General information for g2993.t23
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as Cathepsin B.
Parent gene
- The parent gene g2993 is located on chr_3: 21868580..21876208 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g2993 | g2993.t23 | TTS | g2993.t23 | 21867629 | 21867629 |
| chr_3 | g2993 | g2993.t23 | isoform | g2993.t23 | 21867833 | 21869132 |
| chr_3 | g2993 | g2993.t23 | exon | g2993.t23.exon1 | 21867833 | 21867921 |
| chr_3 | g2993 | g2993.t23 | cds | g2993.t23.CDS1 | 21867833 | 21867921 |
| chr_3 | g2993 | g2993.t23 | exon | g2993.t23.exon2 | 21867986 | 21868355 |
| chr_3 | g2993 | g2993.t23 | cds | g2993.t23.CDS2 | 21867986 | 21868355 |
| chr_3 | g2993 | g2993.t23 | exon | g2993.t23.exon3 | 21868417 | 21868479 |
| chr_3 | g2993 | g2993.t23 | cds | g2993.t23.CDS3 | 21868417 | 21868479 |
| chr_3 | g2993 | g2993.t23 | exon | g2993.t23.exon4 | 21868542 | 21868694 |
| chr_3 | g2993 | g2993.t23 | cds | g2993.t23.CDS4 | 21868542 | 21868562 |
| chr_3 | g2993 | g2993.t23 | exon | g2993.t23.exon5 | 21868752 | 21868817 |
| chr_3 | g2993 | g2993.t23 | exon | g2993.t23.exon6 | 21868882 | 21868992 |
| chr_3 | g2993 | g2993.t23 | exon | g2993.t23.exon7 | 21869064 | 21869132 |
| chr_3 | g2993 | g2993.t23 | TSS | g2993.t23 | 21869220 | 21869220 |
Sequences
>g2993.t23 Gene=g2993 Length=921
ATGAAATATTTCATATTATTTGCTGCATTGACAGCAGTTTGCTTTGGAGCTGACATTTTT
TCTGATGAATTCATCAATGAAATTAATAAAAAAGCAACAACATGGAAGGCTGGCCATAAT
TTTCATCCAGATACTAATTTGAAATATATCAAGAATTTACTTGGTGTTCATTCCGATTCT
TTGATGCTCGTGAACAATGGCCTGATTGTCCAACATTGAGAGAAATAAGAGATCAAGGAA
GTTGTGGATCTTGTTGGGCTTTTGGCGCTGTTGAGGCAATGAGTGACAGAGTATGCATTC
ATAGCAACGCAACTGAACATTTCCACTTTTCTGCTGAACATTTGGTTTCTTGCTGTCACA
CTTGTGGATTTGGTTGCAATGGTGGCTTTCCAGGATCAGCTTGGAGCTATTGGGTTAGAA
AAGGTATTGTTAGTGGTGGACCATACAATTCTTCAATTGGATCCATATGAAATCGCTCCT
TGTGAACATCATGTCAATGGAACTCGTATGCCATGCTCTGGAGAAGGACATACACCAAAA
TGCATGAATAAATGCTCGAATCCCGCTTATAAAGTTGATTTCAAAACAGACAAACACTTT
GGCAAATCAAGCTATTCAGTAAAGCGTAATGAAGATCAAATTCGTTTGGAAATTTTCAAA
AATGGTCCAGTTGAAGGTGCATTCACAGTCTATGAAGATTTCGTTCAATATAAATCTGGA
GTTTATCAACATGTTACTGGTAAAGCACTTGGTGGCCATGCTATTAAAATTTTCGGATGG
GGAGTTGAAAATGGTGTCAAATACTGGTTGATTGCTAATAGCTGGAATTCAGATTGGGGT
GATAATGGAACCTTCAAAATATTGCGAGGAGAAGACCATGTCGGTATTGAGAGTGAGATT
AGCGCTGGTTTGCCAAAGTAA
>g2993.t23 Gene=g2993 Length=180
MVAFQDQLGAIGLEKVLLVVDHTILQLDPYEIAPCEHHVNGTRMPCSGEGHTPKCMNKCS
NPAYKVDFKTDKHFGKSSYSVKRNEDQIRLEIFKNGPVEGAFTVYEDFVQYKSGVYQHVT
GKALGGHAIKIFGWGVENGVKYWLIANSWNSDWGDNGTFKILRGEDHVGIESEISAGLPK
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 6 | g2993.t23 | Gene3D | G3DSA:3.90.70.10 | Cysteine proteinases | 19 | 180 | 0 |
| 2 | g2993.t23 | PANTHER | PTHR12411:SF737 | CATHEPSIN B | 29 | 177 | 0 |
| 3 | g2993.t23 | PANTHER | PTHR12411 | CYSTEINE PROTEASE FAMILY C1-RELATED | 29 | 177 | 0 |
| 1 | g2993.t23 | Pfam | PF00112 | Papain family cysteine protease | 51 | 177 | 0 |
| 5 | g2993.t23 | SMART | SM00645 | pept_c1 | 1 | 178 | 0 |
| 4 | g2993.t23 | SUPERFAMILY | SSF54001 | Cysteine proteinases | 27 | 179 | 0 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0008234 | cysteine-type peptidase activity | MF |
| GO:0006508 | proteolysis | BP |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
