General information for g2925.t18
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Hexokinase type 2.
Parent gene
- The parent gene g2925 is located on chr_3: 21273540..21284647 (+ strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2925 | g2925.t18 | TSS | g2925.t18 | 21264718 | 21264718 |
| chr_3 | g2925 | g2925.t18 | isoform | g2925.t18 | 21264957 | 21274282 |
| chr_3 | g2925 | g2925.t18 | exon | g2925.t18.exon1 | 21264957 | 21264995 |
| chr_3 | g2925 | g2925.t18 | exon | g2925.t18.exon2 | 21271023 | 21271180 |
| chr_3 | g2925 | g2925.t18 | cds | g2925.t18.CDS1 | 21271177 | 21271180 |
| chr_3 | g2925 | g2925.t18 | exon | g2925.t18.exon3 | 21271251 | 21271435 |
| chr_3 | g2925 | g2925.t18 | cds | g2925.t18.CDS2 | 21271251 | 21271435 |
| chr_3 | g2925 | g2925.t18 | exon | g2925.t18.exon4 | 21271497 | 21271670 |
| chr_3 | g2925 | g2925.t18 | cds | g2925.t18.CDS3 | 21271497 | 21271670 |
| chr_3 | g2925 | g2925.t18 | exon | g2925.t18.exon5 | 21272698 | 21272797 |
| chr_3 | g2925 | g2925.t18 | cds | g2925.t18.CDS4 | 21272698 | 21272797 |
| chr_3 | g2925 | g2925.t18 | exon | g2925.t18.exon6 | 21272950 | 21273142 |
| chr_3 | g2925 | g2925.t18 | cds | g2925.t18.CDS5 | 21272950 | 21273142 |
| chr_3 | g2925 | g2925.t18 | exon | g2925.t18.exon7 | 21273203 | 21273542 |
| chr_3 | g2925 | g2925.t18 | cds | g2925.t18.CDS6 | 21273203 | 21273542 |
| chr_3 | g2925 | g2925.t18 | exon | g2925.t18.exon8 | 21273600 | 21274282 |
| chr_3 | g2925 | g2925.t18 | cds | g2925.t18.CDS7 | 21273600 | 21273776 |
| chr_3 | g2925 | g2925.t18 | TTS | g2925.t18 | 21274517 | 21274517 |
Sequences
>g2925.t18 Gene=g2925 Length=1872
ATGTCCAAAGGTGTAGTAATGACTAAACCAACAAAAGAGATCAAGGAAGCCTGTCAGGAG
TTGATATTGGATGACAAAACAATGAGAGAAATCATGAAGAGATTTCTTCATGAAATTCAA
CTTGGGTTAAAGAAAGAGACACATCCAGCAGCTGACATTAAGTGCTTCATAACTTACGTT
CAAGATTTGCCAAATGGAAAAAGGCAGATTCCTTGCATTGGATTTAGGTGGTACGAATTT
CCGTGTCCTTCTTATTCATCTCAAAGGTGACAGTGAGTTCGAAATGCAATCAAAGATTTA
CGCCATCCCACAAAGTATTATGATTGGTTCGGGAACACAATTGTTTGACCATATTGCTGA
ATGTCTTGCAAATTTCATCAAGGAACATAAACTTCAAAATGAACGGCTGCCATTAGGTTT
TACTTTCTCCTTCCCTCTTAAACAGTTAGGTTTAACAAAGGGTATTTTAATCAGATGGAC
TAAAGGTTTCAATTGTGAGGGAGTTGTTGATCGTGATGTCGTTGAACTGTTAGAAGAGGC
ATTAAAAAGACGTGGAGATGTTTCTATTGAAATTTGTGCTATTCTTAATGATACAACTGG
AACTCTTATGTCATGTGCCTGGAAAAATCACAACTGTAAAATCGGAGCTATTGTTGGTAC
TGGAAGTAATGCATGTTACGTAGAGCGTGTTGAGAATGCAGAACTTTACGATGGTCCAGC
AAATGGAAAAGAATATGTGTTGATCAATACAGAGTGGGGTGCTTTTGGTGACAATGGTGC
TCTTGATTTTATTCGTACACAGTATGATCGGGAGATGGATGAATTTAGTATCAATAAAGG
AAAACAGACAGTTGAAAAGATGATTTCGGGAATGTATATGGGTGAATTAGTGAGACTTGC
ACTTGTTAGATTCACAAAAGAAGGACTTTTGTTTGGTGGACAAGGATCTGATTTACTCTT
CAAACGTTACCAATTTTTCACAAAATACGTGTCTGAAATTGAGAGCGATAAGCCTGGAAC
TTTCTTTAATTGTTATGATGTGCTTGAGGAAATTGGAATTTTCCATGCCACTGATGAGGA
CTGTGCAAATGTGAGATATATTTGCGAGTGCATTTCAAGTCGTGCTGCTCATTTATCATC
AGCTGGTATTGCCACGCTTATAAACAAAATGAATGATCCAAGTGTTACTGTCGGTGTTGA
TGGATCTGTCTATCGTTTCCATCCTAAATTCCATGATTTAATGATGGTAAAAATTCGTGA
ACTTGTTCATGATCACATTCAATTTGACATCATGCTGTCTGAAGATGGGTCTGGAAGAGG
AGCTGCTCTTGTTGCTGCTGTTGCTTCACGTGATGCACATGAATAAGACTCTTATGTGTA
ATGAGAATCTTTAAACAAAATAACTCTCGAGACGAACAATTCTGAAACGGGAGTCTAAAT
CATTTTAATTTTTAGTTGTAAGAATCAAAAAGTGTTTAAATTTTATTGTTTTGTATTAGT
TCTTAGTATGTAGTCGTATGCAATGTGGAGTGCATGGATATTTTTGTAAAAAATCTCTTG
TGAATCGCTCGATTTTGAGGTTGATGCAAAAAAAATAAATTTTTTATTATTTATTATAAT
TTTTCTTGTCGTACTCTTCATTTCAAAACAAGATCATACATATAGTTCCAACTGATAAAA
AAATATTAAAATAACCTTTTAAAGAAGCAATAACTTTAACATCCAGCCGATTACAAAAAA
TTAAAAATCAAATGAAGAGGGCAGAATCAAAAAAAAAAAAAGAGTGAATGTGGCAAAGCA
TTATATAAGAAGAGTGAAACTATGATTTTTATTAAACTGTAAGACTAGATTCTATAATTT
AGTTGCTAGATA
>g2925.t18 Gene=g2925 Length=390
MEKGRFLALDLGGTNFRVLLIHLKGDSEFEMQSKIYAIPQSIMIGSGTQLFDHIAECLAN
FIKEHKLQNERLPLGFTFSFPLKQLGLTKGILIRWTKGFNCEGVVDRDVVELLEEALKRR
GDVSIEICAILNDTTGTLMSCAWKNHNCKIGAIVGTGSNACYVERVENAELYDGPANGKE
YVLINTEWGAFGDNGALDFIRTQYDREMDEFSINKGKQTVEKMISGMYMGELVRLALVRF
TKEGLLFGGQGSDLLFKRYQFFTKYVSEIESDKPGTFFNCYDVLEEIGIFHATDEDCANV
RYICECISSRAAHLSSAGIATLINKMNDPSVTVGVDGSVYRFHPKFHDLMMVKIRELVHD
HIQFDIMLSEDGSGRGAALVAAVASRDAHE
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 16 | g2925.t18 | CDD | cd00012 | NBD_sugar-kinase_HSP70_actin | 7 | 189 | 1.70797E-8 |
| 14 | g2925.t18 | Gene3D | G3DSA:3.30.420.40 | - | 2 | 380 | 1.7E-155 |
| 15 | g2925.t18 | Gene3D | G3DSA:3.40.367.20 | - | 144 | 370 | 1.7E-155 |
| 3 | g2925.t18 | PANTHER | PTHR19443:SF4 | HEXOKINASE-2 | 2 | 387 | 6.5E-161 |
| 4 | g2925.t18 | PANTHER | PTHR19443 | HEXOKINASE | 2 | 387 | 6.5E-161 |
| 9 | g2925.t18 | PRINTS | PR00475 | Hexokinase family signature | 7 | 23 | 8.5E-72 |
| 6 | g2925.t18 | PRINTS | PR00475 | Hexokinase family signature | 74 | 99 | 8.5E-72 |
| 11 | g2925.t18 | PRINTS | PR00475 | Hexokinase family signature | 127 | 143 | 8.5E-72 |
| 5 | g2925.t18 | PRINTS | PR00475 | Hexokinase family signature | 150 | 164 | 8.5E-72 |
| 8 | g2925.t18 | PRINTS | PR00475 | Hexokinase family signature | 218 | 240 | 8.5E-72 |
| 7 | g2925.t18 | PRINTS | PR00475 | Hexokinase family signature | 300 | 322 | 8.5E-72 |
| 10 | g2925.t18 | PRINTS | PR00475 | Hexokinase family signature | 367 | 383 | 8.5E-72 |
| 2 | g2925.t18 | Pfam | PF00349 | Hexokinase | 2 | 143 | 1.4E-56 |
| 1 | g2925.t18 | Pfam | PF03727 | Hexokinase | 149 | 383 | 3.1E-83 |
| 17 | g2925.t18 | ProSitePatterns | PS00378 | Hexokinase domain signature. | 74 | 99 | - |
| 18 | g2925.t18 | ProSiteProfiles | PS51748 | Hexokinase domain profile. | 1 | 382 | 48.119 |
| 12 | g2925.t18 | SUPERFAMILY | SSF53067 | Actin-like ATPase domain | 1 | 145 | 5.18E-61 |
| 13 | g2925.t18 | SUPERFAMILY | SSF53067 | Actin-like ATPase domain | 147 | 386 | 3.44E-84 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0001678 | cellular glucose homeostasis | BP |
| GO:0005524 | ATP binding | MF |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | MF |
| GO:0006096 | glycolytic process | BP |
| GO:0005975 | carbohydrate metabolic process | BP |
| GO:0005536 | glucose binding | MF |
| GO:0004396 | hexokinase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below. There were no conditions that were differentially expressed