General information for g3365.t8
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as 6-phosphogluconate dehydrogenase, decarboxylating.
Parent gene
- The parent gene g3365 is located on chr_3: 24878799..24880042 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g3365 | g3365.t8 | TTS | g3365.t8 | 24877436 | 24877436 |
| chr_3 | g3365 | g3365.t8 | isoform | g3365.t8 | 24877527 | 24879862 |
| chr_3 | g3365 | g3365.t8 | exon | g3365.t8.exon1 | 24877527 | 24878344 |
| chr_3 | g3365 | g3365.t8 | cds | g3365.t8.CDS1 | 24877527 | 24878344 |
| chr_3 | g3365 | g3365.t8 | exon | g3365.t8.exon2 | 24878607 | 24878810 |
| chr_3 | g3365 | g3365.t8 | cds | g3365.t8.CDS2 | 24878607 | 24878810 |
| chr_3 | g3365 | g3365.t8 | exon | g3365.t8.exon3 | 24879231 | 24879345 |
| chr_3 | g3365 | g3365.t8 | cds | g3365.t8.CDS3 | 24879231 | 24879345 |
| chr_3 | g3365 | g3365.t8 | exon | g3365.t8.exon4 | 24879649 | 24879862 |
| chr_3 | g3365 | g3365.t8 | cds | g3365.t8.CDS4 | 24879649 | 24879723 |
| chr_3 | g3365 | g3365.t8 | TSS | g3365.t8 | 24879992 | 24879992 |
Sequences
>g3365.t8 Gene=g3365 Length=1351
ATGGCACAGTAAGTTCAATATTTATTCTTTTTACATGTGAAAATGTGATAATTTGCAAGA
GAAATTTGTGATAAATGATAAATGTTTTGCTTTCTTACAATGTAGAAAAGCTGATATCGC
ATTAATTGGGCTCGCAGTGATGGGTCAAAATTTGATACTTAATATGGATTCAAAAGGTTT
CGTTGTGTGTGCATTTAATCGTACTGTCGATAAGGTCAAGCAATTTTTGGAAAATGAGGC
AAAGGGAACAAAAATAATCGGTGCAACATCAATGGAAGATATGGTTAGCAAATTGAAGAC
TCCTCGACGTGTTATGCTTCTGGTCAAAGCTGGGAGTGCTGTTGATGATTTTATCAAACA
ATTAACTCCATTACTTTCACCTGGTGATATCATCATTGATGGTGGAAATTCTGAATATCA
AGATACTGCAAGACGTGTTGAAGAATGCAAAAAGAATAAATTATTGTTTGTTGGTTCAGG
TGTAAGCGGAGGTGAAGAAGGTGCACGTTATGGACCATCATTAATGCCTGGCGTGAGTCA
AAAAGAAATGGCTGATGCATTTACTGAATGGAACAAAGGCGAACTTGATTCTTTCCTCAT
TGAAATTACCAGTAGTATTCTCAATTATAAAGATAAGGAAGGATATTTGCTTGAACGTAT
TCGTGACACTGCTGGTCAAAAAGGTACTGGGAAATGGACTGCAATTGCTGCTCTTCAATA
CGGTGTACCCGTTACTCTAATTGGTGAAGCTGTCTTCTCTCGTTGCTTATCTGCTCTTAA
AAGTGAACGAGTTGCTGCAAGCAAAGTACTGAATGGTCCAGACACAAAACCAACTGTCGC
TAACAAGGCTGAATTCTTGAATCACATTAAGAATGCTCTTTATTGTGCAAAAATTGTTTC
ATATGCTCAAGGTTTTATGTTGATGCGTGAGGCTGCAAAGGAAAATGGCTGGCACTTAAA
TTATGGCGGTATTGCTTTGATGTGGAGAGGTGGTTGCATCATAAGAAGTGTATTCTTAGG
AAACATTAAAGAAGCATTCACTCGTAATCCACAATTATCAAATTTATTACTTGATGACTT
TTTCAAGAATGCAATTACTAAAAATCAAAATTCCTGGCGACAAGTTGTATCAAATGCGAC
ACTTTGGGGAATTCCAGTTCCAGCACTTTCAGCTGCTCTTGCCTTCTTTGACGGCTATCG
TGCTGATCGTCTTCCGGCTAATCTATTGCAAGCACAAAGAGACTTCTTTGGTGCTCATAC
ATATGAATTGTTAGGTCAAGAGGGCAAATTTGTTCATACAAATTGGACTGGAACTGGTGG
AAATGTTAGTGCATCATCATATAATGCATAA
>g3365.t8 Gene=g3365 Length=403
MGQNLILNMDSKGFVVCAFNRTVDKVKQFLENEAKGTKIIGATSMEDMVSKLKTPRRVML
LVKAGSAVDDFIKQLTPLLSPGDIIIDGGNSEYQDTARRVEECKKNKLLFVGSGVSGGEE
GARYGPSLMPGVSQKEMADAFTEWNKGELDSFLIEITSSILNYKDKEGYLLERIRDTAGQ
KGTGKWTAIAALQYGVPVTLIGEAVFSRCLSALKSERVAASKVLNGPDTKPTVANKAEFL
NHIKNALYCAKIVSYAQGFMLMREAAKENGWHLNYGGIALMWRGGCIIRSVFLGNIKEAF
TRNPQLSNLLLDDFFKNAITKNQNSWRQVVSNATLWGIPVPALSAALAFFDGYRADRLPA
NLLQAQRDFFGAHTYELLGQEGKFVHTNWTGTGGNVSASSYNA
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 13 | g3365.t8 | Gene3D | G3DSA:3.40.50.720 | - | 1 | 122 | 3.3E-7 |
| 15 | g3365.t8 | Gene3D | G3DSA:1.10.1040.10 | - | 127 | 356 | 1.8E-89 |
| 14 | g3365.t8 | Gene3D | G3DSA:1.20.5.320 | - | 357 | 403 | 3.6E-25 |
| 4 | g3365.t8 | PANTHER | PTHR11811:SF50 | 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING | 1 | 131 | 1.7E-184 |
| 6 | g3365.t8 | PANTHER | PTHR11811 | 6-PHOSPHOGLUCONATE DEHYDROGENASE | 1 | 131 | 1.7E-184 |
| 3 | g3365.t8 | PANTHER | PTHR11811:SF50 | 6-PHOSPHOGLUCONATE DEHYDROGENASE, DECARBOXYLATING | 131 | 402 | 1.7E-184 |
| 5 | g3365.t8 | PANTHER | PTHR11811 | 6-PHOSPHOGLUCONATE DEHYDROGENASE | 131 | 402 | 1.7E-184 |
| 8 | g3365.t8 | PRINTS | PR00076 | 6-phosphogluconate dehydrogenase signature | 54 | 83 | 7.4E-26 |
| 7 | g3365.t8 | PRINTS | PR00076 | 6-phosphogluconate dehydrogenase signature | 107 | 132 | 7.4E-26 |
| 2 | g3365.t8 | Pfam | PF03446 | NAD binding domain of 6-phosphogluconate dehydrogenase | 1 | 138 | 7.1E-37 |
| 1 | g3365.t8 | Pfam | PF00393 | 6-phosphogluconate dehydrogenase, C-terminal domain | 131 | 389 | 2.0E-107 |
| 12 | g3365.t8 | ProSitePatterns | PS00461 | 6-phosphogluconate dehydrogenase signature. | 174 | 186 | - |
| 11 | g3365.t8 | SMART | SM01350 | 6PGD_2 | 127 | 390 | 2.2E-169 |
| 9 | g3365.t8 | SUPERFAMILY | SSF51735 | NAD(P)-binding Rossmann-fold domains | 1 | 136 | 2.63E-37 |
| 10 | g3365.t8 | SUPERFAMILY | SSF48179 | 6-phosphogluconate dehydrogenase C-terminal domain-like | 130 | 393 | 1.31E-106 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0050661 | NADP binding | MF |
| GO:0006098 | pentose-phosphate shunt | BP |
| GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | MF |
| GO:0055114 | NA | NA |
| GO:0016491 | oxidoreductase activity | MF |
KEGG
Orthology
This gene did not have any KEGG ortholog annotations (KAAS, GHOSTZ).
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
