGGAAAAATCACAACTGTAAAATCGGAGCTATTGT

>g2925.t11 Gene=g2925 Length=219
MSKGVVMTKPTKEIKEACQELILDDKTMREIMKRFLHEIQLGLKKETHPAADIKCFITYV
QDLPNGKEKGRFLALDLGGTNFRVLLIHLKGDSEFEMQSKIYAIPQSIMIGSGTQLFDHI
AECLANFIKEHKLQNERLPLGFTFSFPLKQLGLTKGILIRWTKGFNCEGVVDRDVVELLE
EALKRRGDVSIEICAILNDTTGTLMSCAWKNHNCKIGAI

Protein features from InterProScan

Transcript Database ID Name Start End E.value
9 g2925.t11 CDD cd00012 NBD_sugar-kinase_HSP70_actin 73 211 2.83884E-7
8 g2925.t11 Gene3D G3DSA:3.30.420.40 - 46 219 7.8E-75
2 g2925.t11 PANTHER PTHR19443:SF4 HEXOKINASE-2 11 219 2.7E-85
3 g2925.t11 PANTHER PTHR19443 HEXOKINASE 11 219 2.7E-85
6 g2925.t11 PRINTS PR00475 Hexokinase family signature 73 89 2.0E-28
5 g2925.t11 PRINTS PR00475 Hexokinase family signature 140 165 2.0E-28
4 g2925.t11 PRINTS PR00475 Hexokinase family signature 193 209 2.0E-28
1 g2925.t11 Pfam PF00349 Hexokinase 14 209 6.5E-73
10 g2925.t11 ProSitePatterns PS00378 Hexokinase domain signature. 140 165 -
11 g2925.t11 ProSiteProfiles PS51748 Hexokinase domain profile. 8 219 26.563
7 g2925.t11 SUPERFAMILY SSF53067 Actin-like ATPase domain 6 211 7.07E-79

Transmembrane regions from TMHMM

Disordered region

IUPRED3 score over 0.5 is predictive of a disordered region.

GO terms from InterProScan

GOID TERM ONTOLOGY
GO:0001678 cellular glucose homeostasis BP
GO:0005524 ATP binding MF
GO:0016773 phosphotransferase activity, alcohol group as acceptor MF
GO:0006096 glycolytic process BP
GO:0005975 carbohydrate metabolic process BP
GO:0005536 glucose binding MF
GO:0004396 hexokinase activity MF

KEGG

Orthology

This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).

Expression

Transcript expression in Pv11 cells

TPM values are indicated as average +/- STDEV.

Differential expression

Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed