General information for g2993.t13
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Cathepsin B.
Parent gene
- The parent gene g2993 is located on chr_3: 21868580..21876208 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2993 | g2993.t13 | TTS | g2993.t13 | 21867629 | 21867629 |
| chr_3 | g2993 | g2993.t13 | isoform | g2993.t13 | 21867833 | 21869132 |
| chr_3 | g2993 | g2993.t13 | exon | g2993.t13.exon1 | 21867833 | 21867921 |
| chr_3 | g2993 | g2993.t13 | cds | g2993.t13.CDS1 | 21867833 | 21867921 |
| chr_3 | g2993 | g2993.t13 | exon | g2993.t13.exon2 | 21867986 | 21868355 |
| chr_3 | g2993 | g2993.t13 | cds | g2993.t13.CDS2 | 21867986 | 21868310 |
| chr_3 | g2993 | g2993.t13 | exon | g2993.t13.exon3 | 21868412 | 21868694 |
| chr_3 | g2993 | g2993.t13 | exon | g2993.t13.exon4 | 21868752 | 21868992 |
| chr_3 | g2993 | g2993.t13 | exon | g2993.t13.exon5 | 21869064 | 21869132 |
| chr_3 | g2993 | g2993.t13 | TSS | g2993.t13 | 21869220 | 21869220 |
Sequences
>g2993.t13 Gene=g2993 Length=1052
ATGAAATATTTCATATTATTTGCTGCATTGACAGCAGTTTGCTTTGGAGCTGACATTTTT
TCTGATGAATTCATCAATGAAATTAATAAAAAAGCAACAACATGGAAGGCTGGCCATAAT
TTTCATCCAGATACTAATTTGAAATATATCAAGAATTTACTTGGTGTTCATTCCGATTCT
AAGCATTTTAAACTACCTGAGTTATTGCATGACTCACGGGACATAAAAGATTTACCTGAA
AATTTTGATGCTCGTGAACAATGGCCTGATTGTCCAACATTGAGAGAAATAAGAGATCAA
GGAAGTTGTGGATCTTGTTGGGCTTTTGGCGCTGTTGAGGCAATGAGTGACAGAGTATGC
ATTCATAGCAACGCAACTGAACATTTCCACTTTTCTGCTGAACATTTGGTTTCTTGCTGT
CACACTTGTGGATTTGGTTGCAATGGTGGCTTTCCAGGATCAGGTTGTTTGACAATTTTA
AAATAAATAAATTTCAATTTATTTATTATATCTAATTTTTTTTAGCTTGGAGCTATTGGG
TTAGAAAAGGTATTGTTAGTGGTGGACCATACAATTCTTCAATTGGATGTCAGCCATATG
AAATCGCTCCTTGTGAACATCATGTCAATGGAACTCGTATGCCATGCTCTGGAGAAGGAC
ATACACCAAAATGCATGAATAAATGCTCGAATCCCGCTTATAAAGTTGATTTCAAAACAG
ACAAACACTTTGGCAAATCAAGCTATTCAGTAAAGCGTAATGAAGATCAAATTCGTTTGG
AAATTTTCAAAAATGGTCCAGTTGAAGGTGCATTCACAGTCTATGAAGATTTCGTTCAAT
ATAAATCTGGAGTTTATCAACATGTTACTGGTAAAGCACTTGGTGGCCATGCTATTAAAA
TTTTCGGATGGGGAGTTGAAAATGGTGTCAAATACTGGTTGATTGCTAATAGCTGGAATT
CAGATTGGGGTGATAATGGAACCTTCAAAATATTGCGAGGAGAAGACCATGTCGGTATTG
AGAGTGAGATTAGCGCTGGTTTGCCAAAGTAA
>g2993.t13 Gene=g2993 Length=137
MPCSGEGHTPKCMNKCSNPAYKVDFKTDKHFGKSSYSVKRNEDQIRLEIFKNGPVEGAFT
VYEDFVQYKSGVYQHVTGKALGGHAIKIFGWGVENGVKYWLIANSWNSDWGDNGTFKILR
GEDHVGIESEISAGLPK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 6 | g2993.t13 | Gene3D | G3DSA:3.90.70.10 | Cysteine proteinases | 1 | 137 | 0 |
| 2 | g2993.t13 | PANTHER | PTHR12411:SF737 | CATHEPSIN B | 9 | 134 | 0 |
| 3 | g2993.t13 | PANTHER | PTHR12411 | CYSTEINE PROTEASE FAMILY C1-RELATED | 9 | 134 | 0 |
| 1 | g2993.t13 | Pfam | PF00112 | Papain family cysteine protease | 14 | 134 | 0 |
| 5 | g2993.t13 | SMART | SM00645 | pept_c1 | 1 | 135 | 0 |
| 4 | g2993.t13 | SUPERFAMILY | SSF54001 | Cysteine proteinases | 4 | 136 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008234 | cysteine-type peptidase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
