General information for g3717.t1
Yuki Yoshida
22/1/2022
Gene loci information
Transcript annotation
- This transcript has been annotated as SH3 and multiple ankyrin repeat domains protein 3.
Parent gene
- The parent gene g3717 is located on chr_3: 27628959..27630956 (- strand)
Gene structure
- The exon-intron structure of all isoforms are indicated below. CDS regions are colored in green. TSS and TTs that were predicted with CTR-Seq data are indicated in solid circle and squares, respectively. More specific data are shown in the table below.
| Chromosome | Gene | Transcript | Category | ID | Start | End |
|---|---|---|---|---|---|---|
| chr_3 | g3717 | g3717.t1 | isoform | g3717.t1 | 27622249 | 27629724 |
| chr_3 | g3717 | g3717.t1 | TTS | g3717.t1 | 27622249 | 27622249 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon1 | 27622249 | 27624339 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS1 | 27622249 | 27624339 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon2 | 27624404 | 27624611 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS2 | 27624404 | 27624611 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon3 | 27624681 | 27625065 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS3 | 27624681 | 27625065 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon4 | 27625719 | 27625994 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS4 | 27625719 | 27625994 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon5 | 27627418 | 27627484 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS5 | 27627418 | 27627484 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon6 | 27627547 | 27627644 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS6 | 27627547 | 27627644 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon7 | 27627705 | 27627801 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS7 | 27627705 | 27627801 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon8 | 27627880 | 27628048 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS8 | 27627880 | 27628048 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon9 | 27628108 | 27628439 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS9 | 27628108 | 27628439 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon10 | 27628952 | 27629077 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS10 | 27628952 | 27629077 |
| chr_3 | g3717 | g3717.t1 | exon | g3717.t1.exon11 | 27629557 | 27629724 |
| chr_3 | g3717 | g3717.t1 | cds | g3717.t1.CDS11 | 27629557 | 27629724 |
| chr_3 | g3717 | g3717.t1 | TSS | g3717.t1 | NA | NA |
Sequences
>g3717.t1 Gene=g3717 Length=4017
ATGGACACTCCATACAATGACGATGAATCTTCAACAGAGATAGCGAGGGAAGGCTGGATA
CTCCTTAGAATTCATGTTCCCGAATTCGATACCTATAAATGCTTGCAATTTCCAATCGAG
CAATTAGTTTGGGATATAAAAAATCAAGTGATTGCTTCATTGCCAAAAGAATTAAAAGAA
GCATTCAACTATGGACTATTTTCGCCACCATCAAATGGAAAAGCAGGAAAATTTCTAGAT
GAAGAGAGACGACTTGGTGACTATCCTTTTAGTGGTCCAGTTGGTTTCTTGGAGCTCAAA
TACAAACGTCGTGTCTATAAAATGTTGAACTTGGACGAACGACAATTGCGTGCATTGCAT
TCTCGATCGAATTTGAGAAGATTTTTGGAATGCATACATGGTGGTCATGTGGATAAAGTG
TCAAAAATGTGTGCAAAAGGACTCGATCCAAATTTTCATTGCAATGAAACTGGCGAGACA
CCATTAACAATAGCAGCATGTGCAAAAAAGCCGCAAAAATTATTAATTGCTCTTGTAAAT
GGTGGAGCATTGCTTGATTATAGAACTAAAGATGGAAGTACAGCTCTTCATCGTGCTGTT
GAAAAGGATTCACTTGAAGCTGTTACAACACTGCTTGAACTCGGTGCTTCACCAAATTAT
AAAGATATGAAAATGCTAACACCCGTTTATATTTCGGTTGCAAAGAAAATCGATCCGAAA
ATAACTGAGGTGCTATTGCATGATCATGCCACATTGGGAACGAAAGATTCGCAGGGTTGG
AATGAAGTTCATCAGGCTTGCCGAAATAACCTAGTTCAGCATTTGGAACATCTGCTGGCC
TACGGTGCGGATATGGATAGTAAAAATTCCACTGGAAACACACCACTGCATGTGTGCGCA
GTCAATAATCAAGAGACATGTGCCAGAATTCTATTGTTTCGTGGTGCCAATCGAGAGGCA
CTAAACTATGCCAATCAGACTCCTTATCAGGTGGCCGTCATTGCAAGTAACTTTGAATTA
GCCGATATGATACAAAACTTCAGGAACGAACATGTTGTTCCTATTCGAGAGTCTCCACGT
TACAATCCACGACGCAGATCTGGCATTCAATTTCTACACACTGAATCGACTTTGACGTCG
TCTATGTCAATGTATAATACTAGTAATATTACGTGGAACAATCAAACTTATCACGCATTT
GCGCGCAACTTTAGTCATCAACCACCGCCATCACCGTGTCTCTCCGATCAGCCATTTAAT
TCTACAAGTTCAAGCTTGTCTGAATCATCATCAAGTCATAGAAGTCAAGAAGACGACATA
AGTTTTGTAACAGATAAGAGTCTTGGTGATACAAGCGATACAAGTTCATCAGGTGTGGGC
ACCAATTCAGAATCAGCAATGTGTTCAATTGGTCATCCAAATACAACTGTTGTTTGTATT
GAAAAATATGAAGCAAAGACTTTCGGCCATCTCTCAATTCAACCGGGTGACGTCATAGAA
GTTGTTGGTTCTACTGATTGTGGTCTGTTGGAAGGATTTGTGCGAGGCACTTCCAACACT
GGACTTTTTCCCTCGCAATATATACAAGAAGTGCAATTTCGACATAAAAATGGTAACGGA
AACATTACAACCACTCTCGATCGTCAAAATAACAATCACACAAAGACAATCGATACAAAT
AATTTCGTTGACTCACAGCATGATGAAATTCTAAAGAAACCTATGTCAGTAACTGAACCT
CGTACGGTTATTCTTCAACGTTCTAAGCGCGGTTTTGGCTTTGTTCTTCGTGGTGCAAAA
GCTGCTTCACCATTGATGCAATTAAAACCATCTAGCAGATGTCCAGCATTGCAATATTTG
GACGATGTCGATCCAGGTGGTGTCGCAGATCTTGCTGGCCTTCGTAAGGGCGACTTTTTA
CTCTCGATAAATGGTGAAGATGTTTCGTGTGCATCGCACGAATATGTCGTTGAATTAATT
AGAAATTCGAGTGAAGTTGTAACTTTGACTGTTGTAACAGTTTTAGATCGAAATAATGAT
GTAATGAATCACTCAAACAGCAATATTCGTCAATTTTCAACATTGCCTCGACGTCTCAGT
ACTGGTGCAAATGCTAAAGCACCCGCTCCACCTAGAAGAGATCCTAAAACAACACTAAGC
GTTGGAAGAGCACGCGCAAGATCGATGGTCGCTGGTCTCGAAGGGAATGGCAATGACGAT
GACATTCATGAAAATATTTCTTTGAAAGCAAGTTCAATTGAATCAATAAATAAACAAAAT
CAGTCAGTTATGTCAACACCAGTTCAAACTTACGATTCATCAACAATGCGAACAGCAAGT
ATCAAATCAAGACCAACTTCAATTGGACGAATAACAGCAGCAGAATTAGAAGACTTGTTC
CAAAGACAGCAAGGCGCTGGAGATAATAAATTTTTGTCTATGATGAGTAGCTCTCGATTC
CAGTCAAGTTATGAGAAAACAACACCACAGGCATCACCATCAAAAGGTCCACTTGTTTAT
GCTAGCATTGCTGAGATGAAACGAAAGAATAAAAAGAATGGAACTTATGCACGACCTGTC
GCCATTCCCACAGTCACTTCAGATTTGAAACGCAGTTTTCACAGTTCACCTGACCTTCCT
AATGCACTAAATGGAAGCTCAACATGGACGAGTGGAATGCTCGTTAAAAAAGGCCATTTA
TCACAAGAAGATGTGCAGAATATTCACATGTCTATTCAAAGATTAAACTTGCCGCCACCT
GATTGTGCACCACCAGCTCCGCCCATCAATAATAATGCTACAATTAATCCAATCGGTGAC
ATTGTAAAAGTCGATGTTTGCCGTAAGTCAGAATACGATTCAACTGTAGCAATTCAGAAA
AAAATTCAACAACAAAAAACTAATCAAGAAATTTACGTTTCGAGCTTCAAACCAACGATC
AATGCAAAAATGTATGCCTCGCCGCAAGATCTCAAAATCAATGTTAATCCAGCAACAGCA
CCTTCAATTTTGCCATCATACAACGAACAAAACATTACAAAAATAAATTTGACCGGTACG
CAAGGCAATCTCAATCCATATGCACAGCCAGGCAAGATCGGAGTTGAACCAACAATAGTC
ATCGATCAAAACATGCCAGCACCTCCTGCCCCTCCAATACCTGAACCTGATTATTCTTCA
TCAGAAGAAGATGAAAAAGAAATGGAACTTGATGATAGTTCGGTTAATGCTATCGCAAAC
ATTCCATATGATGATGAGTGCACGAATACAATTAGAAAGAATGTGCAACGACCTAAAGAA
GAACAACAACAGCATCAATTAATGGTTGCAGAAACCTCAGGCTCAAGTGTTTCCTCGAAT
AATTCCAATGCAGTCCAACATTCCTTTACCGTAGATGAAATTAAAAAAATCCGTACAAAT
CTAAAATCATCATCGAAATCCATTGCAGCAACATCACTTGAAGGTGATAACAATTCATCA
TCTGGCGTTAGCAGTGATCAAGAAGTGAAAAATTCAACACCAGTCATCGTTCCTAAAGAA
ATTGAGCCGAAGAAAGTAATAATTTCGACTGAAGATGCACCAAGTGATGAAGACAGTCCA
CCTTTGGCTGAATTTCAACGTAATAATTCGCTCACAAGAAAGCAAGCATCAATTATTGCT
GCAAATAGAGCGAAAGCAATTTCAAACCGACAAATGGCACATGGAATTGTTTCTTTAACT
CAACTGCCACCACCAATTGAAGCCTATTCTGATGATGAGGATGAAAATGATAAGGAAATT
TTTGCACCACCTCCACCAGAATTTAGTGACATTGTTTCGAACACTAGATCATTGCATATT
AATAGTCATGACTATCATCAACCAAATCATCATCATGTACAGCAAAAAAGTGTAAGAATT
GTTGGTGCATTACCGAAACAAGTCAACTATGTGCCATCAACTGAAAAAGTTCGAAGTGGT
TCGCATCAACATCATCATATTCATCATTTTCATCATGGTCATCATCAACACCATTAG
>g3717.t1 Gene=g3717 Length=1338
MDTPYNDDESSTEIAREGWILLRIHVPEFDTYKCLQFPIEQLVWDIKNQVIASLPKELKE
AFNYGLFSPPSNGKAGKFLDEERRLGDYPFSGPVGFLELKYKRRVYKMLNLDERQLRALH
SRSNLRRFLECIHGGHVDKVSKMCAKGLDPNFHCNETGETPLTIAACAKKPQKLLIALVN
GGALLDYRTKDGSTALHRAVEKDSLEAVTTLLELGASPNYKDMKMLTPVYISVAKKIDPK
ITEVLLHDHATLGTKDSQGWNEVHQACRNNLVQHLEHLLAYGADMDSKNSTGNTPLHVCA
VNNQETCARILLFRGANREALNYANQTPYQVAVIASNFELADMIQNFRNEHVVPIRESPR
YNPRRRSGIQFLHTESTLTSSMSMYNTSNITWNNQTYHAFARNFSHQPPPSPCLSDQPFN
STSSSLSESSSSHRSQEDDISFVTDKSLGDTSDTSSSGVGTNSESAMCSIGHPNTTVVCI
EKYEAKTFGHLSIQPGDVIEVVGSTDCGLLEGFVRGTSNTGLFPSQYIQEVQFRHKNGNG
NITTTLDRQNNNHTKTIDTNNFVDSQHDEILKKPMSVTEPRTVILQRSKRGFGFVLRGAK
AASPLMQLKPSSRCPALQYLDDVDPGGVADLAGLRKGDFLLSINGEDVSCASHEYVVELI
RNSSEVVTLTVVTVLDRNNDVMNHSNSNIRQFSTLPRRLSTGANAKAPAPPRRDPKTTLS
VGRARARSMVAGLEGNGNDDDIHENISLKASSIESINKQNQSVMSTPVQTYDSSTMRTAS
IKSRPTSIGRITAAELEDLFQRQQGAGDNKFLSMMSSSRFQSSYEKTTPQASPSKGPLVY
ASIAEMKRKNKKNGTYARPVAIPTVTSDLKRSFHSSPDLPNALNGSSTWTSGMLVKKGHL
SQEDVQNIHMSIQRLNLPPPDCAPPAPPINNNATINPIGDIVKVDVCRKSEYDSTVAIQK
KIQQQKTNQEIYVSSFKPTINAKMYASPQDLKINVNPATAPSILPSYNEQNITKINLTGT
QGNLNPYAQPGKIGVEPTIVIDQNMPAPPAPPIPEPDYSSSEEDEKEMELDDSSVNAIAN
IPYDDECTNTIRKNVQRPKEEQQQHQLMVAETSGSSVSSNNSNAVQHSFTVDEIKKIRTN
LKSSSKSIAATSLEGDNNSSSGVSSDQEVKNSTPVIVPKEIEPKKVIISTEDAPSDEDSP
PLAEFQRNNSLTRKQASIIAANRAKAISNRQMAHGIVSLTQLPPPIEAYSDDEDENDKEI
FAPPPPEFSDIVSNTRSLHINSHDYHQPNHHHVQQKSVRIVGALPKQVNYVPSTEKVRSG
SHQHHHIHHFHHGHHQHH
Protein features from InterProScan
| Transcript | Database | ID | Name | Start | End | E.value | |
|---|---|---|---|---|---|---|---|
| 16 | g3717.t1 | CDD | cd17091 | FERM_F0_SHANK | 20 | 103 | 8.77E-44 |
| 17 | g3717.t1 | CDD | cd00992 | PDZ_signaling | 580 | 665 | 5.83947E-18 |
| 11 | g3717.t1 | Gene3D | G3DSA:3.10.20.90 | - | 20 | 100 | 7.3E-7 |
| 13 | g3717.t1 | Gene3D | G3DSA:1.25.40.20 | - | 101 | 257 | 2.5E-23 |
| 12 | g3717.t1 | Gene3D | G3DSA:1.25.40.20 | - | 258 | 352 | 5.3E-18 |
| 14 | g3717.t1 | Gene3D | G3DSA:2.30.30.40 | SH3 Domains | 474 | 531 | 8.0E-9 |
| 15 | g3717.t1 | Gene3D | G3DSA:2.30.42.10 | - | 572 | 680 | 7.0E-35 |
| 29 | g3717.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 409 | 462 | - |
| 24 | g3717.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 416 | 431 | - |
| 27 | g3717.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 445 | 462 | - |
| 30 | g3717.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 702 | 723 | - |
| 28 | g3717.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 764 | 783 | - |
| 25 | g3717.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1152 | 1172 | - |
| 31 | g3717.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1152 | 1175 | - |
| 26 | g3717.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1315 | 1338 | - |
| 32 | g3717.t1 | MobiDBLite | mobidb-lite | consensus disorder prediction | 1321 | 1338 | - |
| 6 | g3717.t1 | PANTHER | PTHR24135:SF18 | LD13733P | 12 | 1286 | 0.0 |
| 7 | g3717.t1 | PANTHER | PTHR24135 | SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN | 12 | 1286 | 0.0 |
| 5 | g3717.t1 | Pfam | PF16511 | N-terminal or F0 domain of Talin-head FERM | 22 | 90 | 3.2E-6 |
| 4 | g3717.t1 | Pfam | PF12796 | Ankyrin repeats (3 copies) | 134 | 222 | 2.6E-9 |
| 3 | g3717.t1 | Pfam | PF12796 | Ankyrin repeats (3 copies) | 264 | 339 | 2.8E-8 |
| 2 | g3717.t1 | Pfam | PF07653 | Variant SH3 domain | 477 | 531 | 5.9E-5 |
| 1 | g3717.t1 | Pfam | PF17820 | PDZ domain | 622 | 672 | 3.2E-11 |
| 33 | g3717.t1 | ProSiteProfiles | PS50297 | Ankyrin repeat region circular profile. | 135 | 344 | 43.529 |
| 36 | g3717.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 191 | 223 | 12.449 |
| 35 | g3717.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 258 | 290 | 9.805 |
| 37 | g3717.t1 | ProSiteProfiles | PS50088 | Ankyrin repeat profile. | 291 | 323 | 10.579 |
| 34 | g3717.t1 | ProSiteProfiles | PS50002 | Src homology 3 (SH3) domain profile. | 472 | 533 | 17.662 |
| 38 | g3717.t1 | ProSiteProfiles | PS50106 | PDZ domain profile. | 582 | 675 | 16.828 |
| 23 | g3717.t1 | SMART | SM00248 | ANK_2a | 157 | 187 | 240.0 |
| 22 | g3717.t1 | SMART | SM00248 | ANK_2a | 191 | 220 | 5.4E-4 |
| 20 | g3717.t1 | SMART | SM00248 | ANK_2a | 258 | 287 | 2.8 |
| 21 | g3717.t1 | SMART | SM00248 | ANK_2a | 291 | 320 | 0.0017 |
| 19 | g3717.t1 | SMART | SM00326 | SH3_2 | 475 | 532 | 1.2E-8 |
| 18 | g3717.t1 | SMART | SM00228 | pdz_new | 590 | 675 | 9.0E-17 |
| 8 | g3717.t1 | SUPERFAMILY | SSF48403 | Ankyrin repeat | 124 | 346 | 1.41E-44 |
| 10 | g3717.t1 | SUPERFAMILY | SSF50044 | SH3-domain | 471 | 537 | 3.15E-12 |
| 9 | g3717.t1 | SUPERFAMILY | SSF50156 | PDZ domain-like | 565 | 673 | 9.46E-20 |
Transmembrane regions from TMHMM
Disordered region
IUPRED3 score over 0.5 is predictive of a disordered region.
GO terms from InterProScan
| GOID | TERM | ONTOLOGY |
|---|---|---|
| GO:0005515 | protein binding | MF |
KEGG
Orthology
- This transcript has been annotated with K15009 (SH3 and multiple ankyrin repeat domains protein)
Pathway
- This transcript belongs to the following pathways
Expression
Transcript expression in Pv11 cells
TPM values are indicated as average +/- STDEV. 
Differential expression
Differentially expressed genes were identified with DESeq2 using the ‘run_DE_analysis.pl’ script from Trinity. Transcripts were determined as differentially expressed when (1) FDR < 0.05 (2) fold change > 2 (TPM calculated by RSEM). DE information and fold change between conditions are indicated in the plot below.
